Cited by 159Nutritional Studies and DietFatty Acid Research and HealthNutrition, Genetics, and Disease

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Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

Llorente-Cortés, Vicenta, Estruch, Ramón, Mena, Mari Pau, Ros, Emilio, González, Miguel Angel Martínez, Fitó, Montserrat, Lamuela-Raventós, Rosa María, Badimon, Lina·2010·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2009.08.004

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Abstract

Experimental and epidemiological studies have demonstrated the beneficial effects of the traditional Mediterranean diet (TMD) on the incidence and progression of atherosclerosis. Several genes play a major role in determining atherosclerosis susceptibility. We compared the short-term effects of two TMD diets versus a control diet on the expression of pro-atherogenic genes. One TMD diet was supplemented with virgin olive oil (VOO) (TMD+VOO) and the other with nuts (TMD+nuts). Gene expression was analyzed in monocytes from 49 asymptomatic high cardiovascular-risk participants (23 men, 26 women), aged 55-80 years. Monocytes were isolated from blood before and 3 months after dietary intervention. We analyzed the expression of genes involved in inflammation [cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein (MCP-1)], genes involved in foam cell formation [low-density lipoprotein receptor-related protein (LRP1), LDL receptor and CD36], and genes involved in thrombosis [tissue factor (TF) and tissue factor pathway inhibitor (TFPI)]. We found that TMD+VOO intervention prevented an increase in COX-2 and LRP1, and reduced MCP-1 expression compared to TMD+nuts or control diet interventions. TMD+nuts specifically increased the expression of CD36 and TFPI compared to TMD+VOO and control diet intervention. Our findings showed that the Mediterranean diet influences expression of key genes involved in vascular inflammation, foam cell formation and thrombosis. Dietary intervention can thus actively modulate the expression of pro-atherothrombotic genes even in a high-risk population.

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Authors: Llorente-Cortés, V., Estruch, R., Mena, M. P., Ros, E., González, M. A. M., Fitó, M., Lamuela-Raventós, R. M., & Badimon, L.
Affiliations: Instituto de Salud Carlos III (ES)
ORCID: Estruch, Ramón
Mena, Mari Pau
Ros, Emilio
Fitó, Montserrat
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2010-02
Volume: 208
Issue: 2
Pages: 442-450
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2009.08.004
OpenAlex: W2113606520
Cited by: 159
References: 60
Citations by year: 2026: 2 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 7 · 2014: 19 · 2013: 11 · 2012: 14
FWCI: 9.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Funders: Instituto de Salud Carlos III (RD06/0003/0015, RD06/0045, PI070473)
MEC (SAF 2006/10091)
MICINN (AGL2006-14228-C03-01/ALI)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: Mediterranean diet, virgin olive oil, nuts, monocytes, gene expression, inflammation, foam cell formation, thrombosis, cyclooxygenase-2, MCP-1, LRP1, CD36, tissue factor, tissue factor pathway inhibitor, high cardiovascular risk, dietary intervention
MeSH terms: Olive Oil, Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Monocytes, Nuts, Plant Oils, Risk, Chemokine CCL2, CD36 Antigens, Low Density Lipoprotein Receptor-Related Protein-1, Diet, Mediterranean, Atherosclerosis, Cyclooxygenase 1, Cyclooxygenase 2

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Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

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