The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk
Abstract
Experimental and epidemiological studies have demonstrated the beneficial effects of the traditional Mediterranean diet (TMD) on the incidence and progression of atherosclerosis. Several genes play a major role in determining atherosclerosis susceptibility. We compared the short-term effects of two TMD diets versus a control diet on the expression of pro-atherogenic genes. One TMD diet was supplemented with virgin olive oil (VOO) (TMD+VOO) and the other with nuts (TMD+nuts). Gene expression was analyzed in monocytes from 49 asymptomatic high cardiovascular-risk participants (23 men, 26 women), aged 55-80 years. Monocytes were isolated from blood before and 3 months after dietary intervention. We analyzed the expression of genes involved in inflammation [cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein (MCP-1)], genes involved in foam cell formation [low-density lipoprotein receptor-related protein (LRP1), LDL receptor and CD36], and genes involved in thrombosis [tissue factor (TF) and tissue factor pathway inhibitor (TFPI)]. We found that TMD+VOO intervention prevented an increase in COX-2 and LRP1, and reduced MCP-1 expression compared to TMD+nuts or control diet interventions. TMD+nuts specifically increased the expression of CD36 and TFPI compared to TMD+VOO and control diet intervention. Our findings showed that the Mediterranean diet influences expression of key genes involved in vascular inflammation, foam cell formation and thrombosis. Dietary intervention can thus actively modulate the expression of pro-atherothrombotic genes even in a high-risk population.
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“In an intervention study conducted by Llorente-Cortés et al. in 2010 on a population with a high risk of ASCVD (n = 49), it was found that after 3 months, subjects who followed MD integrated with virgin olive oil or nuts showed not only a reduction in interleukin-6 and soluble intercellular adhesion molecule-1, significant inflammation mediators in the adhesion of leukocytes to the endothelial”
From Mediterranean Diet and Obesity-related Disorders: What is the Evidence? (2022) · cites this paper as [120]
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The Mediterranean Diet, its Components, and Cardiovascular Disease
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“Further RCT evidence supports the use of a Mediterranean diet to reduce genetic predisposition for risk factors, not cardiovascular disease morbidity or mortality and their complications, in a high-risk population (9).”
BackgroundThe Mediterranean Diet and Cardiovascular Health: A Critical Review
Martínez-González, M. A., Gea, A., & Ruiz-Canela, M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313348 · Cited by 878
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Benefits of the Mediterranean Diet: Insights From the PREDIMED Study
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Self-citationMediterranean diet and cardiovascular health: teachings of the PREDIMED study
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Metadata
- Authors
- Llorente-Cortés, V., Estruch, R., Mena, M. P., Ros, E., González, M. A. M., Fitó, M., Lamuela-Raventós, R. M., & Badimon, L.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 208
- Issue
- 2
- Pages
- 442-450
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W2113606520
- Cited by
- 159
- References
- 60
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 7 · 2014: 19 · 2013: 11 · 2012: 14
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III (RD06/0003/0015, RD06/0045, PI070473)
- MEC (SAF 2006/10091)
- MICINN (AGL2006-14228-C03-01/ALI)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- Mediterranean diet, virgin olive oil, nuts, monocytes, gene expression, inflammation, foam cell formation, thrombosis, cyclooxygenase-2, MCP-1, LRP1, CD36, tissue factor, tissue factor pathway inhibitor, high cardiovascular risk, dietary intervention
- MeSH terms
- Olive Oil, Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Monocytes, Nuts, Plant Oils, Risk, Chemokine CCL2, CD36 Antigens, Low Density Lipoprotein Receptor-Related Protein-1, Diet, Mediterranean, Atherosclerosis, Cyclooxygenase 1, Cyclooxygenase 2
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