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Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

Llorente-Cortés, Vicenta, Estruch, Ramón, Mena, Mari Pau, Ros, Emilio, González, Miguel Angel Martínez, Fitó, Montserrat, Lamuela-Raventós, Rosa María, Badimon, Lina·2010·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2009.08.004

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Abstract

Experimental and epidemiological studies have demonstrated the beneficial effects of the traditional Mediterranean diet (TMD) on the incidence and progression of atherosclerosis. Several genes play a major role in determining atherosclerosis susceptibility. We compared the short-term effects of two TMD diets versus a control diet on the expression of pro-atherogenic genes. One TMD diet was supplemented with virgin olive oil (VOO) (TMD+VOO) and the other with nuts (TMD+nuts). Gene expression was analyzed in monocytes from 49 asymptomatic high cardiovascular-risk participants (23 men, 26 women), aged 55-80 years. Monocytes were isolated from blood before and 3 months after dietary intervention. We analyzed the expression of genes involved in inflammation [cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein (MCP-1)], genes involved in foam cell formation [low-density lipoprotein receptor-related protein (LRP1), LDL receptor and CD36], and genes involved in thrombosis [tissue factor (TF) and tissue factor pathway inhibitor (TFPI)]. We found that TMD+VOO intervention prevented an increase in COX-2 and LRP1, and reduced MCP-1 expression compared to TMD+nuts or control diet interventions. TMD+nuts specifically increased the expression of CD36 and TFPI compared to TMD+VOO and control diet intervention. Our findings showed that the Mediterranean diet influences expression of key genes involved in vascular inflammation, foam cell formation and thrombosis. Dietary intervention can thus actively modulate the expression of pro-atherothrombotic genes even in a high-risk population.

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Cyclooxygenases: Structural, cellular, and molecular biology
Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925
THE DIET AND 15-YEAR DEATH RATE IN THE SEVEN COUNTRIES STUDY
KEYS, A., MIENOTTI, A., KARVONEN, M. J., ARAVANIS, C., BLACKBURN, H., BUZINA, R., DJORDJEVIC, B. S., DONTAS, A. S., FIDANZA, F., KEYS, M. H., et al. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114480 · Cited by 1,790
Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial
Estruch, R., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Vinyoles, E., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-1-200607040-00004 · Cited by 1,704
Self-citation
AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W., Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., et al. (2000) · Circulation · doi:10.1161/01.cir.102.18.2284 · Cited by 1,458
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Suzuki, H. I., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T., et al. (1997) · Nature · doi:10.1038/386292a0 · Cited by 1,226
Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages*
Kunjathoor, V., Febbraio, M., Podrez, E., Moore, K., Andersson, L., Koehn, S. L., Rhee, J. S., Silverstein, R., Hoff, H., & Freeman, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209649200 · Cited by 1,064
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9259 · Cited by 1,037
Development and Validation of a Food Frequency Questionnaire in Spain
Martin-Moreno, J. M., Boyle, P., Gorgojo, L., Maisonneuve, P., Fernandez‐Rodriguez, J. C., Salvini, S., & Willett, W. C. (1993) · International Journal of Epidemiology · doi:10.1093/ije/22.3.512 · Cited by 909
Ibuprofen-like activity in extra-virgin olive oil
Beauchamp, G. K., Keast, R. S. J., Morel, D., Lin, J., Pika, J., Han, Q., Lee, C.-H., Smith, A. B., & Breslin, P. A. S. (2005) · Nature · doi:10.1038/437045a · Cited by 885
Chemokines in the Pathogenesis of Vascular Disease
Charo, I. F., & Taubman, M. B. (2004) · Circulation Research · doi:10.1161/01.res.0000146672.10582.17 · Cited by 758

Show all 60 references

Research works printed but not linked: 3

Harris, 2005, Alpha-linolelic acid: a gift from the land? Circulation, 111, 2872
Belton, 2000, Cyclooxigenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis, Circulation, 102, 840, 10.1161/01.CIR.102.8.840 · DOI
Dragomir, 2006, Monocyte chemoattractant protein-1, a major contributor to the inflammatory process associated with diabetes, Arch Physiol Biochem, 112, 239, 10.1080/13813450601094672 · DOI

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Authors: Llorente-Cortés, V., Estruch, R., Mena, M. P., Ros, E., González, M. A. M., Fitó, M., Lamuela-Raventós, R. M., & Badimon, L.
Affiliations: Instituto de Salud Carlos III (ES)
ORCID: Estruch, Ramón
Mena, Mari Pau
Ros, Emilio
Fitó, Montserrat
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2010-02
Volume: 208
Issue: 2
Pages: 442-450
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2009.08.004
OpenAlex: W2113606520
Cited by: 159
References: 60
Citations by year: 2026: 2 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 8 · 2019: 14 · 2018: 6 · 2017: 8 · 2016: 15 · 2015: 7 · 2014: 19 · 2013: 11 · 2012: 14
FWCI: 9.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Funders: Instituto de Salud Carlos III (RD06/0003/0015, RD06/0045, PI070473)
MEC (SAF 2006/10091)
MICINN (AGL2006-14228-C03-01/ALI)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: Mediterranean diet, virgin olive oil, nuts, monocytes, gene expression, inflammation, foam cell formation, thrombosis, cyclooxygenase-2, MCP-1, LRP1, CD36, tissue factor, tissue factor pathway inhibitor, high cardiovascular risk, dietary intervention
MeSH terms: Olive Oil, Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Humans, Inflammation, Lipoproteins, Male, Middle Aged, Monocytes, Nuts, Plant Oils, Risk, Chemokine CCL2, CD36 Antigens, Low Density Lipoprotein Receptor-Related Protein-1, Diet, Mediterranean, Atherosclerosis, Cyclooxygenase 1, Cyclooxygenase 2

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Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk

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