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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Furin Is the Primary in Vivo Convertase of Angiopoietin-like 3 and Endothelial Lipase in Hepatocytes

Essalmani, Rachid, Susan-Resiga, Delia, Chamberland, Ann, Asselin, Marie-Claude, Canuel, Maryssa, Constam, Daniel, Creemers, John W., Day, Robert, Gauthier, Dany, Prat, Annik, Seidah, Nabil G.·2013·Journal of Biological Chemistry
DOI 10.1074/jbc.m113.501304
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  • ANGPTL3 contains a protease cleavage site and in vivo can be cleaved into two domains both intracellularly by PCSK3 and extracellularly by PACE4.

    “ANGPTL3 contains a protease cleavage site, and in vivo can be cleaved into two domains both intracellularly by PCSK3 and extracellularly by PACE4 (107, 124, 131, 132).”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [131]

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Research works printed but not linked: 41

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  2. Mayer, 2008, The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates, J. Biol. Chem, 283, 2373, 10.1074/jbc.M708763200 · DOI
  3. Seidah, 2013, The multifaceted Proprotein Convertases: their unique, redundant, complementary and opposite functions, J. Biol. Chem, 288, 21473, 10.1074/jbc.R113.481549 · DOI
  4. Roebroek, 1998, Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin, Development, 125, 4863, 10.1242/dev.125.24.4863 · DOI
  5. Essalmani, 2008, In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate, Proc. Natl. Acad. Sci. U.S.A, 105, 5750, 10.1073/pnas.0709428105 · DOI
  6. Szumska, 2008, VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5, Genes Dev, 22, 1465, 10.1101/gad.479408 · DOI
  7. Constam, 2000, SPC4/PACE4 regulates a TGFβ signaling network during axis formation, Genes Dev, 14, 1146, 10.1101/gad.14.9.1146 · DOI
  8. Hirata, 1999, Cloning of a unique lipase from endothelial cells extends the lipase gene family, J. Biol. Chem, 274, 14170, 10.1074/jbc.274.20.14170 · DOI
  9. Broedl, 2004, Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation, Trends Cardiovasc. Med, 14, 202, 10.1016/j.tcm.2004.03.003 · DOI
  10. Jaye, 1999, A novel endothelial-derived lipase that modulates HDL metabolism, Nat. Genet, 21, 424, 10.1038/7766 · DOI · Paper page
  11. Ma, 2003, Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism, Proc. Natl. Acad. Sci. U.S.A, 100, 2748, 10.1073/pnas.0438039100 · DOI · Paper page
  12. Hara, 2011, Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo, J. Lipid Res, 52, 57, 10.1194/jlr.M008417 · DOI
  13. Jin, 2003, Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo, J. Clin. Invest, 111, 357, 10.1172/JCI16146 · DOI
  14. Ishida, 2003, Endothelial lipase is a major determinant of HDL level, J. Clin. Invest, 111, 347, 10.1172/JCI16306 · DOI
  15. Nijstad, 2009, Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase, J. Biol. Chem, 284, 6093, 10.1074/jbc.M807683200 · DOI
  16. McCoy, 2002, Characterization of the lipolytic activity of endothelial lipase, J. Lipid Res, 43, 921, 10.1016/S0022-2275(20)30466-1 · DOI · Paper page
  17. Jin, 2007, Hepatic proprotein convertases modulate HDL metabolism, Cell Metabolism, 6, 129, 10.1016/j.cmet.2007.07.009 · DOI · Paper page
  18. Fuki, 2003, Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway, J. Biol. Chem, 278, 34331, 10.1074/jbc.M302181200 · DOI
  19. Qiu, 2007, Endothelial lipase enhances low density lipoprotein binding and cell association in THP-1 macrophages, Cardiovasc. Res, 76, 528, 10.1016/j.cardiores.2007.08.002 · DOI
  20. Gauster, 2005, Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family, J. Lipid Res, 46, 977, 10.1194/jlr.M400500-JLR200 · DOI
  21. Jin, 2005, Proprotein convertases are responsible for proteolysis and inactivation of endothelial lipase, J. Biol. Chem, 280, 36551, 10.1074/jbc.M502264200 · DOI · Paper page
  22. Ono, 2003, Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo, J. Biol. Chem, 278, 41804, 10.1074/jbc.M302861200 · DOI · Paper page
  23. Shimamura, 2007, Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase, Arterioscler. Thromb. Vasc. Biol, 27, 366, 10.1161/01.ATV.0000252827.51626.89 · DOI · Paper page
  24. Quagliarini, 2012, Atypical angiopoietin-like protein that regulates ANGPTL3, Proc. Natl. Acad. Sci. U.S.A, 109, 19751, 10.1073/pnas.1217552109 · DOI · Paper page
  25. Camenisch, 2002, ANGPTL3 stimulates endothelial cell adhesion and migration via integrin αvβ3 and induces blood vessel formation in vivo, J. Biol. Chem, 277, 17281, 10.1074/jbc.M109768200 · DOI
  26. Kim, 1999, Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting, J. Biol. Chem, 274, 26523, 10.1074/jbc.274.37.26523 · DOI
  27. Koishi, 2002, Angptl3 regulates lipid metabolism in mice, Nat. Genet, 30, 151, 10.1038/ng814 · DOI · Paper page
  28. Lee, 2009, Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL), J. Biol. Chem, 284, 13735, 10.1074/jbc.M807899200 · DOI · Paper page
  29. Liu, 2010, Angiopoietin-like protein 3 inhibits lipoprotein lipase activity through enhancing its cleavage by proprotein convertases, J. Biol. Chem, 285, 27561, 10.1074/jbc.M110.144279 · DOI · Paper page
  30. Essalmani, 2011, In vivo evidence that furin from hepatocytes inactivates PCSK9, J. Biol. Chem, 286, 4257, 10.1074/jbc.M110.192104 · DOI · Paper page
  31. Roebroek, 2004, Limited redundancy of the proprotein convertase furin in mouse liver, J. Biol. Chem, 279, 53442, 10.1074/jbc.M407152200 · DOI
  32. Susan-Resiga, 2011, Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10, J. Biol. Chem, 286, 22785, 10.1074/jbc.M111.233577 · DOI
  33. Zhong, 1999, The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity, J. Biol. Chem, 274, 33913, 10.1074/jbc.274.48.33913 · DOI
  34. Benjannet, 1997, Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway, J. Biol. Chem, 272, 26210, 10.1074/jbc.272.42.26210 · DOI
  35. Kim, 2012, Loss of endothelial furin leads to cardiac malformation and early postnatal death, Mol. Cell Biol, 32, 3382, 10.1128/MCB.06331-11 · DOI
  36. Marchesi, 2011, Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy, J. Mol. Med, 89, 1103, 10.1007/s00109-011-0776-9 · DOI
  37. Basu, 2013, Measurement of the phospholipase activity of endothelial lipase in mouse plasma, J. Lipid Res, 54, 282, 10.1194/jlr.D031112 · DOI
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  39. Seidah, 2008, The activation and physiological functions of the proprotein convertases, Int. J. Biochem. Cell Biol, 40, 1111, 10.1016/j.biocel.2008.01.030 · DOI · Paper page
  40. Schjoldager, 2010, O-Glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-like Protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipids, J. Biol. Chem, 285, 36293, 10.1074/jbc.M110.156950 · DOI
  41. Lei, 2011, Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity, J. Biol. Chem, 286, 15747, 10.1074/jbc.M110.217638 · DOI · Paper page

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Metadata

Authors
Essalmani, R., Susan-Resiga, D., Chamberland, A., Asselin, M.-C., Canuel, M., Constam, D., Creemers, J. W., Day, R., Gauthier, D., Prat, A., & Seidah, N. G.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2013-09
Volume
288
Issue
37
Pages
26410-26418
ISSN
0021-9258
DOI
10.1074/jbc.m113.501304
Cited by
54
References
5
Language
en
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