The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
The neural basis of cognitive control: Response selection and inhibition
Open accessAbstract
The functional neuroanatomy of tasks that recruit different forms of response selection and inhibition has to our knowledge, never been directly addressed in a single fMRI study using similar stimulus-response paradigms where differences between scanning time and sequence, stimuli, and experimenter instructions were minimized. Twelve right-handed participants were scanned on two standard cognitive control tasks, a stimulus-response incompatibility task, and a response inhibition task. A compound trial design allowed comparison of preparing to inhibit an upcoming automatic response to wholly inhibiting an automatic response. Furthermore, inhibiting an automatic response to perform an alternative task-relevant response was compared to wholly inhibiting an automatic response. No differences were found in prefrontal activity when preparing to inhibit an automatic response was compared to wholly inhibiting an automatic response, suggesting a mostly common network. The left inferior frontal gyrus was found to be commonly recruited during both tasks when controlled responses were required, likely due to its role in response selection. In contrast, the right inferior frontal gyrus was found to be more involved when task demands were stronger for response inhibition. Our results are largely consistent with models of cognitive control that postulate that separate psychological constructs, such as response selection and inhibition, are related processes largely served by a common prefrontal network. This prefrontal network is recruited to a greater or lesser extent depending on specific task demands.
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Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · cited 4×
“Cognitive control is the ability to engage in goal-oriented behaviors, allowing the brain to solve difficult, novel, or complex tasks, such as correcting errors or overcoming automatic responses in favor of weaker, task-relevant responses (Miller & Cohen, 2001).”
InfluentialMacDonald, A. W., Cohen, J. D., Stenger, V. A., & Carter, C. S. (2000) · Science · doi:10.1126/science.288.5472.1835 · Cited by 3,666
Self-citationForman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · cited 2×
“Functional activations were considered over threshold if 8 contiguous voxels were activated at p 0.005 (df = 11) (Forman et al., 1995).”
InfluentialInhibition and the right inferior frontal cortex
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.02.010 · Cited by 3,197
Common regions of the human frontal lobe recruited by diverse cognitive demands
Duncan, J., & Owen, A. M. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01633-7 · Cited by 2,498 · cited 8×
“all these explanations played a role in the functional imaging findings reviewed by Duncan and Owen (2000). The goal of the current study was to investigate two forms of response selection and inhibition at different points in a trial, while to the extent possible equate the cognitive paradigms utilized for methodolog…”
InfluentialCohen, J. D., Dunbar, K. N., & McClelland, J. L. (1990) · Psychological Review · doi:10.1037/0033-295x.97.3.332 · Cited by 2,192
Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans
Aron, A. R., Fletcher, P. C., Bullmore, E. T., Sahakian, B. J., & Robbins, T. W. (2003) · Nature Neuroscience · doi:10.1038/nn1003 · Cited by 1,771
(2008) · doi:10.1093/acprof:oso/9780195168648.001.0001 · Cited by 1,529
Vogt, B. A., Finch, D. M., & Olson, C. R. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.6.435-a · Cited by 1,315
Immature Frontal Lobe Contributions to Cognitive Control in Children
Bunge, S. A., Dudukovic, N. M., Thomason, M. E., Vaidya, C. J., & Gabrieli, J. D. E. (2002) · Neuron · doi:10.1016/s0896-6273(01)00583-9 · Cited by 1,291 · cited 1×
“It is important to note though in this study we found the right inferior frontal gyrus to be activated above threshold during response-related activity for both tasks and this is consistent with both tasks involving variations of response inhibition (Bunge et al., 2002a; Konishi et al., 1999).”
Simmonds, D. J., Pekar, J. J., & Mostofsky, S. H. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.07.015 · Cited by 1,015 · cited 1×
“The middle temporal gyrus has been found to be activated in a meta-analysis of complex Go/ NoGo tasks involving working memory (Simmonds et al., 2008).”
Learned predictions of error likelihood in the anterior cingulate cortex
Brown, J. W., & Braver, T. S. (2005) · Science · doi:10.1126/science.1105783 · Cited by 928 · cited 1×
“…we expected activations in the middle frontal (BA 9, 10, and 46), inferior frontal (BA 44, 45, and 47), anterior cingulate (BA 24, and 32), and parietal cortices (BA 7, 40; Barber & Carter, 2005; Brown & Braver, 2005; Goghari & MacDonald, 2008; Weissman, Gopalakrishnan, Hazlett, & Woldorff, 2005).”
Badre, D., Poldrack, R. A., Paré-Blagoev, E. J., Insler, R. Z., & Wagner, A. D. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.023 · Cited by 914 · cited 5×
“Similarly, Badre et al. (2005) demonstrated that the left mid-inferior frontal region ( BA 45), which is similar to the region we found, may be useful for general selection processes. In addition, the Badre and colleagues found that the role of the left mid-inferior frontal gyrus was distinct from the role of the left…”
InfluentialExplaining the Many Varieties of Working Memory Variation: Dual Mechanisms of Cognitive Control
Braver, T. S., Gray, J. R., & Burgess, G. C. (2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195168648.003.0004 · Cited by 886
Rubia, K., Smith, A. B., Brammer, M. J., & Taylor, E. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00275-1 · Cited by 852
Konishi, S., Nakajima, K., Uchida, I., Kikyo, H., Kameyama, M., & Miyashita, Y. (1999) · Brain · doi:10.1093/brain/122.5.981 · Cited by 823 · cited 1×
“It is important to note though in this study we found the right inferior frontal gyrus to be activated above threshold during response-related activity for both tasks and this is consistent with both tasks involving variations of response inhibition (Bunge et al., 2002a; Konishi et al., 1999).”
Cognitive and Brain Consequences of Conflict
Fan, J., Flombaum, J., McCandliss, B. D., Thomas, K. M., & Posner, M. I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1319 · Cited by 712
The Role of Parietal Cortex in Verbal Working Memory
Jonides, J., Schumacher, E. H., Smith, E. E., Koeppe, R. A., Awh, E., Reuter‐Lorenz, P. A., Marshuetz, C., & Willis, C. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-13-05026.1998 · Cited by 575 · cited 1×
“Parietal regions (BA 40) have also been found to be important for the short-term storage of verbal material (Jonides et al., 1998).”
Guidelines for reporting an fMRI study
Poldrack, R. A., Fletcher, P. C., Henson, R. N., Worsley, K. J., Brett, M., & Nichols, T. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.048 · Cited by 550 · cited 1×
“In the future, investigators may wish to carefully consider and report how characteristics of their tasks, analysis pipeline, and imaging design may be affecting their results when attempting to reconcile the functional neuroanatomy of inter-connected cognitive processes (Poldrack et al., 2008).”
Response Inhibition and Response Selection: Two Sides of the Same Coin
Mostofsky, S. H., & Simmonds, D. J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20500 · Cited by 514 · cited 2×
“In support of this theory, behavioral, neuroimaging, and lesion data suggest that pre-supplementary motor circuits are critical to both engaging in a motor response as well as selecting to withhold a response (reviewed in Mostofsky & Simmonds, 2008).”
Common and unique components of response inhibition revealed by fMRI
Wager, T. D., Sylvester, C.-Y. C., Lacey, S. C., Nee, D. E., Franklin, M., & Jonides, J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.054 · Cited by 486 · cited 1×
“Wager et al. (2005) compared three forms of response inhibition: stimulus–response incompatibility, which involved inhibiting an automatic response to select a task-relevant response; a Go/NoGo paradigm, which involved wholly inhibiting a response (i.e., omitting a response); and a flanker task,…”
Dissociable contributions of prefrontal and parietal cortices to response selection
Bunge, S. A., Hazeltine, E., Scanlon, M. D., Rosen, A. C., & Gabrieli, J. D. E. (2002) · NeuroImage · doi:10.1006/nimg.2002.1252 · Cited by 468 · cited 1×
“It is important to note though in this study we found the right inferior frontal gyrus to be activated above threshold during response-related activity for both tasks and this is consistent with both tasks involving variations of response inhibition (Bunge et al., 2002a; Konishi et al., 1999).”
Rushworth, M. F. S., Krams, M., & Passingham, R. E. (2001) · Journal of Cognitive Neuroscience · doi:10.1162/089892901750363244 · Cited by 390
Variability in fMRI: An Examination of Intersession Differences
McGonigle, D. J., Howseman, A., Athwal, B. S., Friston, K. J., Frackowiak, R. S. J., & Holmes, A. P. (2000) · NeuroImage · doi:10.1006/nimg.2000.0562 · Cited by 350
Weissman, D. H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh125 · Cited by 314
Selecting Among Competing Alternatives: Selection and Retrieval in the Left Inferior Frontal Gyrus
Moss, H. E., Abdallah, S., Fletcher, P., Bright, P., Pilgrim, L., Acres, K., & Tyler, L. K. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi049 · Cited by 244 · cited 1×
“Moss et al. (2005) varied selection demands while controlling for retrieval demands and found evidence for increased activation in the left inferior frontal gyrus with increased selection demands.”
Dissociable mechanisms of cognitive control in prefrontal and premotor cortex
Chambers, C. D., Bellgrove, M. A., Gould, I. C., English, T., Garavan, H., McNaught, E., Kamke, M., & Mattingley, J. B. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00685.2007 · Cited by 239 · cited 2×
“Additional evidence is provided by a study which used repetitive transcranial magnetic stimulation and compared a stop/signal task (more response inhibition) to a flanker task (more response competition) and found the right inferior frontal gyrus to be especially crucial for inhibiting a response tendency especially i…”
Who Comes First? The Role of the Prefrontal and Parietal Cortex in Cognitive Control
Brass, M., Ullsperger, M., Knoesche, T. R., Cramon, D. Y. V., & Phillips, N. A. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929054985400 · Cited by 236
Cognitive Control Involved in Overcoming Prepotent Response Tendencies and Switching Between Tasks
Barber, A. D., & Carter, C. S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh189 · Cited by 183 · cited 1×
“…we expected activations in the middle frontal (BA 9, 10, and 46), inferior frontal (BA 44, 45, and 47), anterior cingulate (BA 24, and 32), and parietal cortices (BA 7, 40; Barber & Carter, 2005; Brown & Braver, 2005; Goghari & MacDonald, 2008; Weissman, Gopalakrishnan, Hazlett, & Woldorff, 2005).”
Variability in fMRI: A re‐examination of inter‐session differences
Smith, S. M., Beckmann, C. F., Ramnani, N., Woolrich, M. W., Bannister, P. R., Jenkinson, M., Matthews, P. M., & McGonigle, D. J. (2005) · Human Brain Mapping · doi:10.1002/hbm.20080 · Cited by 173 · cited 1×
“In addition, even inter-session variability can create subtly disparate results (Smith et al., 2005).”
Motor response suppression and the prepotent tendency to respond: a parametric fMRI study
de Zubicaray, G. I., Andrew, C., Zelaya, F. O., Williams, S., & Dumanoir, C. (2000) · Neuropsychologia · doi:10.1016/s0028-3932(00)00033-6 · Cited by 156
Neural Evidence for Representation-Specific Response Selection
Schumacher, E. H., Elston, P. A., & D’Esposito, M. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903322598085 · Cited by 137 · cited 1×
“Schumacher, Elston, and D’Esposito (2003) investigated the common and unique neural correlates of response selection processes during spatial and non-spatial tasks.”
Is left inferior frontal gyrus a general mechanism for selection?
Zhang, J. X., Feng, C.-M., Fox, P., Gao, J.-H., & Tan, L. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.006 · Cited by 131
Common Neural Substrates for Response Selection across Modalities and Mapping Paradigms
Jiang, Y. V., & Kanwisher, N. (2003) · Journal of Cognitive Neuroscience · doi:10.1162/089892903322598067 · Cited by 120
Verbruggen, F., Liefooghe, B., Notebaert, W., & Vandierendonck, A. (2005) · Acta Psychologica · doi:10.1016/j.actpsy.2005.05.003 · Cited by 98
Greater Working Memory Load Results in Greater Medial Temporal Activity at Retrieval
Schön, K., Quiroz, Y. T., Hasselmo, M. E., & Stern, C. E. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp006 · Cited by 74 · cited 1×
“The middle temporal gyrus has been found to be activated in a meta-analysis of complex Go/ NoGo tasks involving working memory (Simmonds et al., 2008). In addition, Badre, Poldrack, Pare-Blagoev, Insler, and Wagner (2005) found that middle temporal cortex was sensitive to the strength of stimulus–response associations…”
Selective Stopping in Task Switching
Verbruggen, F., Liefooghe, B., & Vandierendonck, A. (2006) · Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) · doi:10.1027/1618-3169.53.1.48 · Cited by 47
Goghari, V. M., & MacDonald, A. W. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20.1.20 · Cited by 23
Goghari, V. M., & MacDonald, A. W. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20007 · Cited by 19 · cited 5×
“We have previously demonstrated that varying the intervals in cue-probe paradigms likely leads to greater response-readiness, evidenced by quicker response reaction times when the probe appears (Goghari & MacDonald, 2008).”
InfluentialSelf-citationXiong (1999) · doi:10.1002/(sici)1097-0193(1999)8:2/3
Cited by
Sorted by citations
Response Inhibition and Response Selection: Two Sides of the Same Coin
Mostofsky, S. H., & Simmonds, D. J. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20500 · Cited by 514
Behavioral components of impulsivity.
Stahl, C., Voss, A., Schmitz, F., Nuszbaum, M., Tüscher, O., Lieb, K., & Klauer, K. C. (2014) · Journal of Experimental Psychology: General · doi:10.1037/a0033981 · Cited by 319
“…during the selection between competing responses might be dissociable from resolving interference during response execution (i.e., withholding or stopping; Aron, 2011; Band & van Boxtel, 1999; Chambers et al., 2009; Eagle et al., 2008; Goghari & MacDonald, 2009; Sebastian, Pohl, et al., 2013).”
BackgroundCritical brain regions for action recognition: lesion symptom mapping in left hemisphere stroke
Kalénine, S., Buxbaum, L. J., & Coslett, H. B. (2010) · Brain · doi:10.1093/brain/awq210 · Cited by 269
Evidence for Two Concurrent Inhibitory Mechanisms during Response Preparation
Duqué, J., Lew, D., Mazzocchio, R., Olivier, E., & Ivry, R. B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5722-09.2010 · Cited by 239
“These models are supported by behavioral observations (Wijnen and Ridderinkhof, 2007), neural recordings in nonhuman primates (Munoz and Everling, 2004), and physiological studies in humans (Goghari and MacDonald, 2009).”
BackgroundLuk, G., Anderson, J. A. E., Craik, F. I. M., Grady, C., & Bialystok, E. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2010.09.004 · Cited by 256
“This network also involved the right inferior frontal regions, which have been implicated in control by other work (Goghari & MacDonald, 2009).”
Result
Metadata
- Authors
- Goghari, V. M., & MacDonald, A. W.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Goghari, Vina M.
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 71
- Issue
- 2
- Pages
- 72-83
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2905055
- OpenAlex
- W2092573319
- Cited by
- 152
- References
- 39
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 11 · 2023: 6 · 2022: 9 · 2021: 13 · 2020: 10 · 2019: 6 · 2018: 3 · 2017: 8 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 10 · 2012: 10
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH066629, R21MH079262)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Arts and Humanities › Philosophy › Free Will and Agency
- Keywords
- cognitive control, response selection, response inhibition, stimulus-response compatibility, prefrontal cortex, inferior frontal gyrus, automated response, task demands
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Cerebral Cortex, Cognition, Female, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Neurons, Neuropsychological Tests, Photic Stimulation, Psychomotor Performance, Reaction Time
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