The DOI matches its Crossref record; 191 of the 195 references it cites were found in a registry or an index.
Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment
Open accessAbstract
Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is typically associated with behavioral activation and heightened forms of appetitive behavior in mammalian species, and this pattern of activation has been described in terms of a neurobehavioral system that underlies incentive-motivated behavior. Adolescence may be a time of elevated activity within this system. This review provides a summary of changes within cortical and subcortical dopaminergic systems that may account for changes in cognition and affect that characterize adolescent behavior. Because there is a dearth of information regarding neurochemical changes in human adolescents, models for assessing links between neurochemical activity and behavior in human adolescents will be described using molecular genetic techniques. Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan.
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“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences (Gladwin et al., 2011;Wahlstrom et al., 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Importantly, biologically determined trait-based individual differences very likely interact with these age-based trends to determine developmental outcomes (Wahlstrom et al. 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al. 2010
In the citing paper
“Dopamine receptor expression also peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations (reviewed in (Wahlstrom et al., 2010)).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wahlstrom et al., 2010
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Citations
Cites
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Cited by
Sorted by citations
Maturation of the adolescent brain
SHARMA, S. K., Arain, Mathur, Rais, Nel, Sandhu, Haque, & Johal (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s39776 · Cited by 1,339
“These changes, which are the consequence of puberty, occur primarily in the brain regions closely linked to emotions, arousal, motivation, as well as to appetite and sleep patterns.”
BackgroundAdolescence as a neurobiological critical period for the development of higher-order cognition
Larsen, B., & Luna, B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.005 · Cited by 853
“This behavior is thought to be linked to the development of the DA system (for Reviews see: (Luciana et al., 2012; Padmanabhan and Luna, 2014; Sturman and Moghaddam, 2011; Telzer, 2016; Wahlstrom et al., 2010)).”
Nicotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 623
“During adolescence, there are also major functional changes in the dopamine system that parallel changes in emotional regulation and cognitive function (Wahlstrom et al. 2010; Naneix et al. 2012; Garske et al. 2013; Spear, 2013).”
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Impulsivity-related personality traits and adolescent alcohol use: A meta-analytic review
Stautz, K., & Cooper, A. J. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.03.003 · Cited by 486
Metadata
- Authors
- Wahlstrom, D., Collins, P., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 72
- Issue
- 1
- Pages
- 146-159
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2815132
- OpenAlex
- W2168203121
- Cited by
- 311
- References
- 195
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 11
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (DA017843, R01DA017843)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine signaling, adolescence, appetitive behavior, risk-taking, novelty seeking, dopaminergic system, molecular genetics, pharmacological evaluation, lifespan development, cognitive and emotional development
- MeSH terms
- Adolescent, Animals, Behavior, Brain, Dopamine, Humans, Neural Pathways, Synaptic Transmission, Adolescent Development
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