The DOI matches its Crossref record; 191 of the 195 references it cites were found in a registry or an index.
Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment
Open accessAbstract
Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is typically associated with behavioral activation and heightened forms of appetitive behavior in mammalian species, and this pattern of activation has been described in terms of a neurobehavioral system that underlies incentive-motivated behavior. Adolescence may be a time of elevated activity within this system. This review provides a summary of changes within cortical and subcortical dopaminergic systems that may account for changes in cognition and affect that characterize adolescent behavior. Because there is a dearth of information regarding neurochemical changes in human adolescents, models for assessing links between neurochemical activity and behavior in human adolescents will be described using molecular genetic techniques. Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences (Gladwin et al., 2011;Wahlstrom et al., 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Importantly, biologically determined trait-based individual differences very likely interact with these age-based trends to determine developmental outcomes (Wahlstrom et al. 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al. 2010
In the citing paper
“Dopamine receptor expression also peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations (reviewed in (Wahlstrom et al., 2010)).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wahlstrom et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · cited 1×
“…such as shifts in brain matter composition (see papers by Paus, Gogtay, Thompson, and Schmithorst (this issue)), modifications of neural synchrony (Uhlhaas et al., 2009), increased hormonal release (Styne, 1994), and neurochemical alterations (Doremus-Fitzwater et al., this issue; Spear, 2000).”
BackgroundDahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
(1998) · Cited by 4,012
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724
Research works printed but not linked: 2
- Jones, 1984, Laminar distribution of cortical efferent cells, Vol. 1, 521
- Seamans, 1995, Selective impairment on a delayed radial arm task following local administration of a selective D1, but not a D2, antagonist into the prefrontal cortex, Abstracts of the Society for Neuroscience, 21, 1942
Cited by
Sorted by citations
Maturation of the adolescent brain
SHARMA, S. K., Arain, Mathur, Rais, Nel, Sandhu, Haque, & Johal (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s39776 · Cited by 1,339
“These changes, which are the consequence of puberty, occur primarily in the brain regions closely linked to emotions, arousal, motivation, as well as to appetite and sleep patterns.”
BackgroundAdolescence as a neurobiological critical period for the development of higher-order cognition
Larsen, B., & Luna, B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.005 · Cited by 853
“This behavior is thought to be linked to the development of the DA system (for Reviews see: (Luciana et al., 2012; Padmanabhan and Luna, 2014; Sturman and Moghaddam, 2011; Telzer, 2016; Wahlstrom et al., 2010)).”
Nicotine and the adolescent brain
Yuan, M., Cross, S. J., Loughlin, S. E., & Leslie, F. M. (2015) · The Journal of Physiology · doi:10.1113/jp270492 · Cited by 623
“During adolescence, there are also major functional changes in the dopamine system that parallel changes in emotional regulation and cognitive function (Wahlstrom et al. 2010; Naneix et al. 2012; Garske et al. 2013; Spear, 2013).”
BackgroundAn Integrative Model of the Maturation of Cognitive Control
Luna, B., Marek, S., Larsen, B., Tervo-Clemmens, B., & Chahal, R. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034054 · Cited by 550
Impulsivity-related personality traits and adolescent alcohol use: A meta-analytic review
Stautz, K., & Cooper, A. J. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.03.003 · Cited by 486
Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context
Römer, D., Reyna, V. F., & Satterthwaite, T. D. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.07.007 · Cited by 466
“This rather striking pattern is regarded as a marker of rising dopaminergic activation during adolescence (Chambers et al., 2003; Wahlstrom et al., 2010) and may reflect activity in the midbrain dopamine pathway ascending from the ventral tegmental region (Ikemoto, 2007; Previc, 2009).”
Oswald, T. K., Rumbold, A. R., Kedzior, S. G. E., & Moore, V. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237725 · Cited by 367
Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?
SPEAR, L. P. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.01.027 · Cited by 383
“, [83]) suggested that elevated PFC DA activity might lead to a functional DA “overdose” there during adolescence and hence a preponderance of subcortical DA activity, although they did not detail when during adolescence such changes might take place.”
Unraveling the Miswired Connectome: A Developmental Perspective
Martino, A. D., Fair, D. A., Kelly, C. A. M., Satterthwaite, T. D., Castellanos, F. X., Thomason, M. E., Craddock, R. C., Luna, B., LEVENTHAL, B. L., Zuo, X., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.050 · Cited by 357
“Schizophrenia research provides a useful example: recent models suggest that frontoparietal dysfunction may in part result from low-level abnormalities in the visual system (Butler et al., 2001).”
BackgroundThe attentive brain: insights from developmental cognitive neuroscience
Amso, D., & Scerif, G. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4025 · Cited by 369
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Crews, F. T., Vetreno, R. P., Broadwater, M., & Robinson, D. L. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.012138 · Cited by 356
Spear, L. P. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.08.001 · Cited by 292
Matt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 293
“While this enables a more standardized comparison, it does not account for substantial variability resulting from differences in species, age, cell type or sex (Arvidsson et al. 2014; Bourque et al. 2011; Cosentino et al. 2000; Pilipović et al. 2008; Wahlstrom et al. 2010).”
Neurobehavioral evidence for changes in dopamine system activity during adolescence
Wahlstrom, D., White, T., & Luciana, M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.007 · Cited by 277
“…this model predicts individual differences in neuroplasticity on the basis of genotype, and indeed, we observe that adolescents who carry the Met-Met genotype have a more protracted rate of working memory development than individuals with the Val-Met and Val-Val genotypes (Wahlstrom et al., 2010).”
BackgroundInfluentialSelf-citationSilverman, M. H., Jedd, K., & Luciana, M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.07.083 · Cited by 277
“Wehypothesize that these structures will represent nodes of the ascending mesocorticolimbic dopamine system (Berridge and Robinson, 1998; Goto and Grace, 2005; Wahlstrom et al., 2010b).”
InfluentialSelf-citationTelzer, E. H. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.10.010 · Cited by 274
Adolescence as a vulnerable period to alter rodent behavior
Schneider, M. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1581-2 · Cited by 266
“1997) and considerable changes in dopaminergic signaling have also been reported to occur in human adolescents (Wahlstrom et al. 2010).”
BackgroundUrošević, S., Collins, P., Muetzel, R., Lim, K., & Luciana, M. (2012) · Developmental Psychology · doi:10.1037/a0027502 · Cited by 258
Self-citationThe triadic model perspective for the study of adolescent motivated behavior
Ernst, M. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.01.006 · Cited by 240
Olson, E. A., Collins, P. F., Hooper, C. J., Muetzel, R., Lim, K. O., & Luciana, M. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21107 · Cited by 185
Self-citationDoes puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, D. J., Johnson, C. M., Boivin, J. R., Thomas, A. W., Lin, W. C., Delevich, K., M. Galarce, E., & Wilbrecht, L. (2017) · Brain Research · doi:10.1016/j.brainres.2016.08.042 · Cited by 175
“Given that reward circuitry is also developing (Benes et al., 1996; Sinclair et al., 2014; Wahlstrom et al., 2010), it is not surprising that animal models of drug abuse reveal unique patterns of drug-related behaviors (Schramm-Sapyta et al., 2009) and heightened sensitivity to the long-term…”
BackgroundInfluentialBuecker, S., Luhmann, M., Haehner, P., Bühler, J. L., Dapp, L. C., Luciano, E. C., & Orth, U. (2023) · Psychological Bulletin · doi:10.1037/bul0000401 · Cited by 218
Luciana, M., Wahlstrom, D., Porter, J. N., & Collins, P. F. (2012) · Developmental Psychology · doi:10.1037/a0027432 · Cited by 156
“Table 1, reprinted from Wahlstrom et al. (2010b), summarizes evidence of adolescentspecific changes in dopamine function.”
BackgroundSelf-citationSilk, J. S., Davis, S., McMakin, D. L., Dahl, R. E., & Forbes, E. E. (2012) · Psychological Medicine · doi:10.1017/s0033291712000207 · Cited by 155
“…to changes in dopaminergic systems in adolescence, including changes in the firing rates, density and concentration of dopamine fibers and receptors and a shift in the balance of dopamine receptors across brain regions (see reviews by Ernst et al. 2009 ; Galvan, 2010 ; Wahlstrom et al. 2010).”
BackgroundAdolescent brain development in normality and psychopathology
Luciana, M. M. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000643 · Cited by 175
Self-citationStojan, R., & Voelcker‐Rehage, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050734 · Cited by 163
“The decrease in cognitive performance is associated with a variety of age-related brain changes, including the shrinkage in grey and white matter volume [11–13], region specific changes in brain connectivity [14,15], losses in brain vascularization and cerebral blood flow [16,17], higher rates of neuroinflammation [18…”
BackgroundDennison, M., Whittle, S., Yücel, M., Vijayakumar, N., Kline, A., Simmons, J., & Allen, N. B. (2013) · Developmental Science · doi:10.1111/desc.12057 · Cited by 146
Brain Development During Adolescence
Konrad, K., Firk, C., & Uhlhaas, P. J. (2013) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2013.0425 · Cited by 323
Salmanzadeh, H., Ahmadi‐Soleimani, S. M., Pachenari, N., Azadi, M., Halliwell, R. F., Rubino, T., & Azizi, H. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.01.007 · Cited by 155
Mesocorticolimbic Dopamine Pathways Across Adolescence: Diversity in Development
Reynolds, L. M., & Flores, C. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.735625 · Cited by 137
Adolescent brain maturation and smoking: What we know and where we’re headed
Lydon‐Staley, D. M., Wilson, S. J., Child, A. E., & Geier, C. F. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.003 · Cited by 143
Spontaneous blink rate as an index of attention and emotion during film clips viewing
Maffei, A., & Angrilli, A. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.02.037 · Cited by 133
Doremus-Fitzwater, T. L., & Spear, L. P. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.015 · Cited by 125
“Additionally, adolescent rodents have been reported to exhibit significant changes in motivational and reward-related behaviors (as reviewed below), as well as marked transformations in reward-relevant neural regions and related neurocircuitry, with similarity in these fundamental neural alterations again evident betw…”
BackgroundIncentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift?
Luciana, M., & Collins, P. F. (2012) · Child Development Perspectives · doi:10.1111/j.1750-8606.2012.00252.x · Cited by 123
“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
BackgroundInfluentialSelf-citationHippocampal BDNF in physiological conditions and social isolation
Zaletel, I. V., Filipović, D., & Puškaš, N. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0072 · Cited by 110
“The period of early adolescence during which this social isolation model was applied is an important period for the maturation of the dopaminergic and glutamatergic neurotransmitter system in which significant changes occur (Wahlstrom et al., 2010; Arain et al., 2013).”
BackgroundBauer, J. A., Devick, K. L., Bobb, J. F., Coull, B. A., Bellinger, D. C., Benedetti, C., Cagna, G., Fedrighi, C., Guazzetti, S., Oppini, M., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6803 · Cited by 110
Adolescent brain development: Implications for the juvenile criminal justice system.
Luna, B., & Wright, C. M. (2015) · American Psychological Association eBooks · doi:10.1037/14643-005 · Cited by 115
The impact of junk foods on the adolescent brain
Reichelt, A. C., & Rank, M. M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1173 · Cited by 102
Ait-Bali, Y., Ba-M’hamed, S., & Bennis, M. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00146 · Cited by 98
“…in functional connectivity between regions of the prefrontal cortex and several areas of the limbic system, especially the dopaminergic and serotoninergic systems, concomitant with changes in emotional and cognitive function regulation (Wahlstrom et al., 2010; Naneix et al., 2012; Spear, 2013).”
BackgroundHo, T. C., Gifuni, A. J., & Gotlib, I. H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01171-5 · Cited by 108
Adolescent brain development, risk-taking and vulnerability to addiction
Dayan, J., Bernard, A., Olliac, B., Mailhes, A.-S., & Kermarrec, S. (2010) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2010.08.007 · Cited by 101
“iour, and thus in reward-seeking, which cannot yet be controlled by the immature frontal regions (Wahlstrom et al., 2010).”
BackgroundFast dopamine release events in the nucleus accumbens of early adolescent rats
Robinson, D. L., Zitzman, D. L., Smith, K. J., & Spear, L. P. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.016 · Cited by 94
“…undergo dynamic changes during adolescence, it is not surprising that behavioral and neurochemical responses to rewards and novel stimuli that may well predict rewards are also dynamic (for reviews, see Chambers et al., 2003; Ernst et al., 2009; Wahlstrom et al., 2010b; Wahlstrom et al., 2010a).”
BackgroundWu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., & Kozorovitskiy, Y. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.022 · Cited by 95
“Because our experiments were carried out in young animals and neural plasticity dynamics are known to change across age (76 – 78), the ef fi cacy of ketamine treatment could vary in clinical populations as a function of age even if mechanisms of action are conserved.”
MethodReichelt, A. C. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00189 · Cited by 101
“Longitudinal neuroimaging studies have demonstrated that the brain, in particular the prefrontal cortex (PFC), continues to mature until ∼24 years old (Giedd et al., 1999; Sowell et al., 2001; Casey et al., 2008b; Wahlstrom et al., 2010; Mills et al., 2014).”
BackgroundOvarian Cycle Effects on Immediate Reward Selection Bias in Humans: A Role for Estradiol
Smith, C. T., Sierra, Y., Oppler, S. H., & Boettiger, C. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0014-14.2014 · Cited by 93
“Measures of frontal DA neurotransmission decrease from adolescence to adulthood (Wahlstrom et al., 2010), including a rise in COMT expression with age (Tunbridge et al.”
BackgroundZisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 101
“…into adulthood (Lenroot & Giedd, 2006), combined with normal upregulation of DA functioning, lead to increased saliency of and motivation to seek rewards that then manifest as increased risk-taking and novelty-seeking behaviors (see Chambers, Taylor, & Potenza, 2003; Wahlstrom et al., 2010).”
BackgroundKendig, M. D., Boakes, R. A., Rooney, K. B., & Corbit, L. H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.08.012 · Cited by 87
“Importantly, adolescence is also characterized by structural refinement to frontal and limbic brain systems involved in higher-order cognition [22,23], and a temporary spike in the activity of the dopaminergic system [24].”
BackgroundAdolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence
Wong, W. C., Ford, K. A., Pagels, N. E., McCutcheon, J. E., & Marinelli, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1371-12.2013 · Cited by 87
“The adolescent brain undergoes extensive organizational and functional changes, including changes in the mesolimbic dopamine system (Andersen et al., 1997; Spear, 2000; Wahlstrom et al., 2010).”
Developmental imaging genetics: Linking dopamine function to adolescent behavior
Padmanabhan, A., & Luna, B. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2013.09.011 · Cited by 87
Effects of reward sensitivity and regional brain volumes on substance use initiation in adolescence
Urošević, S., Collins, P. F., Muetzel, R. L., Schissel, A. M., Lim, K. O., & Luciana, M. M. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu022 · Cited by 89
“This DA-modulated network is implicated in adolescent brain development (Ernst et al., 2006b; Wahlstrom et al., 2010) and it contributes to rewarding aspects of abused substances (Koob and Volkow, 2010).”
BackgroundSelf-citationLongitudinal changes in white matter microstructure after heavy cannabis use
Becker, M. P., Collins, P. F., Lim, K. O., Muetzel, R. L., & Luciana, M. M. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.10.004 · Cited by 82
Self-citationKhurana, A., Römer, D., Betancourt, L. M., & Hurt, H. (2018) · Journal of Youth and Adolescence · doi:10.1007/s10964-018-0891-9 · Cited by 80
“This finding is consistent with the interpretation of sensation seeking as an indicator of rising dopamine expression that leads to heightened reward sensitivity (Wahlstrom et al., 2010) but that is also a critical modulator of working memory performance (Cools & D’Esposito, 2011).”
ResultAlloy, L. B., & Nusslock, R. (2019) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2019.1567347 · Cited by 75
“Dopamine expression also increases in adolescence underlying such traits as sensation seeking and reward sensitivity (Wahlstrom, Collins, White, & Luciana, 2010).”
Lukie, C. N., Montazer-Hojat, S., & Holroyd, C. B. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.04.003 · Cited by 68
Adolescent peer interaction and trait surgency weaken medial prefrontal cortex responses to failure
Segalowitz, S. J., Santesso, D. L., Willoughby, T., Reker, D. L., Campbell, K., Chalmers, H., & Rose-Krasnor, L. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq090 · Cited by 58
Parr, A. C., Calabro, F., Larsen, B., Tervo-Clemmens, B., Elliot, S., Foran, W., Olafsson, V., & Luna, B. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.101997 · Cited by 60
Li, M., Du, W., Shao, F., & Wang, W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.025 · Cited by 67
Saragosa‐Harris, N. M., Cohen, A. O., Reneau, T. R., Villano, W. J., Heller, A. S., & Hartley, C. A. (2022) · Psychological Science · doi:10.1177/09567976221102070 · Cited by 63
“, 1999; Philpot & Wecker, 2008; Stansfield & Kirstein, 2006), potentially reflecting reorganization of dopaminergic reward circuitry during adolescence (Crews et al., 2007; Doremus-Fitzwater et al., 2010; Galván, 2010; Spear, 2000a, 2011; Wahlstrom et al., 2010).”
BackgroundAge modulates the effect of COMT genotype on delay discounting behavior
Smith, C. T., & Boettiger, C. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2653-9 · Cited by 59
“As noted earlier, several measures of frontal DA signaling decrease from adolescence to adulthood (see (Wahlstrom et al. 2010) for recent review).”
BackgroundInfluentialUrošević, S., Collins, P. F., Muetzel, R. L., Lim, K. O., & Luciana, M. M. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.01.007 · Cited by 64
Self-citationUse and abuse of dissociative and psychedelic drugs in adolescence
Bates, M. L. S., & Trujillo, K. A. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173129 · Cited by 59
“For a more detailed review of developmental differences in dopamine neurotransmission, see (Wahlstrom et al., 2010).”
Laviolette, S. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108411 · Cited by 57
Neuroimaging of the dopamine/reward system in adolescent drug use
Ernst, M., & Luciana, M. M. (2015) · CNS Spectrums · doi:10.1017/s1092852915000395 · Cited by 59
“For the purpose of this review, it is important to note that these behavioral patterns are influenced by ontogenic changes in neurotransmitter systems, including the dopamine (DA) system, which is fundamental in the neural coding of reward processes, and, more generally, in motivated approach behavior.(16,17) Reward s…”
BackgroundSelf-citationIn‐Albon, T., Bürli, M., Ruf, C., & Schmid, M. (2013) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-7-5 · Cited by 55
“, [59]) and changes in endocrinology and hormonal status (e.”
BackgroundDoumas, D. M., Miller, R., & Esp, S. M. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.08.003 · Cited by 62
A Combination of Dopamine Genes Predicts Success by Professional Wall Street Traders
Sapra, S., Beavin, L. E., & Zak, P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030844 · Cited by 54
“Levels of synaptic dopamine have an inverted-U relationship with several cognitive abilities as shown by both animal and human data [21].”
BackgroundPredictors of recurrent sprains after an index lateral ankle sprain: a longitudinal study
Pourkazemi, F., Hiller, C. E., Raymond, J., Black, D. A., Nightingale, E. J., & Refshauge, K. M. (2017) · Physiotherapy · doi:10.1016/j.physio.2017.10.004 · Cited by 54
On the normative advantages of dopamine and striatal opponency for learning and choice
Jaskir, A., & Frank, M. J. (2023) · eLife · doi:10.7554/elife.85107 · Cited by 56
Zhou, M., Rebholz, H., Brocia, C., Warner‐Schmidt, J. L., Fienberg, A. A., Nairn, A. C., Greengard, P., & Flajolet, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915173107 · Cited by 51
Sakurai, T., & Gamo, N. J. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.007 · Cited by 54
A longitudinal analysis of adolescent decision-making with the Iowa Gambling Task.
Almy, B., Kuskowski, M. A., Malone, S. M., Myers, E. J., & Luciana, M. M. (2017) · Developmental Psychology · doi:10.1037/dev0000460 · Cited by 55
Self-citationWu, M., Minkowicz, S., Dumrongprechachan, V., Hamilton, P., Xiao, L., & Kozorovitskiy, Y. (2021) · eLife · doi:10.7554/elife.64041 · Cited by 54
“One interesting possibility is that projections and activity profiles of DA neuron subgroups could be related to earlylife and adolescent experience (O’Donnell, 2010; Peña et al., 2019; Peña et al., 2017; Wahlstrom et al., 2010), resulting in variability of the overall low- dimensional activity pattern of the VTA DA p…”
van den Bos, R., Davies, W., Dellu-Hagedorn, F., Goudriaan, A. E., Granon, S., Homberg, J. R., Rivalan, M., Swendsen, J. D., & Adriani, W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.005 · Cited by 57
Puberty Predicts Approach But Not Avoidance on the Iowa Gambling Task in a Multinational Sample
Icenogle, G., Steinberg, L. D., Olino, T. M., Shulman, E. P., Chein, J. M., Alampay, L. P., Al‐Hassan, S. M., Takash, H. M. S., Bacchini, D., Chang, L., et al. (2016) · Child Development · doi:10.1111/cdev.12655 · Cited by 50
Adolescent social defeat alters markers of adult dopaminergic function
Novick, A. M., Forster, G. L., Tejani‐Butt, S. M., & Watt, M. J. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.009 · Cited by 49
“Adolescence marks a period of critical change in which the mesocorticolimbic dopamine (DA) system undergoes substantial reorganization, enabling emotional and cognitive development that aids in the transition to adulthood [61, 70].”
BackgroundHämmerer, D., Müller, V., & Li, S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.06.008 · Cited by 50
“With regard to neuromodulators, a protracted development in the cortical dopamine system is observed, which reaches adult levels only in late adolescence (Diamond et al., 2004; Wahlstrom et al., 2010; see Li, 2013 for review).”
Kameda, S. R., Fukushiro, D. F., Trombin, T. F., Procópio‐Souza, R., Patti, C. L., Hollais, A. W., Calzavara, M. B., Abílio, V. C., Ribeiro, R. A., Tufik, S., et al. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.013 · Cited by 44
Karkhanis, A. N., Leach, A. C., Yorgason, J. T., Uneri, A., Barth, S. H., Niere, F., Alexander, N. J., Weiner, J. L., McCool, B. A., Raab‐Graham, K. F., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00360 · Cited by 48
A Positive Affective Neuroendocrinology Approach to Reward and Behavioral Dysregulation
Welker, K. M., Gruber, J., & Mehta, P. H. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00093 · Cited by 47
Juvenile stress affects anxiety-like behavior and limbic monoamines in adult rats
Luo, X.-M., Yuan, S., Guan, X., Xie, X., Shao, F., & Wang, W. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.035 · Cited by 44
Overman, W., & Pierce, A. M. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00935 · Cited by 54
“Males as young as 7–15 years of age years perform significantly higher than females on a child-friendly variant of the IGT, the hungry donkey task (Crone et al., 2005).”
BackgroundMethodSuryanarayana, S. M., Kotaleski, J. H., Grillner, S. E., & GURNEY, K. N. (2018) · Neural Networks · doi:10.1016/j.neunet.2018.10.003 · Cited by 39
Meyer, B. M., Huemer, J., Rabl, U., Boubela, R. N., Kalcher, K., Berger, A., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Büchel, C., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0895-5 · Cited by 41
“…adolescence such as increases of basal dopamine (DA) levels and changes of DA turnover resulting in a peak of prefrontal dopaminergic neurotransmission in early adolescence that declines thereafter (Andersen et al. 1997; Rosenberg and Lewis 1994, 1995; Teicher et al. 1993; Wahlstrom et al. 2010).”
BackgroundVan Beveren, M.-L., Mezulis, A., Wante, L., & Braet, C. (2019) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1233499 · Cited by 38
Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review
Tetteh-Quarshie, S., & Risher, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1040049 · Cited by 51
Binge drinking and illicit drug use among adolescent students
Raposo, J. C. D. S., Costa, A. C. D. Q., Valença, P. A. D. M., Zarzar, P. M., Diniz, A. D. S., Colares, V., & da Franca›, C. (2017) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2017051006863 · Cited by 38
Fowler, J. A., Gullo, M. J., & Elphinston, R. A. (2020) · Personality and Individual Differences · doi:10.1016/j.paid.2020.109965 · Cited by 41
Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats
Zbukvic, I., Ganella, D. E., Perry, C. J., Madsen, H. B., Bye, C. R., Lawrence, A. J., & Kim, J. H. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw051 · Cited by 38
“Adolescence constitutes a period of dramatic maturation of the mPFC, including alterations in dopamine receptor density (Andersen et al. 2000), fiber infiltration (Kalsbeek et al. 1988), and dopamine availability (Wahlstrom et al. 2010).”
BackgroundRocha, A., Hart, N., & Trujillo, K. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.04.007 · Cited by 37
“…parameters related to NMDA receptor/dopamine interactions in the forebrain are immature in early adolescence, and the adult pattern does not emerge until late adolescence (Flores-Barrera et al., 2014; O'Donnell, 2011; Tseng and O'Donnell, 2005; Tseng et al., 2007; Wahlstrom et al., 2010).”
Murty, V. P., Shah, H., Montez, D. F., Foran, W., Calabro, F. J., & Luna, B. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3508-17.2018 · Cited by 36
“Prior animal work has shown that dopamine receptor availability as well as baseline firing rate of dopamine neurons are enhanced in adolescent rodents (Wahlstrom et al., 2010a,b), both of which are putative neurobiological mechanisms of enhanced motivation (Lisman and Grace, 2005; Luo et al., 2011).”
BackgroundAzadi, M., Azizi, H., & Haghparast, A. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.02.004 · Cited by 36
Kim, J. H., Perry, C. J., Ganella, D. E., & Madsen, H. B. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.018 · Cited by 34
Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior
Moazen, P., Azizi, H., Salmanzadeh, H., & Semnanian, S. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5051-0 · Cited by 34
Bauer, J. A., White, R. F., Coull, B. A., Austin, C. E., Oppini, M., Zoni, S., Fedrighi, C., Cagna, G., Placidi, D., Guazzetti, S., et al. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.08.014 · Cited by 35
Perica, M. I., & Luna, B. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105378 · Cited by 35
Tielbeek, J. J., Al-Itejawi, Z., Zijlmans, J., Polderman, T. J. C., Buckholtz, J. W., & Popma, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.009 · Cited by 36
Adolescence is the starting point of sex-dichotomous COMT genetic effects
Sannino, S., Padula, M. C., Managò, F., Schaer, M., Schneider, M., Armando, M., Scariati, E., Béna, F., Mereu, M., Pontillo, M., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.109 · Cited by 35
Traumatic Brain Injury and Juvenile Offending
Williams, W. H., McAuliffe, K., Cohen, M. H., Parsonage, M., & Ramsbotham, J. (2015) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000134 · Cited by 34
A neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood
Victor, E. C., & Hariri, A. R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415001042 · Cited by 37
“…rewards, coding reward prediction in response to cues that signal reward delivery and providing cues to reward prediction fails (see in depth reviews of DA function and development and implications for adolescent behavior: Luciana et al., 2012; O’Donnell, 2010; Spear, 2000; Wahlstrom et al., 2010).”
BackgroundModulation of Reward-Related Neural Activation on Sensation Seeking across Development
Hawes, S., Chahal, R., Hallquist, M., Paulsen, D. J., Geier, C., & Luna, B. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.12.020 · Cited by 29
“Participants were assessed for IQ using the Wechsler Abbreviated Scale of Intelligence (WASI; Wechsler, 1999), and demonstrated scores in the normal range (M=110.99, SD=11.64).”
Influential
Metadata
- Authors
- Wahlstrom, D., Collins, P., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 72
- Issue
- 1
- Pages
- 146-159
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2815132
- OpenAlex
- W2168203121
- Cited by
- 311
- References
- 195
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 11
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (DA017843, R01DA017843)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine signaling, adolescence, appetitive behavior, risk-taking, novelty seeking, dopaminergic system, molecular genetics, pharmacological evaluation, lifespan development, cognitive and emotional development
- MeSH terms
- Adolescent, Animals, Behavior, Brain, Dopamine, Humans, Neural Pathways, Synaptic Transmission, Adolescent Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
