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Developmental changes in dopamine neurotransmission in adolescence: Behavioral implications and issues in assessment
Open accessAbstract
Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is typically associated with behavioral activation and heightened forms of appetitive behavior in mammalian species, and this pattern of activation has been described in terms of a neurobehavioral system that underlies incentive-motivated behavior. Adolescence may be a time of elevated activity within this system. This review provides a summary of changes within cortical and subcortical dopaminergic systems that may account for changes in cognition and affect that characterize adolescent behavior. Because there is a dearth of information regarding neurochemical changes in human adolescents, models for assessing links between neurochemical activity and behavior in human adolescents will be described using molecular genetic techniques. Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan.
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“An adolescent-limited increase in IM is a positive development that may confer evolutionary advantages and that serves ultimately--through the promotion of learning--to encourage a sense of agency as youth make the transition to adult independence (Spear, 2000; Wahlstrom et al., 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al., 2010
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“Childhood and adolescence are sensitive periods in which these systems develop and change [26–29], making them particularly vulnerable to insult.”
From Psychological impacts of “screen time” and “green time” for children and adolescents: A systematic scoping review (2020) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“The brain mechanisms of interest here show a distinctive pattern of development: subcortical regions involved in incentive motivation develop faster than the prefrontal regions that exert inhibition in the interests of long-term consequences (Gladwin et al., 2011;Wahlstrom et al., 2010).”
From A motivation model of sex addiction – Relevance to the controversy over the concept (2022) · cites this paper as Wahlstrom et al., 2010
Experimental — accuracy not yet measuredIn the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
In the citing paper
“Marked developmental alterations are seen in the DA system through adolescence and into adulthood, as reviewed recently elsewhere (Ernst et al, 2009; Galvan, 2010; Wahlstrom et al, 2010).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Wahlstrom et al, 2010
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“Importantly, biologically determined trait-based individual differences very likely interact with these age-based trends to determine developmental outcomes (Wahlstrom et al. 2010).”
From Incentive Motivation, Cognitive Control, and the Adolescent Brain: Is It Time for a Paradigm Shift? (2012) · cites this paper as Wahlstrom et al. 2010
In the citing paper
“Dopamine receptor expression also peaks around the age of puberty, though only for specific receptor subtypes in specific neuronal populations (reviewed in (Wahlstrom et al., 2010)).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wahlstrom et al., 2010
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“These associations may be especially relevant to adolescence, given the broad changes in cognition and affect that occur during this time as well as increased rates of psychiatric disorders (Costello et al., 1999; Kessler et al., 2005; Paus, Keshaven & Giedd, 2008; Shedler & Block, 1990, Szymanski et al., 1995).”
BackgroundVariation in dopamine genes influences responsivity of the human reward system
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“These animals are also more vulnerable to drug reinstatement after extinction (Economidou et al., 2009; Robinson et al., 2009).”
BackgroundAge-related decline in brain resources magnifies genetic effects on cognitive functioning
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“For example, numerous groups have used functional MRI techniques to document developmental differences in neural systems during the completion of reward-related tasks, which implicate differences in regions innervated by dopamine such as the OFC and ventral striatum (Van Leijenhorst, Zanolie1, Van Meel, Westenberg, Ro…”
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“(2006) study, though based on a small sample and not replicated, indicates that adolescents exhibit hyperresponsivity of the ventral striatum in response to reward compared to adults, which could reflect hyperactivity of the modulatory dopamine system or of other neurochemicals involved in reward processing, such as o…”
BackgroundOlson, E. A., Collins, P. F., Hooper, C. J., Muetzel, R., Lim, K. O., & Luciana, M. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21107 · Cited by 185 · cited 1×
“Age-related sources of variation in structure–function relations are relatively small in magnitude (Olson et al., 2009; Schmithorst et al., 2005; Shaw et al., 2006), and some structure– function relations are not easily attributable to maturational processes (Olesen, Nagy, Westerberg, & Klingberg,…”
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“Dopamine decreases the voltage threshold required for cell firing in these pyramidal cells (Henze et al., 2000); thus, adolescence may by characterized by increased excitability of the neural networks underlying prefrontally Wahlstrom et al.”
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BackgroundMacrı̀, S., Adriani, W., Chiarotti, F., & Laviola, G. (2002) · Animal Behaviour · doi:10.1006/anbe.2002.4004 · Cited by 174
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BackgroundInvestigating the dopaminergic basis of extraversion in humans: A multilevel approach.
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“However, D1 and D2 densities do appear to peak in subcortical structures such as the striatum and nucleus accumbens, as do the densities of D2-like D3 and D4 receptors (Andersen et al., 2002; Tarazi, Tomasini, & Baldessarini, 1998b).”
BackgroundCognitive processes in the development of TOL performance
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“making, planning, working memory, and inhibitory control (Asato et al., 2006; Crone et al., 2004; Hooper et al., 2004; Luciana et al., 2005; Luciana et al., 2009; Luna et al., 2004).”
BackgroundSelf Regulatory Behavior and Risk Taking: Causes and Consequences
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“Similar studies have found that adolescents exhibit a unique pattern of amygdaloid activation in response to emotional facial expressions (Baird et al., 2001; Thomas et al., 2001).”
ResultThe Dynamics of Self-Esteem and Delinquency
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“making, planning, working memory, and inhibitory control (Asato et al., 2006; Crone et al., 2004; Hooper et al., 2004; Luciana et al., 2005; Luciana et al., 2009; Luna et al., 2004).”
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“The D4 dopamine receptor and the dopamine transporter genes are also likely candidates for analysis, because individual differences in SNPs associated with these genes have been linked to variations in personality traits, externalizing behaviors, and higherorder cognition (DeYoung et al., 2006; Durston et al., 2008; M…”
BackgroundDevelopment and Ageing of the Rat Nigrostriatal Dopamine System Studied with Fast Cyclic Voltammetry
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“This latter interpretation seems possible given that the PFC dopamine system is less rigorously regulated in terms of autoreceptor and dopamine transporter activity (Bannon & Roth, 1983; Sesack et al., 1998).”
BackgroundDistribution of Dopamine in the rat cerebral cortex
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BackgroundSerotonergic mechanisms in anxiety
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“Few studies have assessed the ontogeny of dopamine receptor density in humans, but those that have indicate that densities decrease between childhood and adulthood (Montague et al., 1999; Seeman et al., 1987).”
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“The D4 dopamine receptor and the dopamine transporter genes are also likely candidates for analysis, because individual differences in SNPs associated with these genes have been linked to variations in personality traits, externalizing behaviors, and higherorder cognition (DeYoung et al., 2006; Durston et al., 2008; M…”
BackgroundElements of the Intrinsic Organization and Information Processing in the Neostriatum
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“Other evidence suggests that changes in dopamine receptors are similar in males and females (Lieb et al., 1996); however, rates of change during adolescence were not directly compared.”
ResultD2 dopamine receptor gene polymorphism discriminates two kinds of novelty seeking
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Maturation of the adolescent brain
SHARMA, S. K., Arain, Mathur, Rais, Nel, Sandhu, Haque, & Johal (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s39776 · Cited by 1,339
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“This behavior is thought to be linked to the development of the DA system (for Reviews see: (Luciana et al., 2012; Padmanabhan and Luna, 2014; Sturman and Moghaddam, 2011; Telzer, 2016; Wahlstrom et al., 2010)).”
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Metadata
- Authors
- Wahlstrom, D., Collins, P., White, T., & Luciana, M.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Luciana, Monica
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 72
- Issue
- 1
- Pages
- 146-159
- ISSN
- 0278-2626 (ISSN-L)
- PMC
- PMC2815132
- OpenAlex
- W2168203121
- Cited by
- 311
- References
- 195
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 15 · 2023: 28 · 2022: 24 · 2021: 21 · 2020: 15 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 25 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 11
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH017069)
- National Institute on Drug Abuse (DA017843, R01DA017843)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine signaling, adolescence, appetitive behavior, risk-taking, novelty seeking, dopaminergic system, molecular genetics, pharmacological evaluation, lifespan development, cognitive and emotional development
- MeSH terms
- Adolescent, Animals, Behavior, Brain, Dopamine, Humans, Neural Pathways, Synaptic Transmission, Adolescent Development
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