Cited by 384Cellular Mechanics and InteractionsCardiac Fibrosis and RemodelingElasticity and Material Modeling

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Tissue mechanics and fibrosis

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Wells, Rebecca G.·2013·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2013.02.007PMC PMC3641165

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Abstract

Mechanical forces are essential to the development and progression of fibrosis, and are likely to be as important as soluble factors. These forces regulate the phenotype and proliferation of myofibroblasts and other cells in damaged tissues, the activation of growth factors, the structure and mechanics of the matrix, and, potentially, tissue patterning. Better understanding of the variety and magnitude of forces, the characteristics of those forces in biological tissues, and their impact on fibrosis in multiple tissues is needed and may lead to identification of important new therapeutic targets. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.

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Authors: Wells, R. G.
Affiliations: University of Pennsylvania (US)
Corresponding author: Wells, Rebecca G.
ORCID: Wells, Rebecca G.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2013-07
Volume: 1832
Issue: 7
Pages: 884-890
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2013.02.007
PMC: PMC3641165
OpenAlex: W2063208689
Cited by: 384
References: 110
Citations by year: 2026: 18 · 2025: 33 · 2024: 42 · 2023: 35 · 2022: 45 · 2021: 54 · 2020: 41 · 2019: 30 · 2018: 33 · 2017: 16 · 2016: 18 · 2015: 12 · 2014: 4 · 2013: 3
FWCI: 7.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01-DK-058123)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Keywords: tissue mechanics, fibrosis, mechanical forces, myofibroblasts, myofibroblast proliferation, growth factor activation, tissue patterning, therapeutic target
MeSH terms: Fibrosis, Humans, Disease Progression, Myofibroblasts

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