Alzheimer’s disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

Methods in Enzymology , Vol

Colowick, S. P., Joshi, M. D., Jagannathan, & KAPLAN, N. O. (1966) · Cited by 26,137 · see citing works

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

Gornall, A. G., Bardawill, C. J., & David, M. M. (1949) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)57021-6 · Cited by 16,164 · see citing works

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331 · see citing works

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works

[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios

Estabrook, R. W. (1967) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(67)10010-4 · Cited by 1,782 · see citing works

Transcriptional paradigms in mammalian mitochondrial biogenesis and function

Scarpulla, R. C. (2008) · Physiological Reviews · doi:10.1152/physrev.00025.2007 · Cited by 1,666 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

Mitochondrial abnormalities in Alzheimer's disease

Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

Yang, L., Li, P., Fu, S., Calay, E. S., & Hotamisligil, G. S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.005 · Cited by 1,274 · see citing works

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R., & Galvan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009979 · Cited by 1,033 · see citing works

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

Yu, W. H., Cuervo, A. M., Kumar, A., Peterhoff, C. M., Schmidt, S. D., Lee, J.-H., Mohan, P. S., Mercken, M., Farmery, M. R., Tjernberg, L. O., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505082 · Cited by 967 · see citing works

Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy

Eskelinen, E. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.005 · Cited by 956 · see citing works

Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state

Kamo, N., Muratsugu, M., Hongoh, R., & Kobatake, Y. (1979) · The Journal of Membrane Biology · doi:10.1007/bf01868720 · Cited by 956 · see citing works

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881 · see citing works

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G., & Zhu, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804871105 · Cited by 835 · see citing works

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680 · see citing works

Autophagy failure in Alzheimer's disease—locating the primary defect

Nixon, R. A., & Yang, D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.021 · Cited by 634 · see citing works

Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons

Kwon, S. E., & Chapman, E. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.001 · Cited by 470 · see citing works

Aβ Secretion and Plaque Formation Depend on Autophagy

Nilsson, P., Loganathan, K., Sekiguchi, M., Matsuba, Y., Hui, K., Tsubuki, S., Tanaka, M., Iwata, N., Saito, T., & Saido, T. C. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.042 · Cited by 459 · see citing works

Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins.

Elias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413 · see citing works

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

Tan, Y., Ichikawa, T., Li, J., Si, Q., Yang, H., Chen, X., Goldblatt, C. S., Meyer, C. J., Li, X., Cai, L., et al. (2011) · Diabetes · doi:10.2337/db10-1164 · Cited by 393 · see citing works

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

Qin, W., Haroutunian, V. H., Katsel, P., Cardozo, C. P., Ho, L., Buxbaum, J. D., & Pasinetti, G. M. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.588 · Cited by 381 · see citing works

Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes

He, C., Zhu, H., Li, H., Zou, M., & Xie, Z. (2012) · Diabetes · doi:10.2337/db12-0533 · Cited by 366 · see citing works

Autophagy in human type 2 diabetes pancreatic beta cells

Masini, M., Bugliani, M., Lupi, R., Guerra, S. D., Boggi, U., Filipponi, F., Marselli, L., Masiello, P., & Marchetti, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1347-2 · Cited by 360 · see citing works

Mitochondrial Participation in Ischemic and Traumatic Neural Cell Death

Fiskum, G. M. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.843 · Cited by 348 · see citing works

Neuronal autophagy and neurodegenerative diseases

Son, J., Shim, J., Kim, K.-H., Ha, J., & Han, J.-Y. (2012) · Experimental and Molecular Medicine · doi:10.3858/emm.2012.44.2.031 · Cited by 342 · see citing works

The Association of Weight Change in Alzheimer's Disease with Severity of Disease and Mortality: A Longitudinal Analysis

White, H., Pieper, C., & Schmader, K. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb04537.x · Cited by 323 · see citing works

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

de Kreutzenberg, S. V., Ceolotto, G., Papparella, I., Bortoluzzi, A., Semplicini, A., Man, C. D., Cobelli, C., Fadini, G. P., & Avogaro, A. (2010) · Diabetes · doi:10.2337/db09-1187 · Cited by 299 · see citing works

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

Yu, W. H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B. T., Cuervo, A. M., & Nixon, R. A. (2004) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2004.05.010 · Cited by 279 · see citing works

Synaptic Changes in Alzheimer's Disease

Gylys, K. H., Fein, J. A., Yang, F., Wiley, D. J., Miller, C. A., & Cole, G. M. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63436-0 · Cited by 253 · see citing works

Mitochondrial biogenesis in exercise and in ageing☆

Viña, J., Gómez‐Cabrera, M. C., Borrás, C., Froio, T., Sanchis‐Gomar, F., Martinez-Bello, V. E., & Pallardó, F. V. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.006 · Cited by 251 · see citing works

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

Uittenbogaard, M. N., & Chiaramello, A. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140305224906 · Cited by 240 · see citing works

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

Yin, W., Signore, A. P., Iwai, M., Cao, G., Gao, Y., & Chen, J. (2008) · Stroke · doi:10.1161/strokeaha.108.520114 · Cited by 229 · see citing works

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

Higashida, K., Kim, S. H., Jung, S. R., Asaka, M., Holloszy, J. O., & Han, D.-H. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001603 · Cited by 228 · see citing works

Ubiquitinated-Protein Aggregates Form in Pancreatic β-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy

Kaniuk, N. A., Kiràly, M. A., Bates, H. E., Vranić, M., Volchuk, A., & Brumell, J. H. (2007) · Diabetes · doi:10.2337/db06-1160 · Cited by 222 · see citing works

mTOR/p70S6k signalling alteration by Aβ exposure as well as in APP‐PS1 transgenic models and in patients with Alzheimer's disease

Lafay‐Chebassier, C., Paccalin, M., Page, G., Barc‐Pain, S., Perault‐Pochat, M. C., Gil, R., Pradier, L., & Hugon, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03187.x · Cited by 211 · see citing works

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

Pedrós, I., Petrov, D., Allgaier, M., Sureda, F. X., Barroso, E., Beas‐Zárate, C., Auladell, C., Pallàs, M., Vázquez‐Carrera, M., Casadesús, G., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.025 · Cited by 203 · see citing works

Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque

Zhai, C., Cheng, J., Mujahid, H., Wang, H., Kong, J., Yin, Y., Li, J., Zhang, Y. L., Ji, X., & Chen, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090563 · Cited by 194 · see citing works

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A in AD models

Khandelwal, P. J., Herman, A. M., Hoe, H., Rebeck, G. W., & Moussa, C. E. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr091 · Cited by 182 · see citing works

Neuronal macroautophagy: from development to degeneration.

Boland, B., & Nixon, R. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.009 · Cited by 181 · see citing works

Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

Jayaraman, A., & Pike, C. J. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0476-2 · Cited by 181 · see citing works

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

Selfridge, J. E., E, L., Lu, J., & Swerdlow, R. H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.057 · Cited by 175 · see citing works

Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression

Heyward, F. D., Walton, R. G., Carle, M. S., Coleman, M. A., Garvey, W. T., & Sweatt, J. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.005 · Cited by 165 · see citing works

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice

Athale, J., Ulrich, A., MacGarvey, N. C., Bartz, R. R., Welty‐Wolf, K. E., Suliman, H. B., & Piantadosi, C. A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.009 · Cited by 155 · see citing works

Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Rato, L., Duarte, A. I., Tomás, G. D., Santos, M. S., Moreira, P. I., Socorro, S., Cavaco, J. E. B., Alves, M. G., & Oliveira, P. F. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.12.008 · Cited by 154 · see citing works

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

Das, A., Durrant, D., Koka, S., Salloum, F. N., Xi, L., & Kukreja, R. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521062 · Cited by 153 · see citing works

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

Carvalho, C., Cardoso, S., Correia, S. C., Santos, R. X., Santos, M. S., Baldeiras, I., Oliveira, C. R., & Moreira, P. I. (2012) · Diabetes · doi:10.2337/db11-1186 · Cited by 152 · see citing works

Circulating Leptin Levels and Weight Loss in Alzheimer’s Disease Patients

Power, D. A., Noel, J., Collins, R., & O’Neill, D. J. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051252 · Cited by 149 · see citing works

Tyrosine kinase inhibition increases functional parkin‐Beclin‐1 interaction and enhances amyloid clearance and cognitive performance

Lonskaya, I., Hebron, M. L., Desforges, N. M., Franjie, A., & Moussa, C. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302771 · Cited by 139 · see citing works

Deconstructing Mitochondrial Dysfunction in Alzheimer Disease

García‐Escudero, V., Martín-Maestro, P., Perry, G. L., & Ávila, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/162152 · Cited by 118 · see citing works

Autophagy: A Potential Link between Obesity and Insulin Resistance

Codogno, P., & Meijer, A. J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.006 · Cited by 115 · see citing works

Autophagy in inflammation, infection, neurodegeneration and cancer

Arroyo, D. S., Gaviglio, E. A., Ramos, J. M. P., Bussi, C., Rodriguez‐Galán, M. C., & Iribarren, P. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.11.001 · Cited by 112 · see citing works

Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease

Armstrong, A., Mattsson, N., Appelqvist, H., Janefjord, C., Sandin, L., Agholme, L., Olsson, B., Svensson, S., Blennow, K., Zetterberg, H., et al. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8269-3 · Cited by 111 · see citing works

Is nuclear respiratory factor 2 a master transcriptional coordinator for all ten nuclear-encoded cytochrome c oxidase subunits in neurons?

Ongwijitwat, S., & Wong‐Riley, M. T. T. (2005) · Gene · doi:10.1016/j.gene.2005.06.015 · Cited by 108 · see citing works

Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin-resistant conditions

Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., Park, Y. J., & Mook‐Jung, I. (2012) · Autophagy · doi:10.4161/auto.21861 · Cited by 98 · see citing works

Role of Mitochondria Biogenesis in the Metabolic Memory Associated with the Continued Progression of Diabetic Retinopathy and Its Regulation by Lipoic Acid

dos Santos, J. M., & Kowluru, R. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8203 · Cited by 97 · see citing works

Type 2 Diabetic and Alzheimer's Disease Mice Present Similar Behavioral, Cognitive, and Vascular Anomalies

Carvalho, C., Machado, N. J., Mota, P. C., Correia, S. C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130005 · Cited by 85 · see citing works

Coupling of Energy Metabolism and Synaptic Transmission at the Transcriptional Level: Role of Nuclear Respiratory Factor 1 in Regulating both CytochromecOxidase and NMDA Glutamate Receptor Subunit Genes

Dhar, S. S., & Wong‐Riley, M. T. T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3704-08.2009 · Cited by 85 · see citing works

Selective electrode for dibenzyl dimethyl amoonium cation as indicator of the membrane potential in biological systems

Muratsugu, M., Kamo, N., Kurihara, K., & Kobatake, Y. (1977) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(77)90035-9 · Cited by 84 · see citing works

Bcl-2 and Bax protein expression in Alzheimer's disease

Tortosa, A., Serrano-López, E. M., & Ferrer, I. (1998) · Acta Neuropathologica · doi:10.1007/s004010050817 · Cited by 78 · see citing works

Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

Son, S., Song, H., Byun, J., Park, K., Jang, H., Park, Y., & Mook-Jung, I. (2012) · Diabetes · doi:10.2337/db11-1735 · Cited by 74 · see citing works

Treatment of cervical intraepithelial neoplasia: Experience withthe low-voltage diathermy loop

Whiteley, P., & Oláh, K. S. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90035-6 · Cited by 72 · see citing works

A Combination of Nutriments Improves Mitochondrial Biogenesis and Function in Skeletal Muscle of Type 2 Diabetic Goto–Kakizaki Rats

Shen, W., Hao, J., Tian, C., Ren, J., Yang, L., Li, X., Luo, C., Cotma, C. W., & Liu, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002328 · Cited by 63 · see citing works

Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy

dos Santos, J. M., & Kowluru, R. A. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2384 · Cited by 56 · see citing works

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

Gaspar, J. M., Baptista, F. I., Galvão, J., Castilho, Á., Cunha, R. A., & Ambrósio, A. F. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.021 · Cited by 53 · see citing works

Glycogen synthase kinase‐3 inhibition prevents learning deficits in diabetic mice

King, M. R., Anderson, N. J., Guernsey, L. S., & Jolivalt, C. G. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23192 · Cited by 53 · see citing works

Upregulation of PGC ‐1α expression by A lzheimer's disease‐associated pathway: presenilin 1/amyloid precursor protein ( APP )/intracellular domain of APP

Robinson, A., Grösgen, S., Mett, J., Zimmer, V. C., Haupenthal, V. J., Hundsdörfer, B., Stahlmann, C. P., Slobodskoy, Y., Müller, U., Hartmann, T., et al. (2013) · Aging Cell · doi:10.1111/acel.12183 · Cited by 49 · see citing works

Peritoneal implantation of macroencapsulated porcine pancreatic islets in diabetic rats ameliorates severe hyperglycemia and prevents retraction and simplification of hippocampal dendrites

Magariños, A. M., Jain, K., Blount, E. D., Reagan, L. P., Smith, B. H., & McEwen, B. S. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02400-3 · Cited by 43 · see citing works

Systemic and Brain Metabolic Dysfunction as a New Paradigm for Approaching Alzheimer’s Dementia

Giordano, V., Peluso, G., Iannuccelli, M., Benatti, P., Nicolai, R., & Calvani, M. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9125-8 · Cited by 42 · see citing works

3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia

Zhang, T., Yan, W., Li, Q., Fu, J., Liu, K., Jia, W., Sun, X., & Liu, X. (2011) · Neurological Research · doi:10.1179/1743132810y.0000000006 · Cited by 38 · see citing works

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

Santos, R. X., Correia, S. C., Alves, M. G., Oliveira, P. F., Cardoso, S., Carvalho, C., Seiça, R. M. F., Santos, M. S., & Moreira, P. I. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2076-5 · Cited by 36 · see citing works

Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high‐force muscle contraction

Katta, A., Karkala, S. K., Wu, M., Meduru, S., Desai, D. H., Rice, K. M., & Blough, E. R. (2009) · Muscle & Nerve · doi:10.1002/mus.21255 · Cited by 35 · see citing works

Transcriptional coupling of synaptic transmission and energy metabolism: Role of nuclear respiratory factor 1 in co-regulating neuronal nitric oxide synthase and cytochrome c oxidase genes in neurons

Dhar, S. S., Liang, H., & Wong‐Riley, M. T. T. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.07.001 · Cited by 30 · see citing works

Regulation of glycosylation of Lamp-1 in the bovine renal epithelial cell line NBL-1 by changes in the concentration of extracellular phosphate

Helps, C. R., & McGivan, J. D. (1994) · Biochemical Journal · doi:10.1042/bj3030613 · Cited by 2 · see citing works

Untitled work

Greber (1999) · doi:10.1002/(sici)1522-2683(19990101)20:4/5

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., Zhang, W., Wang, L., Wang, Q., Wang, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14676-4 · Cited by 549 · see citing works

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

Uddin, M. S., Stachowiak, A., Mamun, A. A., Tzvetkov, N. T., Takeda, S., Atanasov, A. G., Bergantin, L. B., Abdel‐Daim, M. M., & Stankiewicz, A. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00004 · Cited by 440 · see citing works

Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis

Pinti, M. V., Fink, G. K., Hathaway, Q. A., Durr, A. J., Kunovac, A., & Hollander, J. M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2018 · Cited by 432 · see citing works

Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

Chatterjee, S., & Mudher, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00383 · Cited by 270 · see citing works

Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress

Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 235 · see citing works

ER stress and impaired autophagy flux in neuronal degeneration and brain injury

Yin, Y., Sun, G., Li, E., Kiselyov, K. I., & Sun, D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.008 · Cited by 212 · see citing works

Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes

Nakano, M. H., Nagaishi, K., Konari, N., Saito, Y., Chikenji, T., Mizue, Y., & Fujimiya, M. (2016) · Scientific Reports · doi:10.1038/srep24805 · Cited by 211 · see citing works

Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease

Zhang, X., Alshakhshir, N., & Zhao, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.662242 · Cited by 134 · see citing works

Cognitive dysfunction: a growing link between diabetes and Alzheimer’s disease

Jash, K., Gondaliya, P., Kirave, P., Kulkarni, B., Sunkaria, A., & Kalia, K. (2020) · Drug Development Research · doi:10.1002/ddr.21579 · Cited by 119 · see citing works

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Vasconcelos, A. R., dos Santos, N. B., Scavone, C., & Munhoz, C. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00033 · Cited by 112 · see citing works

Caveolin-1 Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulating Neuronal Ferroptosis-Mediated Mitochondrial Homeostasis

Tang, W., Li, Y., He, S., Jiang, T., Wang, N., Du, M., Cheng, B., Gao, W., Li, Y., & Wang, Q. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0233 · Cited by 110 · see citing works

Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia

Li, Y., Zhang, Y., Wang, L., Wang, P., Xue, Y., Li, X., Qiao, X., Zhang, X., Xu, T., Liu, G., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1320467 · Cited by 107 · see citing works

The diabetic brain and cognition

Riederer, P., Korczyn, A. D., Ali, S. S., Bajenaru, O. A., Choi, M. S., Chopp, M., Dobrota, V. Đ., Grünblatt, E., Jellinger, K. A., Kamal, M. A., et al. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1763-2 · Cited by 96 · see citing works

Type 2 Diabetes Mellitus as a Risk Factor for Alzheimer’s Disease: Review and Meta-Analysis

Athanasaki, A., Melanis, K., Tsantzali, I., Stefanou, M., Ntymenou, S., Paraskevas, S. G., Κalamatianos, T., Boutati, E. I., Lambadiari, V., Voumvourakis, K. I., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10040778 · Cited by 99 · see citing works

A novel synbiotic delays Alzheimer’s disease onset via combinatorial gut-brain-axis signaling in Drosophila melanogaster

Westfall, S., Lomis, N., & Prakash, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214985 · Cited by 96 · see citing works

Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer’s Disease and Other Neurodegenerative Diseases

Calsolaro, V., & Edison, P. (2015) · CNS Drugs · doi:10.1007/s40263-015-0301-8 · Cited by 93 · see citing works

Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models?

García-Serrano, A. M., & Duarte, J. M. N. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00229 · Cited by 94 · see citing works

Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease

Butterfield, D. A., & Boyd-Kimball, D. (2020) · Antioxidants · doi:10.3390/antiox9090818 · Cited by 85 · see citing works

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats

Candeias, E., Sebastião, I., Cardoso, S., Carvalho, C., Santos, M. S., Oliveira, C. R., Moreira, P. I., & Duarte, A. I. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0622-3 · Cited by 88 · see citing works

Cognitive disorder and dementia in type 2 diabetes mellitus

Ortíz, G. G., Huerta, M., González-Usigli, H., Torres-Sánchez, E. D., Delgado-Lara, D. L. C., Pacheco-Moisés, F. P., Mireles-Ramírez, M. A., Torres-Mendoza, B. M., Moreno-Cih, R. I., & Velázquez-Brizuela, I. E. (2022) · World Journal of Diabetes · doi:10.4239/wjd.v13.i4.319 · Cited by 90 · see citing works

Nicotinamide Mononucleotide Administration Prevents Experimental Diabetes-Induced Cognitive Impairment and Loss of Hippocampal Neurons

Chandrasekaran, K., Choi, J., Arvas, M. I., Salimian, M., Singh, S., Xu, S., Gullapalli, R. P., Kristián, T., & Russell, J. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113756 · Cited by 82 · see citing works

Bioactive Food Abates Metabolic and Synaptic Alterations by Modulation of Gut Microbiota in a Mouse Model of Alzheimer’s Disease

Syeda, T., Sánchez‐Tapia, M., Pinedo‐Vargas, L., Granados, O., Cuervo-Zanatta, D., Rojas-Santiago, E., Díaz-Cintra, S. Y., Torres, N., & Perez‐Cruz, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180556 · Cited by 78 · see citing works

Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System

Fujimaki, S., & Kuwabara, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102147 · Cited by 75 · see citing works

Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease

Ding, X.-W., Robinson, M., Li, R., Aldhowayan, H., Geetha, T., & Babu, J. R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105783 · Cited by 73 · see citing works

Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts

Cullinane, P. W., Pablo‐Fernández, E. D., König, A., Outeiro, T. F., Jaunmuktane, Z., & Warner, T. T. (2022) · Movement Disorders · doi:10.1002/mds.29298 · Cited by 73 · see citing works

Understanding the Role of Autophagy in Cancer Formation and Progression Is a Real Opportunity to Treat and Cure Human Cancers

Patergnani, S., Missiroli, S., Morciano, G., Perrone, M., Mantovani, C. M., Anania, G., Fiorica, F., Pinton, P., & Giorgi, C. (2021) · Cancers · doi:10.3390/cancers13225622 · Cited by 72 · see citing works

Liraglutide improves cognitive impairment via the AMPK and PI3K/Akt signaling pathways in type 2 diabetic rats

Yang, Y., Fang, H., Xu, G., Zhen, Y., Zhang, Y., Tian, J., Zhang, D., Zhang, G., & Xu, J. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9180 · Cited by 72 · see citing works

A multitude of signaling pathways associated with Alzheimer's disease and their roles in AD pathogenesis and therapy

Gadhave, K., Kumar, D., Uversky, V. N., & Giri, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21719 · Cited by 70 · see citing works

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease

Sheng, C., Xu, P., Zhou, K., Deng, D., Zhang, C., & Wang, Z. (2017) · BioMed Research International · doi:10.1155/2017/7464872 · Cited by 69 · see citing works

Sitagliptin enhances the neuroprotective effect of pregabalin against pentylenetetrazole-induced acute epileptogenesis in mice: Implication of oxidative, inflammatory, apoptotic and autophagy pathways

Nader, M. A., Ateyya, H., El‐Shafey, M., & El-Sherbeeny, N. A. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.10.006 · Cited by 68 · see citing works

Alzheimer's Disease: From Mitochondrial Perturbations to Mitochondrial Medicine

Cardoso, S., Carvalho, C., Correia, S. C., Seiça, R. M. F., & Moreira, P. I. (2016) · Brain Pathology · doi:10.1111/bpa.12402 · Cited by 67 · see citing works

Non-coding RNAs and Berberine: A new mechanism of its anti-diabetic activities

Chang, W. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.055 · Cited by 66 · see citing works

Hypoglycemic medicines in the treatment of Alzheimer’s disease: Pathophysiological links between AD and glucose metabolism

Wang, Y., Hu, H., Liu, X., & Guo, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1138499 · Cited by 67 · see citing works

Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans

Silzer, T. K., Barber, R. C., Sun, J., Pathak, G. A., Johnson, L., O’Bryant, S. E., & Phillips, N. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213527 · Cited by 63 · see citing works

ERβ promotes Aβ degradation via the modulation of autophagy

Wei, Y. Q., Zhou, J., Wu, J., & Huang, J. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1786-8 · Cited by 65 · see citing works

Metabolic defects shared by Alzheimer's disease and diabetes: A focus on mitochondria

Carvalho, C., & Moreira, P. I. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102694 · Cited by 60 · see citing works

Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones

(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.02.010 · Cited by 58 · see citing works

Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress

Song, X., Zhou, B., Cui, L., Lei, D., Zhang, P., Yao, G., Xia, M., Hayashi, T., Hattori, S., Ushiki‐Kaku, Y., et al. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2141-4 · Cited by 58 · see citing works

Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58 · see citing works

Autophagy-lysosome dysfunction is involved in Aβ deposition in STZ-induced diabetic rats

Ma, L., Lv, Y.-L., Huo, K., Liu, J., Shang, S., Fei, Y., Li, Y., Zhao, B., Wei, M., Deng, Y., et al. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.031 · Cited by 55 · see citing works

Mitochondria and Oxidative Stress as a Link between Alzheimer’s Disease and Diabetes Mellitus

Veselov, I. M., Vinogradova, D. V., Maltsev, A. V., Shevtsov, P. N., Spirkova, E. A., Бачурин, С. О., & Shevtsova, E. F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914450 · Cited by 55 · see citing works

Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis

Li, X., Zhao, T., Gu, J., Wang, Z., Lin, J., Wang, R.-S., Duan, T., Li, Z., Dong, R., Wang, W., et al. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00578-8 · Cited by 49 · see citing works

Diabetes–Alzheimer's Disease Link: Targeting Mitochondrial Dysfunction and Redox Imbalance

Carvalho, C., & Cardoso, S. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8056 · Cited by 47 · see citing works

Resveratrol: A Potential Hippocampal Plasticity Enhancer

Dias, G. P., Cocks, G. D., Bevilaqua, M. C. D. N., Nardi, A. E., & Thuret, S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9651236 · Cited by 47 · see citing works

Beneficial effects of white wine polyphenols-enriched diet on Alzheimer’s disease-like pathology

Mendes, D., Oliveira, M. M., Moreira, P. I., Coutinho, J., Nunes, F. M., Pereira, D. M., Valentão, P., Andrade, P. B., & Videira, R. A. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.001 · Cited by 45 · see citing works

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

Chiquita, S., Campos, E. J., Castelhano, J., Ribeiro, M., Sereno, J., Moreira, P. I., Castelo-Branco, M. S., & Ambrósio, A. F. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0542-8 · Cited by 44 · see citing works

Mitochondrial Dysfunction and Mitophagy Closely Cooperate in Neurological Deficits Associated with Alzheimer’s Disease and Type 2 Diabetes

Paul, S. C., Saha, D., & Binukumar, B. K. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02365-2 · Cited by 43 · see citing works

Purple sweet potato color protects against high-fat diet-induced cognitive deficits through AMPK-mediated autophagy in mouse hippocampus

Zhuang, J., Lu, J. L., Wang, X., Wang, X., Hu, W., Hong, F., Zhao, X., & Zheng, Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.015 · Cited by 40 · see citing works

Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells

Ren, J.-M., Zhang, S.-L., Wang, X., Guan, Z., & Qi, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11253 · Cited by 43 · see citing works

Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease

de Almeida, M. F., Bahr, B. A., & Kinsey, S. T. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.02.012 · Cited by 40 · see citing works

Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications

Cheng, L., Li, W., Chen, Y., Lin, Y., & Miao, Y. (2022) · Aging and Disease · doi:10.14336/ad.2021.0823 · Cited by 40 · see citing works

Autophagy Balances Neuroinflammation in Alzheimer’s Disease

Cheng, X., Wei, Y. Q., Qian, Z., & Han, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01269-6 · Cited by 38 · see citing works

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation

Dias, C., Lourenço, C. F., Ferreiro, E. B., Barbosa, R. M., Laranjinha, J. A. N., & Ledo, A. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.06.012 · Cited by 36 · see citing works

Unravelling neuronal death mechanisms: The role of cytokines and chemokines in immune imbalance in Alzheimer’s disease progression

Kumari, S., Dhapola, R., Sharma, P., Paidlewar, M., Vellingiri, B., Medhi, B., & HariKrishnaReddy, D. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102883 · Cited by 34 · see citing works

Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases

Suresh, S., Chakravorty, A., Giridharan, M., Garimella, L., & Manjithaya, R. R. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.02.023 · Cited by 32 · see citing works

High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer’s Disease Signatures

Zuliani, I., Lanzillotta, C., Tramutola, A., Barone, E., Marzia Perluigi, A., Rinaldo, S., Paone, A., Cutruzzolà, F., Bellanti, F., Spinelli, M., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073746 · Cited by 32 · see citing works

The Mighty Mitochondria Are Unifying Organelles and Metabolic Hubs in Multiple Organs of Obesity, Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes: An Observational Ultrastructure Study

Hayden, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094820 · Cited by 31 · see citing works

Mitochondria in Alzheimer’s Disease and Diabetes-Associated Neurodegeneration: License to Heal!

Cardoso, S., Correia, S. C., Carvalho, C., & Moreira, P. I. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_3 · Cited by 29 · see citing works

Brain insulin resistance linked Alzheimer’s and Parkinson’s disease pathology: An undying implication of epigenetic and autophagy modulation

Kakoty, V., Sarathlal, K. C., Kumari, S., Yang, C., Dubey, S. K., Sahebkar, A., Kesharwani, P., & Taliyan, R. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01187-z · Cited by 29 · see citing works

Alzheimer’s Disease Treatment: The Search for a Breakthrough

Reiss, A. B., Muhieddine, D., Jacob, B., Mesbah, M., Pinkhasov, A., Gomolin, I. H., Stecker, M. M., Wısnıewskı, T., & Leon, J. D. (2023) · Medicina · doi:10.3390/medicina59061084 · Cited by 29 · see citing works

Diabesity and brain disturbances: A metabolic perspective

Cardoso, S., & Moreira, P. I. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.10.002 · Cited by 28 · see citing works

The Association of Preoperative Diabetes With Postoperative Delirium in Older Patients Undergoing Major Orthopedic Surgery: A Prospective Matched Cohort Study

Shang, Z., Yu, J., Fang, P., Zhu, W., Guo, J., Li, L., Liang, Y., Zhang, S., Ma, S., Mei, B., et al. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006893 · Cited by 27 · see citing works

Diabetes Promotes Development of Alzheimer’s Disease Through Suppression of Autophagy

Miao, Y., Guo, D., Li, W., & Zhong, Y. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190156 · Cited by 27 · see citing works

Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

Magalhães, J. D., Fão, L., Vilaça, R., Cardoso, S. M., & Rego, A. C. (2021) · Biomedicines · doi:10.3390/biomedicines9111625 · Cited by 27 · see citing works

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

Cardoso, S., Seiça, R. M. F., & Moreira, P. I. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1205488 · Cited by 27 · see citing works

High intensity interval training ameliorates cognitive impairment in T2DM mice possibly by improving PI3K/Akt/mTOR Signaling-regulated autophagy in the hippocampus

Li, X., He, Q., Zhao, N., Chen, X., Li, T., & Cheng, B. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147703 · Cited by 26 · see citing works

Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through pharmacological interventions

Bennici, G., Almahasheer, H., Alghrably, M., Valensin, D., Kola, A., Kokotidou, C., Lachowicz, J. I., & Jaremko, M. (2024) · RSC Advances · doi:10.1039/d4ra02349h · Cited by 28 · see citing works

Proteotoxicity and mitochondrial dynamics in aging diabetic brain

Fernandes, V., Choudhary, M., Kumar, A., & Singh, S. B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104948 · Cited by 24 · see citing works

Calcium (Ca2+) hemostasis, mitochondria, autophagy, and mitophagy contribute to Alzheimer's disease as early moderators

Hadi, F., Mortaja, M., & Hadi, Z. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4085 · Cited by 23 · see citing works

Gut microbiota—a positive contributor in the process of intermittent fasting-mediated obesity control

Rong, B., Wu, Q., Saeed, M., & Sun, C. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.09.009 · Cited by 24 · see citing works

DL-3-n-butylphthalide (NBP) ameliorates cognitive deficits and CaMKII-mediated long-term potentiation impairment in the hippocampus of diabetic db/db mice

Gao, M., Ji, S., Li, J., & Zhang, S. (2019) · Neurological Research · doi:10.1080/01616412.2019.1672387 · Cited by 23 · see citing works

Effect of ceftriaxone on paired-pulse response and long-term potentiation of hippocampal dentate gyrus neurons in rats with Alzheimer-like disease

Hamidi, N., Nozad, A., Milan, H. S., Salari, A., & Amani, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116969 · Cited by 23 · see citing works

Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer’s Disease

Correia, S. C., Machado, N. J., Alves, M. G., Oliveira, P. F., & Moreira, P. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010461 · Cited by 23 · see citing works

Phlorizin ameliorates cognitive and behavioral impairments via the microbiota-gut-brain axis in high-fat and high-fructose diet-induced obese male mice

Zhang, S. Q., Wang, X., Liu, S., Hu, C. Y., & Meng, Y. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.008 · Cited by 22 · see citing works

Recent trends of natural based therapeutics for mitochondria targeting in Alzheimer’s disease

Dhiman, A., Handa, M., Ruwali, M., Singh, D. P., Kesharwani, P., & Shukla, R. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.03.006 · Cited by 21 · see citing works

Hyperglycemia induced the Alzheimer’s proteins and promoted loss of synaptic proteins in advanced-age female Goto-Kakizaki (GK) rats

Pintana, H., Apaijai, N., Kerdphoo, S., Pratchayasakul, W., Sripetchwandee, J., Suntornsaratoon, P., Charoenphandhu, N., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.041 · Cited by 21 · see citing works

Zonisamide Ameliorates Cognitive Impairment by Inhibiting ER Stress in a Mouse Model of Type 2 Diabetes Mellitus

He, Y.-X., Shen, Q., Tian, J., Wu, Q., Qin, X. Y., Zhang, G., Wei, W., & Liu, Y. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00192 · Cited by 21 · see citing works

Sweet Mitochondria: A Shortcut to Alzheimer’s Disease

Moreira, P. I. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170931 · Cited by 20 · see citing works

Soluble Epoxide Hydrolase Blockade after Stroke Onset Protects Normal but Not Diabetic Mice

Davis, C. M., Zhang, W. H., Allen, E. M., Bah, T. M., Shangraw, R. E., & Alkayed, N. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115419 · Cited by 18 · see citing works

Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats

Hassan, S. F., Ghoneim, A. I., Ghareeb, D. A., & Nematalla, H. A. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105566 · Cited by 18 · see citing works

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Rodrigues‐Neves, A. C., Carecho, R., Correia, S. C., Carvalho, C., Campos, E. J., Baptista, F. I., Moreira, P. I., & Ambrósio, A. F. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02316-x · Cited by 18 · see citing works

Autophagy in alzheimer disease pathogenesis and its therapeutic values

Angst, G., Jia, N., Esqueda, L. T., Fan, Y., Cai, Q., & Wang, C. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2471677 · Cited by 19 · see citing works

Aerobic exercise training improves memory function through modulation of brain-derived neurotrophic factor and synaptic proteins in the hippocampus and prefrontal cortex of type 2 diabetic rats

Sadri, I., Nikookheslat, S. D., Karimi, P., Khani, M., & Nadimi, S. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01360-9 · Cited by 17 · see citing works

Emendation of autophagic dysfuction in neurological disorders: a potential therapeutic target

Sainani, S. R., Pansare, P. A., Rode, K., Bhalchim, V. M., Doke, R. R., & Desai, S. M. (2020) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1822356 · Cited by 15 · see citing works

Physical activity in a swimming pool attenuates memory impairment by reducing glutamate and inflammatory cytokines and increasing BDNF in the brain of mice with type 2 diabetes

Shekarchian, M., Peeri, M., & Azarbayjani, M. A. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110725 · Cited by 15 · see citing works

Sodium butyrate improves cognitive dysfunction in high-fat diet/ streptozotocin-induced type 2 diabetic mice by ameliorating hippocampal mitochondrial damage through regulating AMPK/PGC-1α pathway

Lu, L., Liu, L.-Z., Li, L., Hu, Y., Xian, X., & Li, W. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110139 · Cited by 14 · see citing works

Endoplasmic reticulum stress and autophagy in HIV-1-associated neurocognitive disorders

Chen, X., Zhang, T., & Zhang, Y. (2020) · Journal of NeuroVirology · doi:10.1007/s13365-020-00906-4 · Cited by 14 · see citing works

Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

Rajab, E., Keogh, M. B., Laiva, A. L., Hannan, F. A., Fateel, M., Abdulwahab, F., Madhoob, F. A., AlHamer, B., Ghazzal, S., Dawaishan, A. A., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104757 · Cited by 14 · see citing works

The circRNA circ-Nbea participates in regulating diabetic encephalopathy

Liu, J., Deng, Z., Yu, Z., Zhou, W., & Yuan, Q. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147702 · Cited by 15 · see citing works

The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology

Ribarič, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084358 · Cited by 13 · see citing works

TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy

Lin, Y., Cheng, L., Chen, Y., Li, W., Guo, Q., & Miao, Y. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00322.2024 · Cited by 13 · see citing works

Mitochondria and its epigenetic dynamics: Insight into synaptic regulation and synaptopathies

Gupta, S., Kishore, A., Rishi, V., & Aggarwal, A. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01530-3 · Cited by 13 · see citing works

Epigenetic Control of CDK5 Promoter Regulates Diabetes-Associated Development of Alzheimer’s Disease

Cai, H., Fan, Z., Tian, T., Zhao, C.-C., & Ge, Z.-M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190227 · Cited by 13 · see citing works

Diabetes-Induced H3K9 Hyperacetylation Promotes Development of Alzheimer’s Disease Through CDK5

Cai, H., Fan, Z., Tian, T., Li, Z.-C., Zhao, C.-C., Guo, W., & Ge, Z.-M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200163 · Cited by 13 · see citing works

Type-2 diabetes mellitus reduces cortical thickness and decreases oxidative metabolism in sensorimotor regions after stroke

Ferris, J. K., Peters, S., Brown, K. E., Tourigny, K., & Boyd, L. A. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17703887 · Cited by 12 · see citing works

Inhibition of COX2/PGD2-Related Autophagy Is Involved in the Mechanism of Brain Injury in T2DM Rat

Yang, Y., Chen, Q., Zhao, Q., Luo, Y., Xu, Y., Du, W., Wang, H., Li, H., Lu, Y., Hu, C., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00068 · Cited by 12 · see citing works

Proteomic Analysis of a Rat Streptozotocin Model Shows Dysregulated Biological Pathways Implicated in Alzheimer’s Disease

da Silva, E. M. G., Fischer, J. D. S. D. G., Signorini-Souza, I. D. L., Andrade, A. C. C., Souza, L. C., Andrade, M. K., Carvalho, P. C., de Souza, R. L. R., Vital, M. A. B. F., & Passetti, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052772 · Cited by 11 · see citing works

Autophagy Dysfunction and Neurodegeneration: Where Does It Go Wrong?

Oettinger, D., & Yamamoto, A. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169219 · Cited by 10 · see citing works

Interaction of human IAPP and Aβ1-42 aggravated the AD-related pathology and impaired the cognition in mice

Chen, H., Cao, J., Cai, Y., Du, H.-L., Xi, X.-X., Sun, J., Yin, J., Gao, L., & Jing, Y. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113490 · Cited by 11 · see citing works

H3K18 lactylation potentiates microglial polarization via the TLR4 pathway in diabetes-induced cognitive impairment

Yang, Y., Chen, F., Song, L., Yu, L., Zhang, J., & Zhang, B. (2025) · JCI Insight · doi:10.1172/jci.insight.188077 · Cited by 10 · see citing works

Applied photocatalysis – at last !!

Comyns, A. E. (2011) · Focus on Catalysts · doi:10.1016/s1351-4180(11)70001-0 · Cited by 2 · see citing works

Mitochondrial Dysfunction and Mitophagy Closely Cooperate in Neurological Deficits Associated with Alzheimer’s Disease and Type 2 Diabetes

Paul, S. C., Saha, D., & Binukumar, B. K. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02365-2 · Cited by 43 · see citing works

[O2–02–02]: ALTERATIONS IN MITOCHONDRIAL NETWORK CONTRIBUTE TO SYNAPTIC DYSFUNCTION IN DIABETIC ALZHEIMER'S DISEASE MOUSE MODELS

Yu, Q., Du, F., Hu, G., Yan, S. F., & Yan, S. S. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.07.150 · Cited by 1 · see citing works

Mitochondrial quality control systems sustain brain mitochondrial bioenergetics in early stages of type 2 diabetes

Santos, R. X., Correia, S. C., Alves, M. G., Oliveira, P. F., Cardoso, S., Carvalho, C., Seiça, R. M. F., Santos, M. S., & Moreira, P. I. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2076-5 · Cited by 36 · see citing works

F4‐01‐01: Crosstalk of Mitochondria to Synaptic Dysfunction in Alzheimer Disease

Yan, S. S. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.588