Cited by 1,655Mitochondrial Function and PathologyAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

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Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

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Bhatti, Jasvinder Singh, Bhatti, Gurjit Kaur, Reddy, P. Hemachandra·2017·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2016.11.010PMC PMC5423868

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Abstract

Mitochondria are the powerhouses of the cell and are involved in essential functions of the cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species production & scavenging, regulation of apoptotic cell death and activation of the caspase family of proteases. Mitochondrial dysfunction and oxidative stress are largely involved in aging, cancer, age-related neurodegenerative and metabolic syndrome. In the last decade, tremendous progress has been made in understanding mitochondrial structure, function and their physiology in metabolic syndromes such as diabetes, obesity, stroke and hypertension, and heart disease. Further, progress has also been made in developing therapeutic strategies, including lifestyle interventions (healthy diet and regular exercise), pharmacological strategies and mitochondria-targeted approaches. These strategies were mainly focused to reduce mitochondrial dysfunction and oxidative stress and to maintain mitochondrial quality in metabolic syndromes. The purpose of our article is to highlight the recent progress on the mitochondrial role in metabolic syndromes and also summarize the progress of mitochondria-targeted molecules as therapeutic targets to treat metabolic syndromes. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy.

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Authors: Bhatti, J. S., Bhatti, G. K., & Reddy, P. H.
Affiliations: Sri Guru Gobind Singh College (IN)
Panjab University (IN)
Texas Tech University (US)
Corresponding author: Bhatti, Jasvinder Singh
ORCID: Bhatti, Jasvinder Singh
Bhatti, Gurjit Kaur
Reddy, P. Hemachandra
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2017-05
Volume: 1863
Issue: 5
Pages: 1066-1077
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2016.11.010
PMC: PMC5423868
OpenAlex: W2553902009
Cited by: 1,655
References: 238
Citations by year: 2026: 168 · 2025: 319 · 2024: 293 · 2023: 235 · 2022: 246 · 2021: 151 · 2020: 115 · 2019: 65 · 2018: 34 · 2017: 29
FWCI: 3.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (AG042178, AG047812)
Garrison Family Foundation
University Grants Commission, India (5-82/2016)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mitochondrial dysfunction, oxidative stress, metabolic syndrome, mitochondrial-targeted therapy, reactive oxygen species, apoptosis, caspases, diabetes mellitus, obesity, hypertension, stroke, heart disease, mitochondrial quality, lifestyle intervention, pharmacotherapy
MeSH terms: Animals, Humans, Metabolic Diseases, Mitochondria, Oxidative Stress

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Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

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