Cited by 290Mitochondrial Function and PathologyGenomics and Chromatin DynamicsAutophagy in Disease and Therapy

Mitochondrial DNA nucleoid structure

Bogenhagen, Daniel F.·2012·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Abstract

Eukaryotic cells are characterized by their content of intracellular membrane-bound organelles, including mitochondria as well as nuclei. These two DNA-containing compartments employ two distinct strategies for storage and readout of genetic information. The diploid nuclei of human cells contain about 6 billion base pairs encoding about 25,000 protein-encoding genes, averaging 120 kB/gene, packaged in chromatin arranged as a regular nucleosomal array. In contrast, human cells contain hundreds to thousands of copies of a ca.16 kB mtDNA genome tightly packed with 13 protein-coding genes along with rRNA and tRNA genes required for their expression. The mtDNAs are dispersed throughout the mitochondrial network as histone-free nucleoids containing single copies or small clusters of genomes. This review will summarize recent advances in understanding the microscopic structure and molecular composition of mtDNA nucleoids in higher eukaryotes. This article is part of a Special Issue entitled: Mitochondrial Gene Expression.

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Crossref · 10.1016/j.bbagrm.2011.11.005

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  • The mtDNA molecule copy number per cell is of difficult estimation.

    “Regarding mtDNA, although its sequence has been exactly determined, the mtDNA molecule copy number per cell is of difficult estimation [52].”

    From On the length, weight and GC content of the human genome (2019) · cites this paper as [52]

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Authors
Bogenhagen, D. F.
Affiliations
State University of New York (US)
Corresponding author
Bogenhagen, Daniel F.
Venue
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher
Elsevier BV
Published
2012-09
Volume
1819
Issue
9-10
Pages
914-920
ISSN
1874-9399 (ISSN-L)
OpenAlex
W2022664710
Cited by
290
References
98
Citations by year
2026: 11 · 2025: 15 · 2024: 15 · 2023: 24 · 2022: 28 · 2021: 24 · 2020: 22 · 2019: 14 · 2018: 23 · 2017: 22 · 2016: 24 · 2015: 25 · 2014: 21 · 2013: 13 · 2012: 9
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ellison Medical Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial DNA, mitochondrial DNA structure, mitochondrial genome organization, mitochondrial gene expression
MeSH terms
Cell Nucleus, DNA, Mitochondrial, Humans, Intracellular Membranes, Mitochondria, Nucleosomes, RNA, Ribosomal, Gene Expression, Mitochondrial Proteins

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