SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex
Open accessAbstract
-dependent deacetylase, is a key regulator of cellular metabolism. Recent genome-wide association studies identified genetic variants of SIRT1 linked to major depressive disorders. SIRT1 is widely expressed in the brain; however, neuronal substrates that mediate SIRT1 action on depressive behaviors remain largely unknown. Here we show that selective deletion of SIRT1 in forebrain excitatory neurons causes depression-like phenotypes in male but not female mice. AAV-Cre-mediated SIRT1 knockdown in the medial prefrontal cortex (mPFC) of adult male mice induces depressive-like behaviors. Whole-cell patch-clamp recordings demonstrate that loss of SIRT1 decreases intrinsic excitability and spontaneous excitatory synaptic transmission in layer V pyramidal neurons in the prelimbic mPFC. Consistent with neuronal hypoexcitability, SIRT1 knockout reduces mitochondrial density and expression levels of genes involved in mitochondrial biogenesis and dynamics in the prelimbic mPFC. When a SIRT1 activator (SRT2104) is injected into the mPFC or lateral ventricle of wild-type mice, it reverses chronic unpredictable stress-induced anhedonia and behavioral despair, indicating an antidepressant-like effect. These results suggest that SIRT1 in mPFC excitatory neurons is required for normal neuronal excitability and synaptic transmission and regulates depression-related behaviors in a sex-specific manner.
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SIRT1 has been shown to modulate mood-related behaviors in rodent models and to be necessary for normal neuronal excitability and synaptic functions.
“It has been shown to modulate mood-related behaviors in rodent models, 42 and to be necessary for normal neuronal excitability and synaptic functions.”
From Epigenetics and depression (2019) · cites this paper as [43]
Chronic unpredictable/mild/variable stress and chronic social defeat stress are the two most commonly used animal models of depression.
“Chronic unpredictable/mild/variable stress and chronic social defeat stress are the two most commonly used animal models of depression [31, 34–38].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [36]
Previous studies have shown that chronic unpredictable stress induces anhedonia and despair behavior in male mice.
“Our previous studies have shown that chronic unpredictable stress induces anhedonia and despair behavior in male mice [36].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [36]
The chronic unpredictable stress paradigm effectively induces anhedonia along with other depression-related behaviors, including reduced sensitivity to sucrose reward, decreased sex-related reward-seeking behavior, and despair behavior.
“we used a chronic unpredictable stress paradigm, which effectively induces anhedonia along with other depression-related behaviors [34–36], including reduced sensitivity to sucrose reward, decreased sex-related reward-seeking behavior, and despair behavior.”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [36]
The chronic unpredictable stress paradigm models unanticipated stressful experiences that occur in humans and has been widely used as a valid animal model of depression.
“This paradigm models unanticipated stressful experiences that occur in humans, and thus has been widely used as a valid animal model of depression [34, 36, 52].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [36]
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Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
Fuster, J. M. (1980) · Cited by 2,367 · see citing works
The prefontral cortex and cognitive control
Miller, E. K. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036228 · Cited by 2,016 · see citing works
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Sirtuins in mammals: insights into their biological function
Michán, S., & Sinclair, D. A. (2007) · Biochemical Journal · doi:10.1042/bj20070140 · Cited by 1,719 · see citing works
Neural mechanisms of the cognitive model of depression.
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3027 · Cited by 1,718 · see citing works
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688 · see citing works
Gorski, J. A., Talley, T., Qiu, M. S., Puelles, L., Rubenstein, J. L. R., & Jones, K. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06309.2002 · Cited by 1,367 · see citing works
SIRT1 and other sirtuins in metabolism
Chang, H.-C., & Guarente, L. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.001 · Cited by 1,138 · see citing works
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Cheng, H.-L., Mostoslavsky, R., Saito, S., Manis, J. P., Gu, Y., Patel, P., Bronson, R., Appella, E., Alt, F. W., & Chua, K. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934713100 · Cited by 1,095 · see citing works
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047 · see citing works
Koenigs, M., & Grafman, J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.004 · Cited by 956 · see citing works
Sparse whole-genome sequencing identifies two loci for major depressive disorder
CONVERGE consortium, Cai, N., Bigdeli, T. B., Kretzschmar, W., Li, Y., Liang, J., Song, L., Hu, J., Li, Q., Jin, W., et al. (2015) · Nature · doi:10.1038/nature14659 · Cited by 864 · see citing works
Self-citationMitochondria and neuronal activity
Kann, O., & Kovács, R. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2006 · Cited by 847 · see citing works
The anatomy of mood disorders—review of structural neuroimaging studies
Soares, J. C., & Mann, J. J. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00006-6 · Cited by 760 · see citing works
Luen Tang, B. (2016) · Molecules and Cells · doi:10.14348/molcells.2016.2318 · Cited by 740 · see citing works
Vidal-Gonzalez, I., Vidal-Gonzalez, B., Rauch, S. L., & Quirk, G. J. (2006) · Learning & Memory · doi:10.1101/lm.306106 · Cited by 705 · see citing works
Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626 · see citing works
Self-citationAntidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Metabolic adaptations through the PGC‐1α and SIRT1 pathways
Rodgers, J. T., Lerín, C., Gerhart‐Hines, Z., & Puigserver, P. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.034 · Cited by 599 · see citing works
SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-10.2010 · Cited by 541 · see citing works
The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear
Giustino, T. F., & Maren, S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00298 · Cited by 519 · see citing works
A Population-Based Twin Study of Lifetime Major Depression in Men and Women
Kendler, K. S., & Prescott, C. A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.1.39 · Cited by 512 · see citing works
Overview of the Genetics of Major Depressive Disorder
Lohoff, F. W. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0150-6 · Cited by 498 · see citing works
Haug, H. (1987) · American Journal of Anatomy · doi:10.1002/aja.1001800203 · Cited by 481 · see citing works
Animal model of depression: Pharmacological sensitivity of a hedonic deficit
Katz, R. J. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90053-3 · Cited by 480 · see citing works
Interlaminar Connections in the Neocortex
Thomson, A. M. (2002) · Cerebral Cortex · doi:10.1093/cercor/13.1.5 · Cited by 468 · see citing works
Lerin, C., Rodgers, J. T., Kalume, D. E., Kim, S.-H., Pandey, A., & Puigserver, P. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.013 · Cited by 443 · see citing works
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Vaquero, A., Scher, M., Erdjument-Bromage, H., Tempst, P., Serrano, L., & Reinberg, D. (2007) · Nature · doi:10.1038/nature06268 · Cited by 439 · see citing works
Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond
Krystal, J. H., Sanacora, G., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.026 · Cited by 406 · see citing works
Kim, Y., Yang, G. R., Pradhan, K., Venkataraju, K. U., Bota, M., García del Molino, L. C., Fitzgerald, G., Ram, K., He, M., Levine, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.020 · Cited by 389 · cited 2× · see citing works
“In contrast to cortical areas, female mouse brains have more inhibitory neurons in most subcortical regions [67].”
BackgroundGlutamate-based antidepressants: 20 years on
Skolnick, P., Popik, P., & Trullás, R. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.09.002 · Cited by 382 · see citing works
A Hospital-Based Twin Register of the Heritability of DSM-IV Unipolar Depression
McGuffin, P. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830020047006 · Cited by 373 · see citing works
Top-Down Control of Motor Cortex Ensembles by Dorsomedial Prefrontal Cortex
Narayanan, N. S., & Laubach, M. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.021 · Cited by 311 · see citing works
Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
Ramadori, G., Lee, C. E., Bookout, A. L., Lee, S., Williams, K. W., Anderson, J. G., Elmquist, J. K., & Coppari, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-08.2008 · Cited by 311 · see citing works
Mitochondrial DNA nucleoid structure
Bogenhagen, D. F. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.11.005 · Cited by 290 · see citing works
Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · see citing works
Projection-Specific Neuromodulation of Medial Prefrontal Cortex Neurons
Dembrow, N. C., Chitwood, R. A., & Johnston, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3644-10.2010 · Cited by 281 · see citing works
Fales, C. L., Barch, D. M., Rundle, M. M., Mintun, M. A., Mathews, J., Snyder, A. Z., & Sheline, Y. I. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.027 · Cited by 266 · see citing works
Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414728112 · Cited by 265 · see citing works
Bierut, L. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.557 · Cited by 253 · see citing works
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Libert, S., Pointer, K. B., Bell, E. L., Das, A., Cohen, D. E., Asara, J. M., Kapur, K., Bergmann, S., Preisig, M., Otowa, T., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.054 · Cited by 252 · see citing works
Molecular Machinery of Mitochondrial Fusion and Fission
Westermann, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800011200 · Cited by 251 · see citing works
Hippocampal Sirtuin 1 signaling mediates depression-like behavior
Abe-Higuchi, N., Uchida, S., Yamagata, H., Higuchi, F., Hobara, T., Hara, K., Kobayashi, A., & Watanabe, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.009 · Cited by 247 · see citing works
Leptin Increases Adult Hippocampal Neurogenesis in Vivo and in Vitro
Garza, J. C., Guo, M., Zhang, W., & Lu, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800053200 · Cited by 236 · see citing works
Self-citationCellular and molecular basis for stress-induced depression
Seo, J.-S., Wei, J., Qin, L., Kim, Y., Yan, Z., & Greengard, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.118 · Cited by 235 · see citing works
Glutamatergic Modulators: The Future of Treating Mood Disorders?
Zarate, C., Machado-Vieira, R., Henter, I., Ibrahim, L., Diazgranados, N., & Salvadore, G. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673229.2010.511059 · Cited by 228 · see citing works
Dietrich, M. O., Antunes, C., Geliang, G., Liu, Z.-W., Borók, E., Nie, Y., Xu, A. W., Souza, D. O., Gao, Q., Diano, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2234-10.2010 · Cited by 224 · see citing works
SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
Peng, L., Yuan, Z., Ling, H., Fukasawa, K., Robertson, K. D., Olashaw, N., Koomen, J. M., Chen, J., Lane, W. S., & Seto, E. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06147-11 · Cited by 222 · see citing works
Amat, R., Planavila, A., Chen, S. L., Iglesias, R., Giralt, M., & Villarroya, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.022749 · Cited by 218 · see citing works
Gender differences in human cortical synaptic density
Alonso‐Nanclares, L., González‐Soriano, J., Rodríguez, J., & DeFelipe, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803652105 · Cited by 210 · see citing works
Garza, J. C., Guo, M., Zhang, W., & Lu, X.-Y. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.161 · Cited by 209 · see citing works
Self-citationOptogenetic dissection of medial prefrontal cortex circuitry
Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works
Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
Hallows, W. C., Yu, W., & Denu, J. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.317404 · Cited by 200 · see citing works
The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents
Malkesman, O., Scattoni, M. L., Paredes, D., Tragon, T. R., Pearson, B. L., Shaltiel, G., Chen, G., Crawley, J. N., & Manji, H. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.018 · Cited by 197 · see citing works
Liu, J., Guo, M., Zhang, D., Cheng, S.-Y., Liu, M., Ding, J., Scherer, P. E., Liu, F., & Lu, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202835109 · Cited by 191 · see citing works
Self-citationDistinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation
Wu, H., Lu, Y., Shen, C., Patel, N., Gan, L., Xiong, W., & Mei, L. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.033 · Cited by 163 · see citing works
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works
Gender Differences in the Human Cerebral Cortex: More Neurons in Males; More Processes in Females
Rabinowicz, T., Dean, D. E., Petétot, J. M.-C., & de Courten‐Myers, G. M. (1999) · Journal of Child Neurology · doi:10.1177/088307389901400207 · Cited by 150 · see citing works
Hamani, C., Diwan, M., Isabella, S., Lozano, A. M., & Nobrega, J. N. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.12.010 · Cited by 145 · see citing works
SIRT1 gene is associated with major depressive disorder in the Japanese population
Kishi, T., Yoshimura, R., Kitajima, T., Okochi, T., Okumura, T., Tsunoka, T., Yamanouchi, Y., Kinoshita, Y., Kawashima, K., Fukuo, Y., et al. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.003 · Cited by 136 · see citing works
Sirtuin‐dependent epigenetic regulation in the maintenance of genome integrity
Bosch‐Presegué, L., & Vaquero, A. (2015) · The FEBS Journal · doi:10.1111/febs.13053 · Cited by 132 · see citing works
Guo, M., Li, C., Lei, Y., Xu, S., Zhao, D., & Lu, X.-Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.225 · Cited by 128 · see citing works
Self-citationHsu, T. M., Noble, E. E., Liu, C. M., Cortella, A. M., Konanur, V., Suarez, A. N., Reiner, D. J., Hahn, J. D., Hayes, M. R., & Kanoski, S. E. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.91 · Cited by 123 · see citing works
Emx1 is a Marker for Pyramidal Neurons of the Cerebral Cortex
Chan, C.-H. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.12.1191 · Cited by 121 · see citing works
Liu, J., Perez, S. M., Zhang, W., Lodge, D. J., & Lu, X.-Y. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.36 · Cited by 118 · see citing works
Self-citationZhang, D., Wang, X., Wang, B., Garza, J. C., Fang, X., Wang, J., Scherer, P., Brenner, R., Zhang, W., & Lu, X.-Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.58 · Cited by 115 · see citing works
Self-citationCortical Control of Affective Networks
Kumar, S., Black, S. J., Hultman, R., Szabo, S. T., DeMaio, K. D., Du, J., Katz, B. M., Feng, G., Covington, H. E., & Dzirasa, K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0092-12.2013 · Cited by 110 · see citing works
Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems
Zakhary, S. M., Ayubcha, D., Dileo, J. N., Jose, R., Leheste, J. R., Horowitz, J. M., & Torres, G. (2010) · The Anatomical Record · doi:10.1002/ar.21116 · Cited by 110 · see citing works
Beevers, C. G., Clasen, P., Stice, E., & Schnyer, D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.047 · Cited by 108 · see citing works
Finley, L. W. S., Lee, J., Souza, A., Desquiret-Dumas, V., Bullock, K., Rowe, G. C., Procaccio, V., Clish, C. B., Arany, Z., & Haigis, M. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115813109 · Cited by 102 · see citing works
Specificity and Efficiency of Cre-Mediated Recombination in Emx1–cre Knock-in Mice
Guo, H., Hong, S., Jin, X.-L., Chen, R.-S., Avasthi, P. P., Tu, Y.-T., Ivanco, T. L., & Li, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2870 · Cited by 102 · see citing works
Veerakumar, A., Challis, C., Gupta, P., Da, J., Upadhyay, A., Beck, S. G., & Berton, O. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.009 · Cited by 102 · see citing works
Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours
Guo, M., Huang, T.-Y., Garza, J. C., Chua, S. C., & Lu, X. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000703 · Cited by 101 · see citing works
Self-citationZhang, D., Wang, X., & Lu, X. (2016) · Endocrinology · doi:10.1210/en.2015-2078 · Cited by 96 · see citing works
Self-citationTang, S., Wang, I.-T. J., Yue, C., Takano, H., Terzic, B., Pance, K., Lee, J. Y., Cui, Y., Coulter, D. A., & Zhou, Z. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0539-17.2017 · Cited by 94 · see citing works
Guo, M., Lu, Y., Garza, J. C., Li, Y., Chua, S. C., Zhang, W., Lu, B., & Lu, X.-Y. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.9 · Cited by 83 · see citing works
Self-citationPreclinical Studies Modeling Deep Brain Stimulation for Depression
Hamani, C., & Nóbrega, J. N. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.024 · Cited by 68 · see citing works
Adversity in childhood and depression: linked through SIRT1
Iacono, L. L., Visco‐Comandini, F., Valzania, A., Viscomi, M. T., Coviello, M., Giampà, A., Roscini, L., Bisicchia, E., Siracusano, A., Troisi, A., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.125 · Cited by 62 · see citing works
Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues
Lu, M. M., Sarruf, D. A., Li, P., Osborn, O., Sánchez-Alavez, M., Talukdar, S., Chen, A., Bandyopadhyay, G. K., Xu, J., Morinaga, H., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.443606 · Cited by 57 · see citing works
Klein, J., Winter, C., Coquery, N., Heinz, A., Morgenstern, R., Kupsch, A. R., & Juckel, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.036 · Cited by 57 · see citing works
Wang, X., Zhang, D., & Lu, X. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.75 · Cited by 42 · see citing works
Self-citationChung, E., Joiner, H. E., Skelton, T., Looten, K. D., Mańczak, M., & Reddy, P. H. (2017) · Physiological Reports · doi:10.14814/phy2.13184 · Cited by 41 · see citing works
Role of Sirtuins in Stem Cell Differentiation
Rodríguez, R. M. A., Fernández, A. F., & Fraga, M. F. (2013) · Genes & Cancer · doi:10.1177/1947601913479798 · Cited by 38 · see citing works
Ferland‐Beckham, C., Hawley, W. R., Puckett, R. E., Wineberg, K., Lubin, F. D., Dohanich, G. P., & Schrader, L. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.029 · Cited by 37 · see citing works
Cyr, N. E., Steger, J. S., Toorie, A. M., Yang, J. Z., Stuart, R. C., & Nillni, E. A. (2014) · Endocrinology · doi:10.1210/en.2014-1970 · Cited by 37 · see citing works
Kovanen, L., Donner, K. M., & Partonen, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141001 · Cited by 36 · see citing works
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Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254 · see citing works
Liu, S., Xiu, J., Zhu, C., Meng, K., Li, C., Han, R., Du, T., Li, L., Xu, L., Liu, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27044-7 · Cited by 118 · see citing works
Self-citationFang, X., Jiang, S., Wang, J., Bai, Y., Kim, C. S., Blake, D., Weintraub, N. L., Lei, Y., & Lu, X.-Y. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01004-x · Cited by 95 · see citing works
Self-citationCai, X., Wu, M., Zhang, Z., Liu, H., Huang, S., Song, J., Ren, S., & Huang, Y. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14200 · Cited by 28 · see citing works
You, B., Dun, Y., Fu, S., Qi, D., Zhang, W., Liu, Y., Qiu, L., Xie, M., & Liu, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.646489 · Cited by 17 · see citing works
- Authors
- Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M., & Lu, X.-Y.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Binzhou Medical College Hospital (CN)
- Augusta University (US)
- Corresponding author
- Lu, Xin-Yun
- Venue
- Molecular Psychiatry
- Published
- 2019-01-31
- Volume
- 25
- Issue
- 5
- Pages
- 1094-1111
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC7192847
- OpenAlex
- W2913193276
- Cited by
- 131
- References
- 95
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 20 · 2023: 26 · 2022: 17 · 2021: 20 · 2020: 11 · 2019: 4
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (MH076929, MH100583, MH096251)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- SIRT1, depression, medial prefrontal cortex, sexual dimorphism, neuronal excitability, synaptic transmission, prelimbic cortex, pyramidal neurons, mitochondrial biogenesis, mitochondrial dynamics, SRT2104, chronic unpredictable mild stress, anhedonia, behavioral despair, excitatory neurons, SIRT1 knockdown
- MeSH terms
- Animals, Depression, Major Depressive Disorder, Female, Male, Mice, Inbred C57BL, Synaptic Transmission, Neurons, Sex Characteristics, Prefrontal Cortex, Pyramidal Cells, Excitatory Postsynaptic Potentials, Mice, Sirtuin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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