Cited by 503MicroRNA in disease regulationPlant Molecular Biology ResearchCancer-related molecular mechanisms research

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

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Pu, Mengfan, Chen, Jing, Tao, Zhouteng, Miao, Lingling, Qi, Xinming, Wang, Yizheng, Ren, Jin·2019·Cellular and Molecular Life Sciences

Abstract

MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3' UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.

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Authors
Pu, M., Chen, J., Tao, Z., Miao, L., Qi, X., Wang, Y., & Ren, J.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
Corresponding author
Ren, Jin
Venue
Cellular and Molecular Life Sciences
Published
2018-10-29
Volume
76
Issue
3
Pages
441-451
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2899058989
Cited by
500
References
82
Citations by year
2026: 48 · 2025: 59 · 2024: 83 · 2023: 73 · 2022: 91 · 2021: 77 · 2020: 53 · 2019: 14
FWCI
3.74
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords
microRNA, microRNA target regulation, transcriptional regulation, post-transcriptional regulation, 3' UTR binding, miRNA seed region, gene silencing, gene activation, regulatory networks, gene expression modulation
MeSH terms
Gene Expression Regulation, Humans, Protein Processing, Post-Translational, Transcriptional Activation, Drug Delivery Systems, Gene Silencing, MicroRNAs

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