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Metabolism and function of coenzyme Q
Open accessAbstract
Coenzyme Q (CoQ) is present in all cells and membranes and in addition to be a member of the mitochondrial respiratory chain it has also several other functions of great importance for the cellular metabolism. This review summarizes the findings available to day concerning CoQ distribution, biosynthesis, regulatory modifications and its participation in cellular metabolism. There are a number of indications that this lipid is not always functioning by its direct presence at the site of action but also using e.g. receptor expression modifications, signal transduction mechanisms and action through its metabolites. The biosynthesis of CoQ is studied in great detail in bacteria and yeast but only to a limited extent in animal tissues and therefore the informations available is restricted. However, it is known that the CoQ is compartmentalized in the cell with multiple sites of biosynthesis, breakdown and regulation which is the basis of functional specialization. Some regulatory mechanisms concerning amount and biosynthesis are established and nuclear transcription factors are partly identified in this process. Using appropriate ligands of nuclear receptors the biosynthetic rate can be increased in experimental system which raises the possibility of drug-induced upregulation of the lipid in deficiency. During aging and pathophysiological conditions the tissue concentration of CoQ is modified which influences cellular functions. In this case the extent of disturbances is dependent on the localization and the modified distribution of the lipid at cellular and membrane levels.
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“HMG-CoA blockade is more potent at inhibiting cholesterol biosynthesis than CoQ biosynthesis because of differing Km values for trans-prenyltransferase (leads to CoQ) and squalene synthetase (leads to cholesterol) at the farnesyl-PP branch point (315).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [315]
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Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Regulation of the mevalonate pathway
Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,072
Flagged first, then by citations
2 of the 323 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- van Duijn, 1987, Influence of dolichols on lipid polymorphism in model membranes and the consequences for phospholipid flip-flop and vesicle fusion, Chem. Scr., 27, 95
- Nobuyoshi, 1984, Levels of coenzyme Q10 in biopsies of left ventricular muscle and influence of administration of coenzyme Q10, vol. 4, 221
- Kitamura, 1984, Myocardial tissue level of coenzyme Q10 in patients with cardiac failure, vol. 4, 243
- J. Grünler, Compartmentalization of lipid metabolism in rat liver, PhD thesis. Stockholm University, 2000.
Cited by
Sorted by citations
Items 101–200 of 999
176th ENMC International Workshop: Diagnosis and treatment of coenzyme Q10 deficiency
Rahman, S., Clarke, C. F., & Hirano, M. (2011) · Neuromuscular Disorders · doi:10.1016/j.nmd.2011.05.001 · Cited by 92
Lapointe, J., Stepanyan, Z., Bigras, E., & Hekimi, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006569 · Cited by 91
Crockett, E. L. (2008) · Journal of Comparative Physiology B · doi:10.1007/s00360-008-0275-7 · Cited by 94
Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91
Lee, S., Lee, J. O., Kim, J. H., Kim, N., You, G. Y., Moon, J. W., Sha, J., Kim, S. J., Lee, Y. W., Kang, H. J., et al. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.07.022 · Cited by 94
Coq3 and Coq4 Define a Polypeptide Complex in Yeast Mitochondria for the Biosynthesis of Coenzyme Q
Marbois, B. N., Gin, P., Faull, K. F., Poon, W. W., Lee, P. T., Strahan, J. R., Shepherd, J. N., & Clarke, C. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501315200 · Cited by 91
Ochoa, J. J., Pamplona, R., Ramírez-Tortosa, M. C., Granados-Principal, S. M., Pérez-López, P., Naudí, A., Portero‐Otín, M., López‐Frías, M., Battino, M. A., & Quiles, J. L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.02.004 · Cited by 90
Tarry‐Adkins, J. L., Fernandez‐Twinn, D. S., Hargreaves, I. P., Neergheen, V., Aiken, C., Martin‐Gronert, M. S., McConnell, J. M. L., & Ozanne, S. E. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.119834 · Cited by 89
Mullen, P. J., Lüscher, B., Scharnagl, H., Krähenbühl, S., & Brecht, K. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.12.007 · Cited by 88
Johnson, J. D., & Hill, G. E. (2012) · Biochimie · doi:10.1016/j.biochi.2012.10.021 · Cited by 87
Yubero‐Serrano, E. M., González-Guardia, L., Rangel-Zúñiga, O. A., Delgado‐Lista, J., Gutierrez-Mariscal, F. M., Pérez‐Martínez, P., Delgado‐Casado, N., Cruz‐Teno, C., Tinahones, F. J., Villalba, J. M., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr167 · Cited by 86
Coenzyme Q10 reduces sevoflurane-induced cognitive deficiency in young mice
Xu, G., Han, L., Dong, Y., Shapoval, D., Soriano, S. G., Liu, X., Zhang, Y., & Xie, Z. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex071 · Cited by 85
CoQ10 a super-vitamin: review on application and biosynthesis
Shukla, S., & Dubey, K. K. (2018) · 3 Biotech · doi:10.1007/s13205-018-1271-6 · Cited by 85
AL-Megrin, W. A., Soliman, D., Kassab, R. B., Metwally, D. M., Moneim, A. E. A., & El-Khadragy, M. F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00064 · Cited by 84
Calcium Binding and Transport by Coenzyme Q
Bogeski, I., Gulaboski, R., Kappl, R., Mirčeski, V., Стефова, М., Станоева, Ј. П., & Hoth, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja110190t · Cited by 84
Localization of coenzyme Q10 in the center of a deuterated lipid membrane by neutron diffraction
Hauß, T., Dante, S., Haines, T. H., & Dencher, N. A. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.08.007 · Cited by 84
López-Pedrera, C., Barbarroja, N., Jiménez, Y., Collantes‐Estévez, E., Aguirre, M. A., & Cuadrado, M. J. (2016) · Rheumatology · doi:10.1093/rheumatology/kew054 · Cited by 84
Gui, B., Meng, X., Chen, Y., Tian, J., Liu, G., Shen, C., Zeller, M., Yuan, D., & Wang, C. H. (2015) · Chemistry of Materials · doi:10.1021/acs.chemmater.5b02648 · Cited by 83
Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
Cordero, M. D., Díaz-Parrado, E., Carrión, Á. M., Alfonsi, S., Sánchez-Alcázar, J. A., Bullón, P., Battino, M. A., & de Miguel, M. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4892 · Cited by 83
Cullen, J. K., Murad, N. A., Yeo, A. J., McKenzie, M., Ward, M. S., Chong, K. L., Schieber, N. L., Parton, R. G., Lim, Y. C., Wolvetang, E. J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148213 · Cited by 85
Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast
Payet, L.-A., Leroux, M., Willison, J. C., Kihara, A., Pélosi, L., & Pierrel, F. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.08.008 · Cited by 82
Bottani, E., Lamperti, C., Prigione, A., Tiranti, V., Persico, N., & Brunetti, D. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111083 · Cited by 89
Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases
Testai, L., Martelli, A., Flori, L., Cicero, A. F. G., & Colletti, A. (2021) · Nutrients · doi:10.3390/nu13051697 · Cited by 86
Shertzer, H. G., Genter, M. B., Shen, D., Nebert, D. W., Chen, Y., & Dalton, T. P. (2006) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.09.014 · Cited by 85
Luna‐Sánchez, M., Díaz-Casado, M. E., Barca, E., Tejada, M. A., Montilla‐García, Á., Cobos, E. J., Escames, G., Acuña-Castroviejo, D., Quinzii, C. M., & López, L. C. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404632 · Cited by 82
Ulla, A., Mohamed, M. K., Sikder, B., Rahman, A. T., Sumi, F. A., Hossain, M., Reza, H. M., Rahman, G. M. S., & Alam, M. A. (2017) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-017-0136-7 · Cited by 80
Coenzyme Q10 and Cardiovascular Diseases
Gutierrez-Mariscal, F. M., de la Cruz, S., Torres-Peña, J. D., Alcala-Diaz, J. F., Yubero‐Serrano, E. M., & López‐Miranda, J. (2021) · Antioxidants · doi:10.3390/antiox10060906 · Cited by 82
Gin, P., & Clarke, C. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411527200 · Cited by 81
Oxidative stress and mitochondrial dysfunction in fibromyalgia.
Cordero, M. D., de Miguel, M., Carmona-López, I., Bonal, P., Campa, F. J., & Moreno‐Fernández, A. M. (2010) · PubMed · Cited by 81
Wang, Y., Lilienfeldt, N., & Hekimi, S. (2024) · Physiological Reviews · doi:10.1152/physrev.00040.2023 · Cited by 88
Coenzyme Q10 distribution in blood is altered in patients with Fibromyalgia
Cordero, M. D., Moreno‐Fernández, A. M., de Miguel, M., Bonal, P., Campa, F. J., Jiménez-Jiménez, L., Ruiz-Losada, A., Sánchez-Domínguez, B., Sánchez-Alcázar, J. A., Salviati, L., et al. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.12.010 · Cited by 80
Biochemical Characterization of Indole Prenyltransferases
Yu, X., Liu, Y., Xie, X., Zheng, X., & Li, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.317982 · Cited by 80
Follicular Fluid redox involvement for ovarian follicle growth
Freitas, C., Neto, A. C., Matos, L., Silva, E., Ribeiro, Â., Silva-Carvalho, J. L., & Almeida, H. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0342-3 · Cited by 80
Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency
García‐Corzo, L., Luna‐Sánchez, M., Doerrier, C., Ortiz, F., Escames, G., Acuña-Castroviejo, D., & López, L. C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.008 · Cited by 82
Barone, E., Domenico, F. D., & Butterfield, D. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.10.030 · Cited by 83
Secondary Coenzyme Q 10 Deficiencies in Oxidative Phosphorylation (OXPHOS) and Non-OXPHOS Disorders
Yubero, D., Montero, R., Martín, M. A., Montoya, J., Ribes, A., Grazina, M., Trevisson, E., Rodriguez-Aguilera, J. C., Hargreaves, I. P., Salviati, L., et al. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.06.007 · Cited by 72
Cytochrome b5 reductases: Redox regulators of cell homeostasis
Hall, R., Yuan, S. S., Wood, K. C., Katona, M., & Straub, A. C. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102654 · Cited by 77
The Role of Antioxidants in the Therapy of Cardiovascular Diseases—A Literature Review
Młynarska, E., Hajdys, J., Czarnik, W., Fularski, P., Leszto, K., Majchrowicz, G., Lisińska, W., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16162587 · Cited by 89
The molecular genetics of coenzyme Q biosynthesis in health and disease
Laredj, L. N., Licitra, F., & Puccio, H. M. (2013) · Biochimie · doi:10.1016/j.biochi.2013.12.006 · Cited by 78
Ubiquinol Effects on Antiphospholipid Syndrome Prothrombotic Profile
Pérez‐Sánchez, C., Aguirre, M. A., Ruiz‐Limón, P., Ábalos-Aguilera, M. C., Jiménez, Y., de la Rosa, I. A., Rodríguez‐Ariza, A., Fernández-del-Río, L., González-Reyes, J. A., Segui, P., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309225 · Cited by 79
Li, Z., Wang, P., Yu, Z., Cong, Y., Sun, H., Zhang, J., Zhang, J., Sun, C., Zhang, Y., & Ju, X. (2015) · European Neurology · doi:10.1159/000377676 · Cited by 80
Targeting the Progression of Parkinsons Disease
George, J., Mok, S., Moses, D., Wilkins, S., Bush, A., Cherny, R., & Finkelstein, D. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602814 · Cited by 77
Zahiri, H. S., Yoon, S. H., Keasling, J. D., Lee, S. H., Kim, S. W., Yoon, S. C., & Shin, Y. C. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.05.002 · Cited by 77
The Paradox of Coenzyme Q10 in Aging
Díaz-Casado, M. E., Quiles, J. L., Barriocanal-Casado, E., González-García, P., Battino, M., López, L. C., & Varela-López, A. (2019) · Nutrients · doi:10.3390/nu11092221 · Cited by 81
High glucose–induced endothelial progenitor cell dysfunction
Kang, H., Ma, X., Liu, J., Fan, Y., & Deng, X. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117719058 · Cited by 79
Optimization of Ultrasound-Assisted Extraction of Some Bioactive Compounds from Tobacco Waste
Banožić, M., Banjari, I., Jakovljević, M., Šubarić, D., Tomas, S., Babić, J., & Jokić, S. (2019) · Molecules · doi:10.3390/molecules24081611 · Cited by 76
Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency
Doimo, M., Trevisson, E., Airik, R., Bergdoll, M., Santos‐Ocaña, C., Hildebrandt, F., Navas, P., Pierrel, F., & Salviati, L. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.007 · Cited by 76
Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy
Gerards, M., van den Bosch, B. J. C., Calis, C., Schoonderwoerd, K., van Engelen, K., Tijssen, M. A. J., de Coo, I. F. M., van der Kooi, A. J., & Smeets, H. J. M. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.05.008 · Cited by 75
Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10
Kon, M., Tanabe, K., Akimoto, T., Kimura, F., Tanimura, Y., Shimizu, K., Okamoto, T., & Kono, I. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508926544 · Cited by 75
Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines
Brea‐Calvo, G., Hernández, M., Fernández‐Ayala, D. J. M., Navas, P., & Sánchez-Alcázar, J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.014 · Cited by 75
Antioxidant actions of nitroxyl (HNO)
Lopez, B. E., Shinyashiki, M., Han, T. H., & Fukuto, J. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.015 · Cited by 77
Recent Advances in Direct Functionalization of Quinones
Wang, Y., Zhu, S., & Zou, L. (2019) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201900028 · Cited by 74
Coenzyme Q and Its Role in the Dietary Therapy against Aging
Varela-López, A., Giampieri, F., Battino, M., & Quiles, J. (2016) · Molecules · doi:10.3390/molecules21030373 · Cited by 86
Antioxidant Vitamins and Ageing
Milisav, I., Ribarič, S., & Poljšak, B. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_1 · Cited by 74
Niu, Z., Acevedo-Fani, A., McDowell, A., Barnett, A. M., Loveday, S. M., & Singh, H. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.025 · Cited by 76
Nutraceuticals and Headache: The Biological Basis
Taylor, F. R. (2011) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2011.01847.x · Cited by 73
Allan, C. M., Awad, A. M., Johnson, J. S., Shirasaki, D., Wang, C., Blaby, C., Merchant, S., Loo, J. A., & Clarke, C. F. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.633131 · Cited by 71
Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation
Langsjoen, P. H., Langsjoen, J., Langsjoen, A. M., & Lucas, L. A. (2005) · BioFactors · doi:10.1002/biof.5520250116 · Cited by 73
Coenzyme Q10: Novel Formulations and Medical Trends
Pastor‐Maldonado, C. J., Suarez-Rivero, J. M., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Munuera-Cabeza, M., Suárez-Carrillo, A., Talaverón-Rey, M., & Sánchez-Alcázar, J. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228432 · Cited by 76
Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry
Morris, G., Walker, A. J., Walder, K. R., Berk, M., Marx, W., Carvalho, A. F., Maes, M. H. J., & Puri, B. K. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02212-w · Cited by 74
Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system
Fernández‐Ayala, D. J. M., Brea‐Calvo, G., López‐Lluch, G., & Navas, P. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.05.010 · Cited by 74
Hendrix, J., Nijs, J., Ickmans, K., Godderis, L., Ghosh, M., & Polli, A. (2020) · Antioxidants · doi:10.3390/antiox9111166 · Cited by 78
Sikorska, M., Lanthier, P., Miller, H., Beyers, M., Sodja, C., Zurakowski, B., Gangaraju, S., Pandey, S., & Sandhu, J. K. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.032 · Cited by 70
Galeshkalami, N. S., Abdollahi, M. R., Najafi, R., Baeeri, M., Jamshidzade, A., Falak, R., Gholami, M. D., Hassanzadeh, G., Mokhtari, T., Hassani, S., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.055 · Cited by 70
Molecular genetics of ubiquinone biosynthesis in animals
Wang, Y., & Hekimi, S. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.741564 · Cited by 71
Yin, W., Ruan, H., Westrich, L., Grundmann, A., & Li, S. (2007) · ChemBioChem · doi:10.1002/cbic.200700079 · Cited by 70
Jun, L., Saiki, R., Tatsumi, K., Nakagawa, T., & Kawamukai, M. (2004) · Plant and Cell Physiology · doi:10.1093/pcp/pch211 · Cited by 69
Dehydrogenases of acetic acid bacteria
Qin, Z., Yu, S., Chen, J., & Zhou, J. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107863 · Cited by 66
Food content of ubiquinol-10 and ubiquinone-10 in the Japanese diet
Kubo, H., Fujii, K., 川辺, 泰., Matsumoto, S., Kishida, H., & Hosoe, K. (2007) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2007.10.003 · Cited by 68
Statins for women with polycystic ovary syndrome not actively trying to conceive
Raval, A. D., Hunter, T., Stuckey, B. G. A., & Hart, R. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008565.pub2 · Cited by 68
Cornelius, N., Byron, C., Hargreaves, I. P., Guerra, P. F., Furdek, A. K., Land, J. M., Radford, W. W., Frerman, F. E., Corydon, T. J., Gregersen, N., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt232 · Cited by 68
Members of Antioxidant Machinery and Their Functions
Mehta, S. K., & Gowder, S. J. (2015) · InTech eBooks · doi:10.5772/61884 · Cited by 68
Pathogenicity of two COQ7 mutations and responses to 2,4‐dihydroxybenzoate bypass treatment
Wang, Y., Smith, C., Parboosingh, J. S., Khan, A., Innes, A. M., & Hekimi, S. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13154 · Cited by 68
Zhang, Y. P., Eber, A. E., Yuan, Y., Yang, Z., Rodriguez, Y. F., Levitt, R. C., Takács, P., & Candiotti, K. A. (2013) · Anesthesiology · doi:10.1097/aln.0b013e3182829b7b · Cited by 69
Scalais, E., Chafai, R., Coster, R. V., Bindl, L., Nuttin, C., Panagiotaraki, C., Seneca, S., Lissens, W., Ribes, A., Geers, C., et al. (2013) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2013.05.013 · Cited by 67
TheCOQ2genotype predicts the severity of coenzyme Q10deficiency
Desbats, M. A., Morbidoni, V., Silic‐Benussi, M., Doimo, M., Ciminale, V., Cassina, M., Sacconi, S., Hirano, M., Basso, G., Pierrel, F., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw257 · Cited by 67
Mortensen, A. L., Rosenfeldt, F., & Filipiak, K. J. (2013) · Cardiology Journal · doi:10.5603/cj.a2019.0022 · Cited by 71
Alcázar‐Fabra, M., Rodríguez‐Sánchez, F., Trevisson, E., & Brea‐Calvo, G. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.046 · Cited by 68
Current state of coenzyme Q10 production and its applications
Jeya, M., Moon, H.-J., Lee, J.-L., Kim, I., & Lee, J.-K. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2380-2 · Cited by 66
Yan, N., Liu, Y., Gong, D., Du, Y., Zhang, H., & Zhang, Z. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-015-9393-5 · Cited by 66
González-Guardia, L., Yubero-Serrano, E. M., Delgado-Lista, J., Perez-Martinez, P., Garcia-Rios, A., Marin, C., Camargo, A., Delgado-Casado, N., Roche, H. M., Perez-Jimenez, F., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu098 · Cited by 64
Yang, Y.-K., Wang, L.-P., Chen, L., Yao, X.-P., Yang, K.-Q., Gao, L.-G., & Zhou, X.-L. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.08.002 · Cited by 78
Functional Conservation of Coenzyme Q Biosynthetic Genes among Yeasts, Plants, and Humans
Hayashi, K., Ogiyama, Y., Kazumasa, Y., Nakagawa, T., Kaino, T., & Kawamukai, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099038 · Cited by 65
Trends in Vital Food and Control Engineering
Eissa, A. H. A. (2012) · InTech eBooks · doi:10.5772/2354 · Cited by 66
Quinone analogues regulate mitochondrial substrate competitive oxidation
Brière, J.-J., Schlemmer, D., Chretien, D., & Rustin, P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.002 · Cited by 65
The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1+/− mice
Lapointe, J., Wang, Y., Bigras, E., & Hekimi, S. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201203090 · Cited by 64
Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats
Kon, M., Kimura, F., Akimoto, T., Tanabe, K., Murase, Y., IKEMUNE, S., & Kono, I. (2026) · PubMed · doi:10.22029/eir.2007.1632 · Cited by 63
A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo
Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. T., Krieg, T., Hartley, R. C., James, A. M., & Murphy, M. P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.028 · Cited by 60
Stability of Vitamins C and E in Topical Microemulsions for Combined Antioxidant Therapy
Rozman, B., & Gašperlin, M. (2007) · Drug Delivery · doi:10.1080/10717540601067786 · Cited by 63
Tran, U. C., Marbois, B. N., Gin, P., Gulmezian, M., Jonassen, T., & Clarke, C. F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513267200 · Cited by 63
Yu, T., Liu, Y., Li, X., Lian, B., Lu, X., Jin, X., Shao, Z., Hu, X., Di, G., & Jiang, Y. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0747 · Cited by 59
Infantile and pediatric quinone deficiency diseases
Rötig, A., Mollet, J., Rio, M., & Münnich, A. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.008 · Cited by 62
CoQ10 deficiency diseases in adults
Quinzii, C. M., Hirano, M., & DiMauro, S. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.004 · Cited by 62
Rodríguez-Ortiz, R., Limón, M. C., & Ávalos, J. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01089-08 · Cited by 62
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Li, L., Naseem, S., Sharma, S., & Konopka, J. B. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005147 · Cited by 61
Mahammad, S., & Parmryd, I. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.02.010 · Cited by 61
Mitochondrial-associated metabolic disorders: foundations, pathologies and recent progress
McInnes, J. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-63 · Cited by 64
Effect of age and caloric restriction on coenzyme Q and α-tocopherol levels in the rat
Kamzalov, S., & Sohal, R. S. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.007 · Cited by 61
Jardim, G. A. M., Bower, J. F., & Júnior, E. N. D. S. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b01586 · Cited by 60
Impact of Coenzyme Q10 Administration on Lead Acetate-Induced Testicular Damage in Rats
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Metadata
- Authors
- Turunen, M., Olsson, J., & Dallner, G.
- Affiliations
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Stockholm University (SE)
- Corresponding author
- Dallner, Gustav
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 1660
- Issue
- 1-2
- Pages
- 171-199
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W1971714188
- Cited by
- 1,026
- References
- 323
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 34 · 2023: 47 · 2022: 63 · 2021: 61 · 2020: 71 · 2019: 49 · 2018: 46 · 2017: 47 · 2016: 49 · 2015: 72 · 2014: 55 · 2013: 44 · 2012: 43
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- coenzyme Q10, mitochondrial respiratory chain, coenzyme Q biosynthesis, cellular metabolism, nuclear transcription factors, nuclear receptors, signal transduction, aging, membrane localization
- MeSH terms
- Aging, Animals, Biological Transport, Diet, Escherichia coli, Half-Life, Humans, Mevalonic Acid, Oxidation-Reduction, Terpenes, Tissue Distribution, Ubiquinone, Models, Animal
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