The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Chronic stress and comfort foods: self-medication and abdominal obesity
Abstract
Central corticotropin-releasing factor (CRF) networks are recruited by chronic stressors and elevated glucocorticoids (GCs) that initiate recruitment of central CRF activity in the amygdala. Increased central activity of the CRF network stimulates all monoaminergic cell groups, as well as premotor autonomic and other limbic structures resulting in the typical arousal, behavioral changes, autonomic, and neuroendocrine changes that accompany the chronic imposition of a stressor. By contrast, elevated GCs appear, through a variety of means to counteract the effects of central CRF, which they have initiated. Together with insulin, the GCs stimulate drive for and ingestion of "comfort foods" that may directly result in reduction of the negative effects of the chronic stressor in the nucleus Accumbens, through stimulation of the anterior, more pleasure-associated part of this cell group, thus reducing the weight of the stress-stimulated posterior, more defensive part. Furthermore, the shift in caloric intake from chow to preference for "comfort foods," together with elevated GCs and insulin, reorganize energy stores from a peripheral to a central distribution, primarily as abdominal fat. A signal associated with this fat depot appears, as with eating "comfort foods," to reduce the influence of the chronic stress network on behaviors, autonomic, and neuroendocrine outflow.
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In the citing paper
“Stressful events such as job strain, unemployment, family caregiving, marital conflicts and chronic adversity including poverty are associated with weight gain and obesity”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Dallman, Pecoraro, &la Fleur, 2005
In the citing paper
“this relationship appears to be strongest among individuals who are overweight and those who binge eat”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Dallman et al., 2005
In the citing paper
“In addition to the hypothalamus being responsive to GCs via negative feedback, it is also responsive to insulin, secreted from the pancreas and integral to glucose metabolism and energy storage (Dallman et al., 2005; Schwartz, Figlewicz, Baskin, Woods, & Porte, 1992), and to hormones like leptin, which inhibits appetite, and ghrelin, which promotes appetite”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Dallman et al., 2005
In the citing paper
“Chronic stress persistently increases GCs and promotes abdominal fat, which in the presence of insulin, decreases HPA axis activity”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Dallman et al., 2005
In the citing paper
“under such acute stress conditions, there is significant evidence that there is a decrease, rather than an increase, in food intake”
From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Dallman et al., 2005
Citations
Cites
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Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369
Self-citationMotivation concepts in behavioral neuroscience
Berridge, K. C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.004 · Cited by 1,302
Corticosteroid inhibition of acth secretion
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Self-citationEpel, E., Lapidus, R., McEwen, B., & Brownell, K. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00035-4 · Cited by 1,060 · cited 2×
“, 2002), and women under acute lab stress increase “comfort food” intake (Epel et al., 2001).”
BackgroundStunkard, A. J., Faith, M. S., & Allison, K. C. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00608-5 · Cited by 841
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Sorted by citations
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089
Stress-induced obesity and the emotional nervous system
Dallman, M. F. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.004 · Cited by 814
Self-citationGariepy, G., Nitka, D., & Schmitz, N. (2010) · International Journal of Obesity · doi:10.1038/ijo.2009.252 · Cited by 753
Metadata
- Authors
- Dallman, M. F., Pecoraro, N. C., & la Fleur, S. E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Dallman, Mary F.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 19
- Issue
- 4
- Pages
- 275-280
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2100183198
- Cited by
- 656
- References
- 36
- Citations by year
- 2026: 24 · 2025: 22 · 2024: 20 · 2023: 21 · 2022: 33 · 2021: 29 · 2020: 26 · 2019: 35 · 2018: 25 · 2017: 37 · 2016: 41 · 2015: 52 · 2014: 53 · 2013: 47 · 2012: 41
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institute on Drug Abuse (DA-16944, R01DA016944)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- chronic stress, comfort food, self-medication, abdominal obesity, corticotropin-releasing factor, glucocorticoids, insulin, nucleus accumbens, amygdala, energy homeostasis, energy intake
- MeSH terms
- Animals, Chronic Disease, Corticotropin-Releasing Hormone, Eating, Food Preferences, Glucocorticoids, Humans, Limbic System, Macaca mulatta, Neural Pathways, Obesity, Self Medication, Stress, Physiological, Rats
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