Glucocorticoids, chronic stress, and obesity

Dallman, Mary F.; Pecoraro, Norman C.; La Fleur, Susanne E.; Warne, James P.; Ginsberg, Abigail B.; Akana, Susan F.; Laugero, Kevin C.; Houshyar, Hani; Strack, Alison M.; Bhatnagar, Seema; Bell, Mary E.

doi:10.1016/s0079-6123(06)53004-3

Cited by 199Stress Responses and CortisolRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

Glucocorticoids, chronic stress, and obesity

Dallman, Mary F., Pecoraro, Norman C., La Fleur, Susanne E., Warne, James P., Ginsberg, Abigail B., Akana, Susan F., Laugero, Kevin C., Houshyar, Hani +3 more·2006·Progress in Brain Research

DOI 10.1016/s0079-6123(06)53004-3

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Abstract

Glucocorticoids either inhibit or sensitize stress-induced activity in the hypothalamo-pituitary-adrenal (HPA) axis, depending on time after their administration, the concentration of the steroids, and whether there is a concurrent stressor input. When there are high glucocorticoids together with a chronic stressor, the steroids act in brain in a feed-forward fashion to recruit a stress-response network that biases ongoing autonomic, neuroendocrine, and behavioral outflow as well as responses to novel stressors. We review evidence for the role of glucocorticoids in activating the central stress-response network, and for mediation of this network by corticotropin-releasing factor (CRF). We briefly review the effects of CRF and its receptor antagonists on motor outflows in rodents, and examine the effects of glucocorticoids and CRF on monoaminergic neurons in brain. Corticosteroids stimulate behaviors that are mediated by dopaminergic mesolimbic "reward" pathways, and increase palatable feeding in rats. Moreover, in the absence of corticosteroids, the typical deficits in adrenalectomized rats are normalized by providing sucrose solutions to drink, suggesting that there is, in addition to the feed-forward action of glucocorticoids on brain, also a feedback action that is based on metabolic well being. Finally, we briefly discuss the problems with this network that normally serves to aid in responses to chronic stress, in our current overindulged, and underexercised society.

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Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat
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Pharmacological Evidence that the Inhibition of Diurnal Adrenocorticotropin Secretion by Corticosteroids Is Mediated via Type I Corticosterone-Preferring Receptors*
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“Liking” and “wanting” food rewards: Brain substrates and roles in eating disorders
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Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress
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Channel-Like Functions of the 18-kDa Translocator Protein (TSPO): Regulation of Apoptosis and Steroidogenesis as Part of the Host-Defense Response
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Palatable Foods, Stress, and Energy Stores Sculpt Corticotropin-Releasing Factor, Adrenocorticotropin, and Corticosterone Concentrations after Restraint
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Stress augments food ‘wanting’ and energy intake in visceral overweight subjects in the absence of hunger
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Obese men respond to cognitive but not to catabolic brain insulin signaling
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Caloric Restriction Experience Reprograms Stress and Orexigenic Pathways and Promotes Binge Eating
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Corticosterone and corticosteroid binding globulin in birds: Relation to urbanization in a desert city
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Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism
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Excessive sugar consumption may be a difficult habit to break: a view from the brain and body
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Ghrelin Indirectly Activates Hypophysiotropic CRF Neurons in Rodents
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Plasma Transcortin Influences Endocrine and Behavioral Stress Responses in Mice
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Opposite actions of hypothalamic vasopressin on circadian corticosterone rhythm in nocturnal versus diurnal species
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Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice
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Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines
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Disturbance of Oligodendrocyte Function Plays a Key Role in the Pathogenesis of Schizophrenia and Major Depressive Disorder
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Functional Organization of Neuronal and Humoral Signals Regulating Feeding Behavior
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High-fructose diet leads to visceral adiposity and hypothalamic leptin resistance in male rats — do glucocorticoids play a role?
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Stress and Obesity as Risk Factors in Cardiovascular Diseases: A Neuroimmune Perspective
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Induction of Adipocyte Differentiation by Polybrominated Diphenyl Ethers (PBDEs) in 3T3-L1 Cells
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Stress Biomarkers in Medical Students Participating in a Mind Body Medicine Skills Program
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Self-rated health and ethnicity: focus on indigenous populations
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Predictive behaviors for anxiety and depression in female Wistar rats subjected to cafeteria diet and stress
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Dallman, M. F., Akana, S. F., Strack, A. M., SCRIBNER, K. S., Pecoraro, N. C., la Fleur, S. E., Houshyar, H., & Gómez-Oliver, F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.017 · Cited by 167 · see citing works
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Glucocorticoids, the Etiology of Obesity and the Metabolic Syndrome
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Authors: Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., & Bell, M. E.
Affiliations: University of California, San Francisco (US)
Corresponding author: Dallman, Mary F.
ORCID: Bhatnagar, Seema
Venue: Progress in Brain Research
Publisher: Elsevier
Published: 2006
Volume: 153
Pages: 75-105
ISSN: 0079-6123 (ISSN-L)
DOI: 10.1016/s0079-6123(06)53004-3
OpenAlex: W1553637564
Cited by: 198
References: 374
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 11 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 12 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 12
FWCI: 33.08
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in brain research (publishedVersion)
PubMed (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
Funders: National Institute on Drug Abuse (DA-16944, R01DA016944)
National Institute of Diabetes and Digestive and Kidney Diseases (DK28172)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: glucocorticoids, chronic stress, obesity, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, CRF receptor antagonists, stress response networks, monoaminergic neurons, dopaminergic reward pathways, sucrose intake, adrenalectomy, metabolic feedback
MeSH terms: Animals, Chronic Disease, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Obesity, Pituitary-Adrenal System, Stress, Physiological

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Glucocorticoids, chronic stress, and obesity

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