CoChat
Sign Up
Cited by 158Stress Responses and CortisolHeart Rate Variability and Autonomic ControlTryptophan and brain disorders

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men

von Känel, Roland, Kudielka, Brigitte M., Preckel, Daniel, Hanebuth, Dirk, Fischer, Joachim E.·2006·Brain Behavior and Immunity
DOI 10.1016/j.bbi.2005.03.013
Open this paper in CoChat — free account

Abstract

Acute mental stress induces a significant increase in plasma interleukin (IL)-6 levels as a possible mechanism for how psychological stress might contribute to atherosclerosis. We investigated whether the IL-6 response would habituate in response to a repetitively applied mental stressor and whether cortisol reactivity would show a relationship with IL-6 reactivity. Study participants were 21 reasonably healthy men (mean age 46+/-7 years) who underwent the Trier Social Stress Test (combination of a 3-min preparation, 5-min speech, and 5-min mental arithmetic) three times with an interval of 1 week. Plasma IL-6 and free salivary cortisol were measured immediately before and after stress, and at 45 and 105 min of recovery from stress. Cortisol samples were also obtained 15 and 30 min after stress. Compared to non-stressed controls, IL-6 significantly increased between rest and 45 min post-stress (p=.022) and between rest and 105 min post-stress (p=.001). Peak cortisol (p=.034) and systolic blood pressure (p=.009) responses to stress both habituated between weeks one and three. No adaptation occurred in diastolic blood pressure, heart rate, and IL-6 responses to stress. The areas under the curve integrating the stress-induced changes in cortisol and IL-6 reactivity were negatively correlated at visit three (r=-.54, p=.011), but not at visit one. The IL-6 response to acute mental stress occurs delayed and shows no adaptation to repeated moderate mental stress. The hypothalamus-pituitary-adrenal axis may attenuate stress reactivity of IL-6. The lack of habituation in IL-6 responses to daily stress could subject at-risk individuals to higher atherosclerotic morbidity and mortality.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bbi.2005.03.013

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 158

Related

See all

Metadata

Authors
von Känel, R., Kudielka, B. M., Preckel, D., Hanebuth, D., & Fischer, J. E.
Affiliations
  • Universität Trier (DE)
  • ETH Zurich (CH)
ORCID
Venue
Brain Behavior and Immunity
Publisher
Elsevier BV
Published
2006-01
Volume
20
Issue
1
Pages
40-48
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2005.03.013
OpenAlex
W2034314450
Cited by
158
References
58
Citations by year
2026: 5 · 2025: 7 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 12 · 2014: 9 · 2013: 8 · 2012: 9
FWCI
3.39
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Bern Open Repository and Information System (University of Bern) (submittedVersion)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
interleukin-6, acute psychological stress, habituation, cortisol, hypothalamic-pituitary-adrenal axis, Trier Social Stress Test, atherosclerosis, blood pressure, heart rate, salivary cortisol
MeSH terms
Acute Disease, Adaptation, Physiological, Adult, Analysis of Variance, Blood Pressure, Habituation, Psychophysiologic, Heart Rate, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Pituitary-Adrenal System, Reference Values, Saliva, Stress, Psychological, Neuroimmunomodulation, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review