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Cited by 88Sleep and Wakefulness ResearchCircadian rhythm and melatoninSleep and Work-Related Fatigue

Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1β receptor 1 and tumor necrosis factor-α receptor 1

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Baracchi, Francesca, Opp, Mark R.·2008·Brain, Behavior, and Immunity
DOI 10.1016/j.bbi.2008.02.001PMC PMC4164115
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Abstract

Data indicate that interleukin (IL)-1 beta and tumor necrosis factor-alpha (TNFalpha) are involved in the regulation of non-rapid eye movement sleep (NREMS). Previous studies demonstrate that mice lacking the IL-1 beta type 1 receptor spend less time in NREMS during the light period, whereas mice lacking the p55 (type 1) receptor for TNFalpha spend less time in NREMS during the dark period. To further investigate roles for IL-1 beta and TNFalpha in sleep regulation we phenotyped sleep and responses to sleep deprivation of mice lacking both the IL-1 beta receptor 1 and TNFalpha receptor 1 (IL-1R1/TNFR1 KO). Male adult mice (IL-1R1/TNFR1 KO, n=14; B6129SF2/J, n=14) were surgically instrumented with EEG electrodes and with a thermistor to measure brain temperature. After recovery and adaptation to the recording apparatus, 48 h of undisturbed baseline recordings were obtained. Mice were then subjected to 6h sleep deprivation at light onset by gentle handling. IL-1R1/TNFR1 KO mice spent less time in NREMS during the last 6h of the dark period and less time in rapid eye movement sleep (REMS) during the light period. There were no differences between strains in the diurnal timing of delta power during NREMS. However, there were strain differences in the relative power spectra of the NREMS EEG during both the light period and the dark period. In addition, during the light period relative power in the theta frequency band of the REMS EEG differed between strains. After sleep deprivation, control mice exhibited prolonged increases in NREMS and REMS, whereas the duration of the NREMS increase was shorter and there was no increase in REMS of IL-1R1/TNFR1 KO mice. Delta power during NREMS increased in both strains after sleep deprivation, but the increase in delta power during NREMS of IL-1R1/TNFR1 KO mice was of greater magnitude and of longer duration than that observed in control mice. These results provide additional evidence that the IL-1 beta and TNFalpha cytokine systems play a role in sleep regulation and in the alterations in sleep that follow prolonged wakefulness.

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  • Knockout strains of mice lacking either the type I IL-1 receptor, the 55 kD TNF receptor, or both receptors sleep less than control strains.

    “knockout strains of mice that lack either the type I IL-1 receptor (Fang et al, 1998), the 55 kD TNF receptor (Fang et al, 1997), or both of these receptors (Baracchi and Opp, 2008) sleep less than control strains.”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Baracchi and Opp, 2008

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Research works printed but not linked: 3

  1. Dantzer R. Cytokines and behavior. The Physiologist. 1994;37:A4–A5. [Google Scholar]
  2. Hohmann HP, Brockhaus M, Bauerle PA, Remy R, Kolbeck R, van Loon APGM. Expression of the type A and B tumor necrosis factor (TNF) receptor is independently regulated, and both receptors mediate activation of the transcription factor NF-κB. J Biol Chem. 1990;265:22409–22417. [PubMed] [Google Scholar]
  3. Toth LA, Opp MR. Infection and sleep. In: Lee-Chiong T, Carskadon MA, Sateia M, editors. Sleep Medicine. Hanley & Belfus, Inc; Philadelphia: 2002. pp. 77–84. [Google Scholar]

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Authors
Baracchi, F., & Opp, M. R.
Affiliations
University of Michigan (US)
ORCID
Opp, Mark R.
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2008-08
Volume
22
Issue
6
Pages
982-993
ISSN
0889-1591 (ISSN-L)
DOI
10.1016/j.bbi.2008.02.001
PMC
PMC4164115
OpenAlex
W2089178801
Cited by
88
References
66
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 13
FWCI
2.58
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL080972, HL080972)
  • National Institute of General Medical Sciences (P01GM067189, GM067189)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
IL-1β, TNF-α, TNF receptor 1, sleep regulation, sleep deprivation, NREM sleep, REM sleep, delta power, EEG power spectra, cytokines, knockout mice
MeSH terms
Animals, Arousal, Body Temperature, Electroencephalography, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Polyethylene Glycols, Sleep, Sleep Deprivation, Sleep Stages, Sleep, REM, Tumor Necrosis Factor-alpha, Wakefulness, Mice, Knockout, Receptors, Tumor Necrosis Factor, Type I, Mice, Receptors, Interleukin-1 Type I, Interleukin-1beta

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