Negative affective responses to a speech task predict changes in interleukin (IL)-6
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Laboratory studies show that individuals differ appreciably in the magnitude of their inflammatory responses to acute psychological stress. These individual differences are poorly understood, yet may contribute to variation in stress-associated disease vulnerability. The present study examined the possibility that affective responses to acute stress contribute to these differences. For this purpose, 102 relatively-healthy community volunteers (mean age 50 years; 60% female; 91.2% white) performed an acute stress protocol and measures of affective state and serum levels of the proinflammatory cytokine, interleukin (IL)-6 were collected at the end of a 30-min resting baseline, a 5-min evaluative public speaking task, and a 30-min recovery period. Results of regression analyses, controlling for age, race, gender, menopausal status, and body mass index, revealed a positive association of task-related increases in anger and anxiety with increases in IL-6 (R² change = .08, p = .004; R² change = .08, p = .005, respectively). Further examination showed that these affective responses to the task were independent predictors of change in IL-6. Cardiovascular reactivity to the task did not explain the association. These results suggest that individuals who exhibit angry or anxious responses to acute challenge are more vulnerable to stress-related increases in markers of systemic inflammation, possibly rendering them more susceptible to inflammatory disease.
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A public speaking task similar to the TSST induced feelings of anxiety, depression, and anger; greater increases in anxiety and anger were independently related to greater increases in circulating IL-6.
“a public speaking task similar to the TSST induced feelings of anxiety, depression, and anger; greater increases in anxiety and anger were, in turn, independently related to greater increases in circulating IL-6”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Carroll, Low, et al., 2011
Higher cytokine levels were associated with increases in negative mood and anxiety in some studies.
“higher cytokine levels were reported to be associated with increases in negative mood and anxiety in some studies (Yamakawa et al., 2009; Moons et al., 2010; Carroll et al., 2011).”
From The interplay between stress, inflammation, and emotional attention: relevance for depression (2019) · cites this paper as Carroll et al., 2011
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Cites
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
Rozanski, A., Blumenthal, J. A., & Kaplan, J. (1999) · Circulation · doi:10.1161/01.cir.99.16.2192 · Cited by 2,846 · see citing works
Stress and Health: Psychological, Behavioral, and Biological Determinants
Schneiderman, N., Ironson, G., & Siegel, S. D. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.144141 · Cited by 2,252 · see citing works
Steptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · see citing works
Depression and cortisol responses to psychological stress: A meta-analysis
Burke, H. M., Davis, M. C., Otte, C., & Mohr, D. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.010 · Cited by 1,194 · see citing works
Cytokines and the hepatic acute phase response
Moshage, H. (1997) · Journal of Pathology · doi:10.1002/(sici)1096-9896(199703)181:3 · Cited by 1,035 · see citing works
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
Autonomic balance revisited: Panic anxiety and heart rate variability
Friedman, B. H., & Thayer, J. F. (1998) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00202-x · Cited by 616 · cited 2× · see citing works
“For example, negative affective responses to an anger recall interview (ARI) are associated with increased beta2-integrin expression (Greeson et al., 2009) and monocytestimulated proinflammatory cytokine production among insulin resistant men (Suarez et al., 2006).”
BackgroundInflammation and atherosclerosis: role of C-Reactive protein in risk assessment
Libby, P., & Ridker, P. M. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.006 · Cited by 596 · see citing works
Black, P. H. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00048-5 · Cited by 502 · see citing works
von Känel, R., Mills, P. J., Fainman, C., & Dimsdale, J. E. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200107000-00003 · Cited by 422 · see citing works
Neural sensitivity to social rejection is associated with inflammatory responses to social stress
Slavich, G. M., Way, B. M., Eisenberger, N. I., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009164107 · Cited by 418 · see citing works
Neuroendocrine, Cardiovascular, and Emotional Responses of Hostile Men
Suarez, E. C., Kuhn, C. M., Schanberg, S. M., Williams, R. B., & Zimmermann, E. A. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199801000-00017 · Cited by 261 · see citing works
Computational identification of gene–social environment interaction at the human <i>IL6</i> locus
Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256 · see citing works
Clinical depression and regulation of the inflammatory response during acute stress
Miller, G. E., Rohleder, N., Stetler, C., & Kirschbaum, C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000174172.82428.ce · Cited by 253 · see citing works
Brosschot, J. F., & Thayer, J. F. (1998) · Annals of Behavioral Medicine · doi:10.1007/bf02886382 · Cited by 233 · see citing works
Individual Differences in Cellular Immune Response to Stress
Manuck, S. B., Cohen, S., Rabin, B. S., Muldoon, M. F., & Bachen, E. A. (1991) · Psychological Science · doi:10.1111/j.1467-9280.1991.tb00110.x · Cited by 227 · see citing works
Self-citationAnger and fear responses to stress have different biological profiles
Moons, W. G., Eisenberger, N. I., & Taylor, S. E. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.009 · Cited by 211 · see citing works
Negative emotions and acute physiological responses to stress
Feldman, P. J., Cohen, S., Lepore, S. J., Matthews, K. A., Kamarck, T. W., & Marsland, A. L. (1999) · Annals of Behavioral Medicine · doi:10.1007/bf02884836 · Cited by 182 · see citing works
Self-citationSuarez, E. C., & Williams, R. B. (1990) · Psychosomatic Medicine · doi:10.1097/00006842-199009000-00008 · Cited by 168 · see citing works
Cohen, S., & Hamrick, N. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00110-7 · Cited by 160 · see citing works
Self-citationMeasurement of Affective States in Adults: Evaluation of an Adjective Rating Scale Instrument
Usala, P. D., & Hertzog, C. (1989) · Research on Aging · doi:10.1177/0164027589114001 · Cited by 146 · see citing works
McNair, D. M., Lorr, M., & Droppleman, L. F. (1989) · Cited by 141 · see citing works
Thrall, G., Lane, D. A., Carroll, D., & Lip, G. Y. H. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.01.004 · Cited by 135 · see citing works
Stimulated Production of Proinflammatory Cytokines Covaries Inversely With Heart Rate Variability
Marsland, A. L., Gianaros, P. J., Prather, A. A., Jennings, J. R., Neumann, S. A., & Manuck, S. B. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181576118 · Cited by 118 · see citing works
Self-citationBrydon, L., & Steptoe, A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000166841.57474.d0 · Cited by 113 · see citing works
Frasure‐Smith, N., Lespérance, F., Irwin, M. R., Talajic, M. R., & Pollock, B. G. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.07.005 · Cited by 110 · see citing works
Transient responses of inflammatory cytokines in acute stress.
Yamakawa, K., Matsunaga, M., Isowa, T., Kimura, K., Kasugai, K., Yoneda, M., Kaneko, H., & Ohira, H. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.05.001 · Cited by 107 · see citing works
β‐Adrenergic stimulation of interleukin‐1α and interleukin‐6 expression in mouse brown adipocytes
Burýšek, L., & Houštěk, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00671-6 · Cited by 106 · see citing works
Psychosocial, Hemostatic, and Inflammatory Correlates of Delayed Poststress Blood Pressure Recovery
Steptoe, A., & Marmot, M. G. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000227751.82103.65 · Cited by 85 · see citing works
Mental Stress and Coronary Artery Disease: A Multidisciplinary Guide
Holmes, S. D., Krantz, D. S., Rogers, H. L., Gottdiener, J. S., & Contrada, R. J. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2006.08.013 · Cited by 78 · see citing works
Stability of Individual Differences in Cellular Immune Responses to Acute Psychological Stress
Marsland, A. L., Manuck, S. B., Fazzari, T. V., Stewart, C. J., & Rabin, B. S. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199505000-00012 · Cited by 72 · see citing works
Self-citationOwen, N., & Steptoe, A. (2003) · Biological Psychology · doi:10.1016/s0301-0511(03)00023-1 · Cited by 56 · see citing works
Suarez, E. C., Boyle, S. H., Lewis, J. G., Hall, R. P., & Young, K. H. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.09.005 · Cited by 44 · see citing works
Ward, J. R., Wilson, H. L., Francis, S., Crossman, D. C., & Sabroe, I. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03886.x · Cited by 40 · see citing works
Lutgendorf, S. K., Logan, H. L., Costanzo, E. S., & Lubaroff, D. M. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00090-4 · Cited by 37 · see citing works
Greeson, J. M., Lewis, J. G., Achanzar, K., Zimmerman, E. A., Young, K. H., & Suarez, E. C. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.09.015 · Cited by 24 · see citing works
Stability of individual differences in cellular immune responses to two different laboratory tasks
Marsland, A. L., Henderson, B. N., Chambers, W. H., & Baum, A. E. (2002) · Psychophysiology · doi:10.1111/1469-8986.3960865 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206 · see citing works
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786 · see citing works
Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.011 · Cited by 691 · see citing works
Self-citationStimulation of systemic low-grade inflammation by psychosocial stress.
Rohleder, N. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000049 · Cited by 497 · see citing works
Rohleder, N. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.021 · Cited by 439 · see citing works
Diamond, L. M., & Alley, J. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104720 · Cited by 412 · see citing works
In Sickness and in Health: The Co-Regulation of Inflammation and Social Behavior
Eisenberger, N. I., Moieni, M., Inagaki, T. K., Muscatell, K. A., & Irwin, M. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.141 · Cited by 396 · see citing works
Rosenkranz, M. A., Davidson, R. J., MacCoon, D. G., Sheridan, J. F., Kalin, N. H., & Lutz, A. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.013 · Cited by 307 · see citing works
Role of interleukin-6 in stress, sleep, and fatigue
Rohleder, N., Aringer, M., & Boentert, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06634.x · Cited by 289 · see citing works
The interplay between stress, inflammation, and emotional attention: relevance for depression
Maydych, V. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00384 · Cited by 193 · see citing works
The role of inflammation in suicidal behaviour
Brundin, L., Erhardt, S., Bryleva, E. Y., Achtyes, E. D., & Postolache, T. T. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12458 · Cited by 174 · see citing works
Neuroinflammation in suicide: Toward a comprehensive model
Courtet, P., Giner, L., Seneque, M., Guillaume, S., Olie, E., & Ducasse, D. (2016) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1054879 · Cited by 146 · see citing works
Acute psychological stress increases serum circulating cell-free mitochondrial DNA
Trumpff, C., Marsland, A. L., Basualto-Alarcón, C., Martin, J. L., Carroll, J. E., Sturm, G., Vincent, A. E., Mosharov, E. V., Gu, Z., Kaufman, B. A., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.026 · Cited by 147 · see citing works
Self-citationO’Donovan, A., Slavich, G. M., Epel, E. S., & Neylan, T. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.013 · Cited by 148 · see citing works
Human sickness behavior: Ultimate and proximate explanations
Shattuck, E. C., & Muehlenbein, M. P. (2015) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22698 · Cited by 145 · see citing works
Jaremka, L. M., Lindgren, M. E., & Kiecolt‐Glaser, J. K. (2013) · Depression and Anxiety · doi:10.1002/da.22078 · Cited by 137 · see citing works
Negative Emotions Predict Elevated Interleukin-6 in the United States but not in Japan
Miyamoto, Y., Boylan, J., Coe, C., Curhan, K. B., Levine, C. S., Markus, H., Park, J., Kitayama, S., Kawakami, N., Karasawa, M., et al. (2013) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2013.07.173 · Cited by 118 · see citing works
Leschak, C. J., & Eisenberger, N. I. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000685 · Cited by 120 · see citing works
The feeling of anger: From brain networks to linguistic expressions
Nelly Alia-klein, A., Gan, G., Gilam, G., Bezek, J. L., Bruno, A., Denson, T. F., Hendler, T., Lowe, L. J., Mariotti, V., Muscatello, M. R. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.002 · Cited by 117 · see citing works
Social Stress and Psychosis Risk: Common Neurochemical Substrates?
Mizrahi, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.274 · Cited by 115 · see citing works
Aschbacher, K., Epel, E., Wolkowitz, O. M., Prather, A. A., Puterman, E., & Dhabhar, F. S. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.010 · Cited by 112 · see citing works
Self-citationStress-Induced Inflammatory Responses in Women
Christian, L. M., Glaser, R., Porter, K. M., & Iams, J. D. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829bbc89 · Cited by 111 · see citing works
Audet, M., Jacobson‐Pick, S., Wann, B. P., & Anisman, H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.03.010 · Cited by 111 · see citing works
Inducing and Measuring Emotion and Affect
Quigley, K. S., Lindquist, K. A., & Barrett, L. F. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511996481.014 · Cited by 104 · see citing works
Chiang, J. J., Turiano, N. A., Mroczek, D. K., & Miller, G. E. (2017) · Health Psychology · doi:10.1037/hea0000567 · Cited by 95 · see citing works
Sandrini, L., Ieraci, A., Amadio, P., Zarà, M., & Barbieri, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217818 · Cited by 86 · see citing works
Exploring the Physiological Link between Psoriasis and Mood Disorders
Connor, C. J., Liu, V., & Fiedorowicz, J. G. (2015) · Dermatology Research and Practice · doi:10.1155/2015/409637 · Cited by 83 · see citing works
Later high school start times associated with longer actigraphic sleep duration in adolescents
Nahmod, N. G., Lee, S., Master, L., Chang, A., Hale, L. E., & Buxton, O. M. (2018) · SLEEP · doi:10.1093/sleep/zsy212 · Cited by 82 · see citing works
Negative and positive affect as predictors of inflammation: Timing matters
Graham-Engeland, J. E., Sin, N. L., Smyth, J. M., Jones, D. R., Knight, E. L., Sliwinski, M. J., Almeida, D. M., Katz, M. J., Lipton, R. B., & Engeland, C. G. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.09.011 · Cited by 77 · see citing works
Izawa, S., Sugaya, N., Kimura, K., Ogawa, N., Yamada, K. C., Shirotsuki, K., Mikami, I., Hirata, K., Nagano, Y., & Nomura, S. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.06.006 · Cited by 75 · see citing works
Finnell, J. E., & Wood, S. K. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.04.001 · Cited by 68 · see citing works
Ricon, I., Hanalis‐Miller, T., Haldar, R., Jacoby, R., & Ben‐Eliyahu, S. (2019) · Cancer · doi:10.1002/cncr.31594 · Cited by 71 · see citing works
Current status of knowledge on public-speaking anxiety
Pull, C. B. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834e06dc · Cited by 66 · see citing works
Moons, W. G., & Shields, G. S. (2015) · Emotion · doi:10.1037/emo0000055 · Cited by 64 · see citing works
A systematic review of associations between emotion regulation characteristics and inflammation
Moriarity, D. P., Grehl, M. M., Walsh, R. F. L., Roos, L. G., Slavich, G. M., & Alloy, L. B. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105162 · Cited by 55 · see citing works
Association between C-reactive protein and suicidal behavior in an adult inpatient population
Gibbs, H. M., Davis, L., Han, X., Clothier, J. L., Eads, L. A., & Cáceda, R. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.04.002 · Cited by 49 · see citing works
Puterman, E. M., Epel, E. S., O’Donovan, A., Prather, A. A., Aschbacher, K., & Dhabhar, F. S. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-013-9368-0 · Cited by 48 · see citing works
Self-citationVarieties of Anger and the Inverse Link Between Education and Inflammation
Boylan, J. M., & Ryff, C. D. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829683bd · Cited by 47 · see citing works
Lockwood, K. G., Marsland, A. L., Cohen, S., & Gianaros, P. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.001 · Cited by 47 · see citing works
Self-citationEnvironmental enrichment influences brain cytokine variations elicited by social defeat in mice
McQuaid, R. J., Audet, M., Jacobson‐Pick, S., & Anisman, H. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.003 · Cited by 46 · see citing works
Chiang, J. J., Bower, J. E., Irwin, M. R., Taylor, S. E., & Fuligni, A. J. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.015 · Cited by 45 · see citing works
Daily Interpersonal Stress, Sleep Duration, and Gene Regulation during Late Adolescence
Chiang, J. J., Cole, S. W., Bower, J. E., Irwin, M. R., Taylor, S. E., Arevalo, J., & Fuligni, A. J. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.026 · Cited by 44 · see citing works
Auer, B. J., Calvi, J. L., Jordan, N. M., Schrader, D., & Byrd‐Craven, J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.011 · Cited by 42 · see citing works
Pope, B. S., & Wood, S. K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.031 · Cited by 41 · see citing works
Cross-species evidence for the role of interleukin-33 in depression risk.
Kudinova, A. Y., Deak, T., Hueston, C. M., McGeary, J. E., Knopik, V. S., Palmer, R. H. C., & Gibb, B. E. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000158 · Cited by 38 · see citing works
Depressive Symptoms and Momentary Mood Predict Momentary Pain Among Rheumatoid Arthritis Patients
Graham‐Engeland, J. E., Zawadzki, M. J., Slavish, D. C., & Smyth, J. M. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-015-9723-2 · Cited by 37 · see citing works
Colonnello, V., Petrocchi, N., Farinelli, M., & Ottaviani, C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160816120209 · Cited by 35 · see citing works
Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders
Kalinichenko, L. S., Kornhuber, J., & Müller, C. P. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100783 · Cited by 34 · see citing works
Aggressiveness, violence, homicidality, homicide, and Lyme disease
Bransfield, R. C. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s155143 · Cited by 33 · see citing works
SCI and depression: Does inflammation commandeer the brain?
Brakel, K., & Hook, M. A. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112977 · Cited by 34 · see citing works
Putative Inflammatory Sensitive Mechanisms Underlying Risk or Resilience to Social Stress
Finnell, J. E., & Wood, S. K. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00240 · Cited by 31 · see citing works
Is anger, but not sadness, associated with chronic inflammation and illness in older adulthood?
Barlow, M. A., Wrosch, C., Gouin, J., & Kunzmann, U. (2019) · Psychology and Aging · doi:10.1037/pag0000348 · Cited by 29 · see citing works
Anger Expression, Momentary Anger, and Symptom Severity in Patients with Chronic Disease
Russell, M. A., Smith, T. W., & Smyth, J. M. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-015-9747-7 · Cited by 30 · see citing works
Affective and inflammatory responses among orchestra musicians in performance situation
Pilger, A., Haslacher, H., Ponocny‐Seliger, E., Perkmann, T., Böhm, K., Budinsky, A. C., Girard, A., Klien, K., Jordakieva, G., Pezawas, L., et al. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.018 · Cited by 28 · see citing works
Affect variability and inflammatory markers in midlife adults.
Jones, D. R., Smyth, J. M., Engeland, C. G., Sliwinski, M. J., Russell, M. A., Sin, N. L., Almeida, D. M., & Graham‐Engeland, J. E. (2020) · Health Psychology · doi:10.1037/hea0000868 · Cited by 27 · see citing works
Lockwood, K. G., John‐Henderson, N. A., & Marsland, A. L. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.02.016 · Cited by 26 · see citing works
Self-citationImmunocognitive Model of Depression Secondary to Anxiety in Adolescents
Moriarity, D. P., McArthur, B. A., Ellman, L. M., Coe, C. L., Abramson, L. Y., & Alloy, L. B. (2018) · Journal of Youth and Adolescence · doi:10.1007/s10964-018-0905-7 · Cited by 24 · see citing works
Garcia-Leal, C., Graeff, F. G., & Del‐Ben, C. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.011 · Cited by 23 · see citing works
Reward Responsiveness and Ruminative Styles Interact to Predict Inflammation and Mood Symptomatology
Moriarity, D. P., Ng, T. H., Titone, M. K., Chat, I. K.-Y., Nusslock, R., Miller, G. E., & Alloy, L. B. (2019) · Behavior Therapy · doi:10.1016/j.beth.2019.11.007 · Cited by 22 · see citing works
Educational Status, Anger, and Inflammation in the MIDUS National Sample: Does Race Matter?
Boylan, J. M., Lewis, T. T., Coe, C. L., & Ryff, C. D. (2015) · Annals of Behavioral Medicine · doi:10.1007/s12160-015-9687-2 · Cited by 20 · see citing works
Szabo, Y. Z., Fernandez-Botrán, R., & Newton, T. L. (2018) · Anxiety Stress & Coping · doi:10.1080/10615806.2018.1524377 · Cited by 18 · see citing works
Madison, A. A., Andridge, R., Shrout, M. R., Renna, M. E., Bennett, J. M., Jaremka, L. M., Fagundes, C. P., Belury, M. A., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2021) · Psychological Science · doi:10.1177/09567976211031225 · Cited by 19 · see citing works
Delèvaux, I., Chamoux, A., & Aumaître, O. (2012) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.10.366 · Cited by 17 · see citing works
High Anger Expression Exacerbates the Relationship Between Age and Metabolic Syndrome
Boylan, J. M., & Ryff, C. D. (2013) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbt092 · Cited by 17 · see citing works
Trumpff, C., Marsland, A. L., Sloan, R. P., Kaufman, B. A., & Picard, M. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.05.001 · Cited by 16 · see citing works
Self-citationInflammation Through a Psychoneuroimmunological Lens
Bennett, J. M., Gillie, B. L., Lindgren, M. E., Fagundes, C. P., & Kiecolt-Glaser, J. K. (2013) · Handbook of Systems and Complexity in Health · doi:10.1007/978-1-4614-4998-0_19 · Cited by 15 · see citing works
Wilson, N., Liu, J., Adamjee, Q., Giorgio, S. D., Steer, S. E., Hutton, J., & Lempp, H. K. (2023) · BMC Rheumatology · doi:10.1186/s41927-023-00351-w · Cited by 15 · see citing works
Moriarity, D. P., Ng, T. H., Curley, E. E., McArthur, B. A., Ellman, L. M., Coe, C. L., Abramson, L. Y., & Alloy, L. B. (2020) · Journal of Youth and Adolescence · doi:10.1007/s10964-020-01216-y · Cited by 15 · see citing works
Sica, G. (2012) · Oncology Reports · doi:10.3892/or.2012.1785 · Cited by 14 · see citing works
Huang, Q., Monzel, A. S., Rausser, S., Haahr, R., Indik, C. E., Savin, M. J., Bobba‐Alves, N., Liu, C. C., Devine, J., Thompson, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.19.590241 · Cited by 13 · see citing works
Self-citationÖzyurt, G., Tunçel, T., Eliaçık, K., Şenol, H. D., Öztürk, Y., & Özdoğru, E. E. (2020) · Journal of Asthma · doi:10.1080/02770903.2020.1782428 · Cited by 12 · see citing works
Sex differences in interleukin‐6 stress responses in people with Type 2 diabetes
Panagi, L., Poole, L., Hackett, R. A., & Steptoe, A. (2019) · Psychophysiology · doi:10.1111/psyp.13334 · Cited by 10 · see citing works
The influence of everyday emotions on mucosal immunity: An intensive longitudinal modeling approach
Seizer, L., & Löchner, J. (2024) · Psychophysiology · doi:10.1111/psyp.14577 · Cited by 10 · see citing works
Carlton, C. N., Garcia, K. M., Sullivan‐Toole, H., Stanton, K. J., McDonnell, C. G., & Richey, J. A. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100366 · Cited by 11 · see citing works
Gonda, X., Serafini, G., & Döme, P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13071078 · Cited by 9 · see citing works
Sichko, S., Bui, T. Q., Vinograd, M., Shields, G. S., Saha, K., Devkota, S., Alvarez, H. A. O., Carroll, J., Cole, S. W., Irwin, M. R., et al. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100334 · Cited by 9 · see citing works
Self-citationThe role of inflammation and oxidative stress in depression and cardiovascular disease
Wood, S. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00008-8 · Cited by 9 · see citing works
Inflammation in Suicidality: Implications for Novel Treatment Options
Janelidze, S., & Brundin, L. (2013) · Modern trends in psychiatry · doi:10.1159/000346085 · Cited by 8 · see citing works
Yun, S. H., Park, J. C., Kim, S. R., & Choi, Y. S. (2016) · PubMed · doi:10.18926/amo/54002 · Cited by 8 · see citing works
Graham‐Engeland, J. E., Song, S., Mathur, A., Wagstaff, D. A., Klein, L. C., Whetzel, C. A., & Ayoub, W. T. (2018) · Psychological Reports · doi:10.1177/0033294118796655 · Cited by 8 · see citing works
Pate, B. S., Smiley, C. E., Harrington, E. N., Bielicki, H., Davis, J. M., Reagan, L. P., Grillo, C. A., & Wood, S. K. (2024) · Autonomic Neuroscience · doi:10.1016/j.autneu.2024.103175 · Cited by 7 · see citing works
Bhasin, E., Mishra, S., Pathak, G., Chauhan, P. S., & Kulshreshtha, A. (2022) · 3 Biotech · doi:10.1007/s13205-022-03375-0 · Cited by 7 · see citing works
Moving toward affective immunology: Legacy and future directions
Graham‐Engeland, J. E. (2024) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2024.100241 · Cited by 7 · see citing works
Does age influence the frequency of anxiety symptoms and disorders in HIV disease?
Brandt, C. P., Sheppard, D. P., Zvolensky, M. J., Morgan, E. E., Atkinson, J. H., & Woods, S. P. (2016) · Journal of HIV/AIDS & Social Services · doi:10.1080/15381501.2016.1189865 · Cited by 7 · see citing works
Facial Expression Recognition of Public Speaking Anxiety
Huang, F., Wen, W., & Liu, G. (2016) · International Symposium on Computational Intelligence and Design · doi:10.1109/iscid.2016.1061 · Cited by 6 · see citing works
Barron, H., Hafizi, S., & Mizrahi, R. (2017) · Modern trends in psychiatry · doi:10.1159/000470810 · Cited by 6 · see citing works
Tezuka, K., Kubota, Y., Ohira, T., Muraki, I., Hayama‐Terada, M., Shimizu, Y., Imano, H., Okada, T., Kiyama, M., & Iso, H. (2021) · Journal of Epidemiology · doi:10.2188/jea.je20200607 · Cited by 5 · see citing works
Sassun, R., Roufael, F., Crippa, J., Magistro, C., Bertoglio, C. L., Achilli, P., Dinuzzi, V. P., Montroni, I., Maggioni, D., Spinelli, A., et al. (2025) · Colorectal Disease · doi:10.1111/codi.70132 · Cited by 4 · see citing works
Rahal, D., Bower, J. E., Fuligni, A. J., & Chiang, J. J. (2023) · Stress and Health · doi:10.1002/smi.3307 · Cited by 4 · see citing works
Affective Reactions as Mediators of the Relationship Between Stigma and Health
Mendes, W. B., & Muscatell, K. A. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190243470.013.10 · Cited by 4 · see citing works
Effects of elevated emotional symptoms on metabolic disease development: a 10-year follow-up study
Sánchez‐Carro, Y., de la Torre‐Luque, A., Vassou, C., López-García, P., Georgousopoulou, E. N., Pitsavos, C. E., Ayuso‐Mateos, J. L., & Panagiotakos, D. B. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1148643 · Cited by 5 · see citing works
Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress
Melanson, B. A., & Leri, F. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.08.002 · Cited by 4 · see citing works
Yamaoka, K., Ishii, Y., & Terasawa, Y. (2025) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2025.101135 · Cited by 3 · see citing works
Berr, K., Ziehfreund, S., Welcker, M., Biedermann, T., & Zink, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-70420-8 · Cited by 3 · see citing works
Religious Sentiment Analysis and Detection on Social Media
Riskhan, B., Hossain, M. S., & Ashfaq, F. (2025) · Lecture notes in networks and systems · doi:10.1007/978-981-97-8090-7_18 · Cited by 3 · see citing works
Neurormonal and inflammatory responses during weaning trials from mechanical ventilation
Routsi, C., Papas, V., & ZAKYNTHINOS, S. G. (2013) · OA Critical Care · doi:10.13172/2052-9309-1-2-992 · Cited by 2 · see citing works
An Inflammatory Perspective of Stress and Human Depressive Disorder
Audet, M., Jacobson‐Pick, S., McQuaid, R. J., & Anisman, H. (2013) · Wiley eBooks · doi:10.1002/9781118314814.ch24 · Cited by 2 · see citing works
Marine‐derived Potential Anti‐inflammatory Agents
Kumar, M. S., & Patravale, V. B. (2020) · Encyclopedia of Marine Biotechnology · doi:10.1002/9781119143802.ch116 · Cited by 2 · see citing works
Improving Cancer Survival Through Perioperative Attenuation of Adrenergic-Inflammatory Signaling
Ricon‐Becker, I., Hiller, J. G., & Ben‐Eliyahu, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-69584-8.00009-8 · Cited by 1 · see citing works
Bastos, D. B., Sarafim‐Costa, B. A. M., Santos‐Sousa, A. L., Yokota, R., Biasoli, É. R., Casarini, D. E., Miyahara, G. I., & Bernabé, D. G. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107947 · Cited by 1 · see citing works
- Authors
- Carroll, J. E., Low, C. A., Prather, A. A., Cohen, S., Fury, J. M., Ross, D. C., & Marsland, A. L.
- Affiliations
- University of Pittsburgh (US)
- Carnegie Mellon University (US)
- Corresponding author
- Marsland, Anna L.
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 25
- Issue
- 2
- Pages
- 232-238
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC3025042
- OpenAlex
- W2019635910
- Cited by
- 128
- References
- 38
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 13 · 2018: 15 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 14 · 2012: 11
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- KiltHub Repository (submittedVersion)
- Figshare (submittedVersion, cc-by)
- KiltHub Repository
- Funders
- National Heart, Lung, and Blood Institute (T32HL007560)
- National Institute of Nursing Research (R01NR008237, NR008237)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- interleukin-6, acute psychological stress, anger, anxiety, inflammatory cytokines, cardiovascular reactivity, systemic inflammation
- MeSH terms
- Affect, Anger, Anxiety, Blood Pressure, Female, Heart Rate, Hemodynamics, Humans, Male, Middle Aged, Neuropsychological Tests, Social Environment, Speech, Stress, Psychological, Sympathetic Nervous System, Interleukin-6
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