Targeting hippocampal neurogenesis to protect astronauts’ cognition and mood from decline due to space radiation effects
Open accessAbstract
Neurogenesis is an essential, lifelong process during which neural stem cells generate new neurons within the hippocampus, a center for learning, memory, and mood control. Neural stem cells are vulnerable to environmental insults spanning from chronic stress to radiation. These insults reduce their numbers and diminish neurogenesis, leading to memory decline, anxiety, and depression. Preserving neural stem cells could thus help prevent these neurogenesis-associated pathologies, an outcome particularly important for long-term space missions where environmental exposure to radiation is significantly higher than on Earth. Multiple developments, from mechanistic discoveries of radiation injury on hippocampal neurogenesis to new platforms for the development of selective, specific, effective, and safe small molecules as neurogenesis-protective agents hold great promise to minimize radiation damage on neurogenesis. In this review, we summarize the effects of space-like radiation on hippocampal neurogenesis. We then focus on current advances in drug discovery and development and discuss the nuclear receptor TLX/NR2E1 (oleic acid receptor) as an example of a neurogenic target that might rescue neurogenesis following radiation.
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Normal hippocampal neurogenesis is important in cognition and mood and is sensitive to radiation.
“M. Maletic-Savatic and colleagues discuss the importance of normal hippocampal neurogenesis in cognition and mood and its sensitivity to radiation.”
From Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight (2022) · cites this paper as McNerlin et al., 2022
TLX/NR2E1 is a novel neurogenic target.
“They also propose a nuclear receptor, TLX/NR2E1 (recently identified as an oleic acid receptor), as a novel neurogenic target (McNerlin et al., 2022).”
From Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight (2022) · cites this paper as McNerlin et al., 2022
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Cited by
Sorted by citations
Dynan, W. S., Chang, P. Y., Sishc, B. J., & Elgart, S. R. (2022) · Life Sciences in Space Research · doi:10.1016/j.lssr.2022.10.003 · Cited by 12 · see citing works
- Authors
- McNerlin, C., Guan, F., Bronk, L., Lei, K., Grosshans, D., Young, D. W., Gaber, M. W., & Maletic-Savatic, M.
- Affiliations
- Georgetown University (US)
- Yale University (US)
- The University of Texas MD Anderson Cancer Center (US)
- Baylor College of Medicine (US)
- ORCID
- Venue
- Life Sciences in Space Research
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 35
- Pages
- 170-179
- ISSN
- 2214-5524 (ISSN-L)
- OpenAlex
- W4288736974
- Cited by
- 11
- References
- 19
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Life Sciences in Space Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NNX16AO69A, RAD01013)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- hippocampal neurogenesis, space radiation, neural stem cells, mood disorders, memory decline, anxiety, depression, drug discovery, nuclear receptors, long-duration spaceflight
- MeSH terms
- Cognition, Hippocampus, Humans, Radiation Injuries, Astronauts, Neurogenesis
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