Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects
Abstract
Impairment in cognitive flexibility and set shifting abilities has been described in obesity. This alteration is critical as it can interfere with obesity management strategies. Recent evidences suggest that chronic low-grade inflammation may be involved in cognitive deficits associated with obesity, but the potential involvement in reduced flexibility remains unknown. The objective of this study was to assess the contribution of low-grade inflammation, determined by circulating levels of high-sensitivity C-reactive protein (hsCRP), in reduced cognitive flexibility and shifting abilities of obese subjects relatively to a group of non-obese participants. Performance in the intra/extra-dimensional set shift (IED) test, extracted from the CANTAB, was assessed in 66 obese subjects and 20 non-obese participants. Obese subjects with concentrations of hsCRP above 5mg/L exhibited reduced performance on the IED test in comparison to obese subjects with lower levels of hsCRP and non-obese participants. This difference was particularly manifest in the number of errors made during the extra-dimensional shift (EDS errors). In contrast, performance before the extra-dimensional shift was spared. Linear regression analyses revealed that the association between obesity and IED alterations was significant only when the condition hsCRP >5mg/L was entered in the model. These findings are important as they indicate that, rather than obesity itself, low-grade inflammation represents a major contributor of IED performance in obese subjects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lasselin et al. showed that in obese individuals, subjects with CRP levels above 5 mg/L performed worse on the IED test compared to obese subjects with lower CRP or non-obese participants.
“Lasselin et al. showed that in obese individuals, a population often showing ongoing low-grade inflammation, subjects with levels of C-reactive protein (CRP) above 5 mg/L performed worse on the IED test compared to obese subjects with lower levels of CRP or non-obese participants [48].”
From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [48]
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · see citing works
Self-citationElevated C-reactive protein levels in overweight and obese adults
Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494 · see citing works
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P. S., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,571 · see citing works
Immune system to brain signaling: Neuropsychopharmacological implications
Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works
Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6
Park, H. S., Park, J. Y., & Yu, R. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.11.007 · Cited by 964 · see citing works
Monchi, O., Petrides, M., Petre, V., Worsley, K., & Dagher, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07733.2001 · Cited by 961 · see citing works
Lower cognitive function in the presence of obesity and hypertension: the Framingham heart study
Elias, M. F., Elias, P. K., SULLIVAN, L. M., Wolf, P. A., & D’Agostino, R. B. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.802225 · Cited by 691 · see citing works
Elevated body mass index is associated with executive dysfunction in otherwise healthy adults
Gunstad, J., Paul, R. H., Cohen, R. A., Tate, D. F., Spitznagel, M. B., & Gordon, E. (2007) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2006.05.001 · Cited by 668 · see citing works
Computerized assessment in neuropsychiatry using CANTAB: discussion paper.
Sahakian, B. J., & Owen, A. M. (1992) · Europe PMC (PubMed Central) · Cited by 664 · see citing works
Fractionating Attentional Control Using Event-Related fMRI
Hampshire, A., & Owen, A. M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj116 · Cited by 329 · see citing works
Hays, N. P., & Roberts, S. B. (2008) · Obesity · doi:10.1038/oby.2007.12 · Cited by 253 · see citing works
The impact of cognitive function on medication management: Three studies.
Stilley, C. S., Bender, C. M., Dunbar-Jacob, J., Sereika, S., & Ryan, C. M. (2010) · Health Psychology · doi:10.1037/a0016940 · Cited by 248 · see citing works
Cognitive Control of Eating Behavior and the Disinhibition Effect
Westenhöfer, J., Broeckmann, P., Münch, A.-K., & Pudel, V. (1994) · Appetite · doi:10.1006/appe.1994.1032 · Cited by 238 · see citing works
Executive Functions Profile in Extreme Eating/Weight Conditions: From Anorexia Nervosa to Obesity
Fagundo, A. B., de la Torre, R., Jiménez‐Múrcia, S., Agüera, Z., Granero, R., Tárrega, S., Botella, C., Baños, R., Fernández‐Real, J. M., Rodríguez, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043382 · Cited by 228 · see citing works
Neuropsychological performance of a clinical sample of extremely obese individuals
Boeka, A. G., & Lokken, K. (2008) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2008.03.003 · Cited by 220 · see citing works
Wu, M., Brockmeyer, T., Hartmann, M., Skunde, M., Herzog, W., & Friederich, H.-C. (2014) · Psychological Medicine · doi:10.1017/s0033291714000294 · Cited by 189 · see citing works
Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers
Marsland, A. L., Petersen, K. L., Sathanoori, R., Muldoon, M. F., Neumann, S. A., Ryan, C. M., Flory, J. D., & Manuck, S. B. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000238451.22174.92 · Cited by 179 · see citing works
Marioni, R. E., Strachan, M. W. J., Reynolds, R. M., Lowe, G. D. O., Mitchell, R. J., Fowkes, F. G. R., Frier, B. M., Lee, A. J., Butcher, I., Rumley, A., et al. (2009) · Diabetes · doi:10.2337/db09-1163 · Cited by 167 · see citing works
Neuropsychiatric Comorbidity in Obesity: Role of Inflammatory Processes
Castanon, N., Lasselin, J., & Capuron, L. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00074 · Cited by 160 · see citing works
Chaput, J., Leblanc, C., Përusse, L., Després, J., Bouchard, C., & Tremblay, A. (2009) · Obesity · doi:10.1038/oby.2009.116 · Cited by 157 · see citing works
Chronic Low-Grade Inflammation in Metabolic Disorders: Relevance for Behavioral Symptoms
Lasselin, J., & Capuron, L. (2014) · NeuroImmunoModulation · doi:10.1159/000356535 · Cited by 129 · see citing works
Marioni, R. E., Stewart, M. C., Murray, G. D., Deary, I. J., Fowkes, F. G. R., Lowe, G. D. O., Rumley, A., & Price, J. F. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181b1e538 · Cited by 86 · see citing works
Cognitive Performance of Morbidly Obese Patients Seeking Bariatric Surgery
Lokken, K., Boeka, A. G., Yellumahanthi, K., Wesley, M. M., & Clements, R. H. (2010) · The American Surgeon · doi:10.1177/000313481007600111 · Cited by 74 · see citing works
C-reactive protein is linked to lower cognitive performance in overweight and obese women
Sweat, V., Starr, V., Bruehl, H., Arentoft, A., Tirsi, A., Javier, E., & Convit, A. (2008) · Inflammation · doi:10.1007/s10753-008-9065-3 · Cited by 72 · see citing works
Gunstad, J., Bausserman, L., Paul, R. H., Tate, D. F., Hoth, K. F., Poppas, A., Jefferson, A. L., & Cohen, R. A. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.08.010 · Cited by 71 · see citing works
Mangiafico, R. A., Sarnataro, F., Mangiafico, M., & Fiore, C. E. (2006) · Age and Ageing · doi:10.1093/ageing/afi219 · Cited by 61 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Obesity-Induced Neuroinflammation: Beyond the Hypothalamus
Guillemot‐Legris, O., & Muccioli, G. G. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.02.005 · Cited by 565 · see citing works
Executive Function Performance in Obesity and Overweight Individuals: A Meta-Analysis and Review
Yang, Y., Shields, G. S., Guo, C., & Liu, Y. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.020 · Cited by 498 · see citing works
The impact of dietary macronutrient intake on cognitive function and the brain
Muth, A.-K., & Park, S. Q. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.043 · Cited by 197 · see citing works
Favieri, F., Forte, G., & Casagrande, M. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02126 · Cited by 170 · see citing works
Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism?
Park, C., Brietzke, E. M., Rosenblat, J. D., Musial, N., Zuckerman, H., Ragguett, R., Pan, Z., Rong, C., Fus, D., & McIntyre, R. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.006 · Cited by 128 · see citing works
Lasselin, J., Lekander, M., Axelsson, J., & Karshikoff, B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.06.005 · Cited by 106 · see citing works
Filho, A. J. M. C., Lima, C. N. D. C., Vasconcelos, S. M. M., de Lucena, D. F., Maes, M. H. J., & Macêdo, D. S. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.035 · Cited by 105 · see citing works
Berding, K., Long-Smith, C., Carbia, C., Bastiaanssen, T., van de Wouw, M., Wiley, N., Strain, C., Fouhy, F., Stanton, C., Cryan, J., et al. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05665-y
Yang, Y., Shields, G. S., Wu, Q., Liu, Y., Chen, H., & Guo, C. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.11.022 · Cited by 52 · see citing works
The impact of frying aerosol on human brain activity
Naseri, M., Jouzizadeh, M., Tabesh, M., Malekipirbazari, M., Gabdrashova, R., Nurzhan, S., Farrokhi, H., Khanbabaie, R., Mehri‐Dehnavi, H., Bekezhankyzy, Z., et al. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.06.008 · Cited by 45 · see citing works
Barreto, F. S., Filho, A. J. M. C., Araújo, M. C., de Moraes, M. O., de Moraes, M. E. A., Maes, M. H. J., de Lucena, D. F., & Macêdo, D. S. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000384 · Cited by 36 · see citing works
Vreeken, D., Seidel, F., Custers, E., Olsthoorn, L., Cools, S., Aarts, E. O., Kleemann, R., Kessels, R. P. C., Wiesmann, M., Hazebroek, E. J., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.15936 · Cited by 33 · see citing works
Adiposity, inflammation, and working memory: Evidence for a vicious cycle
Shields, G. S., Deer, L. K., Hastings, P. D., & Hostinar, C. E. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100202 · Cited by 32 · see citing works
Allostatic load and executive functions in overweight adults
Ottino-González, J., Jurado, M. A., García-García, I., Caldú, X., Prats-Soteras, X., Tor, E., Sender-Palacios, M. J., & Garolera, M. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.009 · Cited by 31 · see citing works
Huet, L., Delgado, I., Dexpert, S., Sauvant, J., Aouizerate, B., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., & Capuron, L. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.031 · Cited by 30 · see citing works
Klinedinst, B. S., Pappas, C. A., Le, S. T., Yu, S., Wang, Q., Wang, L., Allenspach‐Jorn, K., Mochel, J. P., & Willette, A. A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.008 · Cited by 27 · see citing works
Marra, M. L., Villano, I., Ilardi, C. R., Carosella, M., Staiano, M., Iavarone, A., Chieffi, S., Messina, G., Polito, R., Porro, C., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12060777 · Cited by 26 · see citing works
Yang, Y., Shields, G. S., Wu, Q., Liu, Y., & Guo, C. (2019) · Eating Behaviors · doi:10.1016/j.eatbeh.2019.101338 · Cited by 24 · see citing works
Dalmaz, C., Barth, B., Pokhvisneva, I., Wang, Z., Patel, S. H., Quillfeldt, J. A., Filho, E. J. D. M., de Lima, R. M. S., Arcego, D. M., Sassi, R. B., et al. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107509 · Cited by 22 · see citing works
Wynchank, D., Bijlenga, D., Lamers, F., Kooij, J. J. S., Bron, T. I., Beekman, A. T. F., & Penninx, B. W. J. H. (2016) · Journal of Attention Disorders · doi:10.1177/1087054716659137 · Cited by 22 · see citing works
Correa‐Burrows, P., Rodriguez, Y., Blanco, E., Gahagan, S., & Burrows, R. A. (2018) · Nutrients · doi:10.3390/nu10091133 · Cited by 21 · see citing works
Relationship between cognitive function and functional outcomes in remitted major depression
Luo, R., Fan, N., Dou, Y., Wang, Y., Wang, M., Yang, X., & Ma, X. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05675-6 · Cited by 15 · see citing works
The role of BMI on cognition following acute physical activity in preadolescent children
Raine, L. B., Kao, S., Drollette, E. S., Pontifex, M. B., Pindus, D. M., Hunt, J., Kramer, A. F., & Hillman, C. H. (2020) · Trends in Neuroscience and Education · doi:10.1016/j.tine.2020.100143 · Cited by 14 · see citing works
Cognitive remediation-enabled cognitive behaviour therapy for obesity: a case series
Gilbert, M., Raman, J., & Sui, Z. (2019) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-019-00823-4 · Cited by 13 · see citing works
Pranckeviciene, A., Deltuva, V. P., Tamasauskas, A., Zegliene, J., & Bunevicius, A. (2020) · BioMed Research International · doi:10.1155/2020/2054859 · Cited by 11 · see citing works
Janet, R., Smallwood, J., Hutcherson, C. A. C., Plaßmann, H., Mckeown, B., & Tusche, A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314224121 · Cited by 11 · see citing works
The application of protein microarray assays in psychoneuroimmunology
Ayling, K., Bowden, T., Tighe, P. J., Todd, I., Dilnot, E. M., Negm, O. H., Fairclough, L. C., & Vedhara, K. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.013 · Cited by 11 · see citing works
Association among Executive Function, Physical Activity, and Weight Status in Youth
Borkertienė, V., Stasiulis, A., Zacharienë, B., Kyguolienė, L., & Bacevičienė, R. (2019) · Medicina · doi:10.3390/medicina55100677 · Cited by 11 · see citing works
Song, T., Chu, C., Nien, J., Li, R., Wang, H., Chen, A., Chang, Y.-C., Yang, K.-T., & Chang, Y. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.862801 · Cited by 10 · see citing works
He, Q., Bennett, A. N., Zhang, C., Zhang, J. Y., Tong, S., & Chan, K. H. K. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.03.040 · Cited by 8 · see citing works
HFD refeeding in mice after fasting impairs learning by activating caspase-1 in the brain
Towers, A. E., Oelschlager, M. L., Juda, M. B., Jain, S., Gainey, S. J., & Freund, G. G. (2019) · Metabolism · doi:10.1016/j.metabol.2019.153989 · Cited by 7 · see citing works
Ariza, M., Béjar, J., Barruè, C., Cano, N., Segura, B., NAUTILUS Project Collaborative Group, Bernia, J. A., Arauzo, V., Balagué‐Marmaña, M., Pérez-Pellejero, C., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01748-x · Cited by 7 · see citing works
Explaining the unexpected COVID-19 trends and potential impact across Africa.
Oduro‐Mensah, D., Oduro‐Mensah, E., Quashie, P. K., Awandare, G. A., & Okine, L. K. N. (2021) · F1000Research · doi:10.12688/f1000research.74363.1 · Cited by 8 · see citing works
Karshikoff, B., Åström, J., Holmström, L., Lekander, M., Kemani, M. K., & Wicksell, R. K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092285 · Cited by 6 · see citing works
“showed that in obese individuals, a population often showing ongoing low-grade inflammation, subjects with levels of C-reactive protein (CRP) above 5 mg/L performed worse on the IED test compared to obese subjects with lower levels of CRP or non-obese participants [48].”
BackgroundEffects of mental workload on manufacturing systems employees: A mediation causal model
Realyvásquez-Vargas, A., García-Alcaráz, J. L., Arredondo-Soto, K. C., Hernández-Escobedo, G., & Baez-Lopez, Y. A. (2023) · Work · doi:10.3233/wor-220148 · Cited by 5 · see citing works
How Can Experimental Endotoxemia Contribute to Our Understanding of Pain? A Narrative Review
Benson, S., & Karshikoff, B. (2023) · NeuroImmunoModulation · doi:10.1159/000534467 · Cited by 6 · see citing works
Explaining the unexpected COVID-19 trends and potential impact across Africa.
Oduro‐Mensah, D., Oduro‐Mensah, E., Quashie, P. K., Awandare, G. A., & Okine, L. K. N. (2022) · F1000Research · doi:10.12688/f1000research.74363.2 · Cited by 4 · see citing works
Hilbert, A., Blume, M., Petroff, D., Neuhaus, P., Smith, E., Hay, P., & Hübner, C. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022616 · Cited by 4 · see citing works
Bieliński, M. K., Lesiewska, N., Junik, R., Kamińska, A., Tretyn, A., & Borkowska, A. (2019) · Current Molecular Medicine · doi:10.2174/1566524019666190424143653 · Cited by 4 · see citing works
Chen, L.-C., Bai, Y.-M., Tsai, S., Hsu, J.-W., & Chen, M.-H. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116644 · Cited by 4 · see citing works
Stress, Reward, and Cognition in the Obese Brain
Verdejo‐García, A., Martín-Pérez, C., & Kakoschke, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813146-6.00016-3 · Cited by 4 · see citing works
Wood, A. C., Momin, S. R., Senn, M. K., & Bridgett, D. J. (2022) · Nutrients · doi:10.3390/nu14122391 · Cited by 2 · see citing works
Role of early life adversities in inflammation-related neuropsychiatric comorbidity in obesity
Montet, J., Dexpert, S., Darnaudéry, M., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., Aouizerate, B., & Capuron, L. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.04.039 · Cited by 1 · see citing works
Iwahara, A., Hatta, T., Nakayama, R., Miyawaki, T., Sakate, S., Hatta, J., & Hatta, T. (2025) · Geriatrics · doi:10.3390/geriatrics10040105 · Cited by 1 · see citing works
Nutrition and Vulnerable Groups
Devine, A., & Lawlis, T. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-121-0 · Cited by 1 · see citing works
Loneliness Modulates Inflammation to Affect the Neurocognitive Function of Older Adults
Jin, R. R., Chan, A. K. Y., & Lee, T. M. C. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_14 · Cited by 1 · see citing works
Chavarría-Ávila, E., Navarro-Hernández, R. E., Guzmán-Ornelas, M.-O., Corona-Meraz, F.-I., Ruíz-Quezada, S. L., & Mercado, M. V.-D. (2017) · InTech eBooks · doi:10.5772/65444 · Cited by 1 · see citing works
Comorbid Metabolic Syndrome and Prodromal Alzheimer's Disease in a Rat Model
Ivanova, N. A. (2019) · Scholarship@Western (Western University)
Investigation and description of the New Brain and New Mind hypotheses
Klinedinst, B. S. (2021) · doi:10.31274/td-20240329-457
Verbiest, I., Giletta, M., Naets, T., Vermeiren, E., Eyck, A. V., Bruyndonckx, L., Winter, B. Y. D., Maele, K. V. D., Hoorenbeeck, K. V., Verhulst, S. L., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106129
Luo, R., Fan, N., Dou, Y., Wang, Y., Wang, M., Yang, X., & Ma, X. (2024) · Figshare · doi:10.6084/m9.figshare.25687544
Etude de la voie de la kynurénine dans la symptomatologie du sujet obèse
Huet, L. (2019) · theses.fr (ABES) · doi:10.70675/ff26d7c8z4c5fz4c86z9e6ezd8d843268447
Belhout, S., Poudevigne, L., Mouton, L., Servonnet, A., Coz, C. L., Gaudin, M.-C., Chennaoui, M., Léger, D., Rabat, A., & Faraut, B. (2026) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2026.101390
- Authors
- Lasselin, J., Magne, E., Beau, C., Aubert, A., Dexpert, S., Carrez, J., Layé, S., Forestier, D., Ledaguenel, P., & Capuron, L.
- Affiliations
- Université de Bordeaux (FR)
- Métaphysique, histoires, transformations, actualités (FR)
- Corresponding author
- Capuron, Lucile
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 58
- Pages
- 63-68
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2395742414
- Cited by
- 53
- References
- 29
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 14 · 2018: 5 · 2017: 4 · 2016: 2
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-11-JSV1-0006)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- obesity, low-grade inflammation, cognitive flexibility, set-shifting, high-sensitivity C-reactive protein, CANTAB
- MeSH terms
- Adult, Attention, C-Reactive Protein, Female, Humans, Inflammation, Male, Obesity, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
