The impact of cognitive function on medication management: Three studies.
Open accessAbstract
OBJECTIVE: Medication nonadherence has been a persistent problem over the past three decades; forgetting and being distracted from regular routines are the barriers most frequently cited by patients. Prior research on cognitive function and medication adherence has yielded mixed results. DESIGN: This report compares findings of three studies: All were longitudinal, two were randomized controlled intervention trials, and one was descriptive. Samples of adult patients taking once daily lipid-lowering medication, diabetic patients with comorbid conditions on complex regimens, and early stage breast cancer patients on hormonal therapy completed similar batteries of standardized, valid, neuropsychological tests at baseline. MAIN OUTCOME MEASURES: Adherence to medication regimens, over time, was tracked with electronic event monitors. RESULTS: Medication nonadherence was prevalent in all studies. Deficits in attention/mental flexibility and/or working memory predicted nonadherence in all studies; impaired executive function was related to poor adherence in one study. CONCLUSION: These findings suggest that better mental efficiency may be the key to better medication adherence with any regimen, and that targeted cognitive functions, which can be easily and quickly assessed, may identify patients at risk of poor adherence regardless of diagnosis or regimen.
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Mild cognitive impairment in older adults is associated with poor medication adherence in most studies.
“Also, mild cognitive impairment (MCI) in older adults has been found to be associated with poor medication adherence in most studies.11–13”
From Effectiveness of eHealth interventions targeted to improve medication adherence among older adults with mild cognitive impairment: a protocol for a systematic review and meta-analysis (2022) · cites this paper as [12]
The Abstract (Results; page unavailable) reports that deficits in attention, mental flexibility, or working memory predicted non-adherence in all three studies. But the Methods describe adult samples, including participants aged 24–60 in Study #1, and do not identify participants as having mild cognitive impairment (MCI). The Introduction also describes prior research findings as mixed, so this paper does not establish the claim about MCI in older adults across most studies. (LLM, conf=0.88)
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- Authors
- Stilley, C. S., Bender, C. M., Dunbar-Jacob, J., Sereika, S., & Ryan, C. M.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Health Psychology
- Published
- 2010
- Volume
- 29
- Issue
- 1
- Pages
- 50-55
- ISSN
- 0278-6133 (ISSN-L)
- 1930-7810
- PMC
- PMC2807986
- OpenAlex
- W2006842057
- Semantic Scholar
- bcb4dab16f76e57a65735f81080e6fd7f1f0bd32
- Cited by
- 248
- References
- 26
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 14 · 2020: 24 · 2019: 14 · 2018: 20 · 2017: 18 · 2016: 15 · 2015: 18 · 2014: 13 · 2013: 23 · 2012: 17
- FWCI
- 16.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pittsburgh
- National Institutes of Health (2 P30 NR003924-15, 5U01HLO 48992-02, R01 DK59048, R01 CA107408-01A1)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- medication adherence, medication non-adherence, cognitive function, attention, cognitive flexibility, working memory, executive function, lipid-lowering drugs, diabetes mellitus, breast cancer, hormone therapy, neuropsychological assessment, risk identification
- MeSH terms
- Adult, Attitude to Health, Mental Disorders, Cognition Disorders, Drug Therapy, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Patient Compliance, Young Adult
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