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Cited by 86Dementia and Cognitive Impairment ResearchBlood properties and coagulationInflammatory Biomarkers in Disease Prognosis

Peripheral levels of fibrinogen, C-reactive protein, and plasma viscosity predict future cognitive decline in individuals without dementia

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Marioni, Riccardo E., Stewart, Marlene C., Murray, Gordon D., Deary, Ian J., Fowkes, F Gerry R., Lowe, Gordon D. O., Rumley, Ann, Price, Jackie F.·2009·Psychosomatic Medicine
DOI 10.1097/psy.0b013e3181b1e538PMC PMC2762963
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Abstract

Objective: To determine whether circulating levels of the biomarkers C-reactive protein (CRP), fibrinogen, plasma viscosity, and hematocrit were associated with cognitive decline in middle-aged to elderly people. Methods: Subjects consisted of 2312 men and women aged 50 to 80 years participating in the Aspirin for Asymptomatic Atherosclerosis Trial, all of whom were free of symptomatic cardiovascular disease at baseline. Biomarker levels and cognitive ability were measured at baseline with cognition assessed in all subjects using the Mill Hill Vocabulary Scale and in a subgroup of 504 persons using tests of memory, nonverbal reasoning, information processing speed, executive function, and mental flexibility. After 5 years, the five-test battery was administered to all participants and scores were used to derive a general cognitive ability factor. Results: Baseline CRP and fibrinogen levels were associated negatively with age and sex-adjusted follow-up scores on the majority of the cognitive tests, and the general cognitive ability factor (correlations = −0.054 to 0.105, p < .05). In analyses adjusting for baseline cognitive scores, asymptomatic atherosclerotic disease, and cardiovascular risk factors, both markers predicted decline in several cognitive domains (excluding memory). Baseline plasma viscosity, but not hematocrit, was associated negatively with follow-up test scores for general cognitive ability, information processing speed, and mental flexibility (correlations = −0.050 to −0.098, p < .05) and with decline across the same domains (p < .05). Conclusions: Increased circulating levels of CRP, fibrinogen, and elevated plasma viscosity predicted poorer subsequent cognitive ability and were associated with age-related cognitive decline in several domains, including general ability. CRP = C-reactive protein; AAA = Aspirin for Asymptomatic Atherosclerosis; ABI = ankle-brachial index; AVLT = Auditory Verbal Learning Test; RAVENS = Raven’s Standard Progressive Matrices; DST = Digit Symbol Test; VFT = Verbal Fluency Test; TMT = Trail Making Test, Part B; MHVS = Mill Hill Vocabulary Scale; CVD = cardiovascular disease; BP = blood pressure; fib = fibrinogen.

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  • CRP blood levels have been associated with reduced performance in the Trail Making Test in several patient groups experiencing ongoing peripheral inflammatory activity.

    “Furthermore, CRP blood levels have been associated with reduced performance in the TMT in several patient groups experiencing ongoing peripheral inflammatory activity, such as those with peripheral arterial disease [49] and brain cancer [50] and aging populations [51].”

    From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [51]

    The Results report that higher CRP was associated with poorer Trail-Making Test performance in an older population. However, the study used a single peripheral CRP measurement and did not establish that participants were experiencing ongoing inflammatory activity; the Discussion identifies single measurements as a limitation. (LLM, conf=0.82)

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  1. [17]Raven J Raven JC Court JH Raven manual: standard progressive matrices 1998 Oxford Psychologists Press Oxford, UK

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Authors
Marioni, R. E., Stewart, M. C., Murray, G. D., Deary, I. J., Fowkes, F. G. R., Lowe, G. D. O., Rumley, A., & Price, J. F.
Affiliations
  • University of Edinburgh (GB)
  • University of Glasgow (GB)
Corresponding author
Marioni, Riccardo E.
ORCID
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-10
Volume
71
Issue
8
Pages
901-906
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0b013e3181b1e538
PMC
PMC2762963
OpenAlex
W2056460343
Cited by
86
References
33
Citations by year
2025: 8 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 3
FWCI
3.30
Type
journal article
Language
en
Open access
Locations
  • Psychosomatic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Wellcome Trust (057762)
  • British Heart Foundation (RG/02/015/14948, RG/07/011/24068)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
cognitive decline, C-reactive protein, fibrinogen, plasma viscosity, hematocrit, biomarkers, asymptomatic atherosclerosis, middle-aged and older adults, processing speed, executive function, cognitive flexibility, general intelligence, cardiovascular risk factors
MeSH terms
Aspirin, Blood Viscosity, C-Reactive Protein, Cognition Disorders, Female, Fibrinogen, Follow-Up Studies, Hematocrit, Humans, Inflammation, Male, Middle Aged, Neuropsychological Tests, Plasma, Risk Factors, Severity of Illness Index, Biomarkers, Inflammation Mediators, Atherosclerosis, Executive Function

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