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Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants
Open accessAbstract
Both increased inflammation and reduced neurogenesis have been associated with the pathophysiology of major depression. We have previously described how interleukin-1 (IL-1) β, a pro-inflammatory cytokine increased in depressed patients, decreases neurogenesis in human hippocampal progenitor cells. Here, using the same human in vitro model, we show how omega-3 (ω-3) polyunsaturated fatty acids and conventional antidepressants reverse this reduction in neurogenesis, while differentially affecting the kynurenine pathway. We allowed neural cells to proliferate for 3days and further differentiate for 7days in the presence of IL-1β (10ng/ml) and either the selective serotonin reuptake inhibitor sertraline (1µM), the serotonin and norepinephrine reuptake inhibitor venlafaxine (1µM), or the ω-3 fatty acids eicosapentaenoic acid (EPA, 10µM) or docosahexaenoic acid (DHA, 10µM). Co-incubation with each of these compounds reversed the IL-1β-induced reduction in neurogenesis (DCX- and MAP2-positive neurons), indicative of a protective effect. Moreover, EPA and DHA also reversed the IL-1β-induced increase in kynurenine, as well as mRNA levels of indolamine-2,3-dioxygenase (IDO); while DHA and sertraline reverted the IL-1β-induced increase in quinolinic acid and mRNA levels of kynurenine 3-monooxygenase (KMO). Our results show common effects of monoaminergic antidepressants and ω-3 fatty acids on the reduction of neurogenesis caused by IL-1β, but acting through both common and different kynurenine pathway-related mechanisms. Further characterization of their individual properties will be of benefit towards improving a future personalized medicine approach.
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Certain foods could relieve or prevent depressive symptoms associated with heightened inflammatory status.
“which raises the possibility that certain foods could relieve or prevent depressive symptoms associated with heightened inflammatory status.21”
From Food and mood: How do diet and nutrition affect mental wellbeing? (2020) · cites this paper as [21]
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Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,184
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Cytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Polyunsaturated fatty acids and their metabolites in brain function and disease
Bazinet, R. P., & Layé, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3820 · Cited by 1,694
Kynurenines in the mammalian brain: when physiology meets pathology
Schwarcz, R., Bruno, J. P., Muchowski, P. J., & Wu, H.-Q. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3257 · Cited by 1,530
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483
Quantitative real-time RT-PCR – a perspective
Bustin, S. A., Benes, V, Nolan, T., & Pfaffl, M. W. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01755 · Cited by 1,321
O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278
Cytokines and major depression
Schiepers, O. J. G., Wichers, M. C., & Maes, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.003 · Cited by 1,235
Adult hippocampal neurogenesis in depression
Sahay, A., & Hen, R. (2007) · Nature Neuroscience · doi:10.1038/nn1969 · Cited by 1,206
Hannestad, J., DellaGioia, N., & Bloch, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.132 · Cited by 914
Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862
Brain inflammation and adult neurogenesis: The dual role of microglia
Ekdahl, C. T., Kokaia, Z., & Lindvall, O. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.052 · Cited by 801
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Inflammation-associated depression: From serotonin to kynurenine
Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726
Antidepressants increase neural progenitor cells in the human hippocampus
Boldrini, M., Underwood, M. D., Hen, R., Rosoklija, G. B., Dwork, A. J., John Mann, J., & Arango, V. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.75 · Cited by 686
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630
Omega-3 fatty acids in major depressive disorder
Su, K.-P., Huang, S.-Y., Chiu, C.-C., & Shen, W. W. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00032-4 · Cited by 596
Self-citationQuinolinic acid, the inescapable neurotoxin
Guillemin, G. J. (2012) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08485.x · Cited by 595
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562
Hill, A. S., Sahay, A., & Hen, R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.85 · Cited by 557
A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530
Self-citationKynurenine pathway in major depression: Evidence of impaired neuroprotection
Myint, A.-M., Kim, Y. K., Verkerk, R., Scharpé, S., Steinbusch, H., & Leonard, B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.013 · Cited by 527
Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
Zwilling, D., Huang, S., Sathyasaikumar, K. V., Notarangelo, F. M., Guidetti, P., Wu, H., Lee, J. H., Truong, J. K., Andrews-Zwilling, Y. S., Hsieh, E., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.020 · Cited by 519
Interferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493
Grosso, G., Pajak, A., Marventano, S., Castellano, S., Galvano, F., Bucolo, C., Drago, F., & Caraci, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096905 · Cited by 449
Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor
Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J., & Pariante, C. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.26 · Cited by 435
Self-citationInterleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis
Zunszain, P. A., Anacker, C., Cattaneo, A., Choudhury, S., Musaelyan, K., Myint, A. M., Thuret, S., Price, J., & Pariante, C. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.277 · Cited by 388
Self-citationConnecting inflammation with glutamate agonism in suicidality
Erhardt, S., Lim, C. K., Linderholm, K. R., Janelidze, S., Lindqvist, D., Samuelsson, M., Lundberg, K., Postolache, T. T., Träskman-Bendz, L., Guillemin, G. J., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.248 · Cited by 345
Indoleamine 2,3 dioxygenase and quinolinic acid Immunoreactivity in Alzheimer's disease hippocampus
Guillemin, G. J., Brew, B. J., Noonan, C. E., Takikawa, O., & Cullen, K. M. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00655.x · Cited by 338
Cytokines mediated inflammation and decreased neurogenesis in animal models of depression
Song, C., & Wang, H. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.020 · Cited by 296
Mocking, R. J. T., Harmsen, I. M., Assies, J., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.29 · Cited by 284
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression
Mößner, R., Mikova, O., Koutsilieri, E., Saoud, M., Ehlis, A., Müller, N., Fallgatter, A. J., & Riederer, P. F. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701263303 · Cited by 248
The contribution of failing adult hippocampal neurogenesis to psychiatric disorders
Kempermann, G., Krebs, J., & Fabel, K. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282fad375 · Cited by 225
Labrousse, V. F., Nadjar, A., Joffre, C., Costes, L., Aubert, A., Gregoire, S., Brétillon, L., & Layé, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036861 · Cited by 218
Savitz, J. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Bellgowan, P. S. F., Victor, T. A., Bodurka, J., Teague, T. K., & Dantzer, R. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.007 · Cited by 215
Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults.
Kiecolt-Glaser, J. K., Belury, M. A., Porter, K., Beversdorf, D. Q., Lemeshow, S., & Glaser, R. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3180313a45 · Cited by 212
Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression
Silvers, K. M., Woolley, C. C., Hamilton, F. C., Watts, P. M., & Watson, R. A. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.11.004 · Cited by 207
Su, K.-P., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Chang, J. P.-C., Chang, H.-C., & Pariante, C. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.008 · Cited by 205
Self-citationBrundin, L., Sellgren, C. M., Lim, C. K., Grit, J., Pålsson, E., Landén, M., Samuelsson, M., Lundgren, K., Brundin, P., Fuchs, D., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.133 · Cited by 195
Antidepressant action: to the nucleus and beyond
Malberg, J. E., & Blendy, J. A. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.005 · Cited by 193
de la Cruz, V. P., Carrillo-Mora, P. U., & Santamarı́a, A. (2012) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s8158 · Cited by 193
Lu, D., Tsao, Y.-Y., Leung, Y., & Su, K. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.98 · Cited by 185
Self-citationMeier, T. B., Drevets, W. C., Wurfel, B. E., Ford, B. N., Morris, H. M., Victor, T. A., Bodurka, J., Teague, T. K., Dantzer, R., & Savitz, J. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.003 · Cited by 175
Parrott, J. M., Redus, L., Santana-Coelho, D., Morales, J., Gao, X., & O'Connor, J. C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.200 · Cited by 174
Su, K. (2009) · Neurosignals · doi:10.1159/000198167 · Cited by 170
Self-citationLarrieu, T., Hilal, L. M., Fourrier, C., Smedt, V. D., Sans, N., Capuron, L., & Layé, S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.77 · Cited by 155
Kaneko, N., Kudo, K., Mabuchi, T., Takemoto, K., Fujimaki, K., Wati, H., Iguchi, H., Tezuka, H., & Kanba, S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301137 · Cited by 152
Lin, P.-Y., Mischoulon, D., Freeman, M. P., Matsuoka, Y., Hibbeln, J., Belmaker, R. H., & Su, K.-P. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.111 · Cited by 145
Self-citationGrenyer, B. F. S., Crowe, T. P., Meyer, B. J., Owen, A. J., Grigonis-Deane, E., Caputi, P., & Howe, P. R. C. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.004 · Cited by 132
The Role of Indoleamine 2,3-Dioxygenase in a Mouse Model of Neuroinflammation-Induced Depression
Dobos, N., de Vries, E. F. J., Kema, I. P., Patas, K., Prins, M., Nijholt, I. M., Dierckx, R., Korf, J., den Boer, J. A., Luiten, P. G. M., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111097 · Cited by 123
Rondanelli, M., Giacosa, A., Opizzi, A., Pelucchi, C., Vecchia, C. L., Montorfano, G., Negroni, M., Berra, B., Politi, P., & Rizzo, A. M. (2010) · Journal of the American College of Nutrition · doi:10.1080/07315724.2010.10719817 · Cited by 119
Heisler, J. M., & O’Connor, J. C. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.022 · Cited by 117
n-3 Polyunsaturated fatty acids in animal models with neuroinflammation
Orr, S. K., Trépanier, M., & Bazinet, R. P. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.05.008 · Cited by 115
Mingam, R., Moranis, A., Bluthé, R.-M., Smedt, V. D., Kelley, K. W., Guesnet, P., Lavialle, M., Dantzer, R., & Layé, S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06470.x · Cited by 106
Molteni, R., Macchi, F., Zecchillo, C., Dell’Agli, M., Colombo, E., Calabrese, F., Guidotti, G., Racagni, G., & Riva, M. A. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.03.008 · Cited by 106
Delpech, J.-C., Thomazeau, A., Madore, C., Bosch‐Bouju, C., Larrieu, T., Lacabanne, C., Rémus-Borel, J., Aubert, A., Joffre, C., Nadjar, A., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.127 · Cited by 102
Kuzumaki, N., Ikegami, D., Imai, S., Narita, M., Tamura, R., Yajima, M., Suzuki, A., Miyashita, K., Niikura, K., Takeshima, H., et al. (2010) · Synapse · doi:10.1002/syn.20800 · Cited by 102
Mozaffari–Khosravi, H., Yassini-Ardakani, M., Karamati, M., & Shariati-Bafghi, S.-E. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.08.003 · Cited by 98
Lotrich, F. E., Sears, B., & McNamara, R. K. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.08.007 · Cited by 91
Does escitalopram reduce neurotoxicity in major depression?
Halaris, A., Myint, A.-M., Savant, V., Meresh, E., Lim, E., Guillemin, G., Hoppensteadt, D., Fareed, J., & Sinacore, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.026 · Cited by 86
Antidepressant Compounds Can Be Both Pro- and Anti-Inflammatory in Human Hippocampal Cells
Horowitz, M. A., Wertz, J., Zhu, D., Cattaneo, A., Musaelyan, K., Nikkheslat, N., Thuret, S., Pariante, C. M., & Zunszain, P. A. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu076 · Cited by 82
Self-citationKatakura, M., Hashimoto, M., Okui, T., Shahdat, H. M., Matsuzaki, K., & Shido, O. (2013) · Stem Cells International · doi:10.1155/2013/490476 · Cited by 80
Inflammation in psychopathology of depression: Clinical, biological, and therapeutic implications
Su, K. (2012) · Biomedicine · doi:10.1016/j.biomed.2012.03.002 · Cited by 77
Self-citationRizzo, A. M., Corsetto, P. A., Montorfano, G., Opizzi, A., Faliva, M. A., Giacosa, A., Ricevuti, G., Pelucchi, C., Berra, B., & Rondanelli, M. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-82 · Cited by 69
Fischer, C. W., Eskelund, A., Budac, D. P., Tillmann, S., Liebenberg, N., Elfving, B., & Wegener, G. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.015 · Cited by 59
Elgarf, A. A., Aboul‐Fotouh, S., Abd-Alkhalek, H. A., El‐Tabbal, M., Hassan, A. N. E.-D., Kassim, S. K., Hammouda, G. A., Farrag, K. A. E.-R., & Abdel-Tawab, A. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.09.014 · Cited by 58
Daniele, S., Pozzo, E. D., Zappelli, E., & Martini, C. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.04.006 · Cited by 57
Norden, D. M., Devine, R. D., Bicer, S., Jing, R., Reiser, P. J., Wold, L. E., Godbout, J. P., & McCarthy, D. O. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.12.045 · Cited by 49
Omega-3 Fatty Acids and Depression: From Cellular Mechanisms to Clinical Care
Freeman, M. P., & Rapaport, M. H. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11ac06830 · Cited by 45
Krause, D., Riedel, M. J., Müller, N., Weidinger, E., Schwarz, M., & Myint, A.-M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0112-6 · Cited by 42
Qiu, G., Helmeste, D. M., Samaranayake, A. N., Lau, B. W.-M., Lee, T. M. C., Tang, S.-W., & So, K. (2007) · Neuroscience Bulletin · doi:10.1007/s12264-007-0019-9 · Cited by 42
Mocking, R. J. T., Nap, T. S., Westerink, A. M., Assies, J., Vaz, F. M., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.02.019 · Cited by 34
Zhang, X., Li, X., Li, M., Ren, J., Yun, K., An, Y., Lin, L., & Zhang, H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.044 · Cited by 24
Peng, Z., Xue, Y., Wang, H., Wang, H., Xue, F., Kuang, F., Wang, B., Chen, Y., Zhang, L.-Y., & Tan, Q. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.08.014 · Cited by 23
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- Anacker, 2011, Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor, Mol. Psychiatry, 16, 738, 10.1038/mp.2011.26 · DOI · Paper page
- Silvers, 2005, Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression, Prostaglandins Leukot. Essent. Fatty Acids, 72, 211, 10.1016/j.plefa.2004.11.004 · DOI
- Grenyer, 2007, Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial, Prog. Neuropsychopharmacol. Biol. Psychiatry, 31, 1393, 10.1016/j.pnpbp.2007.06.004 · DOI
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“In particular, inflammation is thought to reduce neurogenesis and promote depressive symptoms via activation of the kynurenine pathway, increasing production of neurotoxic kynurenine pathway metabolites (Zunszain et al., 2012; Borsini et al., 2017; Savitz, 2020).”
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Metadata
- Authors
- Borsini, A., Alboni, S., Horowitz, M. A., Tojo, L. M., Cannazza, G., Su, K.-P., Pariante, C. M., & Zunszain, P. A.
- Affiliations
- King's College London (GB)
- University of Modena and Reggio Emilia (IT)
- China Medical University (TW)
- Corresponding author
- Zunszain, Patricia A.
- ORCID
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 65
- Pages
- 230-238
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC5540223
- OpenAlex
- W2615561485
- Cited by
- 126
- References
- 80
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 18 · 2023: 9 · 2022: 16 · 2021: 20 · 2020: 25 · 2019: 10 · 2018: 12 · 2017: 4
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Behavior and Immunity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- King's College London
- Medical Research Council (MR/N029488/1)
- Ministry of Science and Technology, Taiwan
- National Institute for Health and Care Research
- South London and Maudsley NHS Foundation Trust
- Royal Society
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- IL-1β, neurogenesis, omega-3 fatty acids, antidepressants, major depressive disorder, kynurenine pathway, eicosapentaenoic acid, docosahexaenoic acid, sertraline, venlafaxine, indoleamine 2,3-dioxygenase, kynurenine 3-monooxygenase, quinolinic acid, hippocampal progenitor cells, neuroinflammation, personalized medicine
- MeSH terms
- Antidepressive Agents, Depression, Major Depressive Disorder, Docosahexaenoic Acids, Hippocampus, Humans, Inflammation, Kynurenine, Stem Cells, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Cytokines, Cell Culture Techniques, Interleukin-1beta, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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