Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial
Open accessAbstract
Background Interferon (IFN)-α therapy for chronic hepatitis C virus infection is frequently associated with depression. The routine prophylaxis with antidepressants might expose patients to adverse effects, hence, the need for alternative preventive interventions. Omega-3 polyunsaturated fatty acids are safe and effective essential nutritional compounds used for the treatment of depression, putatively through an anti-inflammatory action. In addition, lower erythrocyte levels of omega-3 polyunsaturated fatty acids have been associated with an increased risk of IFN-induced depression.Methods We conducted a 2-week, double-blind, placebo-controlled trial comparing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and placebo for the prevention of IFN-α-induced depression. A total of 162 patients consented to participate and were randomized to the study. All of the patients completed the 2-week trial; 152 participants were followed throughout the 24 weeks of IFN-α treatment and were included in the analysis.Results Compared with placebo, the incident rates of IFN-α-induced depression were significantly lower in EPA-treated but not in DHA-treated patients (10% and 28%, respectively, versus 30% for placebo, p = .037). Both EPA and DHA significantly delayed the onset of IFN-induced depression (week of onset: 12.0 and 11.7, respectively, versus 5.3 for placebo, p = .002). EPA and DHA were both well tolerated in this population. EPA treatment increased both EPA and DHA erythrocyte levels, but DHA only increased DHA erythrocyte levels.Conclusions EPA is effective in the prevention of depression in hepatitis C virus patients received IFN-α therapy. Our study confirms the notion that anti-inflammatory strategies are effective antidepressants in the context of depression associated with inflammation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pretreatment with EPA may reduce the risk of developing depression in patients with hepatitis C treated with INF-α.
“Pretreatment with EPA may reduce the risk of developing depression in patients with hepatitis C treated with INF- α (167).”
From Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories (2023) · cites this paper as [167]
Giving omega-3 fatty acids before medication seems to prevent the onset of cytokine induced depression.
“and that giving omega-3 fatty acids, which have anti-inflammatory properties, before the medication seems to prevent the onset of cytokine induced depression.20”
From Food and mood: How do diet and nutrition affect mental wellbeing? (2020) · cites this paper as [20]
Medications that stimulate inflammation typically induce depressive states in people treated.
“The study shows that medications that stimulate inflammation typically induce depressive states in people treated”
From Food and mood: How do diet and nutrition affect mental wellbeing? (2020) · cites this paper as [20]
Specific nutritional components and general dietary patterns may have anti-inflammatory effects.
“Specific nutritional components (eg, polyphenols and polyunsaturated fats) and general dietary patterns (eg, consumption of a Mediterranean diet) may also have anti-inflammatory effects,14 19 20”
From Food and mood: How do diet and nutrition affect mental wellbeing? (2020) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Rao, J. S., Ertley, R. N., Lee, H.-J., DeMar, J. C., Arnold, J. T., Rapoport, S. I., & Bazinet, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001888 · Cited by 280 · see citing works
RetractedHamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection
Fried, M. W., Shiffman, M. L., Reddy, K. R., Smith, C. I., Marinos, G., Gonçales, F. L., Häussinger, D., Moisés Diago, M., Carosi, G., Dhumeaux, D., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020047 · Cited by 6,386 · see citing works
The mini international neuropsychiatric interview
Lecrubier, Y., Sheehan, D. V., Hergueta, T., & Weiller, E. (1998) · European Psychiatry · doi:10.1016/s0924-9338(99)80239-9 · Cited by 5,882 · see citing works
Lauer, G. M., & Walker, B. D. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107053450107 · Cited by 3,010 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Davis, G. L., Esteban, R., Rustgi, V. K., Hoefs, J. C., Gordon, S. C., TREPO, C. G., Shiffman, M. L., Zeuzem, S., Craxı̀, A., Ling, M.-H., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811193392102 · Cited by 1,271 · see citing works
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works
Fish consumption and major depression
Hibbeln, J. R. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79168-6 · Cited by 897 · see citing works
Amminger, G. P., Schäfer, M. R., Papageorgiou, K., Klier, C. M., Cotton, S. M., Harrigan, S. M., Mackinnon, A., McGorry, P. D., & Berger, G. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.192 · Cited by 896 · see citing works
Omega 3 Fatty Acids in Bipolar Disorder: A Preliminary Double-blind, Placebo-Controlled Trial
Stoll, A. L., Severus, W. E., Freeman, M. P., Rueter, S., Zboyan, H. A., Diamond, E., Cress, K. K., & Marangell, L. B. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.5.407 · Cited by 814 · see citing works
Poynard, T., Yuen, M., Ratzin, V., & Lai, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)15109-4 · Cited by 806 · see citing works
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797 · see citing works
Raison, C. L., Dantzer, R., Kelley, K. W., Lawson, M. A., Woolwine, B. J., Vogt, G., Spivey, J. R., Saito, K., & Miller, A. H. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.116 · Cited by 630 · see citing works
Omega-3 fatty acids in major depressive disorder
Su, K.-P., Huang, S.-Y., Chiu, C.-C., & Shen, W. W. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00032-4 · Cited by 596 · see citing works
Self-citationA meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Self-citationDepression and Hippocampal Neurogenesis: A Road to Remission?
Eisch, A. J., & Petrik, D. (2012) · Science · doi:10.1126/science.1222941 · Cited by 516 · see citing works
Efficiency of conversion of α-linolenic acid to long chain n-3 fatty acids in man
Brenna, J. T. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200203000-00002 · Cited by 514 · see citing works
Lin, P.-Y., & Su, K.-P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0712 · Cited by 481 · see citing works
Self-citationPeginterferon and Ribavirin for Chronic Hepatitis C
Hoofnagle, J. H., & Seeff, L. B. (2006) · New England Journal of Medicine · doi:10.1056/nejmct061675 · Cited by 476 · see citing works
Omega-3 fatty acids and monoamine neurotransmission
Chalon, S. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.07.005 · Cited by 448 · see citing works
Cattaneo, A., Gennarelli, M., Uher, R., Breen, G., Farmer, A., Aitchison, K. J., Craig, I. W., Anacker, C., Zunsztain, P. A., McGuffin, P., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.191 · Cited by 436 · see citing works
Self-citationMeta-Analysis of the Effects of Eicosapentaenoic Acid (EPA) in Clinical Trials in Depression
Sublette, M. E., Ellis, S. P., Geant, A. L., & Mann, J. J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06634 · Cited by 421 · see citing works
Psychiatric Complications of Long-term Interferon Alfa Therapy
Renault, P. F. (1987) · Archives of Internal Medicine · doi:10.1001/archinte.1987.00370090055011 · Cited by 413 · see citing works
Side effects of α interferon in chronic hepatitis C
Dusheiko, G. M. (1997) · Hepatology · doi:10.1002/hep.510260720 · Cited by 394 · see citing works
Dalton, S. O., Johansen, C., Mellemkjær, L., Sørensen, H. T., Nørgård, B., & Olsen, J. H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.1.59 · Cited by 389 · see citing works
Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis
Zunszain, P. A., Anacker, C., Cattaneo, A., Choudhury, S., Musaelyan, K., Myint, A. M., Thuret, S., Price, J., & Pariante, C. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.277 · Cited by 388 · see citing works
Self-citationMarangell, L. B., Martinez, J. M., Zboyan, H. A., Kertz, B. L., Kim, H. F. S., & Puryear, L. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.5.996 · Cited by 379 · see citing works
Farooqui, A. A., Ong, W., & Horrocks, L. A. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.7 · Cited by 368 · see citing works
Martins, J. G. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719785 · Cited by 362 · see citing works
Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353 · see citing works
Su, K.-P., Huang, S.-Y., Chiu, T.-H., Huang, K.-C., Huang, C.-L., Chang, H.-C., & Pariante, C. M. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0418 · Cited by 308 · see citing works
Self-citationInterferon-Induced Depression in Chronic Hepatitis C: A Systematic Review and Meta-Analysis
Udina, M., Castellví, P., Moreno-España, J., Navinés, R., Valdés, M., Forns, X., Langohr, K., Solà, R., Vieta, E., & Martín-Santos, R. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r07694 · Cited by 297 · see citing works
Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
Bloch, M. H., & Hannestad, J. O. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.100 · Cited by 293 · see citing works
Fish Consumption, Depression, and Suicidality in a General Population
Tanskanen, A., Hibbeln, J. R., Hintikka, J., Haatainen, K., Honkalampi, K., & Viinamäki, H. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.512 · Cited by 275 · see citing works
Neuronal plasticity and antidepressant actions
Castrén, E., & Hen, R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.010 · Cited by 243 · see citing works
Safety Considerations with Omega-3 Fatty Acid Therapy
Bays, H. E. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.020 · Cited by 235 · see citing works
Hepatitis C infection, antiviral treatment and mental health: A European expert consensus statement
Schaefer, M., Capuron, L., Friebe, A., Diez-Quevedo, C., Robaeys, G., Neri, S., Foster, G. R., Kautz, A., Forton, D., & Pariante, C. M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.037 · Cited by 225 · see citing works
Self-citationDieperink, E. W., Ho, S. B., THURAS, P. D., & Willenbring, M. L. (2003) · Psychosomatics · doi:10.1176/appi.psy.44.2.104 · Cited by 217 · see citing works
Randomised double-blind placebo-controlled trial of fish oil in the treatment of depression
Silvers, K. M., Woolley, C. C., Hamilton, F. C., Watts, P. M., & Watson, R. A. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.11.004 · Cited by 207 · see citing works
Interferon alpha (IFNα) and psychiatric syndromes
Schaefer, M., Engelbrechta, M. A., Gut, O., Fiebich, B. L., Bauer, J., Schmidt, F., Grunze, H., & Lieb, K. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00324-4 · Cited by 203 · see citing works
Omega-3 fatty acids upregulate adult neurogenesis
Beltz, B. S., Tlusty, M. F., Benton, J. L., & Sandeman, D. C. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.010 · Cited by 201 · see citing works
Expert Opinion: Omega-3 Fatty Acids and Bleeding—Cause for Concern?
Harris, W. S. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.11.021 · Cited by 191 · see citing works
Lu, D., Tsao, Y.-Y., Leung, Y., & Su, K. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.98 · Cited by 180 · see citing works
Self-citationSu, K. (2009) · Neurosignals · doi:10.1159/000198167 · Cited by 168 · see citing works
Self-citationCarvalho, L. A., Torre, J. P., Papadopoulos, A. S., Poon, L., Juruena, M. F., Markopoulou, K., Cleare, A. J., & Pariante, C. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.036 · Cited by 167 · see citing works
Self-citationSu, K., Huang, S., Peng, C., Lai, H., Huang, C., Chen, Y.-C., Aitchison, K. J., & Pariante, C. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.005 · Cited by 165 · see citing works
Self-citationPolyunsaturated fatty acid deficit in patients with bipolar mania
Chiu, C.-C., Huang, S., Su, K., Lu, M., Huang, M., Chen, C., & Shen, W. W. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00130-x · Cited by 151 · see citing works
Self-citationLin, P.-Y., Mischoulon, D., Freeman, M. P., Matsuoka, Y., Hibbeln, J., Belmaker, R. H., & Su, K.-P. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.111 · Cited by 145 · see citing works
Self-citationEicosapentaenoic acid confers neuroprotection in the amyloid-β challenged aged hippocampus
Lynch, A. M., Loane, D. J., Minogue, A. M., Clarke, R. M., Kilroy, D., Nally, R. E., Roche, Ó. J., O'Connell, F., & Lynch, M. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.04.006 · Cited by 144 · see citing works
RAISON, C. L., WOOLWINE, B. J., DEMETRASHVILI, M. F., BORISOV, A. S., WEINREIB, R., STAAB, J. P., ZAJECKA, J. M., BRUNO, C. J., HENDERSON, M. A., REINUS, J. F., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03316.x · Cited by 142 · see citing works
Martins, J. G., Bentsen, H., & Puri, B. K. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.25 · Cited by 139 · see citing works
Treatment of Neurotoxic Side Effects of Interferon-α with Naltrexone
Valentine, A. D., Meyers, C. A., & Talpaz, M. (1995) · Cancer Investigation · doi:10.3109/07357909509024923 · Cited by 137 · see citing works
Clinical Overview of Omacor: A Concentrated Formulation of Omega-3 Polyunsaturated Fatty Acids
Bays, H. E. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.12.029 · Cited by 121 · see citing works
Song, C., Manku, M. S., & Horrobin, D. F. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.954 · Cited by 108 · see citing works
Retinopathy associated with high-dose interferon alfa-2b therapy
Hejny, C., Sternberg, P., Lawson, D. H., Greiner, K., & Aaberg, T. M. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(01)00836-4 · Cited by 108 · see citing works
Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients
Valentine, A. D., & Meyers, C. A. (2001) · Cancer · doi:10.1002/1097-0142(20010915)92:6+ · Cited by 106 · see citing works
Omega-3 fatty acids on the forced-swimming test
Huang, S., Yang, H.-T., Chiu, C.-C., Pariante, C. M., & Su, K. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.09.004 · Cited by 99 · see citing works
Self-citationEvaluation of depression as a risk factor for treatment failure in chronic hepatitis C†
Leutscher, P. D. C., Lagging, M., Buhl, M. R., Pedersen, C., Norkrans, G., Langeland, N., Mørch, K., Färkkilä, M. A., Hjerrild, S., Hellstrand, K., et al. (2010) · Hepatology · doi:10.1002/hep.23699 · Cited by 97 · see citing works
Morasco, B. J., Rifai, M. A., Loftis, J. M., Indest, D. W., Moles, J. K., & Hauser, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.007 · Cited by 96 · see citing works
Song, C., Phillips, A. G., Leonard, B. E., & Horrobin, D. F. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001462 · Cited by 91 · see citing works
A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder
Mischoulon, D., Best-Popescu, C. A., Laposata, M., Merens, W., Murakami, J. L., Wu, S. L., Papakostas, G. I., Dording, C. M., Sonawalla, S. B., Nierenberg, A. A., et al. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.04.011 · Cited by 86 · see citing works
Cesario, A., Rocca, B., & Rutella, S. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711795656063 · Cited by 77 · see citing works
Inflammation in psychopathology of depression: Clinical, biological, and therapeutic implications
Su, K. (2012) · Biomedicine · doi:10.1016/j.biomed.2012.03.002 · Cited by 76 · see citing works
Self-citationSong, C., Leonard, B. E., & Horrobin, D. F. (2004) · Stress · doi:10.1080/10253890410001667188 · Cited by 72 · see citing works
Kawashima, A., Harada, T., Kami, H., Yano, T., Imada, K., & Mizuguchi, K. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.12.015 · Cited by 68 · see citing works
Schaefer, M., Sarkar, R., Knop, V., Effenberger, S., Friebe, A., Heinze, L., Spengler, U., Schlaepfer, T. E., Reimer, J., Buggisch, P., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-2-201207170-00006 · Cited by 68 · see citing works
Moon, Y., & Pestka, J. J. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.08.009 · Cited by 63 · see citing works
Are ω3 Fatty Acids Beneficial in Depression but Not Mania?
Su, K., Shen, W. W., & Huang, S. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.716 · Cited by 61 · see citing works
Self-citationMcNutt, M. D., Liu, S., Manatunga, A., Royster, E. B., Raison, C. L., Woolwine, B. J., Demetrashvili, M. F., Miller, A. H., & Musselman, D. L. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.330 · Cited by 56 · see citing works
Morasco, B. J., Loftis, J. M., Indest, D. W., Ruimy, S., Davison, J. W., Felker, B. L., & Hauser, P. (2010) · Psychosomatics · doi:10.1176/appi.psy.51.5.401 · Cited by 53 · see citing works
Schäfer, A., Wïttchen, H., Seufert, J., & Kraus, M. R. (2007) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.229 · Cited by 53 · see citing works
Matsuoka, Y., Nishi, D., Yonemoto, N., Hamazaki, K., Hashimoto, K., & Hamazaki, T. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181d48830 · Cited by 49 · see citing works
Díez, C., Masnou, H., Planas, R., Castellví, P., Giménez, M. D., Morillas, R. M., Martín‐Santos, R., Navinés, R., Sola, R. L., Giner, P., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05282blu · Cited by 45 · see citing works
de Knegt, R. J., Bezemer, G., Gool, A. R. V., Drenth, J. P. H., Hansen, B. E., Fortuyn, H. A. D., Weegink, C. J., Hengeveld, M. W., & Janssen, H. L. A. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04867.x · Cited by 42 · see citing works
Sugiura, T., Kondo, S., Kodaka, T., et al. (1996) · IUBMB Life · doi:10.1080/15216549600201553 · Cited by 39 · see citing works
Plasma Levels of Citalopram in Depressed Patients With Hepatitis C
Gleason, O. C., Yates, W. R., Philipsen, M. A., Isbell, M. D., & Pollock, B. G. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.1.29 · Cited by 29 · see citing works
Safety of the Treatment of Interferon-Alpha-Induced Depression
Loftis, J. M., & Hauser, P. (2003) · Psychosomatics · doi:10.1176/appi.psy.44.6.524 · Cited by 27 · see citing works
The Effects of Olive Oil on ω3 Fatty Acids and Mood Disorders
Puri, B. K., & Richardson, A. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.715 · Cited by 26 · see citing works
Omega-3 and depression research: Hold the olive oil
Logan, A. C. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.02.006 · Cited by 23 · see citing works
Wu, P.-L., Liao, K.-F., Peng, C., Pariante, C. M., & Su, K. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.04.006 · Cited by 16 · see citing works
Self-citationBronowicki, J.-P., Canva, V., Tran, A., et al. (2010) · Journal of Hepatology · doi:10.1016/s0168-8278(10)60248-6 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Omega-3 polyunsaturated fatty acids and their health benefits
Shahidi, F., & Ambigaipalan, P. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111317-095850 · Cited by 1,390 · see citing works
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,061 · see citing works
Inflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works
Diet and depression: Exploring the biological mechanisms of action
Marx, W., Lane, M., Hockey, M., Aslam, H., Berk, M., Walder, K., Borsini, A., Firth, J., Pariante, C. M., Berding, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00925-x · Cited by 685 · see citing works
Self-citationHassamal, S. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1130989 · Cited by 578 · see citing works
“Yamano and colleagues reversed INF-α induced stress susceptibility in mice with a corticotropin-releasing hormone receptor antagonist in a dose dependent fashion, suggesting that overactivity of the HPA axis mediates the cytokine depression response (64).”
BackgroundFood and mood: How do diet and nutrition affect mental wellbeing?
Firth, J., Gangwisch, J. E., Borsini, A., Wootton, R. E., & Mayer, E. A. (2020) · BMJ · doi:10.1136/bmj.m2382 · Cited by 475 · see citing works
Nutritional psychiatry: Towards improving mental health by what you eat
Adan, R. A. H., van der Beek, E. M., Buitelaar, J. K., Cryan, J. F., Hebebrand, J., Higgs, S., Schellekens, H., & Dickson, S. L. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.10.011 · Cited by 454 · see citing works
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works
Efficacy of omega-3 PUFAs in depression: A meta-analysis
Liao, Y., Xie, B., Zhang, H., He, Q., Guo, L., Subramanieapillai, M., Fan, B., Lu, C., & McIntyre, R. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0515-5 · Cited by 404 · see citing works
Pariante, C. M. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.04.001 · Cited by 382 · see citing works
Self-citationChang, J. P.-C., Su, K.-P., Mondelli, V., & Pariante, C. M. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.160 · Cited by 248 · see citing works
Self-citationRole of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Inflammatory cytokine-associated depression
Lotrich, F. E. (2015) · Brain Research · doi:10.1016/j.brainres.2014.06.032 · Cited by 183 · see citing works
Lipids in Psychiatric Disorders and Preventive Medicine
Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.002 · Cited by 175 · see citing works
Giacobbe, J., Benoiton, B., Zunszain, P., Pariante, C. M., & Borsini, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00122 · Cited by 159 · see citing works
Self-citationInflammation-induced depression: Its pathophysiology and therapeutic implications
Jeon, S. W., & Kim, Y.-K. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.016 · Cited by 134 · see citing works
Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants
Borsini, A., Alboni, S., Horowitz, M. A., Tojo, L. M., Cannazza, G., Su, K.-P., Pariante, C. M., & Zunszain, P. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.05.006 · Cited by 126 · see citing works
Self-citationAbbott, R., Whear, R., Nikolaou, V., Bethel, A., Coon, J. T., Stein, K., & Dickens, C. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.04.008 · Cited by 121 · see citing works
Chang, C.-H., Tseng, P.-T., Chen, N.-Y., Lin, P.-C., Lin, P.-Y., Chang, J. P. C., Kuo, F.-Y., Lin, J., Wu, M.-C., & Su, K.-P. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.01.001 · Cited by 103 · see citing works
Omega-3 fatty acids and the treatment of depression: a review of scientific evidence
Wani, A. L., Bhat, S. A., & Ara, A. (2015) · Integrative Medicine Research · doi:10.1016/j.imr.2015.07.003 · Cited by 97 · see citing works
N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology
Pusceddu, M. M., Kelly, P., Stanton, C., Cryan, J. F., & Dinan, T. G. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw078 · Cited by 70 · see citing works
Omega-3 fatty acids for depression in adults
Appleton, K. M., Voyias, P. D., Sallis, H. M., Dawson, S., Ness, A. R., Churchill, R., & Perry, R. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004692.pub5 · Cited by 84 · see citing works
Demers, G., Roy, J., Machuca-Parra, A. I., Dashtehei pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0623-6 · Cited by 53 · see citing works
Omega-3 fatty acids in the psychological and physiological resilience against COVID-19
Chang, J. P.-C., Pariante, C. M., & Su, K.-P. (2020) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2020.102177 · Cited by 36 · see citing works
Self-citationOmega‐3 fatty acid in ultra‐high‐risk psychosis: A systematic review based on functional outcome
Susai, S. R., Sabherwal, S., Mongan, D., Föcking, M., & Cotter, D. R. (2022) · Early Intervention in Psychiatry · doi:10.1111/eip.13133 · Cited by 19 · see citing works
Chang, J. P.-C., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Gałecki, P., Walczewska, A., Pariante, C. M., & Su, K.-P. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1123378 · Cited by 19 · see citing works
Self-citationCheng, Y.-C., Chen, W.-Y., Lin, C., Lee, S.-H., Chiu, C.-C., & Kuo, P.-H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.129 · Cited by 5 · see citing works
- Authors
- Su, K.-P., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Chang, J. P.-C., Chang, H.-C., & Pariante, C. M.
- Affiliations
- King's College London (GB)
- China Medical University Hospital (TW)
- China Medical University (TW)
- Corresponding author
- Pariante, Carmine M.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 76
- Issue
- 7
- Pages
- 559-566
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1983925259
- Cited by
- 205
- References
- 84
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 14 · 2023: 20 · 2022: 13 · 2021: 17 · 2020: 23 · 2019: 23 · 2018: 12 · 2017: 20 · 2016: 18 · 2015: 22 · 2014: 6
- FWCI
- 20.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Science Council (102-2911-I-039-501, 101-2628-B-039-001-MY3, 101-2320-B-038-020-MY2)
- National Health Research Institute (NHRI-EX101-10144NI)
- China Medical University in Taiwan (CMR99-114, DMR-101-081)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- omega-3 fatty acids, chronic hepatitis C, eicosapentaenoic acid, docosahexaenoic acid, depression prevention, inflammation and depression
- MeSH terms
- Depression, Docosahexaenoic Acids, Double-Blind Method, Female, Hepatitis C, Humans, Male, Middle Aged, Eicosapentaenoic Acid, Interferon-alpha
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
