Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression
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Subsequent studies did not find that combined citalopram and anti-inflammatory drugs resulted in more treatment failures than citalopram alone.
“These results were not found in subsequent studies[69].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [69]
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Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Davis, J. M., Mischoulon, D., Peet, M., Keck, P. E., Marangell, L. B., Richardson, A. J., Lake, J., et al. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1217 · Cited by 709 · see citing works
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Lin, P.-Y., Huang, S.-Y., & Su, K.-P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.018 · Cited by 530 · see citing works
Self-citationLin, P.-Y., & Su, K.-P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0712 · Cited by 481 · see citing works
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Sublette, M. E., Ellis, S. P., Geant, A. L., & Mann, J. J. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06634 · Cited by 421 · see citing works
Appleton, K. M., Rogers, P. J., & Ness, A. R. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28313 · Cited by 353 · see citing works
Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
Bloch, M. H., & Hannestad, J. O. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.100 · Cited by 293 · see citing works
The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Rogers, P. J., Appleton, K. M., Kessler, D., Peters, T. J., Gunnell, D., Hayward, R. C., Heatherley, S. V., Christian, L. M., McNaughton, S. A., & Ness, A. R. (2008) · British Journal of Nutrition · doi:10.1017/s0007114507801097 · Cited by 243 · see citing works
Rare structural variation of synapse and neurotransmission genes in autism
Gai, X., Xie, H. M., Perin, J. C., Takahashi, N., Murphy, K., Wenocur, A. S., D'arcy, M., O'Hara, R. J., Goldmuntz, E., Grice, D. E., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.10 · Cited by 177 · see citing works
Lucas, M., Asselin, G., Mérette, C., Poulin, M.-J., & Dodin, S. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26749 · Cited by 111 · see citing works
Complementary and Alternative Medicine for Major Depressive Disorder
Freeman, M. P., Mischoulon, D., Tedeschini, E., Goodness, T. M., Cohen, L. S., D, M. F. M., & Papakostas, G. I. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10r05976blu · Cited by 64 · see citing works
Self-citationLucas, M., Asselin, G., Mérette, C., Poulin, M.-J., & Dodin, S. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181865386 · Cited by 51 · see citing works
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Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943 · see citing works
Malhi, G. S., Bassett, D., Boyce, P., Bryant, R., Fitzgerald, P. B., Fritz, K., Hopwood, M., Lyndon, B., Mulder, R., Murray, G., et al. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415617657 · Cited by 842 · see citing works
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BackgroundGrosso, G., Pajak, A., Marventano, S., Castellano, S., Galvano, F., Bucolo, C., Drago, F., & Caraci, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096905 · Cited by 449 · see citing works
Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Sarris, J., Murphy, J., Mischoulon, D., Papakostas, G. I., Fava, M., Berk, M., & Ng, C. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15091228 · Cited by 436 · see citing works
Self-citationOmega-3 fatty acids and depression: scientific evidence and biological mechanisms
Grosso, G., Galvano, F., Marventano, S., Malaguarnera, M., Bucolo, C., Drago, F., & Caraci, F. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/313570 · Cited by 351 · see citing works
Brain membrane lipids in major depression and anxiety disorders
Müller, C. P., Reichel, M., Mühle, C., Rhein, C., Gulbins, E., & Kornhuber, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.014 · Cited by 308 · see citing works
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Opie, R. S., Itsiopoulos, C., Parletta, N., Sanchez-Villegas, A., Akbaraly, T. N., Ruusunen, A., & Jacka, F. N. (2017) · Nutritional Neuroscience · doi:10.1179/1476830515y.0000000043 · Cited by 287 · see citing works
Mocking, R. J. T., Harmsen, I. M., Assies, J., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.29 · Cited by 280 · see citing works
Wagner, K. M., McReynolds, C. B., Schmidt, W. K., & Hammock, B. D. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.06.006 · Cited by 279 · see citing works
Rapaport, M. H., Nierenberg, A. A., Schettler, P. J., Kinkead, B. L., Cardoos, A., Walker, R., & Mischoulon, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.22 · Cited by 271 · see citing works
Self-citationJeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247 · see citing works
Grosso, G., Micek, A., Marventano, S., Castellano, S., Mistretta, A., Pajak, A., & Galvano, F. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.08.011 · Cited by 244 · see citing works
Liu, J. J., Green, P., Mann, J. J., Rapoport, S. I., & Sublette, M. E. (2014) · Brain Research · doi:10.1016/j.brainres.2014.11.059 · Cited by 234 · see citing works
Borsini, A., Nicolaou, A., Camacho‐Muñoz, D., Kendall, A. C., Benedetto, M. G. D., Giacobbe, J., Su, K., & Pariante, C. M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01160-8 · Cited by 235 · see citing works
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Su, K.-P., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Chang, J. P.-C., Chang, H.-C., & Pariante, C. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.01.008 · Cited by 205 · see citing works
Self-citationGuu, T., Mischoulon, D., Sarris, J. J., Hibbeln, J. R., McNamara, R. K., Hamazaki, K., Freeman, M. P., Maes, M. H. J., Matsuoka, Y., Belmaker, R. H., et al. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000502652 · Cited by 196 · see citing works
Self-citationOmega-3 fatty acids for depression in adults
Appleton, K. M., Sallis, H., Perry, R. E., Ness, A., & Churchill, R. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004692.pub4 · Cited by 181 · see citing works
Su, K., Tseng, P., Lin, P., Okubo, R., Chen, T., Chen, Y., & Matsuoka, Y. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.2327 · Cited by 156 · see citing works
Self-citationVan Dael, P. (2021) · Nutrition Research and Practice · doi:10.4162/nrp.2021.15.2.137 · Cited by 138 · see citing works
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Su, K., Matsuoka, Y., & Pae, C. (2015) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2015.13.2.129 · Cited by 135 · see citing works
Self-citationRescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants
Borsini, A., Alboni, S., Horowitz, M. A., Tojo, L. M., Cannazza, G., Su, K.-P., Pariante, C. M., & Zunszain, P. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.05.006 · Cited by 126 · see citing works
Self-citationSchefft, C., Kilarski, L. L., Bschor, T., & Köhler, S. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.07.004 · Cited by 123 · see citing works
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Omega-3 Fatty Acid and Nutrient Deficits in Adverse Neurodevelopment and Childhood Behaviors
Gow, R. V., & Hibbeln, J. R. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.02.002 · Cited by 121 · see citing works
Self-citationChang, C.-H., Tseng, P.-T., Chen, N.-Y., Lin, P.-C., Lin, P.-Y., Chang, J. P. C., Kuo, F.-Y., Lin, J., Wu, M.-C., & Su, K.-P. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.01.001 · Cited by 103 · see citing works
Self-citationMatsuoka, Y., Sawada, N., Mimura, M., Shikimoto, R., Nozaki, S., Hamazaki, K., Uchitomi, Y., & Tsugane, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.206 · Cited by 97 · see citing works
Self-citationChang, J. P., Su, K., Mondelli, V., Satyanarayanan, S. K., Yang, H.-T., Chiang, Y.-J., Chen, H.-T., & Pariante, C. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0633-0 · Cited by 90 · see citing works
Self-citationPolyunsaturated Fatty Acids in Perinatal Depression: A Systematic Review and Meta-analysis
Lin, P., Chang, C., Chong, M. F., Chen, H., & Su, K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.1182 · Cited by 88 · see citing works
Self-citationTrebatická, J., Hradečná, Z., Surovcová, A., Katrenčíková, B., Gushina, I., Waczulı́ková, I., Sušienková, K., Garaiová, I., Šuba, J., & Ďuračková, Z. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112911 · Cited by 78 · see citing works
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Dacks, P. A., Shineman, D. W., & Fillit, H. M. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0431-3 · Cited by 70 · see citing works
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Chang, J. P., & Su, K. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.4.469 · Cited by 68 · see citing works
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Beurel, E., Medina-Rodriguez, E. M., & Jope, R. S. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000256 · Cited by 60 · see citing works
ω-3 Fatty acids for major depressive disorder in adults: an abridged Cochrane review
Appleton, K. M., Sallis, H., Perry, R. E., Ness, A., & Churchill, R. C. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010172 · Cited by 60 · see citing works
Molecular Neurobiology and Promising New Treatment in Depression
Jeon, S. R., & Kim, Y. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030381 · Cited by 61 · see citing works
Omega-3 fatty acids for depression in adults
Appleton, K. M., Voyias, P. D., Sallis, H. M., Dawson, S., Ness, A. R., Churchill, R., & Perry, R. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004692.pub5 · Cited by 84 · see citing works
Beydoun, M. A., Kuczmarski, M. F., Beydoun, H. A., Hibbeln, J. R., Evans, M. K., & Zonderman, A. B. (2013) · Journal of Nutrition · doi:10.3945/jn.113.179119 · Cited by 58 · see citing works
Self-citationPolyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder
Sublette, M. E., Galfalvy, H., Hibbeln, J. R., Keilp, J. G., Malone, K. M., Oquendo, M. A., & Mann, J. J. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001399 · Cited by 58 · see citing works
Self-citationHashimoto, M., Maekawa, M., Katakura, M., Hamazaki, K., & Matsuoka, Y. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r14cp · Cited by 57 · see citing works
Self-citationWolters, M., von der Haar, A., Baalmann, A.-K., Wellbrock, M., Heise, T. L., & Rach, S. (2021) · Nutrients · doi:10.3390/nu13041070 · Cited by 57 · see citing works
Simon, M. S., Arteaga-Henríquez, G., Algendy, A. F., Siepmann, T., & Illigens, B. M. W. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s385117 · Cited by 56 · see citing works
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Saunders, E. F. H., Ramsden, C. E., Sherazy, M. S., Gelenberg, A. J., Davis, J. M., & Rapoport, S. I. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15r09925 · Cited by 55 · see citing works
Kalkman, H. O., Hersberger, M., Walitza, S., & Berger, G. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094393 · Cited by 53 · see citing works
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Mocking, R., Assies, J., Ruhé, H., & Schene, A. (2018) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-018-0158-3 · Cited by 46 · see citing works
Tsai, A. C., Lucas, M., Okereke, O. I., O’Reilly, É. J., Mirzaei, F., Kawachi, I. I., Ascherio, A., & Willett, W. C. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu086 · Cited by 48 · see citing works
Matsuoka, Y., Nishi, D., Hamazaki, K., Yonemoto, N., Matsumura, K., Noguchi, H., Hashimoto, K., & Hamazaki, T. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09260 · Cited by 47 · see citing works
Self-citationMocking, R. J. T., Verburg, H. F., Westerink, A. M., Assies, J., Vaz, F. M., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.027 · Cited by 44 · see citing works
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Self-citationWatanabe, N., Furukawa, T. A., Horikoshi, M., Katsuki, F., Narisawa, T., Kumachi, M., Oe, Y., Shinmei, I., Noguchi, H., Hamazaki, K., et al. (2015) · Trials · doi:10.1186/s13063-015-0554-z · Cited by 36 · see citing works
Self-citationSu, K. (2015) · Biomedicine · doi:10.7603/s40681-015-0021-x · Cited by 35 · see citing works
Self-citationSaunders, E. F. H., Reider, A., Singh, G., Gelenberg, A. J., & Rapoport, S. I. (2015) · Bipolar Disorders · doi:10.1111/bdi.12337 · Cited by 33 · see citing works
Su, K., Yang, H.-T., Chang, J. P., Shih, Y.-H., Guu, T., Satyanarayanan, S. K., Gałecki, P., Walczewska, A., & Pariante, C. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.020 · Cited by 33 · see citing works
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Nishi, D., Su, K., Usuda, K., Chang, J. P., Hamazaki, K., Ishima, T., Sano, Y., Ito, H., Isaka, K., Tachibana, Y., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.014 · Cited by 33 · see citing works
Self-citationSublette, M. E., Daray, F. M., Ganança, L., & Shaikh, S. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02322-6 · Cited by 34 · see citing works
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Hashimoto, K. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1226284 · Cited by 32 · see citing works
Beier, A. M., Lauritzen, L., Galfalvy, H., Cooper, T. B., Oquendo, M. A., Grunebaum, M. F., Mann, J. J., & Sublette, M. E. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.06.012 · Cited by 31 · see citing works
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Sakayori, N., Kimura, R., & Osumi, N. (2013) · Stem Cells International · doi:10.1155/2013/973508 · Cited by 28 · see citing works
Wang, H., Liu, W., Zailani, H., Yang, C., Chen, T., Chang, C., Tsai, I., Yang, C., & Su, K. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.019 · Cited by 34 · see citing works
Self-citationClinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders
Sarris, J. J. (2017) · Australasian Psychiatry · doi:10.1177/1039856216689533 · Cited by 29 · see citing works
The role of n-3 polyunsaturated fatty acids (n-3PUFAs) in affective disorders
Ciappolino, V., Delvecchio, G., Agostoni, C. V., Mazzocchi, A., Altamura, A. C., & Brambilla, P. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.034 · Cited by 29 · see citing works
Trebatická, J., Hradečná, Z., Böhmer, F., Vaváková, M., Waczulı́ková, I., Garaiová, I., Luha, J., Škodáček, I., Šuba, J., & Ďuračková, Z. (2017) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-017-0167-2 · Cited by 29 · see citing works
Guu, T., Mischoulon, D., Sarris, J. J., Hibbeln, J. R., McNamara, R. K., Hamazaki, K., Freeman, M. P., Maes, M. H. J., Matsuoka, Y., Belmaker, R. H., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.050 · Cited by 28 · see citing works
Self-citationGanança, L., Galfalvy, H., Oquendo, M. A., Hezghia, A., Cooper, T. B., Mann, J. J., & Sublette, M. E. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.03.004 · Cited by 25 · see citing works
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Luberto, C. M., White, C., Sears, R. W., & Cotton, S. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0391-2 · Cited by 23 · see citing works
Chang, J. P., & Su, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.022 · Cited by 23 · see citing works
Self-citationZailani, H., Satyanarayanan, S. K., Liao, W.-C., Liao, H.-F., Huang, S., Gałecki, P., Su, K., & Chang, J. P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072653 · Cited by 23 · see citing works
Self-citationGuertin, M.-H., Robitaille, K., Pelletier, J.-F., Duchesne, T., Julien, P., Savard, J., Bairati, I., & Fradet, V. (2018) · BMC Cancer · doi:10.1186/s12885-017-3979-9 · Cited by 23 · see citing works
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Sikka, P., Behl, T., Sharma, S., Sehgal, A., Bhatia, S., Al‐Harrasi, A., Singh, S., Sharma, N., & Aleya, L. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14884-5 · Cited by 22 · see citing works
Chang, J. P., Jingling, L., Huang, Y., Lu, Y. “., & Su, K. (2016) · Clinical Psychological Science · doi:10.1177/2167702616637820 · Cited by 23 · see citing works
Self-citationTong, J., Satyanarayanan, S. K., & Su, H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.08.027 · Cited by 24 · see citing works
Rice, S., Hickie, I. B., Yung, A. R., Mackinnon, A. J., Berk, M., Davey, C. G., Hermens, D. F., Hetrick, S. E., Parker, A. G., Schäfer, M. R., et al. (2014) · Early Intervention in Psychiatry · doi:10.1111/eip.12166 · Cited by 24 · see citing works
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Chang, J. P., Zamparelli, A., Nettis, M. A., & Pariante, C. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819641-0.00105-5 · Cited by 22 · see citing works
Shibata, M., Ohara, T., Yoshida, D., Hata, J., Mukai, N., Kawano, H., Kanba, S., Kitazono, T., & Ninomiya, T. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.05.004 · Cited by 22 · see citing works
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Ali, A. M. (2018) · Novel Approaches in Drug Designing & Development · doi:10.19080/napdd.2018.04.555636 · Cited by 21 · see citing works
Chang, J. P. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100310 · Cited by 20 · see citing works
Chang, J. P.-C., Lai, H.-C., Yang, H.-T., Su, W.-P., Peng, C.-Y., Gałecki, P., Walczewska, A., Pariante, C. M., & Su, K.-P. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2015.1123378 · Cited by 19 · see citing works
Self-citationLiu, T., Ho, C., Chen, D. T.-L., Wu, J., Huang, P., Lai, C., Hsieh, K.-Y., & Su, K. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.008 · Cited by 19 · see citing works
Self-citationWhat is the Role of Alternative Treatments in Late-life Depression?
Nyer, M., Doorley, J. D., Durham, K. E., Yeung, A., Freeman, M. P., & Mischoulon, D. (2013) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2013.08.012 · Cited by 19 · see citing works
Self-citationSu, K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.011 · Cited by 19 · see citing works
Self-citationSublette, M. E. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_163 · Cited by 18 · see citing works
Okubo, R., Chen, C., Sekiguchi, M., Hamazaki, K., & Matsuoka, Y. (2018) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.03.006 · Cited by 18 · see citing works
Self-citationThesing, C. S., Bot, M., Milaneschi, Y., Giltay, E. J., & Penninx, B. W. J. H. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.011 · Cited by 18 · see citing works
Sparkes, C., Sinclair, A. J., Gibson, R. A., Else, P. L., & Meyer, B. J. (2020) · Nutrients · doi:10.3390/nu12041017 · Cited by 17 · see citing works
Chang, J. P., Guu, T., Chen, Y., Gałecki, P., Walczewska, A., & Su, K. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.01.001 · Cited by 16 · see citing works
Self-citationWu, S., Yang, K.-J., Liu, W., Malau, I. A., Zailani, H., Chang, C., Huang, S., Chang, J. P., Chiu, W., & Su, K. (2024) · Nutrients · doi:10.3390/nu16213688 · Cited by 15 · see citing works
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Kanoh, M., Inai, K., Shinohara, T., Tomimatsu, H., & Nakanishi, T. (2017) · Heart and Vessels · doi:10.1007/s00380-017-1015-2 · Cited by 15 · see citing works
Tu, C., Chen, C., Yang, C.-C., Gałecki, P., & Su, K. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040283 · Cited by 15 · see citing works
Self-citationThe Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review
Shamsi, H. S. S. A., Rainey‐Smith, S. R., Gardener, S. L., Sohrabi, H. R., Cánovas, R., Martins, R. N., & Fernando, W. M. A. D. B. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300419 · Cited by 16 · see citing works
Chang, J. P., Iqbal, A. Z., Do, Q. L., Yaseen, M., Wu, S., Malau, I. A., Zailani, H., & Su, K. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107857 · Cited by 13 · see citing works
Self-citationAdjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
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Self-citationBerger, G. E. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5080069 · Cited by 13 · see citing works
Nishi, D., Su, K., Usuda, K., Chiang, Y. J., Guu, T., Hamazaki, K., Nakaya, N., Sone, T., Sano, Y., Tachibana, Y., et al. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1031-2 · Cited by 12 · see citing works
Self-citationWang, J., Li, S., Wang, D., Gao, Y., Wang, Q., Wang, T., Wang, G., Peng, D., Qiao, Y., Zhou, J., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103617 · Cited by 12 · see citing works
- Authors
- Lin, P.-Y., Mischoulon, D., Freeman, M. P., Matsuoka, Y., Hibbeln, J., Belmaker, R. H., & Su, K.-P.
- Affiliations
- Chang Gung University (TW)
- Harvard University (US)
- National Center of Neurology and Psychiatry (JP)
- National Institutes of Health (US)
- Ben-Gurion University of the Negev (IL)
- China Medical University (TW)
- Corresponding author
- Su, K-P
- Venue
- Molecular Psychiatry
- Published
- 2012-07-24
- Volume
- 17
- Issue
- 12
- Pages
- 1161-1163
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3504139
- OpenAlex
- W2021596625
- Cited by
- 145
- References
- 12
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 11 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 12 · 2017: 14 · 2016: 19 · 2015: 16 · 2014: 11 · 2013: 9 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (ZIAAA000115)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- omega-3 fatty acids, depression, eicosapentaenoic acid, polyunsaturated fatty acids, antidepressant effects, mood improvement, depression severity, omega-3 supplementation
- MeSH terms
- Depressive Disorder, Major, Major Depressive Disorder, Humans, Meta-Analysis as Topic, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic
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