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Cited by 34Treatment of Major DepressionTryptophan and brain disordersStress Responses and Cortisol

Biological Profiling of Prospective Antidepressant Response in Major Depressive Disorder: Associations with (Neuro)Inflammation, Fatty Acid Metabolism, and Amygdala-Reactivity

Mocking, R.J.T., Nap, T.S., Westerink, A.M., Assies, J., Vaz, F.M., Koeter, M.W.J., Ruhé, H.G., Schene, A.H.·2017·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2017.02.019
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Abstract

Background A better understanding of factors underlying antidepressant non-response may improve the prediction of which patients will respond to what treatment. Major depressive disorder (MDD) is associated with alterations in fatty acid metabolism, (neuro)inflammation and amygdala-reactivity. However, their mutual relations, and the extent to which they are associated with prospective antidepressant-response, remain unknown.Purpose To test (I) alterations in (neuro)inflammation and its associations with fatty acid metabolism and amygdala-reactivity in MDD-patients compared to controls, and (II) whether these alterations are associated with prospective paroxetine response.Methods We compared 70 unmedicated MDD-patients with 51 matched healthy controls at baseline, regarding erythrocyte membrane omega-6 arachidonic acid (AA), inflammation [serum (high-sensitivity) C-reactive protein (CRP)], and in a subgroup amygdala-reactivity to emotional faces using functional magnetic resonance imaging (fMRI) (N=42). Subsequently, we treated patients with 12 weeks paroxetine, and repeated baseline measures after 6 and 12 weeks to compare non-responders, early-responders (response at 6 weeks), and late-responders (response at 12 weeks).Results Compared to controls, MDD-patients showed higher CRP (p=0.016) and AA (p=0.019) after adjustment for confounders at baseline. AA and CRP were mutually correlated (p=0.043). In addition, patients showed a more negative relation between AA and left amygdala-reactivity (p=0.014). Moreover, AA and CRP were associated with antidepressant-response: early responders showed lower AA (p=0.018) and higher CRP-concentrations (p=0.008) than non-responders throughout the study.Conclusion Higher observed CRP and AA, their mutual association, and relation with amygdala-reactivity, are corroborative with a role for (neuro)inflammation in MDD. In addition, observed associations of these factors with prospective antidepressant-response suggest a potential role as biomarkers. Future studies in independent samples are needed to replicate and test the clinical applicability of these biological predictors for treatment response to result in a precision/personalized medicine approach for treatment.

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Authors
Mocking, R. J. T., Nap, T. S., Westerink, A. M., Assies, J., Vaz, F. M., Koeter, M. W. J., Ruhé, H. G., & Schene, A. H.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Radboud University Nijmegen (NL)
Corresponding author
Mocking, R.J.T.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2017-05
Volume
79
Pages
84-92
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2017.02.019
OpenAlex
W2589609430
Cited by
34
References
72
Citations by year
2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 3
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, antidepressant response, paroxetine, neuroinflammation, C-reactive protein, arachidonic acid, omega-6 fatty acids, fatty acid metabolism, amygdala reactivity, emotional face processing, biomarkers, treatment response prediction, personalized medicine
MeSH terms
Adult, Amygdala, Antidepressive Agents, C-Reactive Protein, Major Depressive Disorder, Fatty Acids, Female, Humans, Inflammation, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Paroxetine, Lipid Metabolism

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