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Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain
Open accessAbstract
Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments. The present studies were designed to confirm and expand earlier work on the intriguing behavioral profile of the C58/J inbred strain, including low social approach and aberrant repetitive movements. Additional tests were selected to reflect aspects of autism, a severe neurodevelopmental disorder characterized by emergence of symptoms early in life, higher prevalence in males, social deficits and abnormal repetitive behavior. Mice from the C57BL/6J inbred strain, which has a similar genetic lineage and physical appearance to C58/J, served as a comparison group. Our results revealed that C58/J mice display elevated activity levels by postnatal day 6, which persist into adulthood. Despite normal olfactory ability, young adult male C58/J mice showed deficits in social approach in the three-chambered choice assay and failed to demonstrate social transmission of food preference. In contrast, female C58/J mice performed similarly to female C57BL/6J mice in both social tests. C58/J mice of both sexes demonstrated abnormal repetitive behaviors, displaying excessive jumping and back flipping in both social and non-social situations. These stereotypies were clearly evident in C58/J pups by postnatal days 20-21, and were also observed in C58/J dams during a test for maternal behavior. Overall, the strain profile for C58/J, including spontaneously developing motor stereotypies emerging early in the developmental trajectory, and social deficits primarily in males, models multiple components of the autism phenotype.
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“Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders (59–70).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [67]
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“C58/J (C58) is another commercially available inbred strain of mouse that displays high levels of stereotyped vertical jumping behaviors, relevant to the motor stereotypies of the third diagnostic symptom category of autism (65, 67).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [67]
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Metadata
- Authors
- Ryan, B. C., Young, N. B., Crawley, J. N., Bodfish, J. W., & Moy, S. S.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Ryan, Bryce C.
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 208
- Issue
- 1
- Pages
- 178-188
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC2822076
- OpenAlex
- W1998109533
- Cited by
- 135
- References
- 63
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 3 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 8 · 2012: 16
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- InSPIRe@Redlands (University of Redlands) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- National Institute of Mental Health (HD40127, R21MH084132, R01 MH73402, MH73402, R21MH085254, R01MH073402, MH084132)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD-40127, P30-HD03110, P30HD003110, T32HD040127)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism model, social dysfunction, social approach, repetitive behavior, motor stereotypies, social transmission of food preference, sex differences, maternal behavior, neurodevelopmental disorders, behavioral phenotypes
- MeSH terms
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Behavior, Animal, Body Weight, Choice Behavior, Female, Habituation, Psychophysiologic, Interpersonal Relations, Locomotion, Male, Maternal Behavior, Mice, Inbred Strains, Olfactory Pathways, Social Behavior Disorders, Stereotyped Behavior, Statistics, Nonparametric, Mice
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