Cited by 69Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain

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Fairless, Andrew H., Dow, Holly C., Toledo, Monica M., Malkus, Kristen A., Edelmann, Michele, Li, Hongzhe, Talbot, Konrad, Arnold, Steven E. +2 more·2008·Brain Research

Abstract

The behavioral manifestations of autism, including reduced sociability (reduced tendency to seek social interaction), may be related to underdevelopment of the corpus callosum (CC). The BALB/cJ inbred mouse strain is a useful model system for testing the relationship between reduced sociability and CC underdevelopment. BALB/cJ mice show low levels of sociability, on average, but substantial intrastrain variability in sociability, as well as striking variability in CC development. This study tested the hypothesis that sociability is positively correlated with CC size within the BALB/cJ inbred strain. 30-day-old BALB/cJ and C57BL/6J mice were tested for sociability towards gonadectomized A/J stimulus mice in a social choice task. The size of the corpus callosum was measured histologically at the midsagittal plane. BALB/cJ mice showed a significant positive correlation between the tendency to sniff the stimulus mouse and size of the CC relative to brain weight. C57BL/6J mice showed consistently high levels of sociability and normal corpus callosum development. These results suggest that abnormal white matter structure is associated with deficits in sociability in BALB/cJ mice. Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system.

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Crossref · 10.1016/j.brainres.2008.07.025

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Authors
Fairless, A. H., Dow, H. C., Toledo, M. M., Malkus, K. A., Edelmann, M., Li, H., Talbot, K., Arnold, S. E., Abel, T., & Brodkin, E. S.
Affiliations
University of Pennsylvania (US)
Corresponding author
Brodkin, Edward S.
Venue
Brain Research
Publisher
Elsevier BV
Published
2008-09
Volume
1230
Pages
211-217
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2132233505
Cited by
69
References
35
Citations by year
2026: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 7 · 2013: 2 · 2012: 8
FWCI
3.10
Type
journal article
Language
en
Open access
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R01MH080718)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
corpus callosum size, BALB/cJ mice, autism model, social behavior, white matter development, brain connectivity, C57BL/6J mice, inbred mouse strains
MeSH terms
Animals, Choice Behavior, Corpus Callosum, Data Interpretation, Statistical, Female, Immunohistochemistry, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Orchiectomy, Organ Size, Ovariectomy, Social Behavior, Species Specificity, Mice

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