Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain
Open accessAbstract
The behavioral manifestations of autism, including reduced sociability (reduced tendency to seek social interaction), may be related to underdevelopment of the corpus callosum (CC). The BALB/cJ inbred mouse strain is a useful model system for testing the relationship between reduced sociability and CC underdevelopment. BALB/cJ mice show low levels of sociability, on average, but substantial intrastrain variability in sociability, as well as striking variability in CC development. This study tested the hypothesis that sociability is positively correlated with CC size within the BALB/cJ inbred strain. 30-day-old BALB/cJ and C57BL/6J mice were tested for sociability towards gonadectomized A/J stimulus mice in a social choice task. The size of the corpus callosum was measured histologically at the midsagittal plane. BALB/cJ mice showed a significant positive correlation between the tendency to sniff the stimulus mouse and size of the CC relative to brain weight. C57BL/6J mice showed consistently high levels of sociability and normal corpus callosum development. These results suggest that abnormal white matter structure is associated with deficits in sociability in BALB/cJ mice. Additional studies are warranted to elucidate the relationship between brain connectivity and sociability in this model system.
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Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders.
“Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders (59–70).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [63]
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Fundamentals of Translational Neuroscience in Toxicologic Pathology
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Bolivar, V. J. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.012 · Cited by 1 · see citing works
Bailey, A. R. (2012) · Digital Commons - University of South Florida (University of South Florida)
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Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010
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Wetsel, W. C., Moy, S. S., & Jiang, Y.-H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391924-3.00026-0
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Fung, L. K., & Hardan, A. Y. (2016) · CRC Press eBooks · doi:10.1201/9781315371375-10
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Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice
Witt, E. A., Stanton‐Turcotte, D., Garay, P., Ge, J., & Iulianella, A. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70474
Ferrari, E. K., Dong, J., Duncan, K. M., Sharma, V., Whipple, S., McCoy, A. J., Marsh, E. D., & Lefebvre, V. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150442
- Authors
- Fairless, A. H., Dow, H. C., Toledo, M. M., Malkus, K. A., Edelmann, M., Li, H., Talbot, K., Arnold, S. E., Abel, T., & Brodkin, E. S.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Brodkin, Edward S.
- ORCID
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 1230
- Pages
- 211-217
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2629607
- OpenAlex
- W2132233505
- Cited by
- 69
- References
- 35
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 1 · 2014: 7 · 2013: 2 · 2012: 8
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH080718)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- corpus callosum size, BALB/cJ mice, autism model, social behavior, white matter development, brain connectivity, C57BL/6J mice, inbred mouse strains
- MeSH terms
- Animals, Choice Behavior, Corpus Callosum, Data Interpretation, Statistical, Female, Immunohistochemistry, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Orchiectomy, Organ Size, Ovariectomy, Social Behavior, Species Specificity, Mice
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