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Cited by 169Stress Responses and CortisolNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Maternal separation decreases adult hippocampal cell proliferation and impairs cognitive performance but has little effect on stress sensitivity and anxiety in adult Wistar rats

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Hulshof, Henriëtte J., Novati, Arianna, Sgoifo, Andrea, Luiten, Paul G.M., den Boer, Johan A., Meerlo, Peter·2011·Behavioural Brain Research
DOI 10.1016/j.bbr.2010.08.038
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Abstract

Stressful events during childhood are thought to increase the risk for the development of adult psychopathology. A widely used animal model for early life stress is maternal separation (MS), which is thought to affect development and cause alterations in neuroendocrine stress reactivity and emotionality lasting into adulthood. However, results obtained with this paradigm are inconsistent. Here we investigated whether this variation may be related to the type of stressor or the tests used to assess adult stress sensitivity and behavioral performance. Rat pups were exposed to a 3h daily MS protocol during postnatal weeks 1-2. In adulthood, animals were subjected to a wide variety of stressors and tests to obtain a better view on the effects of MS on adult hypothalamic-pituitary-adrenal (HPA) axis regulation, anxiety-like behavior, social interaction and cognition. Also, the influence of MS on adult hippocampal neurogenesis was studied because it might underlie changes in neuroendocrine regulation and behavioral performance. The results show that, independent of the nature of the stressor, MS did not affect the neuroendocrine response. MS did not influence anxiety-like behavior, explorative behavior and social interaction, but did affect cognitive function in an object recognition task. The amount of new born cells in the hippocampal dentate gyrus was significantly decreased in MS animals; yet, cell differentiation and survival were not altered. In conclusion, while interfering with the mother-infant relationship early in life did affect some aspects of adult neuroplasticity and cognitive function, it did not lead to permanent changes in stress sensitivity and emotionality.

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Metadata

Authors
Hulshof, H. J., Novati, A., Sgoifo, A., Luiten, P. G. M., den Boer, J. A., & Meerlo, P.
Affiliations
  • University Medical Center Groningen (NL)
  • University of Groningen (NL)
  • University of Parma (IT)
Corresponding author
Hulshof, Henriëtte J.
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2011-01-20
Volume
216
Issue
2
Pages
552-560
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2010.08.038
OpenAlex
W2066295027
Cited by
169
References
55
Citations by year
2026: 7 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 12 · 2020: 13 · 2019: 14 · 2018: 20 · 2017: 10 · 2016: 17 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 14
FWCI
4.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
maternal separation, early life stress, hippocampal neurogenesis, dentate gyrus, cognitive function, object recognition memory, anxiety-like behavior, stress sensitivity, hypothalamic-pituitary-adrenal axis, social interaction, exploratory behavior, neuroplasticity
MeSH terms
Age Factors, Analysis of Variance, Animals, Anxiety, Critical Period, Psychological, Exploratory Behavior, Female, Hippocampus, Hypothalamo-Hypophyseal System, Male, Maternal Deprivation, Neuronal Plasticity, Pituitary-Adrenal System, Random Allocation, Social Behavior, Stress, Psychological, Rats, Wistar, Recognition, Psychology, Behavioral Research, Rats, Adult Stem Cells, Neurogenesis

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