Conditioned taste aversion to ethanol in a social context: impact of age and sex
Open accessAbstract
Given that human adolescents place a high value on social interactions-particularly while consuming alcohol-the current study utilized a novel social drinking paradigm to examine rewarding and aversive properties of ethanol in non-water deprived rats that were housed and tested in groups of five same-sex littermates. On postnatal day P34 (adolescents) or P69 (adults), rats were habituated to the testing apparatus for 30 min. On the next day, animals were placed into the test apparatus and given 30 min access to a supersaccharin solution (3% sucrose; 0.125% saccharin), followed immediately by an intraperitoneal injection of ethanol (0, 0.25, 0.5, 1.0, 1.5 g/kg). Subsequent intake of the supersacharrin solution was assessed on three consecutive test days. Adolescent males were less sensitive to ethanol's aversive effects than adult males, with adolescent males maintaining an aversion on all three test days only at the 1.5 g/kg dose, whereas adults demonstrated aversions across test days to 1 and 1.5 g/kg. Adolescent females maintained aversions to 1 and 1.5 g/kg across days, whereas adult females continued to show an aversion to the 1.5 g/kg dose only. These opposite patterns of sensitivity that emerged among males and females at each age in the propensity to maintain an ethanol-induced taste aversion under social conditions may contribute to age- and sex-related differences in ethanol intake. Testing in social groups may be useful for future work when studying rodent models of adolescent alcohol use given the importance that human adolescents place on drinking in social settings.
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Several studies have selected PND25 as the boundary for early adolescence.
“Several studies have selected PND25 as the boundary for early adolescence (Morales et al., 2014; Rajendran and Spear, 2004)”
From Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults. (2023) · cites this paper as Morales et al., 2014
The paper’s Abstract places early-to-mid adolescence in rodents at postnatal days 28–42, not PND25. Its Procedure uses P34 rats as adolescents; neither passage selects PND25 as a boundary. (LLM, conf=0.86)
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Colyer-Patel, K., Kuhns, L., Weidema, A., Lesscher, H., & Cousijn, J. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105038 · Cited by 54 · see citing works
- Authors
- Morales, M., Schatz, K. C., Anderson, R. I., Spear, L. P., & Varlinskaya, E. I.
- Affiliations
- Binghamton University (US)
- Corresponding author
- Morales, Melissa
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 261
- Pages
- 323-327
- ISSN
- 0166-4328 (ISSN-L)
- PMC
- PMC3955706
- OpenAlex
- W2086254444
- Cited by
- 32
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (U01 AA19972, U01AA019972, R01AA017355, P50AA017823)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- ethanol, conditioned taste aversion, social drinking, adolescent alcohol use, age differences, sex differences, social environment, rats, alcohol consumption
- MeSH terms
- Aging, Ethanol, Analysis of Variance, Animals, Central Nervous System Depressants, Conditioning, Classical, Dose-Response Relationship, Drug, Eating, Female, Interpersonal Relations, Male, Saccharin, Sex Characteristics, Sweetening Agents, Taste, Rats
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