Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking
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Background: Many people experiment with alcohol and other drugs of abuse during their teenage years. Epidemiological evidence suggests that younger initiates into drug taking are more likely to develop problematic drug seeking behavior, including binge and other high‐intake behaviors. The level of drug intake for any individual depends on the balance of rewarding and aversive effects of the drug in that individual. Multiple rodent studies have demonstrated that aversive effects of drugs of abuse are reduced in adolescent compared to adult animals. In this study, we addressed 2 key questions: First, do reduced aversive effects of ethanol in younger rats correlate with increased ethanol consumption? Second, are the reduced aversive effects in adolescents attributable to reduced sensitivity to ethanol’s physiologic effects? Methods: Adolescent and adult rats were tested for ethanol conditioned taste aversion (CTA) followed by a voluntary drinking period, including postdeprivation consumption. Multivariate regression was used to assess correlations. In separate experiments, adolescent and adult rats were tested for their sensitivity to the hypothermic and sedative effects of ethanol, and for blood ethanol concentrations (BECs). Results: We observed that in adolescent rats but not adults, taste aversion was inversely correlated with postdeprivation consumption. Adolescents also exhibited a greater increase in consumption after deprivation than adults. Furthermore, the age difference in ethanol CTA was not attributable to differences in hypothermia, sedation, or BECs. Conclusions: These results suggest that during adolescence, individuals that are insensitive to aversive effects are most likely to develop problem drinking behaviors. These results underscore the importance of the interaction between developmental stage and individual variation in sensitivity to alcohol.
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Among adolescent rats, those least sensitive to alcohol conditioned taste aversion show the highest alcohol consumption.
“among adolescent rats, those that were the least sensitive to alcohol CTA showed the highest levels of alcohol consumption”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Schramm-Sapyta et al, 2010
Insensitivity to adverse alcohol consequences may contribute to elevated drinking patterns.
“evidence supporting the suggestion that insensitivity to adverse alcohol consequences may contribute to elevated drinking patterns”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Schramm-Sapyta et al, 2010
Among adolescent rats, those least sensitive to alcohol CTA showed the highest alcohol consumption.
“among adolescent rats, those that were the least sensitive to alcohol CTA showed the highest levels of alcohol consumption”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Schramm-Sapyta et al, 2010
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- Authors
- Schramm‐Sapyta, N. L., DiFeliceantonio, A. G., Foscue, E., Glowacz, S., Haseeb, N., Wang, N., Zhou, C., & Kuhn, C. M.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Schramm‐Sapyta, Nicole L.
- Venue
- Alcoholism: Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2010-09-22
- Volume
- 34
- Issue
- 12
- Pages
- 2061-2069
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- PMC
- PMC2988872
- OpenAlex
- W2140229121
- Cited by
- 53
- References
- 59
- Citations by year
- 2024: 3 · 2022: 2 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 3
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA017621)
- National Institute on Drug Abuse (DA020729, K01DA020729)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- ethanol, adolescent rats, conditioned taste aversion, aversive effects, voluntary ethanol drinking, hypothermia, sedation, blood alcohol concentration, developmental stages, binge drinking, problem drinking
- MeSH terms
- Age Factors, Alcohol Drinking, Ethanol, Animals, Avoidance Learning, Body Temperature, Conditioning, Classical, Male, Sleep, Taste, Rats, Sprague-Dawley, Rats, Drug-Seeking Behavior
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