mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

Mammalian autophagy: core molecular machinery and signaling regulation

Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956 · see citing works

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works

Loneliness and Risk of Alzheimer Disease

Wilson, R. S., Krueger, K. R., Arnold, S. E., Schneider, J. A., Kelly, J. F., Barnes, L. L., Tang, Y., & Bennett, D. A. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.234 · Cited by 1,363 · see citing works

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works

Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis

Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 879 · see citing works

BDNF is essential to promote persistence of long-term memory storage

Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L. N., Rossato, J. I., Goldin, A. P., Izquierdo, I., & Medina, J. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711863105 · Cited by 658 · see citing works

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Demontis, F., & Perrimon, N. (2010) · Cell · doi:10.1016/j.cell.2010.10.007 · Cited by 656 · see citing works

Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines

Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · see citing works

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death & Disease · doi:10.1038/cddis.2009.8 · Cited by 613 · see citing works

Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway

Jaworski, J., Spangler, S. A., Seeburg, D. P., Hoogenraad, C. C., & Sheng, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2270-05.2005 · Cited by 576 · see citing works

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

Tai, H., Serrano‐Pozo, A., Hashimoto, T., Frosch, M. P., Spires‐Jones, T. L., & Hyman, B. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.033 · Cited by 456 · see citing works

Assessment of spatial memory in mice

Sharma, S., Rakoczy, S. G., & Brown‐Borg, H. M. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.09.004 · Cited by 370 · see citing works

Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification

Wolfe, D. M., Lee, J., Kumar, A. R., Lee, S., Orenstein, S. J., & Nixon, R. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12169 · Cited by 348 · see citing works

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

Osellame, L. D., Rahim, A. A., Hargreaves, I. P., Gegg, M. E., Richard-Loendt, A., Brandner, S., Waddington, S. N., Schapira, A. H. V., & Duchen, M. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.014 · Cited by 329 · see citing works

Beclin1: A role in membrane dynamics and beyond

Wirawan, E., Lippens, S., Berghe, T. V., Romagnoli, A., Fimia, G. M., Piacentini, M., & Vandenabeele, P. (2012) · Autophagy · doi:10.4161/auto.8.1.16645 · Cited by 292 · see citing works

Brain-Derived Neurotrophic Factor Promotes the Maturation of GABAergic Mechanisms in Cultured Hippocampal Neurons

Yamada, M. K., Nakanishi, K., Ohba, S., Nakamura, T., Ikegaya, Y., Nishiyama, N., & Matsuki, N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07580.2002 · Cited by 235 · see citing works

Autophagy in health and disease. 5. Mitophagy as a way of life

Gottlieb, R. A., & Carreira, R. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2010 · Cited by 228 · see citing works

mTOR: on target for novel therapeutic strategies in the nervous system

Maiese, K., Chong, Z. Z., Shang, Y., & Wang, S. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.11.001 · Cited by 226 · see citing works

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

Blagosklonny, M. V. (2010) · Cell Cycle · doi:10.4161/cc.9.4.10766 · Cited by 211 · see citing works

Resveratrol as a calorie restriction mimetic: therapeutic implications

Chung, J. H., Manganiello, V., & Dyck, J. R. B. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.004 · Cited by 192 · see citing works

Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability

Adams, M. M., Shi, L., Linville, M. C., Forbes, M. E., Long, A. B., Bennett, C., Newton, I. G., Carter, C. S., Sonntag, W. E., Riddle, D. R., et al. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.01.016 · Cited by 170 · see citing works

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

McAlpine, F. E., Williamson, L. E., Tooze, S. A., & Chan, E. Y. W. (2013) · Autophagy · doi:10.4161/auto.23066 · Cited by 150 · see citing works

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

Urbańska, M., Góźdź, A., Swiech, L. J., & Jaworski, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374405 · Cited by 149 · see citing works

Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling

Eiland, L. R., & McEwen, B. S. (2010) · Hippocampus · doi:10.1002/hipo.20862 · Cited by 148 · see citing works

Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin–proteasomal and autophagy systems

Jia, H., Kast, R. J., Steffan, J. S., & Thomas, E. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds379 · Cited by 143 · see citing works

Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures

Jin, X., Hu, H., Mathers, P. H., & Agmon, A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05662.2003 · Cited by 137 · see citing works

Cognitive Performances Are Selectively Enhanced during Chronic Caloric Restriction or Resveratrol Supplementation in a Primate

Dal‐Pan, A., Pifferi, F., Marchal, J., Picq, J., & Aujard, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016581 · Cited by 123 · see citing works

NF-κB Signaling in the Aging Process

Salminen, A., & Kaarniranta, K. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9296-6 · Cited by 123 · see citing works

Autophagy as a Therapeutic Target in Diabetic Nephropathy

Tanaka, Y., Kume, S., Kitada, M., Kanasaki, K., Uzu, T., Maegawa, H., & Koya, D. (2011) · Experimental Diabetes Research · doi:10.1155/2012/628978 · Cited by 111 · see citing works

Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease

Beauquis, J., Vinuesa, Á., Pomilio, C. J., Pavía, P., Galván, V., & Saravia, F. (2013) · Hippocampus · doi:10.1002/hipo.22219 · Cited by 101 · see citing works

Phosphatidylinositol 3-Kinase Activation Is Required for Stress Protocol-induced Modification of Hippocampal Synaptic Plasticity

Yang, P.-C., Yang, C. H., Huang, C., & Hsu, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706954200 · Cited by 83 · see citing works

Calorie restriction: what recent results suggest for the future of ageing research

Smith, D. L., Nagy, T. R., & Allison, D. B. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02276.x · Cited by 80 · see citing works

An Increase in Basal BDNF Provokes Hyperactivation of the Akt-Mammalian Target of Rapamycin Pathway and Deregulation of Local Dendritic Translation in a Mouse Model of Down's Syndrome

Troca-Marín, J. A., Alves-Sampaio, A., & Montesinos, M. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0011-11.2011 · Cited by 79 · see citing works

Role of Zinc in the Regulation of Autophagy During Ethanol Exposure in Human Hepatoma Cells

Liuzzi, J. P., & Yoo, C. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9816-3 · Cited by 78 · see citing works

Impaired GABAergic inhibition in the visual cortex of brain‐derived neurotrophic factor heterozygous knockout mice

Abidin, İ., Eysel, U. T., Leßmann, V., & Mittmann, T. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.148627 · Cited by 69 · see citing works

Potential Compensatory Responses Through Autophagic/Lysosomal Pathways in Neurodegenerative Diseases

Butler, D., Nixon, R. A., & Bahr, B. A. (2006) · Autophagy · doi:10.4161/auto.2729 · Cited by 56 · see citing works

Fibroblasts from long‐lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress

Wang, M., & Miller, R. A. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00833.x · Cited by 53 · see citing works

An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain.

Caballero, B., & Coto‐Montes, A. M. (2012) · PubMed · doi:10.14670/hh-27.263 · Cited by 45 · see citing works

Autophagy gets a brake

Koren, I., Reem, E., & Kimchi, A. (2010) · Autophagy · doi:10.4161/auto.6.8.13338 · Cited by 43 · see citing works

Systematic gene expression profile of hypothalamus in calorie-restricted mice implicates the involvement of mTOR signaling in neuroprotective activity

Wu, P., Jiang, C., Shen, Q., & Hu, Y. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.07.005 · Cited by 34 · see citing works

Cognition: The brain's decline

Abbott, A. (2012) · Nature · doi:10.1038/492s4a · Cited by 18 · see citing works

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

Heras-Sandoval, D., Pérez-Rojas, J. M., Hernández-Damián, J., & Pedraza-Chaverri, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.08.019 · Cited by 1,091 · see citing works

Oxidative stress response and Nrf2 signaling in aging

Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804 · see citing works

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323 · see citing works

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

Escobar, K. A., Cole, N. H., Mermier, C. M., & VanDusseldorp, T. A. (2018) · Aging Cell · doi:10.1111/acel.12876 · Cited by 226 · see citing works

Dietary spermidine improves cognitive function

Schroeder, S., Hofer, S. J., Zimmermann, A., Pechlaner, R., Dammbrueck, C., Pendl, T., Marcello, G. M., Pogatschnigg, V., Bergmann, M., Müller, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108985 · Cited by 225 · see citing works

Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications

Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works

HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia

Zhang, S., Hu, L., Jiang, J., Li, H., Wu, Q. J., Ooi, K., Wang, J., Feng, Y., Zhu, D., & Xia, C. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1673-3 · Cited by 179 · see citing works

Activation of mTOR: a culprit of Alzheimer’s disease?

Cai, Z., Zhou, Y., Xiao, M., Yan, L.-J., & He, W. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75717 · Cited by 161 · see citing works

Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging

Sarubbo, F., Esteban, S., Miralles, A., & Moranta, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113212 · Cited by 144 · see citing works

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

Panda, P. K., Mukhopadhyay, S., Das, D. N., Sinha, N., Naik, P. P., & Bhutia, S. K. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.02.013 · Cited by 137 · see citing works

Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy

Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, C., Maciel-Barón, L. A., Konigsberg, M., Massieu, L., & Castro-Obregón, S. (2019) · Aging · doi:10.18632/aging.102181 · Cited by 128 · see citing works

Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival

Russo, R., Varano, G. P., Adornetto, A., Nazio, F., Tettamanti, G., Girardello, R., Cianfanelli, V., Cavaliere, F., Morrone, L. A., Corasaniti, M. T., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1044-5 · Cited by 127 · see citing works

Autophagy in Age-Associated Neurodegeneration

Metaxakis, A., Ploumi, C., & Tavernarakis, N. (2018) · Cells · doi:10.3390/cells7050037 · Cited by 121 · see citing works

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

Wei, Y.-N., Hu, H.-Y., Xie, G.-C., Fu, N., Ning, Z.-B., Zeng, R., & Khaitovich, P. (2015) · Genome Biology · doi:10.1186/s13059-015-0608-2 · Cited by 117 · see citing works

Key Signaling Pathways in Aging and Potential Interventions for Healthy Aging

Yu, M., Zhang, H., Wang, B. Z., Zhang, Y., Zheng, X., Shao, B., Zhuge, Q., & Jin, K. (2021) · Cells · doi:10.3390/cells10030660 · Cited by 114 · see citing works

4-hydroxynonenal-mediated signaling and aging

Zhang, H., & Forman, H. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.032 · Cited by 114 · see citing works

Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and Neurodegeneration.

Mazucanti, C., Cabral-Costa, J. V., Vasconcelos, A., Andreotti, D., Scavone, C., & Kawamoto, E. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150610125715 · Cited by 89 · see citing works

Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis

Carroll, B., Korolchuk, V. I., & Sarkar, S. (2014) · Amino Acids · doi:10.1007/s00726-014-1775-2 · Cited by 95 · see citing works

Can dietary patterns prevent cognitive impairment and reduce Alzheimer's disease risk: Exploring the underlying mechanisms of effects

Chu, C., Yu, L., Qi, G., Mi, Y., Wu, W., Lee, Y. K., Zhai, Q., Tian, F., & Chen, W. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104556 · Cited by 85 · see citing works

Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function

Garza-Lombó, C., & Gonsebatt, M. E. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00157 · Cited by 86 · see citing works

Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice

Quipildor, G. F., Mao, K., Hu, Z., Novaj, A., Cui, M., Gulinello, M. E., Branch, C. A., Gubbi, S., Patel, K., Moellering, D. R., et al. (2019) · GeroScience · doi:10.1007/s11357-019-00065-3 · Cited by 85 · see citing works

Could Alzheimer’s Disease Originate in the Periphery and If So How So?

Morris, G., Berk, M., Maes, M. H. J., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1092-y · Cited by 83 · see citing works

The aging rat retina: from function to anatomy

Nadal-Nicolás, F. M., Vidal‐Sanz, M., & Agudo‐Barriuso, M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.021 · Cited by 81 · see citing works

Autophagy in axonal degeneration in glaucomatous optic neuropathy

Munemasa, Y., & Kitaoka, Y. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.03.002 · Cited by 81 · see citing works

Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition

Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77 · see citing works

Autophagy and proteostasis in the control of synapse aging and disease

Liang, Y., & Sigrist, S. J. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.006 · Cited by 72 · see citing works

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

Bhukel, A., Beuschel, C. B., Maglione, M., Lehmann, M., Juhász, G., Madeo, F., & Sigrist, S. J. (2019) · Nature Communications · doi:10.1038/s41467-019-09262-2 · Cited by 72 · see citing works

Effect of caloric restriction on depression

Manchishi, S. M., Cui, R., Zou, X. H., Cheng, Z. Q., & Li, B. J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13418 · Cited by 70 · see citing works

Necroptosis increases with age in the brain and contributes to age-related neuroinflammation

Thadathil, N., Nicklas, E. H., Mohammed, S., Lewis, T. L., Richardson, A. G., & Deepa, S. S. (2021) · GeroScience · doi:10.1007/s11357-021-00448-5 · Cited by 72 · see citing works

Multifarious roles of mTOR signaling in cognitive aging and cerebrovascular dysfunction of Alzheimer's disease

Uddin, M. S., Rahman, M. A., Kabir, M. T., Behl, T., Mathew, B., Perveen, A., Barreto, G. E., Bin-Jumah, M. N., Abdel‐Daim, M. M., & Ashraf, G. M. (2020) · IUBMB Life · doi:10.1002/iub.2324 · Cited by 66 · see citing works

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

Ishikawa, S., & Ishikawa, F. (2020) · Aging Cell · doi:10.1111/acel.13071 · Cited by 67 · see citing works

Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy

Subramanian, A., Tamilanban, T., Alsayari, A., Ramachawolran, G., Wong, L. S., Sekar, M., Gan, S. H., Subramaniyan, V., Chinni, S. V., Rani, N. N. I. M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1094351 · Cited by 67 · see citing works

Ageing in the brain: mechanisms and rejuvenating strategies

Gaspar-Silva, F., Trigo, D., & Magalhães, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04832-6 · Cited by 75 · see citing works

Novel strategies for anti-aging drug discovery

Saraswat, K., & Rizvi, S. I. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2017.1349750 · Cited by 66 · see citing works

Autophagy and Akt/CREB signalling play an important role in the neuroprotective effect of nimodipine in a rat model of vascular dementia

Hu, M. C., Liu, Z., Lv, P., Wang, H., Zhu, Y., Qi, Q., & Xu, J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.11.053 · Cited by 62 · see citing works

The tyrosine kinase inhibitor, sunitinib malate, induces cognitive impairment in vivo via dysregulating VEGFR signaling, apoptotic and autophagic machineries

Abdel‐Aziz, A. K., Mantawy, E. M., Said, R. S., & Helwa, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.06.004 · Cited by 61 · see citing works

Augmenting brain metabolism to increase macro- and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and aging

Loos, B., Klionsky, D. J., & Wong, E. S. P. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.001 · Cited by 61 · see citing works

Beneficial effects of dietary restriction in aging brain

Hadem, I. K. H., Majaw, T., Kharbuli, B., & Sharma, R. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.10.001 · Cited by 59 · see citing works

Brain ageing and neurodegenerative disease: The role of cellular waste management

Daniele, S., Giacomelli, C., & Martini, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.030 · Cited by 59 · see citing works

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

Yang, Y., & Zhang, L. (2020) · Food & Function · doi:10.1039/c9fo02611h · Cited by 57 · see citing works

Irisin and Autophagy: First Update

Pesce, M., Ballerini, P., Paolucci, T., Puca, I., Farzaei, M. H., & Patruno, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207587 · Cited by 59 · see citing works

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00532 · Cited by 59 · see citing works

Lysosomal Proteolysis Is Associated With Exercise-Induced Improvement of Mitochondrial Quality Control in Aged Hippocampus

Luo, L., Dai, J.-R., Guo, S., Lu, A.-M., Gao, X., Gu, Y., Zhang, X., Xu, H., Wang, Y., Zhu, Z., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw242 · Cited by 51 · see citing works

Physical Activity Alleviates Cognitive Dysfunction of Alzheimer’s Disease through Regulating the mTOR Signaling Pathway

Kou, X., Chen, D., & Chen, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071591 · Cited by 49 · see citing works

Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review

Maissan, P., Mooij, E., & Barberis, M. (2021) · Biology · doi:10.3390/biology10030194 · Cited by 50 · see citing works

Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet

Dong, W., Wang, R., Ma, L., Xu, B., Zhang, J., Zhao, Z., Wang, Y., & Zhang, X. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0398-0 · Cited by 50 · see citing works

The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?

García-Huerta, P., Troncoso-Escudero, P., Jerez, C., Hetz, C. A., & Vidal, R. L. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.052 · Cited by 47 · see citing works

Food restriction affects Y‐maze spatial recognition memory in developing mice

Fu, Y., Chen, Y., Li, L., Wang, Y., Kong, X., & Wang, J. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.03.010 · Cited by 47 · see citing works

Energy restriction and potential energy restriction mimetics

Nikolai, S., Pallauf, K., Huebbe, P., & Rimbach, G. H. (2015) · Nutrition Research Reviews · doi:10.1017/s0954422415000062 · Cited by 43 · see citing works

Longevity‐related molecular pathways are subject to midlife “switch” in humans

Timmons, J. A., Volmar, C., Crossland, H., Phillips, B. E., Sood, S., Janczura, K. J., Törmäkangas, T., Kujala, U. M., Kraus, W. E., Atherton, P. J., et al. (2019) · Aging Cell · doi:10.1111/acel.12970 · Cited by 43 · see citing works

Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis.

Jeong, J. H., Yu, K., Dong, H.-B., Lee, J.-H., Lee, N.-S., Jeong, Y., Kim, D. K., Kim, J.-J., & Han, S.-Y. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3852 · Cited by 37 · see citing works

Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Caristia, S., Vito, M. D., Sarro, A., Leone, A., Pecere, A., Zibetti, A., Filigheddu, N., Zeppegno, P., Prodam, F., Faggiano, F., et al. (2020) · Nutrients · doi:10.3390/nu12082290 · Cited by 42 · see citing works

Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice.

Dong, W., Wang, R., Ma, L., Xu, B., Zhang, J., Zhao, Z., Wang, Y., & Zhang, X. (2015) · PubMed Central · Cited by 40 · see citing works

Environmental enrichment enhances autophagy signaling in the rat hippocampus

Takahashi, T., Shimizu, K., Shimazaki, K., Toda, H., & Nibuya, M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.026 · Cited by 39 · see citing works

The antidepressant effects of rosiglitazone on rats with depression induced by neuropathic pain

Zong, J., Liao, X., Ren, B., & Wang, Z. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.04.057 · Cited by 37 · see citing works

Recent Advances in Anti-Aging Medicine

Son, D., Park, W.-J., & Lee, Y. (2019) · Korean Journal of Family Medicine · doi:10.4082/kjfm.19.0087 · Cited by 37 · see citing works

Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells

Vucicevic, L. M., Misirkic-Marjanovic, M., Ćirić, D., Martinović, T., Jovanović, M., Isaković, A., Marković, I., Šaponjić, J., Foretz, M., Rabanal‐Ruiz, Y., et al. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03356-2 · Cited by 37 · see citing works

How autophagy can restore proteostasis defects in multiple diseases?

Joshi, V., Upadhyay, A., Prajapati, V. K., & Mishra, A. (2020) · Medicinal Research Reviews · doi:10.1002/med.21662 · Cited by 38 · see citing works

Molecular mechanisms of action of Trehalose in cancer: A comprehensive review

Chaitanya, N. S. N., Devi, A., Sahu, S., & Alugoju, P. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118968 · Cited by 37 · see citing works

Mechanism of CNS regulation by irisin, a multifunctional protein

Qi, J., Yang, L.-K., Wang, X., Wang, M., Li, X., Feng, B., Wu, Y., Liu, S., & Zhang, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.007 · Cited by 36 · see citing works

Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet

Gratuze, M., Julien, J., Morin, F., Marette, A., & Planel, E. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.001 · Cited by 34 · see citing works

Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy

Gregosa, A., Vinuesa, Á., Todero, M. F., Pomilio, C. J., Rossi, S. P., Bentivegna, M., Presa, J., Wenker, S. D., Saravia, F., & Beauquis, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104542 · Cited by 34 · see citing works

Does calorie restriction improve cognition?

Dias, I. R., SANTOS, C. D. S., Magalhães, C. O. D. E., de Oliveira, L. R. S., Dias‐Peixoto, M. F., Sousa, R. A. L. D., & Cassilhas, R. C. (2020) · IBRO Reports · doi:10.1016/j.ibror.2020.05.001 · Cited by 32 · see citing works

Mitophagy impairment in neurodegenerative diseases: Pathogenesis and therapeutic interventions

Mani, S., Swargiary, G., & Chadha, R. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.01.001 · Cited by 32 · see citing works

Metformin Plus Caloric Restriction Show Anti-epileptic Effects Mediated by mTOR Pathway Inhibition

Rubio, C., Ramírez, V. C., Gámez, D. C., Paz, C., Carvajal, K., & Phillips-Farfán, B. V. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0611-8 · Cited by 31 · see citing works

Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project

Bray, E. E., Zheng, Z., Tolbert, M. K., McCoy, B. M., Akey, J. M., Benton, B., Borenstein, E., Castelhano, M. G., Coleman, A. E., Creevy, K. E., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00575-7 · Cited by 30 · see citing works

Autophagy and amino acid metabolism in the brain: implications for epilepsy

Bejarano, E., & Rodríguez‐Navarro, J. A. (2014) · Amino Acids · doi:10.1007/s00726-014-1822-z · Cited by 30 · see citing works

Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice

Gureev, A. P., Syromyatnikov, M., Gorbacheva, T., Starkov, A. A., & Popov, V. N. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.07.006 · Cited by 30 · see citing works

Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death

Porras, M. A. G., Sieck, G. C., & Mantilla, C. B. (2018) · Physiology · doi:10.1152/physiol.00008.2018 · Cited by 30 · see citing works

Effects of lifelong exercise on age-related body composition, oxidative stress, inflammatory cytokines, and skeletal muscle proteome in rats

Gao, H.-E., Wu, D.-S., Sun, L., Yang, L., Qiao, Y., Ma, S., Wu, Z., Ruan, L., & Li, F. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111262 · Cited by 29 · see citing works

Age-related impairment of autophagy in cervical motor neurons

Pareja‐Cajiao, M., Gransee, H. M., Stowe, J. M., Rana, S. D., Sieck, G. C., & Mantilla, C. B. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111193 · Cited by 29 · see citing works

Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice

Zeng, M., Qi, L., Guo, Y., Zhu, X., Tang, X., Yong, T., Xie, Y., Wu, Q., Zhang, M., & Chen, D. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.628860 · Cited by 28 · see citing works

Beta-hydroxy-beta-methylbutyrate ameliorates aging effects in the dendritic tree of pyramidal neurons in the medial prefrontal cortex of both male and female rats

Kougias, D. G., Nolan, S. O., Koss, W. A., Kim, T., Hankosky, E. R., Gulley, J. M., & Juraska, J. M. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.01.004 · Cited by 28 · see citing works

Normal ageing of the brain: Histological and biological aspects

Teissier, T., Boulanger, É., & Deramecourt, V. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.03.017 · Cited by 27 · see citing works

Cognitive Impact of Calorie Restriction: A Narrative Review

Yu, Q., Zou, L., Kong, Z., & Yang, L. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.05.047 · Cited by 28 · see citing works

Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B

Kuga, G. K., Muñoz, V. R., Gaspar, R. C., Nakandakari, S. C. B. R., da Silva, A. S. R., Botezelli, J. D., Leme, J. A. C. D. A., Gomes, R. J., de Moura, L. P., Cintra, D. E., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.005 · Cited by 27 · see citing works

Combined immunotherapy with “anti-insulin resistance” therapy as a novel therapeutic strategy against neurodegenerative diseases

Takamatsu, Y., Ho, G. J., Koike, W., Sugama, S., Takenouchi, T., Waragai, M., Wei, J., Sekiyama, K., & Hashimoto, M. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-016-0001-1 · Cited by 25 · see citing works

Neuroprotection by dipeptidyl-peptidase-4 inhibitors and glucagon-like peptide-1 analogs via the modulation of AKT-signaling pathway in Alzheimer’s disease

Ikeda, Y., Nagase, N., Tsuji, A., Kitagishi, Y., & Matsuda, S. (2021) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v12.i6.104 · Cited by 25 · see citing works

Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

Xia, Z., Gao, M., Sheng, P., Shen, M., Zhao, L., Gao, L., & Yan, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126463 · Cited by 25 · see citing works

Creatine as a Therapeutic Target in Alzheimer's Disease

Smith, A. N., Morris, J. K., Carbuhn, A. F., Herda, T. J., Keller, J. E., Sullivan, D. K., & Taylor, M. K. (2023) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2023.102011 · Cited by 29 · see citing works

Caloric restriction and redox homeostasis in various regions of aging male rat brain: Is caloric restriction still worth trying even after early-adulthood?

Yanar, K., Simsek, B., Çaylı, N., Bozkır, H. Ö., Mengi, M., Belce, A., Aydın, S., & Çakatay, U. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12740 · Cited by 24 · see citing works

Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging

Choi, H.-S., Ahn, J. H., Park, J. H., Won, M., & Lee, C. H. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4835 · Cited by 23 · see citing works

Nimodipine represses AMPK phosphorylation and excessive autophagy after chronic cerebral hypoperfusion in rats

Chen, Y., Guo, Z., Peng, X.-M., Xie, W., Chen, L., & Tan, Z. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.03.019 · Cited by 23 · see citing works

Keeping synapses in shape: degradation pathways in the healthy and aging brain

Kuijpers, M. (2022) · Neuronal Signaling · doi:10.1042/ns20210063 · Cited by 22 · see citing works

5-Aza-2′-deoxycytidine increases hypoxia tolerance-dependent autophagy in mouse neuronal cells by initiating the TSC1/mTOR pathway

Qi, R., Zhang, X., Xie, Y., Jiang, S., Liu, Y., Liu, X., Xie, W., Jia, X., Bade, R., Shi, R., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109219 · Cited by 21 · see citing works

An Overview of the Perspective of Cellular Autophagy

Alharbi, Y. M., Bima, A. I. H., & Elsamanoudy, A. Z. (2021) · Journal of Microscopy and Ultrastructure · doi:10.4103/jmau.jmau_33_20 · Cited by 23 · see citing works

Coenzyme Q10 ameliorates aging-induced memory deficits via modulation of apoptosis, oxidative stress, and mitophagy in aged rats

Hosseini, L., Majdi, A., Sadigh‐Eteghad, S., Farajdokht, F., Ziaee, M., Aghsan, S. R., Farzipour, M., & Mahmoudi, J. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111950 · Cited by 21 · see citing works

Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway

Phillips-Farfán, B. V., Rubio, C., Ramírez, V. C., Paz, C., & Carvajal, K. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00090 · Cited by 18 · see citing works

Decoding the secrets of longevity: unraveling nutraceutical and miRNA-Mediated aging pathways and therapeutic strategies

Salama, R. M., Eissa, N., Doghish, A., Abulsoud, A., Abdelmaksoud, N. M., Mohammed, O. A., Mageed, S. S. A., & Darwish, S. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1373741 · Cited by 15 · see citing works

Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats

Kougias, D. G., Hankosky, E. R., Gulley, J. M., & Juraska, J. M. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.12.025 · Cited by 17 · see citing works

Accelerated Aging Characterizes the Early Stage of Alzheimer’s Disease

Leparulo, A., Bisio, M., Redolfi, N., Pozzan, T., Vassanelli, S., & Fasolato, C. (2022) · Cells · doi:10.3390/cells11020238 · Cited by 17 · see citing works

Duration-dependent regulation of autophagy by isoflurane exposure in aged rats

Li, Z., Li, L., Mo, N., Cao, Y., Kuerban, B., Liang, Y., Fan, D., Chui, D., & Guo, X. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1549-1 · Cited by 17 · see citing works

Prepubertal exposure to Pb alters autophagy in the brain of aging mice: A time-series based model

Bai, L., Wu, Y., Wang, R., Liu, R., Liu, M., Li, Q., Ba, Y., Zhang, H., Zhou, G., Yu, F., et al. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.08.013 · Cited by 16 · see citing works

Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice

Xie, D., Huang, J., Zhang, Q., Zhao, S., Xue, H., Yu, Q., Sun, Z., Li, J., Yang, X., Shao, M., et al. (2022) · Nutrition & Metabolism · doi:10.1186/s12986-022-00674-4 · Cited by 15 · see citing works

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

Abdulghani, A., Poghosyan, M., Mehren, A., Philipsen, A., & Anderzhanova, E. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.997054 · Cited by 15 · see citing works

Effects of lifespan-extending interventions on cognitive healthspan

Čulig, L., Sahbaz, B. D., & Bohr, V. A. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.36 · Cited by 14 · see citing works

Metabolic Adaptations to Exercise Training

Liu, S., Niu, Y., & Fu, L. (2019) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-019-0018-3 · Cited by 14 · see citing works

Aging inverts the effects of p75 NTR ‐modulated mTOR manipulation on hippocampal neuron synaptic plasticity in male mice

Wang, Z., Kennedy, B. K., Wong, L., & Sajikumar, S. (2023) · The FASEB Journal · doi:10.1096/fj.202201640rrr · Cited by 14 · see citing works

Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy

Liu, D.-X., Zhang, D., Hu, W., Chang, Y.-F., Wang, X., & Li, L. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2021.01.242 · Cited by 14 · see citing works

Caloric restriction, physical activity, and cognitive performance: A review of evidence and a discussion of the potential mediators of BDNF and TrkB

Slutsky, A. B., & Etnier, J. L. (2016) · International Journal of Sport and Exercise Psychology · doi:10.1080/1612197x.2016.1223422 · Cited by 13 · see citing works

mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy

Perluigi, M., Di Domenico, F., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.014 · Cited by 339 · see citing works

Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model

Wang, Y., Ma, Q., Ma, X., Zhongxia, Z., Liu, N., & Wang, M. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4618 · Cited by 16 · see citing works

Autophagy Dysfunction and mTOR Hyperactivation Is Involved in Surgery: Induced Behavioral Deficits in Aged C57BL/6J Mice

Jiang, Y., Zhou, Y., Ma, H., Cao, X., Li, Z., Chen, F., & Wang, H. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02918-x · Cited by 19 · see citing works

Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice.

Dong, W., Wang, R., Ma, L., Xu, B., Zhang, J., Zhao, Z., Wang, Y., & Zhang, X. (2015) · PubMed Central · Cited by 40 · see citing works

The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits

Yu, Y., Feng, L., Li, J., Lan, X., Lixiang, A., Lv, X., Zhang, M., & Chen, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.003 · Cited by 82 · see citing works