Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
Abstract
Resveratrol (3,4',5-trihydroxy stilbene), a phytoalexin found in the skin and seeds of grapes, has been reported to possess anti-inflammatory, anticarcinogenic, and antioxidant activities. In this work, we assessed the ability of resveratrol to upregulate heme oxygenase-1 (HO-1) gene expression via activation of NF-E2-related factor 2 (Nrf2) in cultured PC12 cells. Nrf2 is a transcription factor involved in the cellular protection against oxidative stress through antioxidant response element (ARE)-directed induction of several phase 2 detoxifying and antioxidant enzymes, such as HO-1. Here, we report that resveratrol induces HO-1 expression via the ARE-mediated transcriptional activation of Nrf2. Moreover, PC12 cells treated with resveratrol exhibited transient activation of Akt/protein kinase B and extracellular signal-regulated protein kinase 1/2 (ERK1/2). LY294002 and U0126, pharmacological inhibitors of phosphatidylinositol 3-kinase and MEK1/2 which are upstream of Akt and ERK1/2, respectively, attenuated resveratrol-induced HO-1 expression and exhibited antioxidant effects. Taken together, the above findings suggest that resveratrol augments cellular antioxidant defense capacity through induction of HO-1 via Nrf2-ARE signaling, thereby protecting PC12 cells from oxidative stress.
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Nrf2 is a key mediator of the beneficial effects of calorie restriction.
“Nrf2 is a pro‐longevity signaling pathway (Harman, 2006) and also a key mediator of the beneficial effects of calorie restriction.”
From Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism (2017) · cites this paper as Chen et al., 2005
In C. elegans, resveratrol, metformin, and rapamycin activate Nrf2 signaling as part of their mechanism of lifespan extension.
“in C. elegans, drugs believed to be ‘calorie restriction mimetics’ (resveratrol, metformin, and rapamycin) activate the Nrf2 signaling pathway as part of their mechanism of lifespan extension”
From Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism (2017) · cites this paper as Chen et al., 2005
Cites
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Johnson, G. L., & Lapadat, R. (2002) · Science · doi:10.1126/science.1072682 · Cited by 4,295 · see citing works
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works
Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works
The Relative Antioxidant Activities of Plant-Derived Polyphenolic Flavonoids
Rice-Evans, C. A., Miller, N. J., Bolwell, P., Bramley, P. M., & Pridham, J. B. (1995) · Free Radical Research · doi:10.3109/10715769509145649 · Cited by 2,163 · see citing works
Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
Maines, M. D. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.10.3290025 · Cited by 1,707 · see citing works
Hayes, J. D., & McLellan, L. I. (1999) · Free Radical Research · doi:10.1080/10715769900300851 · Cited by 1,528 · see citing works
Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464 · see citing works
Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene
Alam, J., Stewart, D. P., Touchard, C. L., Boinapally, S., Choi, A. M. K., & Cook, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26071 · Cited by 1,284 · see citing works
Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element
Nguyen, T., Sherratt, P. J., & Pickett, C. B. (2003) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140229 · Cited by 1,232 · see citing works
Oxidative Stress: Oxidants and Antioxidants.
Haddock, P. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.8.816a · Cited by 1,187 · see citing works
Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102 · see citing works
Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation
Kobayashi, M., & Yamamoto, M. P. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.385 · Cited by 1,075 · see citing works
Balogun, E. A., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J., & Motterlini, R. (2003) · Biochemical Journal · doi:10.1042/bj20021619 · Cited by 1,038 · see citing works
Glutathione: an overview of biosynthesis and modulation
Anderson, M. E. (1998) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(97)00146-4 · Cited by 917 · see citing works
Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. J., & Goldberg, D. M. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06045-1 · Cited by 871 · see citing works
Regulation of hepatic glutathione synthesis: current concepts and controversies
Lu, S. C.-L. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.10.1169 · Cited by 857 · see citing works
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
Chan, K., Han, X.-D., & Kan, Y. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081082098 · Cited by 766 · see citing works
Phytochemicals from Cruciferous Plants Protect against Cancer by Modulating Carcinogen Metabolism
Talalay, P., & Fahey, J. W. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.3027s · Cited by 610 · see citing works
Kwak, M.-K., Itoh, K., Yamamoto, M. P., & Kensler, T. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.2883-2892.2002 · Cited by 597 · see citing works
Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2
Wild, A. C., Moinova, H., & Mulcahy, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33627 · Cited by 595 · see citing works
Dinkova‐Kostova, A. T., Massiah, M. A., Bozak, R. E., Hicks, R. J., & Talalay, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051632198 · Cited by 594 · see citing works
Nrf2 is essential for protection against acute pulmonary injury in mice
Chan, K., & Kan, Y. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12731 · Cited by 574 · see citing works
Yamada, N., Yamaya, M., Okinaga, S., Nakayama, K., Sekizawa, K., Shibahara, S., & Sasaki, H. (2000) · The American Journal of Human Genetics · doi:10.1086/302729 · Cited by 559 · see citing works
Meister, A. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)51106-7 · Cited by 429 · see citing works
Regulation of genes encoding NAD(P)H:quinone oxidoreductases
Jaiswal, A. K. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00306-3 · Cited by 428 · see citing works
Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Kôyama, A., Yamamoto, M. P., & Takahashi, S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00939.x · Cited by 345 · see citing works
Hayes, J. D., Chanas, S. A., Henderson, C. J., McMahon, M. J., Sun, C., Moffat, G. J., Wolf, C. R., & Yamamoto, M. P. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280033 · Cited by 321 · see citing works
Sun, A. Y., Simonyi, Á., & Sun, G. Y. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00803-6 · Cited by 315 · see citing works
Hemin-induced Activation of the Thioredoxin Gene by Nrf2
Kim, Y. C., Masutani, H., Yamaguchi, Y., Itoh, K., Yamamoto, M. P., & Yodoi, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100103200 · Cited by 313 · see citing works
Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells
Elbirt, K. K., Whitmarsh, A. J., Davis, R. J., & Bonkovsky, H. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8922 · Cited by 252 · see citing works
Cardioprotection of red wine: role of polyphenolic antioxidants.
Das, D. K., Sato, M. H., Ray, P. S., Maulik, G., Engelman, R. M., Bertelli, A., & Bertelli, A. A. A. (1999) · PubMed · Cited by 249 · see citing works
Salinas, M., Díaz, R. G., Abraham, N. G., de Galarreta, C. M. R., & Cuadrado, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209164200 · Cited by 248 · see citing works
Huang, C. S., Anderson, M. E., & Meister, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80764-9 · Cited by 237 · see citing works
Virgili, M., & Contestabile, A. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00820-x · Cited by 234 · see citing works
Lee, J., Hanson, J. M., Chu, W. A., & Johnson, J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100734200 · Cited by 227 · see citing works
Alam, J., Camhi, S. L., & Choi, A. M. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.11977 · Cited by 219 · see citing works
Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells
Chanvitayapongs, S., Draczynska‐Lusiak, B., & Sun, A. Y. (1997) · Neuroreport · doi:10.1097/00001756-199704140-00035 · Cited by 206 · see citing works
Jeyapaul, J., & Jaiswal, A. K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00256-2 · Cited by 193 · see citing works
Kietzmann, T., Samoylenko, A., & Immenschuh, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m203929200 · Cited by 182 · see citing works
Juan, S., Cheng, T., Lin, H., Chu, Y.-L., & Lee, W. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.09.015 · Cited by 153 · see citing works
Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries
Tulis, D. A., Durante, W., Peyton, K. J., Evans, A. J., & Schafer, A. I. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00552-9 · Cited by 132 · see citing works
An Antiplatelet Principle ofVeratrum formosanum
Chung, M., Teng, C., Cheng, K.-L., Ko, F., & Lin, C. (1992) · Planta Medica · doi:10.1055/s-2006-961453 · Cited by 114 · see citing works
Ethanol-Induced Cell Death by Lipid Peroxidation in PC12 Cells
Sun, A. Y., Chen, Y., James-Kracke, M., Wixom, P., & Cheng, Y. (1997) · Neurochemical Research · doi:10.1023/a:1021968526696 · Cited by 111 · see citing works
Zhang, X., Bédard, E. L. R., Potter, R. F., Zhong, R., Alam, J., Choi, A. M. K., & Lee, P. J. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00485.2001 · Cited by 106 · see citing works
Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease
Draczynska‐Lusiak, B., Doung, A., & Sun, A. Y. (1998) · Molecular and Chemical Neuropathology · doi:10.1007/bf02870187 · Cited by 103 · see citing works
Biological Oxidants and Antioxidants: Molecular Mechanisms and Health Effects
Packer, L., & Ong, A. S. H. (1998) · Medical Entomology and Zoology · Cited by 83 · see citing works
Oxidized lipoproteins activate NF-κB binding activity and apoptosis in PC12 cells
Draczynska‐Lusiak, B., Chen, Y. M., & Sun, A. Y. (1998) · Neuroreport · doi:10.1097/00001756-199802160-00028 · Cited by 72 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081 · see citing works
The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
Bryan, H. K., Olayanju, A., Goldring, C. E., & Park, B. K. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.016 · Cited by 1,026 · see citing works
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,029 · see citing works
Regulation of inflammation and redox signaling by dietary polyphenols
Rahman, I., Biswas, S. K., & Kirkham, P. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.004 · Cited by 992 · see citing works
Surh, Y., Kundu, J. K., & Na, H. (2008) · Planta Medica · doi:10.1055/s-0028-1088302 · Cited by 759 · see citing works
Self-citationLiu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.002 · Cited by 697 · see citing works
Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 683 · see citing works
LAU, A., VILLENEUVE, N., Sun, Z., Wong, P. K., & Zhang, D. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.09.003 · Cited by 645 · see citing works
Ungvari, Z. I., Bagi, Z. A., Fehér, A., Recchia, F. A., Sonntag, W. E., Pearson, K. J., de Cabo, R., & Csiszár, A. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00260.2010 · Cited by 571 · see citing works
Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment
Chikara, S., Nagaprashantha, L. D., Singhal, J., Horne, D. A., Awasthi, S., & Singhal, S. S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.002 · Cited by 561 · see citing works
Redox regulation of SIRT1 in inflammation and cellular senescence
Hwang, J.-W., Yao, H., Caito, S., Sundar, I. K., & Rahman, I. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.015 · Cited by 503 · see citing works
The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants
Jung, K.-A., & Kwak, M. (2010) · Molecules · doi:10.3390/molecules15107266 · Cited by 476 · see citing works
Rada, P., Rojo, A. I., Evrard‐Todeschi, N., Innamorato, N. G., Cotte, A., Jaworski, T., Tobón-Velasco, J. C., Devijver, H., García‐Mayoral, M. F., LEUVEN, F. V., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00180-12 · Cited by 476 · see citing works
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
Kundu, J. K., & Surh, Y. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.057 · Cited by 472 · see citing works
Self-citationKode, A., Rajendrasozhan, S., Caito, S., Yang, S.-R., Megson, I. L., & Rahman, I. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00361.2007 · Cited by 447 · see citing works
Vauzour, D. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/914273 · Cited by 431 · see citing works
Regulation of inflammation by the antioxidant haem oxygenase 1
Campbell, N. K., Fitzgerald, H. K., & Dunne, A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00491-x · Cited by 428 · see citing works
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Iavicoli, I., Paola, R. D., Koverech, A., Cuzzocrea, S., Rizzarelli, E., & Calabrese, E. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.002 · Cited by 420 · see citing works
Resveratrol: Its Biologic Targets and Functional Activity
Pervaiz, S., & Holme, A. L. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2412 · Cited by 411 · see citing works
Role of resveratrol in regulation of cellular defense systems against oxidative stress
Truong, V., Jun, M., & Jeong, W. (2017) · BioFactors · doi:10.1002/biof.1399 · Cited by 397 · see citing works
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Ryter, S. W., & Choi, A. M. K. (2015) · Translational research · doi:10.1016/j.trsl.2015.06.011 · Cited by 363 · see citing works
Surh, Y., Kundu, J. K., Na, H., & Lee, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2993s · Cited by 361 · see citing works
Self-citationRapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
Wang, R., Yu, Z., Sunchu, B., Shoaf, J., Dang, I., Zhao, S., Caples, K., Bradley, L., Beaver, L. M., Ho, E., et al. (2017) · Aging Cell · doi:10.1111/acel.12587 · Cited by 360 · see citing works
Neurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses
Mattson, M. P., & Cheng, A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.001 · Cited by 356 · see citing works
Shih, P., Yeh, C., & Yen, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071933i · Cited by 333 · see citing works
Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases
Sun, A. Y., Wang, Q., Simonyi, Á., & Sun, G. Y. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8111-y · Cited by 330 · see citing works
Krajka‐Kuźniak, V., Paluszczak, J., & Baer‐Dubowska, W. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.12.011 · Cited by 288 · see citing works
The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
Farkhondeh, T., Llorens, S., Pourbagher‐Shahri, A. M., Ashrafizadeh, M., & Samarghandian, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110234 · Cited by 279 · see citing works
Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Stella, A. M. G., Schapira, T., Dinkova‐Kostova, A. T., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9775-9 · Cited by 267 · see citing works
Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities
Łoboda, A., Jaźwa, A., Grochot‐Przeczek, A., Rutkowski, A. J., Cisowski, J., Agarwal, A., Józkowicz, A., & Dulak, J. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2043 · Cited by 263 · see citing works
Zhang, F., Liu, J., & Shi, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.043 · Cited by 265 · see citing works
Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP
Cuadrado, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.029 · Cited by 264 · see citing works
Virgili, F., & Marino, M. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.001 · Cited by 250 · see citing works
Kweon, M., Adhami, V. M., Lee, J., & Mukhtar, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604748200 · Cited by 250 · see citing works
Eom, H.-J., & Choi, J. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.01.028 · Cited by 249 · see citing works
Wu, C., Hsu, M. C., Hsieh, C., Lin, J., Lai, P. H., & Wung, B. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.11.013 · Cited by 246 · see citing works
Neuroprotective effects of resveratrol in Alzheimer disease pathology
Rege, S. D., Geetha, T., Griffin, G. D., Broderick, T. L., & Babu, J. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00218 · Cited by 243 · see citing works
Mechanisms Underlying Caloric Restriction and Lifespan Regulation
Ungvari, Z. I., Parrado‐Fernández, C., Csiszár, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 239 · see citing works
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
Pearson, K. J., Lewis, K. N., Price, N. L., Chang, J. W., Perez, E., Cascajo, M. V., Tamashiro, K. L., Poosala, S., Csiszár, A., Ungvari, Z. I., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712162105 · Cited by 238 · see citing works
Activation of the Nrf2–ARE signaling pathway: a promising strategy in cancer prevention
Giudice, A., & Montella, M. (2006) · BioEssays · doi:10.1002/bies.20359 · Cited by 232 · see citing works
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarelli, E., & Calabrese, E. J. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.007 · Cited by 225 · see citing works
Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Yan, T., Yan, N., Wang, P., Xia, Y., Hao, H., Wang, G., & Gonzalez, F. J. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.11.017 · Cited by 225 · see citing works
Surh, Y., & Na, H. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0063-0 · Cited by 224 · see citing works
Self-citationNRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease
Boutten, A., Goven, D., Artaud-Macari, É., Boczkowski, J., & Bonay, M. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.006 · Cited by 223 · see citing works
Wagner, A. E., Boesch, C., Breckwoldt, D., Schrader, C., Schmelzer, C., Döring, F., Hashida, K., Hori, O., Matsugo, S., & Rimbach, G. H. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-1 · Cited by 221 · see citing works
Neurotherapeutic applications of nanoparticles in Alzheimer’s disease
Sahni, J. K., Doggui, S., Ali, J., Baboota, S., Dao, L., & Ramassamy, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.033 · Cited by 219 · see citing works
Huang, T.-C., Lu, K., Wo, Y.-Y. P., Wu, Y.-J., & Yang, Y.-L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029102 · Cited by 217 · see citing works
The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation
Sykiotis, G. P., Habeos, I. G., Samuelson, A. V., & Bohmann, D. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834136f2 · Cited by 214 · see citing works
Xue, M., Weickert, M. O., Qureshi, S. A., Kandala, N., Anwar, A., Waldron, M., Shafie, A., Messenger, D. J., Fowler, M. I., Jenkins, G., et al. (2016) · Diabetes · doi:10.2337/db16-0153 · Cited by 213 · see citing works
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works
The Heme Catabolic Pathway and its Protective Effects on Oxidative Stress‐Mediated Diseases
Vı́tek, L., & Schwertner, H. A. (2006) · Advances in clinical chemistry · doi:10.1016/s0065-2423(06)43001-8 · Cited by 208 · see citing works
Chiou, Y.-S., Tsai, M.-L., Nagabhushanam, K., Wang, Y.-J., Wu, C., Ho, C., & Pan, M. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf2000103 · Cited by 205 · see citing works
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Matzinger, M., Fischhuber, K., & Heiß, E. H. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.015 · Cited by 205 · see citing works
Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases
Carrizzo, A., Forte, M., Damato, A., Trimarco, V., Salzano, F., Bartolo, M., Maciag, A., Puca, A. A., & Vecchione, C. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.021 · Cited by 203 · see citing works
Cardozo, L., Pedruzzi, L. M., Stenvinkel, P., Stockler‐Pinto, M. B., Daleprane, J. B., Leite, M., & Mafra, D. (2013) · Biochimie · doi:10.1016/j.biochi.2013.04.012 · Cited by 201 · see citing works
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
Okawara, M., Katsuki, H., Kurimoto, E., Shibata, H., Kume, T., & Akaike, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.11.003 · Cited by 201 · see citing works
Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death
Fukui, M., Choi, H. J., & Zhu, B. T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.002 · Cited by 197 · see citing works
Chen, Z.-H., Saito, Y., Yoshida, Y., Sekine, A., Noguchi, N., & Niki, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508556200 · Cited by 197 · see citing works
Rojo, A. I., Medina‐Campos, O. N., Rada, P., Zúñiga-Toalá, A., López-Gazcón, A., Espada, S., Pedraza‐Chaverrí, J., & Cuadrado, A. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.003 · Cited by 195 · see citing works
Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals
Qin, S., & Hou, D. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501017 · Cited by 190 · see citing works
The role of different SIRT1-mediated signaling pathways in toxic injury
Ren, Z., He, H., Zuo, Z., Xu, Z., Wei, Z., & Deng, J. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0158-9 · Cited by 192 · see citing works
Hwang, Y. P., & Jeong, H. G. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.09.009 · Cited by 187 · see citing works
The roles of polyphenols in cancer chemoprevention
Lee, K. W., & Lee, H. J. (2006) · BioFactors · doi:10.1002/biof.5520260202 · Cited by 185 · see citing works
Csiszár, A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05848.x · Cited by 184 · see citing works
Singh, N., Agrawal, M., & Doré, S. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400094w · Cited by 184 · see citing works
Tüfekçi, K. U., Bayin, E. C., Genç, Ş., & Genç, K. (2011) · Parkinson s Disease · doi:10.4061/2011/314082 · Cited by 181 · see citing works
Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress
Akbar, M. D., Essa, M. M., Daradkeh, G., Abdelmegeed, M. A., Choi, Y., Mahmood, L., & Song, B. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.016 · Cited by 176 · see citing works
Ferrándiz, M. L., & Devesa, I. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783597399 · Cited by 174 · see citing works
Resveratrol neuroprotection in stroke and traumatic CNS injury
Lopez, M. S., Dempsey, R. J., & Vemuganti, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.009 · Cited by 171 · see citing works
Patel, N., Joseph, C. K., Corcoran, G. B., & Ray, S. D. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.02.002 · Cited by 169 · see citing works
Resveratrol: a cardioprotective substance
WU, J. M., & Hsieh, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05854.x · Cited by 168 · see citing works
Zhang, Q., Zhang, C., Ge, J., Lv, M., Talukder, M., Guo, K. X., Li, Y.-H., & Li, J. (2020) · Food & Function · doi:10.1039/c9fo02287b · Cited by 167 · see citing works
Rushworth, S. A., Ogborne, R. M., Charalambos, C., & O'Connell, M. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.065 · Cited by 164 · see citing works
Bishayee, A., Barnes, K. F., Bhatia, D., Darvesh, A. S., & Carroll, R. T. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0171 · Cited by 161 · see citing works
Neuroprotective Role of Phytochemicals
Velmurugan, B. K., Baskaran, R., Lohanathan, B. P., Thiyagarajan, V., & Weng, C. (2018) · Molecules · doi:10.3390/molecules23102485 · Cited by 163 · see citing works
Ungvari, Z. I., Bailey‐Downs, L. C., Gautam, T., Jiménez, R., Losonczy, G., Zhang, C., Ballabh, P., Recchia, F. A., Wilkerson, D. C., Sonntag, W. E., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00402.2010 · Cited by 162 · see citing works
Natural antioxidants in Alzheimer's disease
Mancuso, C., Bates, T. E., Butterfield, D. A., Calafato, S., Cornelius, C., LORENZO, A. D., Dinkova‐Kostova, A. T., & Calabrese, V. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.12.1921 · Cited by 159 · see citing works
Cheng, A.-S., Cheng, Y., Chiou, C.-H., & Chang, T.-L. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302831d · Cited by 155 · see citing works
Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products
Yu, J. Z., Wang, C., Kong, Q., Wu, X., Lu, J., & Chen, X. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.01.009 · Cited by 146 · see citing works
Funes, S. C., Ríos, M., Fernández‐Fierro, A., Covián, C., Bueno, S. M., Riedel, C. A., Mackern‐Oberti, J. P., & Kalergis, A. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01467 · Cited by 146 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones
Erlank, H., Elmann, A., Kohen, R., & Kanner, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.033 · Cited by 137 · see citing works
Targeting the NF-κB Pathway in Cancer Therapy
Erstad, D. J., & Cusack, J. C. (2013) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2013.06.011 · Cited by 137 · see citing works
Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration
Uddin, M. S., Mamun, A. A., Kabir, M. T., Ahmad, J., Jeandet, P., Sarwar, M. S., Ashraf, G. M., & Aleya, L. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173412 · Cited by 138 · see citing works
Siow, R. C. M., Li, F. Y. L., Rowlands, D. J., de Winter, P., & Mann, G. E. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.004 · Cited by 135 · see citing works
Chen, M.-C., Ye, Y.-Y., Ji, G., & Liu, J. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf904549s · Cited by 130 · see citing works
Kim, S.-W., Lee, H., Shin, J., & Lee, J.-K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.028 · Cited by 129 · see citing works
The Nrf2 Pathway in Ischemic Stroke: A Review
Farina, M., Vieira, L. E., Buttari, B., Profumo, E., & Saso, L. (2021) · Molecules · doi:10.3390/molecules26165001 · Cited by 128 · see citing works
Liu, Y., Chan, F., Sun, H., Yan, J., Fan, D., Zhao, D., An, J., & Zhou, D. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.009 · Cited by 125 · see citing works
Lee, S., Lim, M., Kim, M., Yu, C., Yun, Y., Ahn, J., & Song, J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.038 · Cited by 126 · see citing works
Inhibitors of Microglial Neurotoxicity: Focus on Natural Products
Choi, D., Koppula, S., & Suk, K. (2011) · Molecules · doi:10.3390/molecules16021021 · Cited by 122 · see citing works
Joung, E.-J., Li, M., Lee, H. G., Somparn, N., Jung, Y. S., Na, H., Kim, S., Cha, Y., & Surh, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1827 · Cited by 119 · see citing works
Self-citationChen, M., Gu, H., Ye, Y., Lin, B., Sun, L., Deng, W., Zhang, J., & Liu, J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.07.037 · Cited by 118 · see citing works
Kelkel, M., Jacob, C., Dicato, M. A., & Diederich, M. F. (2010) · Molecules · doi:10.3390/molecules15107035 · Cited by 117 · see citing works
Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease
Ghosh, N., Ghosh, R. B., & Mandal, S. C. (2011) · Free Radical Research · doi:10.3109/10715762.2011.574290 · Cited by 116 · see citing works
Speciale, A., Canali, R., Chirafisi, J., Saija, A., Virgili, F., & Cimino, F. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1029515 · Cited by 116 · see citing works
Son, Y. H., Lee, J. H., Chung, H., & Pae, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/639541 · Cited by 115 · see citing works
Less-known botanical cosmeceuticals
Baumann, L. (2007) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2007.00147.x · Cited by 114 · see citing works
Ogborne, R. M., Rushworth, S. A., & O'Connell, M. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000183745.37161.6e · Cited by 113 · see citing works
Das, S., Fraga, C. G., & Das, D. K. (2006) · Free Radical Research · doi:10.1080/10715760600833085 · Cited by 112 · see citing works
Retracted
- Authors
- Chen, C.-Y., Jang, J.-H., Li, M.-H., & Surh, Y.-J.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Surh, Young-Joon
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 331
- Issue
- 4
- Pages
- 993-1000
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2073679813
- Cited by
- 428
- References
- 48
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 19 · 2020: 23 · 2019: 22 · 2018: 9 · 2017: 25 · 2016: 16 · 2015: 29 · 2014: 27 · 2013: 25 · 2012: 28
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Fonds National de la Recherche Luxembourg
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- resveratrol, heme oxygenase-1, Nrf2, antioxidant response element, PC12 cells, oxidative stress, Akt signaling, ERK signaling, phosphatidylinositol 3-kinase, MEK1/2, antioxidant defense, transcriptional activation
- MeSH terms
- Resveratrol, Animals, Base Sequence, Enzyme Induction, Glutamate-Cysteine Ligase, Heme Oxygenase (Decyclizing), Hydrogen Peroxide, Membrane Proteins, Phosphorylation, Repressor Proteins, Stilbenes, Gene Expression Regulation, Enzymologic, PC12 Cells, DNA Primers, Reverse Transcriptase Polymerase Chain Reaction, Rats
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