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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels

Zhang, Ren·2012·Biochemical and Biophysical Research Communications
DOI 10.1016/j.bbrc.2012.07.038
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Abstract

The metabolic syndrome, a common disorder including glucose intolerance and dyslipidemia, poses a major public health issue. Patients with high blood lipids, such as triglycerides, are at high risk in developing atherosclerotic cardiovascular diseases. To identify genes involved in metabolism, we performed RNA-seq experiments on the liver and fat in mice treated with a high-fat diet or fasting, and identified Gm6484 (named Lipasin) as a novel nutritionally regulated gene. Human LIPASIN is liver specific, while the mouse one is enriched in the liver and fat, including both brown and white adipose tissues. Obesity increases liver Lipasin, whereas fasting reduces its expression in fat. ANGPTL3 (Angiopoietin-like 3) and ANGPTL4 are critical regulators of blood lipids. LIPASIN shares homology with ANGPTL3's N-terminal domain that is needed for lipid regulation, and with ANGPTL4's N-terminal segment that mediates lipoprotein lipase (LPL) binding. Lipasin overexpression by adenoviruses in mice increases serum triglyceride levels, and a recombinant Lipasin inhibits LPL activity. Therefore, a potential mechanism for Lipasin-mediated triglyceride elevation is through reduced triglyceride clearance by LPL inhibition. Lipasin is thus a novel nutritionally-regulated liver-enriched factor that plays a role in lipid metabolism.

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Crossref · 10.1016/j.bbrc.2012.07.038

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5 of 5 references verified0 citation errors · 0 not checkable

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  • ANGPTL8 is expressed primarily in the adipose tissue and liver of mice, and its expression is much higher in the fed state than in the fasted state.

    “All three studies also found that ANGPTL8 is expressed primarily in the adipose tissue and liver of mice and that expression was much higher in the fed state than in the fasted state.”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [35]

  • Overexpression of ANGPTL8 increases plasma triglyceride levels in mice.

    “they found that overexpression of ANGPTL8 increased plasma TG levels.”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [35]

  • ANGPTL8 is expressed in adipose tissue where ANGPTL3 is not expressed.

    “Both ANGPTL8 and ANGPTL3 are expressed in the liver, but ANGPTL8 is also expressed in adipose tissue where ANGPTL3 is not expressed (15, 19, 35, 40, 72, 103, 139)”

    From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [35]

Citations

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Research works printed but not linked: 26

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Metadata

Authors
Zhang, R.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2012-08
Volume
424
Issue
4
Pages
786-792
ISSN
0006-291X
DOI
10.1016/j.bbrc.2012.07.038
Cited by
311
References
5
Language
en
Licence
Funders
Wayne State University

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