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Effects of oxysterols on the blood–brain barrier: Implications for Alzheimer’s disease
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Dysregulation of brain cholesterol metabolism and Aβ peptide transport across the BBB are thought to have a key role in Alzheimer's disease.
“Dysregulation of brain cholesterol metabolism and A peptide transport across the BBB are thought to have a key role in the development of AD [25,47].”
The levels of ApoE and HDL (or HDL-like particles) are important parameters for the cholesterol shuttle between neurons and astrocytes and for the BBB-mediated clearance of Aβ peptides.
“The levels of ApoE and HDL (or HDL-like particles) are important parameters for the cholesterol shuttle between neurons and astrocytes and for the BBBmediated clearance of A peptides [9,25,47].”
The expression of ABCB1 is regulated by the liver X receptor (LXR) partner.
“Previous studies have reported that the expression of this transporter is regulated by the liver X receptor (LXR) partner [47,71].”
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Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., & Zlokovic, B. V. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600419 · Cited by 670
Cirrito, J. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25247 · Cited by 660
Solomon, A., Kivipelto, M., Wolozin, B., Zhou, J., & Whitmer, R. A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000231980 · Cited by 557
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Wahrle, S. E., Jiang, H., Parsadanian, M., Kim, J., Li, A., Knoten, A., Jain, S., Hirsch-Reinshagen, V., Wellington, C. L., Bales, K. R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33622 · Cited by 370 · cited 1×
“It is, however, likely that the effect of oxysterols on BBB cholesterol homeostasis modifies the lipoprotein content of the brain and consequently, indirectly Ab peptide clearance [59,60].”
BackgroundDysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
Vance, J. E. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010124 · Cited by 342
Dehouck, B., Dehouck, M. P., Fruchart, J. C., & Cecchelli, R. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.2.465 · Cited by 240
Candela, P., Gosselet, F., Miller, F., Buee-Scherrer, V., Torpier, G., Cecchelli, R., & Fenart, L. (2008) · Endothelium · doi:10.1080/10623320802487759 · Cited by 117
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Research works printed but not linked: 54
- Martins, 2009, Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease, J. Neurochem., 111, 1275, 10.1111/j.1471-4159.2009.06408.x · DOI
- Abildayeva, 2006, 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux, J. Biol. Chem., 281, 12799, 10.1074/jbc.M601019200 · DOI · Paper page
- Karten, 2006, Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia, J. Biol. Chem., 281, 4049, 10.1074/jbc.M508915200 · DOI · Paper page
- Kim, 2007, Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation, J. Biol. Chem., 282, 2851, 10.1074/jbc.M607831200 · DOI · Paper page
- Lund, 1999, CDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain, Proc. Natl. Acad. Sci. USA, 96, 7238, 10.1073/pnas.96.13.7238 · DOI · Paper page
- Ohyama, 2006, Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes, J. Biol. Chem., 281, 3810, 10.1074/jbc.M505179200 · DOI
- Lutjohann, 1996, Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation, Proc. Natl. Acad. Sci. USA, 93, 9799, 10.1073/pnas.93.18.9799 · DOI · Paper page
- Heverin, 2005, Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain, J. Lipid Res., 46, 1047, 10.1194/jlr.M500024-JLR200 · DOI
- Vaya, 2007, Oxysterols, cholesterol homeostasis, and Alzheimer disease, J. Neurochem., 102, 1727, 10.1111/j.1471-4159.2007.04689.x · DOI
- Spady, 1987, Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit, J. Lipid Res., 28, 32, 10.1016/S0022-2275(20)38731-9 · DOI
- Wilson, 1970, The measurement of the exchangeable pools of cholesterol in the baboon, J. Clin. Invest., 49, 655, 10.1172/JCI106277 · DOI
- Chobanian, 1962, Body cholesterol metabolism in man. II. Measurement of the body cholesterol miscible pool and turnover rate, J. Clin. Invest., 41, 1738, 10.1172/JCI104632 · DOI
- Chobanian, 1962, Body cholesterol metabolism in man. I. The equilibration of serum and tissue cholesterol, J. Clin. Invest., 41, 1732, 10.1172/JCI104631 · DOI
- Golomb, 2000, Low cholesterol and violent crime, J. Psychiatr. Res., 34, 301, 10.1016/S0022-3956(00)00024-8 · DOI
- Virkkunen, 1984, Serum cholesterol in aggressive conduct disorder: a preliminary study, Biol. Psychiatry, 19, 435
- Golomb, 1998, Cholesterol and violence: is there a connection?, Ann. Intern. Med., 128, 478, 10.7326/0003-4819-128-6-199803150-00009 · DOI
- Fitz, 2012, Abca1 deficiency affects Alzheimer’s disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice, J. Neurosci., 32, 13125, 10.1523/JNEUROSCI.1937-12.2012 · DOI · Paper page
- George, 2004, APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease, Neurobiol. Dis., 16, 124, 10.1016/j.nbd.2004.01.009 · DOI
- Refolo, 2000, Hypercholesterolemia accelerates the Alzheimer’s amyloid pathology in a transgenic mouse model, Neurobiol. Dis., 7, 321, 10.1006/nbdi.2000.0304 · DOI · Paper page
- Sparks, 1994, Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol, Exp. Neurol., 126, 88, 10.1006/exnr.1994.1044 · DOI · Paper page
- Kivipelto, 2001, Midlife vascular risk factors and Alzheimer’s disease in later life: longitudinal, population based study, BMJ, 322, 1447, 10.1136/bmj.322.7300.1447 · DOI · Paper page
- Karasinska, 2009, Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function, J. Neurosci., 29, 3579, 10.1523/JNEUROSCI.4741-08.2009 · DOI · Paper page
- Dehouck, 1997, A new function for the LDL receptor: transcytosis of LDL across the blood–brain barrier, J. Cell Biol., 138, 877, 10.1083/jcb.138.4.877 · DOI · Paper page
- Gosselet, 2011, The mysterious link between cholesterol and Alzheimer’s Disease: is the blood–brain barrier a suspect?, J. Alzheimer’s Dis. Parkinsonism, 1
- Cecchelli, 2007, Modelling of the blood–brain barrier in drug discovery and development, Nat. Rev. Drug Discov., 6, 650, 10.1038/nrd2368 · DOI
- Abbott, 2010, Structure and function of the blood–brain barrier, Neurobiol. Dis., 37, 13, 10.1016/j.nbd.2009.07.030 · DOI · Paper page
- Gosselet, 2011, Role of the blood–brain barrier in Alzheimer’s disease, Med. Sci. (Paris), 27, 987, 10.1051/medsci/20112711015 · DOI
- Abbott, 2006, Astrocyte-endothelial interactions at the blood–brain barrier, Nat. Rev. Neurosci., 7, 41, 10.1038/nrn1824 · DOI · Paper page
- Ohtsuki, 2004, MRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells, Biol. Pharm. Bull., 27, 1437, 10.1248/bpb.27.1437 · DOI
- Akanuma, 2008, Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood–brain barrier, Neurochem. Int., 52, 669, 10.1016/j.neuint.2007.08.012 · DOI · Paper page
- Gosselet, 2009, Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: use of an in vitro model, Brain Res., 1249, 34, 10.1016/j.brainres.2008.10.036 · DOI
- Panzenboeck, 2002, ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood–brain barrier constituted of porcine brain capillary endothelial cells, J. Biol. Chem., 277, 42781, 10.1074/jbc.M207601200 · DOI · Paper page
- Do, 2011, Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier, Mol. Cell. Biochem., 357, 397, 10.1007/s11010-011-0910-6 · DOI · Paper page
- Saint-Pol, 2013, Oxysterols decrease apical-to-basolateral transport of Ass peptides via an ABCB1-mediated process in an in vitro blood–brain barrier model constituted of bovine brain capillary endothelial cells, Brain Res., 1517, 1, 10.1016/j.brainres.2013.04.008 · DOI · Paper page
- Saint-Pol, 2012, Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-beta peptide accumulation, J. Alzheimers Dis., 30, 489, 10.3233/JAD-2012-112090 · DOI · Paper page
- Panzenboeck, 2006, Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells, Int. J. Biochem. Cell Biol., 38, 1314, 10.1016/j.biocel.2006.01.013 · DOI
- Schweinzer, 2011, Processing of endogenous AbetaPP in blood–brain barrier endothelial cells is modulated by liver-X receptor agonists and altered cellular cholesterol homeostasis, J. Alzheimers Dis., 27, 341, 10.3233/JAD-2011-110854 · DOI
- Meaney, 2002, On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function, J. Lipid Res., 43, 2130, 10.1194/jlr.M200293-JLR200 · DOI
- Ohtsuki, 2007, Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood–brain barrier, J. Neurochem., 103, 1430, 10.1111/j.1471-4159.2007.04901.x · DOI
- Leoni, 2013, 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases, Biochimie, 95, 595, 10.1016/j.biochi.2012.09.025 · DOI
- Jeitner, 2011, Oxysterol derivatives of cholesterol in neurodegenerative disorders, Curr. Med. Chem., 18, 1515, 10.2174/092986711795328445 · DOI
- Lynch, 2006, Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures, J. Neurosci. Res., 83, 1262, 10.1002/jnr.20809 · DOI
- Candela, 2010, Apical-to-basolateral transport of amyloid-beta peptides through blood–brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein, J. Alzheimers Dis., 22, 849, 10.3233/JAD-2010-100462 · DOI · Paper page
- Pahnke, 2008, Clinico-pathologic function of cerebral ABC transporters – implications for the pathogenesis of Alzheimer’s disease, Curr. Alzheimer Res., 5, 396, 10.2174/156720508785132262 · DOI
- Krohn, 2011, Cerebral amyloid-beta proteostasis is regulated by the membrane transport protein ABCC1 in mice, J. Clin. Invest., 121, 3924, 10.1172/JCI57867 · DOI · Paper page
- ElAli, 2012, Liver X receptor activation enhances blood–brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells, Brain Pathol., 22, 175, 10.1111/j.1750-3639.2011.00517.x · DOI · Paper page
- van Assema, 2012, Blood–brain barrier P-glycoprotein function in Alzheimer’s disease, Brain, 135, 181, 10.1093/brain/awr298 · DOI · Paper page
- Vogelgesang, 2004, The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer’s disease, Curr. Alzheimer Res., 1, 121, 10.2174/1567205043332225 · DOI
- Qosa, 2012, Enhanced brain amyloid-beta clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer’s disease, J. Alzheimers Dis., 31, 151, 10.3233/JAD-2012-120319 · DOI
- Hartz, 2010, Restoring blood–brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer’s disease, Mol. Pharmacol., 77, 715, 10.1124/mol.109.061754 · DOI
- Chan, 2013, Role of nuclear receptors in the regulation of drug transporters in the brain, Trends Pharmacol. Sci., 34, 361, 10.1016/j.tips.2013.05.004 · DOI
- Hudry, 2010, Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer’s disease, Mol. Ther., 18, 44, 10.1038/mt.2009.175 · DOI
- Akanuma, 2008, ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1–40) at the blood–brain barrier, Neurochem. Int., 52, 956, 10.1016/j.neuint.2007.12.002 · DOI · Paper page
- Ehehalt, 2003, Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts, J. Cell Biol., 160, 113, 10.1083/jcb.200207113 · DOI · Paper page
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Self-citationLoiola, R. A., Nguyen, C., Dib, S., Saint-Pol, J., Dehouck, L., Sevin, E., Naudot, M., Landry, C., Pahnke, J., Pot, C., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167479 · Cited by 20
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Metadata
- Authors
- Gosselet, F., Saint-Pol, J., & Fenart, L.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 446
- Issue
- 3
- Pages
- 687-691
- ISSN
- 0006-291X
- Cited by
- 53
- References
- 7
- Language
- en
- Funders
- French Ministry for Higher Education and Research, the “Coeur et Artères” Research Foundation (06T6)
- Ligue Européenne Contre la Maladie d’Alzheimer (09752)
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