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Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia
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Treatment of astrocytes with LXR agonists upregulates expression of ABCA1 and ABCG1, promoting expression and secretion of ApoE from astrocytes.
“Treatment of astrocytes with LXR agonists has been previously reported to upregulate the expression of ABCA1 and ABCG1, promoting the expression and secretion of ApoE from astrocytes (63, 64).”
From Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differences based on cell type and ApoE isoform (2026) · cites this paper as [64]
The Abstract reports that the LXR agonist TO901317 upregulated ABCA1 and ABCG1 in cultured cerebellar murine astroglia. The section on cholesterol efflux to exogenous ApoA1 reports increased apoE secretion after treatment, but the passages do not establish increased apoE expression or show that transporter upregulation caused the secretion increase. (LLM, conf=0.87)
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Cites
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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
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Metadata
- Authors
- Karten, B., Campenot, R. B., Vance, D. E., & Vance, J. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 281
- Issue
- 7
- Pages
- 4049-4057
- ISSN
- 0021-9258
- Cited by
- 124
- References
- 7
- Language
- en
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