Linoleic acid rescues microglia inflammation triggered by saturated fatty acid
Abstract
Elevated saturated free fatty acid levels during over-nutrition lead to hypothalamic inflammation, which perturbs energy homeostasis. Whether brain-derived metabolites are coupled to the development of obesity pathogenesis during the early over-nutrition period has not been thoroughly investigated. In this study, we found increased linoleic acid, an unsaturated fatty acid, in both the whole brain and hypothalamus of mice fed a high-fat diet for 4 weeks. Furthermore, we observed that linoleic acid effectively reversed the inflammatory responses induced by palmitic acid treatment in microglial cells. Collectively, this study suggests the reversible function of linoleic acid on brain inflammation in association with microglial activation during short-term exposure to a high-fat diet.
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Altered lipid metabolism and extrinsic supplementation with various lipid substrates have a major impact on microglial reprogramming.
“Altered lipid metabolism and extrinsic supplementation with various lipid substrates both have a major impact on microglial reprogramming [60,61,62,63,64].”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [63]
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- Authors
- Tu, T. H., Kim, H., Yang, S., Kim, J. K., & Kim, J. G.
- Affiliations
- Incheon National University (KR)
- Corresponding author
- Kim, Hyojin
- Kim, Jae Kwang
- Kim, Jae Geun
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 513
- Issue
- 1
- Pages
- 201-206
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2931095856
- Cited by
- 84
- References
- 32
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 13 · 2023: 7 · 2022: 14 · 2021: 16 · 2020: 6 · 2019: 4
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Incheon National University
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- linoleic acid, microglial inflammation, microglial activation, saturated fatty acids, palmitic acid, hypothalamic inflammation, high-fat diet, obesity, energy homeostasis, neuroinflammation, unsaturated fatty acids
- MeSH terms
- Animals, Anti-Inflammatory Agents, Encephalitis, Mice, Inbred C57BL, Microglia, Palmitic Acid, Linoleic Acid, Diet, High-Fat
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