Cited by 85Fatty Acid Research and HealthNeuroinflammation and Neurodegeneration MechanismsAdipokines, Inflammation, and Metabolic Diseases

Linoleic acid rescues microglia inflammation triggered by saturated fatty acid

Tu, Thai Hien, Kim, Hyojin, Yang, Sunggu, Kim, Jae Kwang, Kim, Jae Geun·2019·Biochemical and Biophysical Research Communications

Abstract

Elevated saturated free fatty acid levels during over-nutrition lead to hypothalamic inflammation, which perturbs energy homeostasis. Whether brain-derived metabolites are coupled to the development of obesity pathogenesis during the early over-nutrition period has not been thoroughly investigated. In this study, we found increased linoleic acid, an unsaturated fatty acid, in both the whole brain and hypothalamus of mice fed a high-fat diet for 4 weeks. Furthermore, we observed that linoleic acid effectively reversed the inflammatory responses induced by palmitic acid treatment in microglial cells. Collectively, this study suggests the reversible function of linoleic acid on brain inflammation in association with microglial activation during short-term exposure to a high-fat diet.

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Crossref · 10.1016/j.bbrc.2019.03.047

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31 of 31 references verified0 citation errors · 0 not checkable

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  • Altered lipid metabolism and extrinsic supplementation with various lipid substrates have a major impact on microglial reprogramming.

    “Altered lipid metabolism and extrinsic supplementation with various lipid substrates both have a major impact on microglial reprogramming [60,61,62,63,64].”

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Authors
Tu, T. H., Kim, H., Yang, S., Kim, J. K., & Kim, J. G.
Affiliations
Incheon National University (KR)
Corresponding author
  • Kim, Hyojin
  • Kim, Jae Kwang
  • Kim, Jae Geun
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2019-05
Volume
513
Issue
1
Pages
201-206
ISSN
0006-291X (ISSN-L)
OpenAlex
W2931095856
Cited by
84
References
32
Citations by year
2026: 7 · 2025: 17 · 2024: 13 · 2023: 7 · 2022: 14 · 2021: 16 · 2020: 6 · 2019: 4
FWCI
7.37
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
Incheon National University
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
linoleic acid, microglial inflammation, microglial activation, saturated fatty acids, palmitic acid, hypothalamic inflammation, high-fat diet, obesity, energy homeostasis, neuroinflammation, unsaturated fatty acids
MeSH terms
Animals, Anti-Inflammatory Agents, Encephalitis, Mice, Inbred C57BL, Microglia, Palmitic Acid, Linoleic Acid, Diet, High-Fat

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