The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols
Abstract
Graphical abstract Figure. No Caption available. ABSTRACT (Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to interest in their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood. Both the chemical structure of the phenolic moiety and any attached chemical groups define whether the polyphenol is absorbed in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged. Although many (poly)phenol catabolites have been identified in human plasma and/or urine, the exact pathways from substrate to final microbial catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol‐rich commodities, such modulation is definitely not an inevitable consequence of supplementation; it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites.
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Cited by
The role of polyphenols in modern nutrition
Williamson, G. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12278 · Cited by 551
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319
Flavonoids and the gastrointestinal tract: local and systemic effects
Oteiza, P. I., Fraga, C. G., Mills, D. A., & Taft, D. H. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.001 · Cited by 281
Gut microbiome catabolites as novel modulators of muscle cell glucose metabolism
Houghton, M. J., Kerimi, A., Mouly, V., Tumova, S., & Williamson, G. (2019) · The FASEB Journal · doi:10.1096/fj.201801209r · Cited by 92
Self-citationBallway, J. W., & Song, B.-J. (2021) · Antioxidants · doi:10.3390/antiox10030384 · Cited by 72
Zhou, J., Wang, M., Grimi, N., Dar, B. N., Calvo-Lerma, J., & Barba, F. J. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2237586 · Cited by 15
Metadata
- Authors
- Williamson, G., & Clifford, M. N.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 139
- Pages
- 24-39
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2596481576
- Cited by
- 337
- References
- 14
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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