Research progress in microalgae nutrients: Emerging extraction and purification technologies, digestive behavior, and potential effects on human gut
Open accessAbstract
Microalgae contain a diverse range of high-value compounds that can be utilized directly or fractionated to obtain components with even greater value-added potential. With the use of microalgae for food and medical purposes, there is a growing interest in their digestive properties and impact on human gut health. The extraction, separation, and purification of these components are key processes in the industrial application of microalgae. Innovative technologies used to extract and purify microalgal high-added-value compounds are key for their efficient utilization and evaluation. This review's comprehensive literature review was performed to highlight the main high-added-value microalgal components. The technologies for obtaining bioactive compounds from microalgae are being developed rapidly, various innovative, efficient, green separation and purification technologies are emerging, thus helping in the scaling-up and subsequent commercialization of microalgae products. Finally, the digestive behavior of microalgae nutrients and their health effects on the human gut microbiota were discussed. Microalgal nutrients exhibit favorable digestive properties and certain components have been shown to benefit gut microbes. The reality that must be faced is that multiple processes are still required for microalgae raw materials to final usable products, involving energy, time consumption and loss of ingredients, which still face challenges.
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Microalgae-derived bioactives beneficially modulate gut microbiota composition and function.
“Increasing evidence suggests that microalgae-derived bioactives beneficially modulate gut microbiota composition and function, thereby supporting overall health [58,59].”
From Microalgae Bioactives for Functional Food Innovation and Health Promotion (2025) · cites this paper as [59]
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1 retracted
Koyande, A. K., Show, P.-L., Guo, R., Tang, B., Ogino, C., & Chang, J.-S. (2019) · Bioengineered · doi:10.1080/21655979.2019.1679697 · Cited by 182 · see citing works
RetractedMinekus, M., Alminger, M., Alvito, P., Ballance, S., Bohn, T., Bourlieu, C., Carrière, F., Boutrou, R., Corredig, M., Dupont, D., et al. (2014) · Food Funct. · doi:10.1039/c3fo60702j · Cited by 5,824 · see citing works
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
INFOGEST static in vitro simulation of gastrointestinal food digestion
Brodkorb, A., Egger, L., Alminger, M., Alvito, P., Assunção, R., Ballance, S., Bohn, T., Bourlieu-Lacanal, C., Boutrou, R., Carrière, F., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0119-1 · Cited by 5,199 · see citing works
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works
Micro-algae as a source of protein
Becker, E. W. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2006.11.002 · Cited by 2,311 · see citing works
Algal Proteins: Extraction, Application, and Challenges Concerning Production
Bleakley, S., & Hayes, M. (2017) · Foods · doi:10.3390/foods6050033 · Cited by 1,092 · see citing works
Impacts of gut bacteria on human health and diseases
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055 · see citing works
Carotenoid extraction methods: A review of recent developments
Saini, R. K., & Keum, Y.-S. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.099 · Cited by 857 · see citing works
Barba, F. J., Parniakov, O., Pereira, S. A., Wiktor, A., Grimi, N., Boussetta, N., Saraiva, J. A., Raso, J., Martín‐Belloso, O., Witrowa‐Rajchert, D., et al. (2015) · Food Research International · doi:10.1016/j.foodres.2015.09.015 · Cited by 781 · see citing works
Self-citation(2013) · doi:10.1007/978-94-007-5479-9 · Cited by 670 · see citing works
Food security: The challenge of the present
Prosekov, A. Y., & Ivanova, S. A. (2018) · Geoforum · doi:10.1016/j.geoforum.2018.02.030 · Cited by 469 · see citing works
Vuolo, M. M., Lima, V. S., & Maróstica, M. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814774-0.00002-5 · Cited by 412 · see citing works
Microalgae of interest as food source: biochemical composition and digestibility.
Niccolai, A., Chini Zittelli, G., Rodolfi, L., Biondi, N., & Tredici, M. R. (2019) · Algal Research · doi:10.1016/j.algal.2019.101617 · Cited by 403 · see citing works
Ursu, A.-V., Marcati, A., Sayd, T., Sante-Lhoutellier, V., Djelveh, G., & Michaud, P. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.01.071 · Cited by 367 · see citing works
Jakobek, L., & Matić, P. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.11.024 · Cited by 353 · see citing works
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols
Williamson, G., & Clifford, M. N. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.012 · Cited by 346 · see citing works
Herrero, M., Sánchez‐Camargo, A. D. P., Cifuentes, A., & Ibáñez, E. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.01.018 · Cited by 344 · see citing works
Hydrogel-Forming Algae Polysaccharides: From Seaweed to Biomedical Applications
Beaumont, M., Tran, R., Vera, G., Niedrist, D., Rousset, A., Pierre, R., Shastri, V. P., & Forget, A. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.0c01406 · Cited by 330 · see citing works
Khanra, S., Mondal, M., Halder, G., Tiwari, O. N., Gayen, K., & Bhowmick, T. K. (2018) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2018.02.002 · Cited by 305 · see citing works
Microalgae: a novel ingredient in nutrition
Christaki, E. V., Florou-Paneri, P. C., & Bonos, E. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.582460 · Cited by 298 · see citing works
Gallego, R., Bueno, M., & Herrero, M. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.04.030 · Cited by 293 · see citing works
Application of pulsed electric fields in meat and fish processing industries: An overview
Gómez, B., Munekata, P. E. S., Gavahian, M., et al. (2019) · Food Research International · doi:10.1016/j.foodres.2019.04.047 · Cited by 290 · see citing works
Adekoya, O. B., Oliyide, J. A., Yaya, O. S., et al. (2022) · Resources Policy · doi:10.1016/j.resourpol.2022.102728 · Cited by 288 · see citing works
Extraction and fractionation of microalgae-based protein products
Soto-Sierra, L., Stoykova, P., & Nikolov, Z. L. (2018) · Algal Research · doi:10.1016/j.algal.2018.10.023 · Cited by 286 · see citing works
The potential of microalgae and their biopolymers as structuring ingredients in food: A review
Bernaerts, T. M. M., Gheysen, L., Foubert, I., Hendrickx, M. E., & Van Loey, A. M. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107419 · Cited by 271 · see citing works
Kazir, M., Abuhassira, Y., Robin, A., Nahor, O., Luo, J., Israel, A., Golberg, A., & Livney, Y. D. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.07.047 · Cited by 269 · see citing works
Multi-Product Microalgae Biorefineries: From Concept Towards Reality
Lam, G. P. ‘., Vermuë, M. H., Eppink, M. H. M., Wijffels, R. H., & van den Berg, C. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.10.011 · Cited by 265 · see citing works
Zheng, L.-X., Chen, X., & Cheong, K. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.168 · Cited by 253 · see citing works
Microalgae-Derived Pigments: A 10-Year Bibliometric Review and Industry and Market Trend Analysis
Silva, S. C., Ferreira, I. C. F. R., Dias, M. M., & Barreiro, M. F. (2020) · Molecules · doi:10.3390/molecules25153406 · Cited by 248 · see citing works
Phenolic compounds recovered from agro-food by-products using membrane technologies: An overview
Castro‐Muñoz, R., Yáñez‐Fernández, J., & Fíla, V. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.030 · Cited by 238 · see citing works
Extraction of lipids from microalgae using classical and innovative approaches
Zhou, J., Wang, M., Saraiva, J. A., Martins, A. P., Pinto, C. A., Prieto, M. A., Simal‐Gándara, J., Cao, H., Xiao, J., & Barba, F. J. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.132236 · Cited by 237 · see citing works
Self-citationAmpofo, J., & Abbey, L. (2022) · Foods · doi:10.3390/foods11121744 · Cited by 237 · see citing works
Caporgno, M. P., Böcker, L., Müssner, C., Stirnemann, E., Haberkorn, I., Adelmann, H., Handschin, S., Windhab, E. J., & Mathys, A. (2019) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2019.102275 · Cited by 230 · see citing works
Jiménez-López, C., Pereira, A. G., Lourenço‐Lopes, C., Garcia‐Oliveira, P., Cassani, L., Fraga‐Corral, M., Prieto, M. A., & Simal‐Gándara, J. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128262 · Cited by 222 · see citing works
Algae biorefinery: Review on a broad spectrum of downstream processes and products
Khoo, C. G., Dasan, Y. K., Lam, M. K., & Lee, K. T. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121964 · Cited by 212 · see citing works
Perspectives from CO+RE: How COVID-19 changed our food systems and food security paradigms
Bakalis, S., Valdramidis, V., Argyropoulos, D., Ahrné, L., Chen, J., Cullen, P. J., Cummins, E., Datta, A. K., Emmanouilidis, C., Foster, T. J., et al. (2020) · Current Research in Food Science · doi:10.1016/j.crfs.2020.05.003 · Cited by 212 · see citing works
Sheng, J., Yu, F., Xin, Z., Zhao, L., Zhu, X., & Hu, Q. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.04.018 · Cited by 211 · see citing works
Separation and purification of phycocyanin from Spirulina sp. using a membrane process
Chaiklahan, R., Chirasuwan, N., Loha, V., Tia, S., & Bunnag, B. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2011.04.067 · Cited by 210 · see citing works
Kumar, R., Hegde, A. S., Sharma, K., Parmar, P., & Srivatsan, V. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111338 · Cited by 209 · see citing works
Tang, W., Liu, D., Yin, J., et al. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.02.015 · Cited by 204 · see citing works
Ashaolu, T. J., Samborska, K., Lee, C. C., Tomas, M., Capanoglu, E., Tarhan, Ö., Taze, B., & Jafari, S. M. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.11.064 · Cited by 184 · see citing works
Alavijeh, R. S., Karimi, K., Wijffels, R. H., van den Berg, C., & Eppink, M. H. M. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123321 · Cited by 182 · see citing works
Di, T., Chen, G., Sun, Y., Ou, S., Zeng, X., & Ye, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.10.040 · Cited by 181 · see citing works
Digestibility, bioaccessibility and bioactivity of compounds from algae
Demarco, M., de Moraes, J. O., Matos, Â. P., Dérner, R. B., Neves, F. D. F., & Tribuzi, G. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.02.004 · Cited by 181 · see citing works
Sierra, L. S., Dixon, C. K., & Wilken, L. R. (2017) · Algal Research · doi:10.1016/j.algal.2017.04.004 · Cited by 176 · see citing works
Chemical and nutritional characteristics of brown seaweed lipids: A review
Miyashita, K., Mikami, N., & Hosokawa, M. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.09.019 · Cited by 173 · see citing works
Mutanda, T., Naidoo, D., Bwapwa, J. K., & Anandraj, A. (2020) · Frontiers in Energy Research · doi:10.3389/fenrg.2020.598803 · Cited by 160 · see citing works
Proteins from Microalgae for the Stabilization of Fluid Interfaces, Emulsions, and Foams
Bertsch, P., Böcker, L., Mathys, A., & Fischer, P. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.12.014 · Cited by 157 · see citing works
Jaime, L., Rodríguez‐Meizoso, I., Cifuentes, A., Santoyo, S., Suarez, S., Ibáñez, E., & Señoráns, F. J. (2009) · LWT · doi:10.1016/j.lwt.2009.06.023 · Cited by 156 · see citing works
Functional properties and health benefits of bioactive peptides derived from Spirulina : A review
Ovando, C. A., de Carvalho, J. C., Pereira, G. V. D. M., Jacques, P., Thomaz‐Soccol, V., & Soccol, C. R. (2016) · Food Reviews International · doi:10.1080/87559129.2016.1210632 · Cited by 156 · see citing works
Molino, A., Mehariya, S., Iovine, A., Larocca, V., Di Sanzo, G., Martino, M., Casella, P., Chianese, S., & Musmarra, D. (2018) · Marine Drugs · doi:10.3390/md16110432 · Cited by 155 · see citing works
Chew, K. W., Chia, S. R., Lee, S. Y., Zhu, L., & Show, P. L. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.02.131 · Cited by 154 · see citing works
Bioactive compounds in microalgae and their potential health benefits
Zhou, L., Li, K., Duan, X., Hill, D., Barrow, C., Dunshea, F., Martin, G., & Suleria, H. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101932 · Cited by 150 · see citing works
Buchmann, L., Brändle, I., Haberkorn, I., Hiestand, M., & Mathys, A. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121870 · Cited by 143 · see citing works
Application Progress of Bioactive Compounds in Microalgae on Pharmaceutical and Cosmetics
Zhuang, D., He, N., Khoo, K. S., Ng, E.-P., Chew, K. W., & Ling, T. C. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2021.132932 · Cited by 142 · see citing works
Chen, L., Xu, W., Chen, D., Chen, G., Liu, J., Zeng, X., Shao, R., & Zhu, H. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.01.183 · Cited by 140 · see citing works
Qiu, S.-M., Aweya, J. J., Liu, X., Liu, Y., Tang, S., Zhang, W., & Cheong, K. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118696 · Cited by 137 · see citing works
Insights into the structure-bioactivity relationships of marine sulfated polysaccharides: A review
Kang, J., Jia, X., Wang, N., Xiao, M., Song, S., Wu, S., Li, Z., Wang, S., Cui, S. W., & Guo, Q. M. (2021) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2021.107049 · Cited by 134 · see citing works
Biotechnological production of lipid and terpenoid from thraustochytrids
Du, F., Wang, Y., Xu, Y., Shi, T., Liu, W., Sun, X., & Huang, H. (2021) · Biotechnology Advances · doi:10.1016/j.biotechadv.2021.107725 · Cited by 124 · see citing works
Mehariya, S., Fratini, F., Lavecchia, R., & Zuorro, A. (2021) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2021.105989 · Cited by 124 · see citing works
Li, T., Huang, Z., Jia, R., Lv, X., Zhao, C., & Liu, B. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110530 · Cited by 122 · see citing works
Martínez, J. M., Gojkovic, Ž., Ferro, L., Maza, M. A., Álvarez, I., Raso, J., & Funk, C. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121694 · Cited by 119 · see citing works
Obeid, S., Beaufils, N., Camy, S., Takache, H., Ismail, A., & Pontalier, P.-Y. (2018) · Algal Research · doi:10.1016/j.algal.2018.07.003 · Cited by 118 · see citing works
In-vitro digestibility of rice starch and factors regulating its digestion process: A review
Qadir, N., & Wani, I. A. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119600 · Cited by 118 · see citing works
Human health benefits of very-long-chain polyunsaturated fatty acids from microalgae
Lupette, J., & Christoph Benning, A. (2020) · Biochimie · doi:10.1016/j.biochi.2020.04.022 · Cited by 117 · see citing works
Chen, Z., Zhang, W., Tang, X., Fan, H., Xie, X., Wan, Q., Wu, X., & Tang, J. Z. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.02.063 · Cited by 114 · see citing works
Conde, E., Moure, A., & Domı́nguez, H. (2014) · Journal of Applied Phycology · doi:10.1007/s10811-014-0389-0 · Cited by 111 · see citing works
Purification and identification of polysaccharide derived from Chlorella pyrenoidosa
Shi, Y., Sheng, J., Yang, F., & Hu, Q. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.07.028 · Cited by 111 · see citing works
Lorenzen, J., Igl-Schmid, N., Tippelt, M., Stege, A., Qoura, F., Sohling, U., & Brück, T. (2017) · Bioprocess and Biosystems Engineering · doi:10.1007/s00449-017-1755-5 · Cited by 111 · see citing works
Silve, A., Papachristou, I., Wüstner, R., Sträßner, R., Schirmer, M., Leber, K., Guo, B., Interrante, L., Posten, C. H., & Frey, W. (2017) · Algal Research · doi:10.1016/j.algal.2017.11.016 · Cited by 111 · see citing works
Cheng, J., Sun, J., Huang, Y. Y., Feng, J., Zhou, J., & Cen, K. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2013.09.126 · Cited by 105 · see citing works
Self-citationChronakis, I. S., Galatanu, A. N., Nylander, T., & Lindman, B. (2000) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/s0927-7757(00)00548-3 · Cited by 105 · see citing works
Li, X., Liu, J., Chen, G., Zhang, J., Wang, C., & Liu, B. (2019) · Algal Research · doi:10.1016/j.algal.2019.101619 · Cited by 105 · see citing works
Böcker, L., Bertsch, P., Wenner, D., Teixeira, S., Bergfreund, J., Eder, S., Fischer, P., & Mathys, A. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.09.067 · Cited by 104 · see citing works
Maehre, H. K., Edvinsen, G. K., Eilertsen, K.-E., & Elvevoll, E. O. (2016) · Journal of Applied Phycology · doi:10.1007/s10811-015-0587-4 · Cited by 102 · see citing works
Pieber, S. M., Schober, S., & Mittelbach, M. (2012) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2012.10.019 · Cited by 101 · see citing works
Ma, H., Xiong, H., Zhu, X., Ji, C., Xue, J., Li, R., Ge, B., & Cui, H. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.209 · Cited by 100 · see citing works
Wu, X., Li, R., Zhao, Y., & Liu, Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.06.023 · Cited by 96 · see citing works
Pataro, G., Carullo, D., Siddique, M. A. B., Falcone, M., Donsı̀, F., & Ferrari, G. (2018) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2018.03.029 · Cited by 96 · see citing works
Li, T., Tong, A.-J., Liu, Y.-Y., Huang, Z., Wan, X., Pan, Y., Jia, R., Liu, B., Chen, X., & Zhao, C. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.06.005 · Cited by 96 · see citing works
Lipid releasing characteristics of microalgae species through continuous ultrasonication
Natarajan, R., Ang, W. M. R., Chen, X., Voigtmann, M., & Lau, R. W. M. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.01.146 · Cited by 94 · see citing works
Jesumani, V., Du, H., Pei, P., Zheng, C., Cheong, K.-L., & Huang, N. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.08.027 · Cited by 93 · see citing works
Algae biorefinery: A promising approach to promote microalgae industry and waste utilization
Chandrasekhar, K., Raj, T., Ramanaiah, S. V., Kumar, G., Banu, J. R., Varjani, S., Sharma, P., Pandey, A., Kumar, S., & Kim, S. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2021.12.008 · Cited by 91 · see citing works
Mild and Selective Protein Release of Cell Wall Deficient Microalgae with Pulsed Electric Field
Lam, G. P. ‘., van der Kolk, J. A., Chordia, A., Vermuë, M. H., Olivieri, G., Eppink, M. H. M., & Wijffels, R. H. (2017) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.7b00892 · Cited by 89 · see citing works
do Nascimento, T. C., Cazarin, C. B. B., Maróstica, M. R., Mercadante, A. Z., Lopes, E. J., & Zepka, L. Q. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108770 · Cited by 85 · see citing works
Recent development in efficient processing technology for edible algae: A review
Wang, J., Zhang, M., & Fang, Z. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.032 · Cited by 84 · see citing works
Gan, Y. Y., Ong, H. C., Chen, W., Sheen, H.-K., Chang, J., Chong, C. T., & Ling, T. C. (2020) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2019.119944 · Cited by 80 · see citing works
García, E. S., Ruiz, C. A. S., Tilaye, T. J., Eppink, M. H. M., Wijffels, R. H., & van den Berg, C. (2018) · Separation and Purification Technology · doi:10.1016/j.seppur.2018.04.043 · Cited by 79 · see citing works
Ionic liquids for the fractionation of microalgae biomass
Ward, V. C. A., & Rehmann, L. (2016) · Current Opinion in Green and Sustainable Chemistry · doi:10.1016/j.cogsc.2016.09.006 · Cited by 77 · see citing works
Golmakani, M., Mendiola, J. A., Rezaei, K., & Ibáñez, E. (2014) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2014.05.001 · Cited by 76 · see citing works
Bernaerts, T., Panozzo, A., Doumen, V., Foubert, I., Gheysen, L., Goiris, K., Moldenaers, P., Hendrickx, M., & Loey, A. M. V. (2017) · Algal Research · doi:10.1016/j.algal.2017.05.014 · Cited by 72 · see citing works
Leema, J. T. M., Jothy, T. P., & Dharani, G. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131151 · Cited by 70 · see citing works
Tavakoli, S., Hong, H., Wang, K., et al. (2021) · Algal Research · doi:10.1016/j.algal.2021.102493 · Cited by 70 · see citing works
Chagas, F. D. D. S., Lima, G. C., dos Santos, V. I. N., Costa, L. E. C., de Sousa, W. M., Sombra, V. G., de Araújo, D. F., Barros, F. C. N., Marinho‐Soriano, E., Feitosa, J. P. D. A., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.05.012 · Cited by 69 · see citing works
Freshwater microalgae biomasses exert a prebiotic effect on human colonic microbiota
de Medeiros, V. P. B., de Souza, E. L., de Albuquerque, T. M. R., Sassi, C. F. D. C., Lima, M. D. S., Sivieri, K., Pimentel, T. C., & Magnani, M. (2021) · Algal Research · doi:10.1016/j.algal.2021.102547 · Cited by 69 · see citing works
Shi, F., Yan, X., Cheong, K., & Liu, Y. (2018) · Process Biochemistry · doi:10.1016/j.procbio.2018.08.011 · Cited by 68 · see citing works
Zhou, J., Wang, M., Berrada, H., Zhu, Z., Grimi, N., & Barba, F. J. (2022) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2022.102989 · Cited by 67 · see citing works
Self-citationEvaluation of protein in vitro digestibility of Palmaria palmata and Gracilaria verrucosa
Marrion, O., Fleurence, J., Schwertz, A., Guéant, J., Mamelouk, L., Ksouri, J., & Villaume, C. (2005) · Journal of Applied Phycology · doi:10.1007/s10811-005-5154-y · Cited by 65 · see citing works
Lu, S., Liu, Y., Tang, S., Zhang, W., Yu, Q., Shi, C., & Cheong, K. (2021) · Food Chemistry X · doi:10.1016/j.fochx.2021.100197 · Cited by 64 · see citing works
Zhou, J., Wang, M., Bäuerl, C., Cortés-Macías, E., Calvo‐Lerma, J., Collado, M. C., & Barba, F. J. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134083 · Cited by 64 · see citing works
Self-citationMicroalgae as a Potential Source of Proteins
Matos, Â. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816695-6.00003-9 · Cited by 62 · see citing works
Mahendran, S., Maheswari, P., Sasikala, V., Rubika, J. J., & Pandiarajan, J. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.07.006 · Cited by 61 · see citing works
Barros, L., Retamal, C., Torres, H., et al. (2016) · Food Research International · doi:10.1016/j.foodres.2016.10.049 · Cited by 60 · see citing works
Amorim, M. L., Soares, J., Vieira, B. B., Batista‐Silva, W., & Martins, M. A. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123190 · Cited by 60 · see citing works
Sivaramakrishnan, R., Suresh, S., Pugazhendhi, A., Pauline, J. M. N., & Incharoensakdi, A. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.123562 · Cited by 60 · see citing works
Fábryová, T., Cheel, J., Kubáč, D., Hrouzek, P., Vu, D. L., Tůmová, L., & Kopecký, J. (2019) · Algal Research · doi:10.1016/j.algal.2019.101574 · Cited by 59 · see citing works
Edible Oil Production From Microalgae: A Review
Xue, Z., Wan, F., Yu, W., Liu, J., Zhang, Z., & Kou, X. (2018) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201700428 · Cited by 57 · see citing works
The biophysics of digestion: lipids
McClements, D. J. (2018) · Current Opinion in Food Science · doi:10.1016/j.cofs.2018.03.009 · Cited by 57 · see citing works
Design strategies for C-phycocyanin purification: Process influence on purity grade
de Amarante, M. C. A., Braga, A. R., Sala, L., Moraes, C., & Kalil, S. (2020) · Separation and Purification Technology · doi:10.1016/j.seppur.2020.117453 · Cited by 57 · see citing works
Peptidomic as a tool for assessing protein digestion
Dupont, D. (2017) · Current Opinion in Food Science · doi:10.1016/j.cofs.2017.08.001 · Cited by 56 · see citing works
Optimisation of ultrasound-assisted extraction of protein from Spirulina platensis using RSM
Yücetepe, A., Saroğlu, Ö., Daşkaya-Dikmen, C., Bildik, F., & Özçelik, B. (2018) · Czech Journal of Food Sciences · doi:10.17221/64/2017-cjfs · Cited by 56 · see citing works
Assessment of water degumming and acid degumming of mixed algal oil
Paisan, S., Chetpattananondh, P., & Chongkhong, S. (2017) · Journal of Environmental Chemical Engineering · doi:10.1016/j.jece.2017.09.045 · Cited by 55 · see citing works
Kwan, T. A., Kwan, S. E., Peccia, J., & Zimmerman, J. B. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.08.081 · Cited by 54 · see citing works
Bueno, M., Gallego, R., Chourio, A. M., Ibáñez, E., Herrero, M., & Saldaña, M. D. A. (2020) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2020.102532 · Cited by 54 · see citing works
Ahmed, J., & Kumar, V. (2022) · Algal Research · doi:10.1016/j.algal.2021.102617 · Cited by 53 · see citing works
Shen, N., Ren, J., Liu, Y., Sun, W., Li, Y., Xin, H., & Cui, Y. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134422 · Cited by 53 · see citing works
Cavalcanti, R. N., Veggi, P. C., & Meireles, M. A. A. (2011) · Procedia Food Science · doi:10.1016/j.profoo.2011.09.247 · Cited by 52 · see citing works
Gorgich, M., Passos, M. L. C., Mata, T. M., Martins, A. A., Saraiva, M. L. M. F. S., & Caetano, N. S. (2020) · Energy Reports · doi:10.1016/j.egyr.2020.11.151 · Cited by 51 · see citing works
Hu, Z., Jiang, E., & Ma, X. (2018) · Energy Conversion and Management · doi:10.1016/j.enconman.2018.01.057 · Cited by 50 · see citing works
Carullo, D., Donsı̀, F., Ferrari, G., & Pataro, G. (2021) · Algal Research · doi:10.1016/j.algal.2021.102341 · Cited by 50 · see citing works
Zhang, R., Gu, X., Xu, G., & Fu, X. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.124933 · Cited by 49 · see citing works
Wang, M., Zhou, J., Tavares, J., Pinto, C. A., Saraiva, J. A., Prieto, M. A., Cao, H., Xiao, J., Simal‐Gándara, J., & Barba, F. J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2054939 · Cited by 49 · see citing works
Self-citationLi, X., Peng, B., Cheung, P. C. K., Wang, J., Zheng, X., & You, L. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2022.107687 · Cited by 49 · see citing works
Ultrasound-assisted extraction of lipids from Mortierella isabellina
Sallet, D., Souza, P. O., Fischer, L. T., et al. (2018) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2018.08.015 · Cited by 48 · see citing works
Khawli, F. A., Martí-Quijal, F. J., Pallarés, N., Barba, F. J., & Ferrer, E. (2021) · Applied Sciences · doi:10.3390/app11041701 · Cited by 48 · see citing works
Self-citationPolyphenols: Bioaccessibility and bioavailability of bioactive components
Lorenzo, J. M., Estévez, M., Barba, F. J., Thirumdas, R., Franco, D., & Munekata, P. E. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814174-8.00011-1 · Cited by 45 · see citing works
Self-citationGómez-Jacinto, V., Navarro, F., Garbayo, I., Vı́lchez, C., Arias‐Borrego, A., & García‐Barrera, T. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103817 · Cited by 45 · see citing works
Chen, K.-H., Wang, S. S. ‐., Show, P. L., Hsu, S.-L., & Chang, Y.-K. (2018) · Separation and Purification Technology · doi:10.1016/j.seppur.2018.08.057 · Cited by 44 · see citing works
Klejdus, B., Plaza, M., Šnóblová, M., & Lojková, L. (2016) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2016.12.015 · Cited by 43 · see citing works
Zhang, R., Lebovka, N., Marchal, L., Vorobiev, E., & Grimi, N. (2020) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2020.102358 · Cited by 41 · see citing works
Self-citationVázquez-Rodríguez, B., Santos‐Zea, L., Heredia‐Olea, E., Acevedo-Pacheco, L., Santacruz, A., Gutierrez-Uribe, J. A., & Cruz‐Suárez, L. E. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104596 · Cited by 41 · see citing works
Canelli, G., Kuster, I., Jaquenod, L., Buchmann, L., Martínez, P. M., Rohfritsch, Z., Dionisi, F., Bolten, C. J., Nanni, P., & Mathys, A. (2021) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2021.102897 · Cited by 41 · see citing works
Júnior, R. G. D. O., Grougnet, R., Bodet, P., et al. (2020) · Algal Research · doi:10.1016/j.algal.2020.102035 · Cited by 40 · see citing works
Li, X., Xie, Q., Huang, S., Shao, P., You, L., & Pedišić, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110406 · Cited by 40 · see citing works
Nikolaeva, T., Rietkerk, T., Sein, A., et al. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.126017 · Cited by 38 · see citing works
Zou, X., Xu, K., Chang, W., Qu, Y., & Li, Y. (2021) · Algal Research · doi:10.1016/j.algal.2021.102431 · Cited by 38 · see citing works
Analytical grade C-phycocyanin obtained by a single-step purification process
de Amarante, M. C. A., Corrêa, L. C. S., Sala, L., & Kalil, S. J. (2019) · Process Biochemistry · doi:10.1016/j.procbio.2019.11.020 · Cited by 37 · see citing works
Bioaccessibility of Antioxidants and Fatty Acids from Fucus Spiralis
Francisco, J., Horta, A., Pedrosa, R., Afonso, C. M., Cardoso, C. L., Bandarra, N. M., & Gil, M. M. (2020) · Foods · doi:10.3390/foods9040440 · Cited by 37 · see citing works
Phospholipase cocktail: A new degumming technique for crude soybean oil
dos Passos, R. M., da Silva, R. M., Pontes, P. V. D. A., et al. (2022) · LWT · doi:10.1016/j.lwt.2022.113197 · Cited by 36 · see citing works
Pulsed microwave pretreatment of fresh microalgae for enhanced lipid extraction
Zhang, Y., Soldatov, S., Papachristou, I., Nazarova, N., Link, G., Frey, W., & Silve, A. (2022) · Energy · doi:10.1016/j.energy.2022.123555 · Cited by 36 · see citing works
Extracting protein from microalgae (Tetraselmis chuii) for proteome analysis
Anjos, L., Estêvão, J., Infante, C., Mantecón, L., & Power, D. M. (2022) · MethodsX · doi:10.1016/j.mex.2022.101637 · Cited by 34 · see citing works
Wang, Q., Liu, F., Chen, X., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.203 · Cited by 33 · see citing works
Pereira, E., Fernandes, J., Gonçalves, R. F. S., Pinheiro, A. C., Duarte, M. S., Alves, M. M., Meirelles, A. J. A., Máximo, G. J., & Vicente, A. A. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.135080 · Cited by 33 · see citing works
Insights on the intestinal absorption of chlorophyll series from microalgae
Fernandes, A. S., do Nascimento, T. C., Pinheiro, P. N., de Rosso, V. V., de Menezes, C. R., Lopes, E. J., & Zepka, L. Q. (2020) · Food Research International · doi:10.1016/j.foodres.2020.110031 · Cited by 31 · see citing works
Zhu, Q., Sun, C., & Zhao, L. (2021) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2021.128753 · Cited by 30 · see citing works
Comparison of three methods for thermostable C-phycocyanin separation and purification
Antecka, A., Klepacz-Smółka, A., Szeląg, R., Pietrzyk, D., & Ledakowicz, S. (2021) · Chemical Engineering and Processing - Process Intensification · doi:10.1016/j.cep.2021.108563 · Cited by 29 · see citing works
Direct extraction of lipids from wet microalgae slurries by super-high hydrostatic pressure
Xu, J., Zhao, F., & Su, X. (2021) · Algal Research · doi:10.1016/j.algal.2021.102412 · Cited by 28 · see citing works
Lu, Y., Peng, B., Lin, Y., Lin, Q., Xia, X., Zhong, S., Luo, L., & Huang, R. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.08.010 · Cited by 28 · see citing works
Microalgae as a source of pigments for food applications
García‐Vaquero, M., Brunton, N. P., & Lafarga, T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821080-2.00014-9 · Cited by 27 · see citing works
Nisoa, M., Plodkaew, A., Sirisathitkul, C., et al. (2022) · Alexandria Engineering Journal · doi:10.1016/j.aej.2022.10.012 · Cited by 26 · see citing works
Green bioprocessing of protein from Chlorella vulgaris microalgae towards circular bioeconomy
bin Azmi, A. A., Chew, K. W., Chia, W. Y., Mubashir, M., Sankaran, R., Lam, M. K., Lim, J. W., Ho, Y., & Show, P. L. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125197 · Cited by 24 · see citing works
Verdel, E. F., Kline, P. C., Wani, S., et al. (2000) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(99)00168-6 · Cited by 21 · see citing works
Kaiser, B. L. D., Wunschel, D. S., Sydor, M. A., et al. (2015) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2015.08.008 · Cited by 19 · see citing works
Han, J. W., Klochkova, T. A., Shim, J. B., et al. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00415-12 · Cited by 19 · see citing works
Muszyńska, B., Krakowska, A., Lazur, J., Jękot, B., Zimmer, Ł., Szewczyk, A., Sułkowska‐Ziaja, K., Poleszak, E., & Opoka, W. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1357-2 · Cited by 19 · see citing works
Wang, A., Islam, M. N., Qin, X., Wang, H., Peng, Y., & Ma, C. (2013) · Carbohydrate Research · doi:10.1016/j.carres.2013.12.010 · Cited by 17 · see citing works
Elemental composition and bioaccessibility of three insufficiently studied Azorean macroalgae
Afonso, C. M., Matos, J., Campos, A. M., Gomes, R., Delgado, I. M., Coelho, I., Castanheira, I. P., Bandarra, N. M., & Cardoso, C. L. (2020) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14647 · Cited by 17 · see citing works
Lee, G., Harada, M., Midorikawa, Y., Yamamoto, M., Nakamura, A., Takahashi, H., & Kuda, T. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101763 · Cited by 17 · see citing works
Iyer, R. (2016) · Biofuels · doi:10.1080/17597269.2015.1118778 · Cited by 15 · see citing works
Congenital disorders of intestinal digestion and absorption (sugars, proteins, lipids, ions)
Peretti, N., & Mas, E. (2022) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2022.101785 · Cited by 9 · see citing works
In vitro and in vivo methods to predict carbohydrate bioaccessibility
Aguiar, L. M., & Cazarin, C. B. B. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.05.002 · Cited by 8 · see citing works
Wang, M., Zhou, J., Calvo‐Lerma, J., Liu, Y., Collado, M. C., & Barba, F. J. (2022) · Nutrients · doi:10.3390/nu14163307 · Cited by 8 · see citing works
Self-citationSeparation, purification, analyses, and preservation of polyphenols
Daccache, M. A., Koubaa, M., Louka, N., Maroun, R. G., Vorobiev, E., & Rajha, H. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85273-9.00007-7 · Cited by 5 · see citing works
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Ali, S. S., Al-Tohamy, R., Al-Zahrani, M., Schagerl, M., Kornaros, M., & Sun, J. (2025) · Microbial Cell Factories · doi:10.1186/s12934-025-02685-1 · Cited by 88 · see citing works
Nunes, E., Odenthal, K., Nunes, N., Fernandes, T., Fernandes, I. A., & Pinheiro de Carvalho, M. A. A. (2024) · Algal Research · doi:10.1016/j.algal.2024.103638 · Cited by 53 · see citing works
Microalgae Bioactives for Functional Food Innovation and Health Promotion
Guil-Guerrero, J. L., & Prates, J. A. M. (2025) · Foods · doi:10.3390/foods14122122 · Cited by 47 · see citing works
“Increasing evidence suggests that microalgae-derived bioactives beneficially modulate gut microbiota composition and function, thereby supporting overall health [58,59].”
Cuesta-Ramos, L., Sánchez-Moreno, N., Salgado-Ramos, M., Castagnini, J. M., Martí-Quijal, F. J., Ferrer, E., Barba, F. J., & Pallarés, N. (2026) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-025-06073-x · Cited by 7 · see citing works
Self-citation
- Authors
- Zhou, J., Wang, M., Grimi, N., Dar, B. N., Calvo-Lerma, J., & Barba, F. J.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Université de Technologie de Compiègne (FR)
- Islamic University of Science and Technology (IN)
- Instituto Universitario de Ingeniería para el Desarrollo (IU-IAD), Universitat Politècnica de València, Valencia, Spain
- Universitat de València (ES)
- Corresponding author
- Grimi, Nabil
- Dar, Basharat N.
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2023-07-25
- Volume
- 64
- Issue
- 31
- Pages
- 11375-11395
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W4385230720
- Cited by
- 15
- References
- 164
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Keywords
- microalgae, bioactive compounds, extraction methods, separation and purification, gut microbiota, digestive properties, gut health, value-added chemicals
- MeSH terms
- Gastrointestinal Microbiome, Nutrients, Digestion, Humans, Gastrointestinal Tract, Microalgae
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