Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia
Abstract
A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections. The highest value measured in urine samples was 7500 mmol/mol creatinine, a value 300 times the median normal adult value, in a patient with acute schizophrenia during an acute psychotic episode. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA. The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Altered patterns of bacterial metabolites were seen in a large number of children with ASD compared to healthy controls, including elevated HPHPA, a catabolic byproduct of Clostridia.
“Altered patterns of bacterial metabolites were seen in a large number of children with ASD compared to healthy control children. These metabolites included elevated 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), a catabolic byproduct of Clostridia [59].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [59]
Cites
Goodman and Gilman's the Pharmacological Basis of Therapeutics
Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796 · see citing works
Harrison's Principles of Internal Medicine.
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-1-167_1 · Cited by 1,527 · see citing works
Zheng, W., & Wang, S. Y. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020728u · Cited by 814 · see citing works
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784 · see citing works
Gastrointestinal Microflora Studies in Late‐Onset Autism
Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742 · see citing works
Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism
Sandler, R. H., Finegold, S. M., Bolte, E. R., Buchanan, C. P., Maxwell, A. P., Väisänen, M.-L., Nelson, M. N., & Wexler, H. M. (2000) · Journal of Child Neurology · doi:10.1177/088307380001500701 · Cited by 614 · see citing works
Major Phenolics in Apple and Their Contribution to the Total Antioxidant Capacity
Lee, K. W., Kim, Y. J., Kim, D., Lee, H. J., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034475w · Cited by 611 · see citing works
Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children
Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556 · see citing works
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467 · see citing works
Antibiotic-Associated Diarrhea
Bartlett, J. G. (1992) · Clinical Infectious Diseases · doi:10.1093/clind/15.4.573 · Cited by 414 · see citing works
The end products of the metabolism of aromatic amino acids by Clostridia
Elsden, S. R., Hilton, M. G., & Waller, J. M. (1976) · Archives of Microbiology · doi:10.1007/bf00425340 · Cited by 396 · see citing works
Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid
Couteau, D., McCartney, A. L., Gibson, G. R., Williamson, G., & Faulds, C. B. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01316.x · Cited by 305 · see citing works
Gonthier, M., Donovan, J. L., Manach, C., Morand, C., Rémésy, C., Scalbert, A., Cheynier, V., Mila, I., & Lapierre, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.2.461 · Cited by 253 · see citing works
Anaerobic Degradation of Flavonoids by Clostridium orbiscindens
Schoefer, L., Mohan, R., Schwiertz, A., Braune, A., & Blaut, M. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.10.5849-5854.2003 · Cited by 253 · see citing works
Bolte, E. R. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90107-4 · Cited by 213 · see citing works
Whitaker, B. D., & Stommel, J. R. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf026250b · Cited by 175 · see citing works
Shahrzad, S., & Bitsch, I. (1996) · Journal of Chromatography A · doi:10.1016/0021-9673(96)00169-0 · Cited by 151 · see citing works
Antioxidative components of sweet potatoes.
Hayase, F., & KATOI, H. (1984) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.30.37 · Cited by 118 · see citing works
Brief report: Ear infections in autistic and normal children
Konstantareas, M. M., & Homatidis, S. (1987) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01486973 · Cited by 108 · see citing works
Enkephalinase inhibition: Regulation of ethanol intake in genetically predisposed mice
Blum, K., Briggs, A. H., Trachtenberg, M. C., DeLallo, L., & Wallace, J. E. (1987) · Alcohol · doi:10.1016/0741-8329(87)90084-x · Cited by 92 · see citing works
Shaw, W., Kassen, E., & Chaves, E. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.8.1094 · Cited by 90 · see citing works
Self-citation(1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-88-4-582_2 · Cited by 61 · see citing works
A New Isomer of Chlorogenic Acid from Peaches
Corse, J. (1953) · Nature · doi:10.1038/172771b0 · Cited by 61 · see citing works
Tomato and garlic can modulate azoxymethane-induced colon carcinogenesis in rats
Sengupta, A., Ghosh, S., & Das, S. (2003) · European Journal of Cancer Prevention · doi:10.1097/00008469-200306000-00005 · Cited by 61 · see citing works
Oxidative conjugation of chlorogenic acid with glutathione
Panzella, L., Napolitano, A., & d’Ischia, M. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(03)00460-7 · Cited by 54 · see citing works
Gonthier, M., Rios, L. Y., Verny, M., Rémésy, C., & Scalbert, A. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00073-4 · Cited by 53 · see citing works
Influence of Cooking Process on Phenolic Marker Compounds of Vegetables
Andlauer, W., Stumpf, Hubert, Rings, & Fürst (2003) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.73.2.152 · Cited by 50 · see citing works
Thermospray-LC-MS analysis of various groups of polyphenols in tea
Kiehne, A., & Engelhardt, U. H. (1996) · European Food Research and Technology · doi:10.1007/bf01206100 · Cited by 49 · see citing works
THE OCCURRENCE OF (-)-β-m-HYDROXYPHENYLHYDRACRYLIC ACID IN HUMAN URINE
Armstrong, M. D., & Shaw, K. N. F. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64928-2 · Cited by 48 · see citing works
Colonization resistance of the digestive tract — Mechanism and clinical consequences
van der Waaij, D. (1987) · Food / Nahrung · doi:10.1002/food.19870310551 · Cited by 45 · see citing works
The use of phenylpropionic acid as a loading test for medium‐chain acyl‐CoA dehydrogenase deficiency
Seakins, J. W. T., & Rumsby, G. (1988) · Journal of Inherited Metabolic Disease · doi:10.1007/bf01804241 · Cited by 30 · see citing works
Ostfeld, E. J., Rubinstein, E., Gazit, E., & Smetana, Z. (1977) · PEDIATRICS · doi:10.1542/peds.60.3.364 · Cited by 19 · see citing works
Aramendı́a, M. A., Garc�a, I. M., Lafont, F., Lizaso, J., Marinas, J. M., & Urbano, F. J. (2000) · Rapid Communications in Mass Spectrometry · doi:10.1002/1097-0231(20000630)14:12 · Cited by 17 · see citing works
Wadman, S. K., van der Heiden, C., Ketting, D., Kamerling, J. P., & Vliegenthart, J. F. G. (1973) · Clinica Chimica Acta · doi:10.1016/0009-8981(73)90328-8 · Cited by 17 · see citing works
Miscellaneous drugs used in the treatment of protozoal infections
Rollo, I. M. (1980) · Medical Entomology and Zoology · Cited by 17 · see citing works
Anaerobic infections and Clostridium difficile colitis emerging during antibacterial therapy.
Sm, F. (1986) · PubMed · Cited by 17 · see citing works
Bennett, M. J., Bhala, A., Poirier, S. F., Ragni, M. C., Willi, S. M., & Hale, D. E. (1992) · Clinical Chemistry · doi:10.1093/clinchem/38.2.278 · Cited by 16 · see citing works
Dyck, L. E., Kazakoff, C. W., & Dourish, C. T. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90196-0 · Cited by 14 · see citing works
Bhala, A., Bennett, M. J., McGowan, K. L., & Hale, D. E. (1993) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)83499-7 · Cited by 10 · see citing works
Identification of aromatic dihydroxy acids in biological fluids
Heindl, A., Rau, O., & Spiteller, G. (1985) · Journal of Mass Spectrometry · doi:10.1002/bms.1200120203 · Cited by 6 · see citing works
Antinociceptive effect of some carboxypeptidase a inhibitors in comparison with D-phenylalanine
Giusti, P., Carrara, M., Cima, L., & Borin, G. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90164-5 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Emerging applications of metabolomics in drug discovery and precision medicine
Wishart, D. S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.32 · Cited by 1,499 · see citing works
Oliphant, K., & Allen-Vercoe, E. (2019) · Microbiome · doi:10.1186/s40168-019-0704-8 · Cited by 1,327 · see citing works
Metabolomics for Investigating Physiological and Pathophysiological Processes
Wishart, D. S. (2019) · Physiological Reviews · doi:10.1152/physrev.00035.2018 · Cited by 1,247 · see citing works
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 913 · see citing works
The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
Góralczyk-Bińkowska, A., Szmajda‐Krygier, D., & Kozłowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911245 · Cited by 534 · see citing works
Microbiome–microglia connections via the gut–brain axis
Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471 · see citing works
“West et al., 2006; Severance et al., 2010, 2015; Shaw, 2010; Diaz Heijtz et al., 2011; Miller et al., 2011; Monji et al., 2013; Hercher et al., 2014; Na et al., 2014; Yolken and Dickerson, 2014; Castro-Nallar et al., 2015; Reisinger et al., 2015; Bloomfield et al., 2016; Sekar et al., 2016; van…”
BackgroundAutism Spectrum Disorders and the Gut Microbiota
Fattorusso, A., Di Genova, L., Dell’Isola, G., Mencaroni, E., & Esposito, S. (2019) · Nutrients · doi:10.3390/nu11030521 · Cited by 484 · see citing works
The Gut Microbiota and Autism Spectrum Disorders
Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works
The microbiota regulate neuronal function and fear extinction learning
Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421 · see citing works
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols
Williamson, G., & Clifford, M. N. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.012 · Cited by 346 · see citing works
Brain-Gut-Microbiota Axis and Mental Health
Dinan, T. G., & Cryan, J. F. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000519 · Cited by 325 · see citing works
Autism spectrum disorders and intestinal microbiota
De Angelis, M., Francavilla, R., Piccolo, M., De Giacomo, A., & Gobbetti, M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1035855 · Cited by 311 · see citing works
Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308 · see citing works
Kieffer, D. A., Piccolo, B. D., Vaziri, N. D., Liu, S., Lau, W. L., Khazaeli, M., Nazertehrani, S., Moore, M. E., Marco, M. L., Martin, R. J., et al. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00513.2015 · Cited by 308 · see citing works
Altered brain-gut axis in autism: comorbidity or causative mechanisms
Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works
Sherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 297 · see citing works
Samsel, A., & Seneff, S. (2013) · Entropy · doi:10.3390/e15041416 · Cited by 293 · see citing works
Communication of gut microbiota and brain via immune and neuroendocrine signaling
Kasarełło, K., Cudnoch‐Jędrzejewska, A., & Czarzasta, K. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1118529 · Cited by 270 · see citing works
The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders
Hughes, H. K., Rose, D., & Ashwood, P. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0887-6 · Cited by 225 · see citing works
Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation
Taniya, M. A., Chung, H.-J., Al Mamun, A., Alam, S., Aziz, M. A., Emon, N. U., Islam, M. M., Hong, S.-T. S., Podder, B. R., Ara Mimi, A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.915701 · Cited by 207 · see citing works
Urinary p-cresol in autism spectrum disorder
Persico, A. M., & Napolioni, V. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.09.002 · Cited by 189 · see citing works
Wasilewska, J., & Klukowski, M. (2015) · Pediatric Health Medicine and Therapeutics · doi:10.2147/phmt.s85717 · Cited by 184 · see citing works
Genomics of schizophrenia: time to consider the gut microbiome?
Dinan, T. G., Borre, Y. E., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.93 · Cited by 175 · see citing works
Krajmalnik‐Brown, R., Lozupone, C., Kang, D., & Adams, J. B. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26914 · Cited by 166 · see citing works
Urinary <i>p</i>-cresol is elevated in small children with severe autism spectrum disorder
Altieri, L., Neri, C., Sacco, R., Curatolo, P., Benvenuto, A., Muratori, F., Santocchi, E., Bravaccio, C., Lenti, C., Saccani, M., et al. (2011) · Biomarkers · doi:10.3109/1354750x.2010.548010 · Cited by 161 · see citing works
Urinary Biomarkers of Brain Diseases
An, M., & Gao, Y. (2015) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2015.08.005 · Cited by 142 · see citing works
Role of the Gut Microbiome in Autism Spectrum Disorders
Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142 · see citing works
Friends or Foes—Microbial Interactions in Nature
Weiland‐Bräuer, N. (2021) · Biology · doi:10.3390/biology10060496 · Cited by 144 · see citing works
The mind-body-microbial continuum
Gonzalez, A., Stombaugh, J., Lozupone, C., Turnbaugh, P. J., Gordon, J. I., & Knight, R. D. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/agonzalez · Cited by 132 · see citing works
Gut microbiota and neurological effects of glyphosate
Rueda‐Ruzafa, L., Cruz, F., Román, P., & Cardona, D. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.08.006 · Cited by 125 · see citing works
The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder
Sivamaruthi, B. S., Suganthy, N., Kesika, P., & Chaiyasut, C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17082647 · Cited by 127 · see citing works
Lefter, R., Ciobica, A., Timofte, D., Stanciu, C., & Trifan, A. (2019) · Medicina · doi:10.3390/medicina56010011 · Cited by 120 · see citing works
Noto, A., Fanos, V., Barberini, L., Grapov, D., Fattuoni, C., Zaffanello, M., Casanova, A., Fenu, G., De Giacomo, A., De Angelis, M., et al. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.954784 · Cited by 113 · see citing works
García-Gutiérrez, E., Narbad, A., & Rodríguez, J. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.578666 · Cited by 115 · see citing works
Eating and feeding problems and gastrointestinal dysfunction in Autism Spectrum Disorders
Vissoker, R. E., Latzer, Y., & Gal, E. (2015) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2014.12.010 · Cited by 105 · see citing works
Sanctuary, M. R., Kain, J. N., Angkustsiri, K., & German, J. B. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00040 · Cited by 96 · see citing works
Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases
Konjevod, M., Perković, M. N., Sáiz, J., Štrac, D. Š., Barbas, C., & Rojo, D. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113681 · Cited by 95 · see citing works
Xiong, X., Liu, D., Wang, Y., Zeng, T., & Peng, Y. (2016) · BioMed Research International · doi:10.1155/2016/9485412 · Cited by 90 · see citing works
Clayton, T. A. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.01.049 · Cited by 81 · see citing works
The gut microbiota in neuropsychiatric disorders
Grochowska, M., Wojnar, M., & Radkowski, M. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-008 · Cited by 73 · see citing works
Approaches to studying and manipulating the enteric microbiome to improve autism symptoms
Frye, R. E., Slattery, J. M., MacFabe, D. F., Allen‐Vercoe, E., Parker, W., Rodakis, J., Adams, J. B., Krajmalnik‐Brown, R., Bolte, E. R., Kahler, S. G., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26878 · Cited by 75 · see citing works
Ahmed, E., & Hens, K. (2021) · AJOB Neuroscience · doi:10.1080/21507740.2021.1958096 · Cited by 70 · see citing works
Mezzelani, A., Landini, M., Facchiano, F., Raggi, M. E., Villa, L. M., Molteni, M., Santis, B. D., Brera, C., Caroli, A. M., Milanesi, L., et al. (2014) · Nutritional Neuroscience · doi:10.1179/1476830513y.0000000108 · Cited by 73 · see citing works
AL-Ayadhi, L. Y., Zayed, N., Bhat, R. S., Moubayed, N., Al-Muammar, M. N., & El-Ansary, A. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00448-y · Cited by 74 · see citing works
Infectious diseases, autoantibodies, and autoimmunity
Johnson, D., & Jiang, W. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102962 · Cited by 73 · see citing works
Gastrointestinal Microbiota and Metabolite Biomarkers in Children With Autism Spectrum Disorders
Wang, L., Conlon, M. A., Christophersen, C. T., Sorich, M. J., & Angley, M. T. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.12 · Cited by 72 · see citing works
Microbiome to Brain: Unravelling the Multidirectional Axes of Communication
Aidy, S. E., Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-20215-0_15 · Cited by 64 · see citing works
Mitochondrial dysfunction: A hidden trigger of autism?
Vellingiri, B., Rajagopalan, K., Jayaramayya, K., Jeevanandam, M., & Iyer, M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.002 · Cited by 61 · see citing works
Carissimi, C., Laudadio, I., Palone, F., Fulci, V., Cesi, V., Cardona, F., Alfonsi, C., Cucchiara, S., Isoldi, S., & Stronati, L. (2019) · Digestive and Liver Disease · doi:10.1016/j.dld.2019.06.006 · Cited by 62 · see citing works
Lei, M., Menon, R., Manteiga, S., Alden, N., Hunt, C. L., Alaniz, R. C., Lee, K., & Jayaraman, A. (2019) · mSystems · doi:10.1128/msystems.00724-19 · Cited by 62 · see citing works
The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders
Marzal, L. N. P., Prince, N., Bajić, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez‐Pardo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810052 · Cited by 63 · see citing works
Feng, P., Zhao, S., Zhang, Y., & Li, E. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1123462 · Cited by 62 · see citing works
Potential etiologic factors of microbiome disruption in autism
Buie, T. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.04.001 · Cited by 55 · see citing works
Liesenfeld, D. B., Habermann, N., Tóth, R., Owen, R. W., Frei, E., Böhm, J., Schrotz‐King, P., Klika, K. D., & Ulrich, C. M. (2014) · Metabolomics · doi:10.1007/s11306-014-0758-3 · Cited by 47 · see citing works
The Urine Metabolome of Young Autistic Children Correlates with Their Clinical Profile Severity
Mussap, M., Siracusano, M., Noto, A., Fattuoni, C., Riccioni, A., Rajula, H. S. R., Fanos, V., Curatolo, P., Barberini, L., & Mazzone, L. (2020) · Metabolites · doi:10.3390/metabo10110476 · Cited by 43 · see citing works
A review of candidate urinary biomarkers for autism spectrum disorder
Wang, L., Angley, M. T., Gerber, C., & Sorich, M. J. (2011) · Biomarkers · doi:10.3109/1354750x.2011.598564 · Cited by 43 · see citing works
Shaw, W. (2017) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
Self-citationMesleh, A. G., Abdulla, S. A., & El‐Agnaf, O. M. A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11010041 · Cited by 41 · see citing works
Keşli, R., Gökçen, C., Buluğ, U., & Terzi, Y. (2013) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2013.792834 · Cited by 39 · see citing works
Gut microbiota metabolites in autistic children: An epigenetic perspective
Sabit, H., Tombuloğlu, H., Rehman, S., Almandil, N. B., Çevik, E., Abdel-Ghany, S. E., Rashwan, S., Abasiyanik, M. F., & Waye, M. M. Y. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06105 · Cited by 38 · see citing works
Jones, L., Kumar, J., Mistry, A., Sankar Chittoor Mana, T., Perry, G., Reddy, V. P., & Obrenovich, M. (2019) · Biomedicines · doi:10.3390/biomedicines7020024 · Cited by 34 · see citing works
Microbes and Monoamines: Potential Neuropsychiatric Consequences of Dysbiosis
Skolnick, S. D., & Greig, N. H. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.005 · Cited by 35 · see citing works
The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders
Faysal, M. F., Zehravi, M., Sutradhar, B., Amin, M. A., Shanmugarajan, T. S., Arjun, U. V. N. V., Ethiraj, S., Durairaj, A., Dayalan, G., Ahamad, S. K., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70593 · Cited by 37 · see citing works
Mental Health Disorders Associated with Foodborne Pathogens
Bolton, D., & Robertson, L. J. (2016) · Journal of Food Protection · doi:10.4315/0362-028x.jfp-15-587 · Cited by 34 · see citing works
Obrenovich, M. E., Donskey, C. J., Schiefer, I. T., Bongiovanni, R., Li, L., & Jaskiw, G. E. (2018) · Bioanalysis · doi:10.4155/bio-2018-0140 · Cited by 32 · see citing works
Agarwala, S., Naik, B., & Ramachandra, N. B. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100269 · Cited by 30 · see citing works
Metabolomics: Perspectives on Clinical Employment in Autism Spectrum Disorder
Siracusano, M., Arturi, L., Riccioni, A., Noto, A., Mussap, M., & Mazzone, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713404 · Cited by 29 · see citing works
Urinary metabolite markers characterizing tuberculosis treatment failure
Luies, L., Mienie, L. J., Motshwane, C., Ronacher, K., Walzl, G., & Loots, D. T. (2017) · Metabolomics · doi:10.1007/s11306-017-1261-4 · Cited by 30 · see citing works
David, M. M., Tataru, C. A., Daniels, J., Schwartz, J. N., Keating, J., Hampton‐Marcell, J., Gottel, N., Gilbert, J. A., & Wall, D. P. (2021) · mSystems · doi:10.1128/msystems.00193-20 · Cited by 31 · see citing works
Mandal, R., Cano, R. J., Davis, C. D., Hayashi, D. K., Jackson, S. A., Jones, C. M., Lampe, J. W., Latulippe, M. E., Lin, N. J., Lippa, K. A., et al. (2020) · Metabolomics · doi:10.1007/s11306-020-01744-5 · Cited by 28 · see citing works
Polyphenols and Small Phenolic Acids as Cellular Metabolic Regulators
Obrenovich, M. E., Li, Y., Tayahi, M. B., & Reddy, V. P. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44090285 · Cited by 28 · see citing works
Scuto, M. C., Anfuso, C. D., Lombardo, C., Fatta, E. D., Ferri, R., Musso, N., Zerbo, G., Terrana, M., Majzúnová, M., Lupo, G., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199391 · Cited by 28 · see citing works
Gut Microbiota as a Source of Uremic Toxins
Popkov, V. A., Zharikova, A. A., Demchenko, E. A., Andrianova, N. V., Zorov, D. B., & Plotnikov, E. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010483 · Cited by 26 · see citing works
The Urinary Metabolome of Healthy Newborns
López‐Hernández, Y., Oropeza-Valdez, J. J., Blanco-Sandate, J. O., Oostdam, A. S. H.-V., Zheng, J., Guo, A. C., Lima‐Rogel, V., Rajabzadeh, R., Salgado‐Bustamante, M., López, J. A., et al. (2020) · Metabolites · doi:10.3390/metabo10040165 · Cited by 26 · see citing works
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2023) · Microbiome · doi:10.1186/s40168-023-01526-w · Cited by 24 · see citing works
Piras, C., Pintus, R., Pruna, D., Dessì, A., Atzori, L., & Fanos, V. (2019) · Current Pediatric Reviews · doi:10.2174/1573396315666191022102925 · Cited by 25 · see citing works
Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia
Morillon, A.-C., Williamson, R. D., Baker, P. N., Kell, D. B., Kenny, L. C., English, J. A., McCarthy, F. P., & McCarthy, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230977 · Cited by 24 · see citing works
Xu, X., Cai, X., Meng, F., Song, T.-J., Wang, X., Wei, Y.-Z., Zhai, F.-J., Long, B., Wang, J., You, X., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.657105 · Cited by 24 · see citing works
Exploration for biomarkers of postpartum depression based on metabolomics: A systematic review
Li, S., Yang, Z., Yao, M., Shen, Y., Zhu, H., Jiang, Y., Ji, Y., & Yin, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.043 · Cited by 24 · see citing works
The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?
Colonetti, K., Roesch, L. F. W., & Schwartz, I. V. D. (2018) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2017-0235 · Cited by 22 · see citing works
Zajkowska, I., Niczyporuk, P., Urbaniak, A. D., Tomaszek, N., Modzelewski, S., & Waszkiewicz, N. (2024) · Nutrients · doi:10.3390/nu16142228 · Cited by 22 · see citing works
Fecal Microbiota Transplant to Treat Recurrent Clostridium difficile Infections
Boyle, M. L., Ruth-Sahd, L. A., & Zhou, Z. (2015) · Critical Care Nurse · doi:10.4037/ccn2015356 · Cited by 20 · see citing works
Clifford, M. N., King, L. J., Kerimi, A., Pereira‐Caro, G., & Williamson, G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2131730 · Cited by 18 · see citing works
Simillion, C., Semmo, N., Idle, J. R., & Beyoğlu, D. (2017) · Metabolites · doi:10.3390/metabo7040051 · Cited by 18 · see citing works
Gątarek, P., & Kałużna‐Czaplińska, J. (2022) · Metabolites · doi:10.3390/metabo12050423 · Cited by 17 · see citing works
Biological plausibility of the gut–brain axis in autism
Vasquez, A. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13516 · Cited by 16 · see citing works
Targeted Biomedical Treatment for Autism Spectrum Disorders
Pacheva, I. H., & Ivanov, I. S. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191205091312 · Cited by 16 · see citing works
Carter, C. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.03.007 · Cited by 15 · see citing works
Kushak, R. I., Sengupta, A., & Winter, H. S. (2021) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.15052 · Cited by 16 · see citing works
Microbiome function and neurodevelopment in Black infants: vitamin B 12 emerges as a key factor
Oliphant, K., Ayala, W. C., Ilyumzhinova, R., Mbayiwa, K., Sroka, A. W., Xie, B., Andrews, B., Keenan, K. E., & Claud, E. C. (2024) · Gut Microbes · doi:10.1080/19490976.2023.2298697 · Cited by 14 · see citing works
Gut Microbiome and Autism: Recent Advances and Future Perspectives
Liu, J., Zhang, M., & Kong, X. (2016) · North American Journal of Medicine and Science · Cited by 14 · see citing works
Khaniani, Y., Lipfert, M., Bhattacharyya, D., Pérez, R., Zheng, J., & Wishart, D. S. (2018) · Metabolites · doi:10.3390/metabo8040080 · Cited by 14 · see citing works
Gut Microorganisms and Neurological Disease Perspectives
Faruqui, N. A., Prium, D. H., Mowna, S. A., Ullah, M. A., Araf, Y., Sarkar, B., Zohora, U. S., & Rahman, M. S. (2021) · Future Neurology · doi:10.2217/fnl-2020-0026 · Cited by 14 · see citing works
Jaskiw, G. E., Obrenovich, M. E., & Donskey, C. J. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05267-3 · Cited by 13 · see citing works
Khoo, S. C., Zhang, N., Luang‐In, V., Goh, M. S., Sonne, C., & Ling, N. (2024) · Environmental Research · doi:10.1016/j.envres.2024.118441 · Cited by 13 · see citing works
FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study
Wang, L., Yu, L., Liu, Z., Che, C., Wang, Y., Zhao, Y., Zhu, M., Yang, G., & Cao, A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1411089 · Cited by 12 · see citing works
Mamun, A. A., Geng, P., Wang, S., Shao, C., & Xiao, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107559 · Cited by 13 · see citing works
Intestinal microbiota, metabolome and gender dimorphism in autism spectrum disorders
Kushak, R. I., & Winter, H. S. (2018) · Research in Autism · doi:10.1016/j.rasd.2018.01.009 · Cited by 12 · see citing works
Coccurello, R., Marrone, M. C., & Maccarrone, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.869606 · Cited by 12 · see citing works
- Authors
- Shaw, W.
- Corresponding author
- Shaw, William
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2010-06
- Volume
- 13
- Issue
- 3
- Pages
- 135-143
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W2016430945
- Cited by
- 162
- References
- 41
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 8 · 2022: 12 · 2021: 17 · 2020: 15 · 2019: 18 · 2018: 10 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 3
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- urinary biomarkers, autism spectrum disorder, schizophrenia, Clostridium, Clostridium difficile infection, m-tyrosine, phenylalanine metabolism, vancomycin, anaerobic gut bacteria, catecholamine depletion
- MeSH terms
- Acute Disease, Adolescent, Adult, Autistic Disorder, Child, Child, Preschool, Clostridium, Clostridium Infections, Enterocolitis, Pseudomembranous, Female, Humans, Male, Middle Aged, Phenylalanine, Phenylpropionates, Schizophrenia, Sex Characteristics, Vancomycin, Clostridioides difficile, Gastrointestinal Tract, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
