The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
New evidence for a role of melatonin in glucose regulation
Abstract
Glucose triggers insulin secretion of the pancreatic β-cells. The pineal hormone melatonin interferes in this process by inhibiting secretion and transmitting circadian timing information to the islets. Circadian insulin secretion is adapted to day/night changes through melatonin-dependent synchronization. In rats and mice, melatonin levels are high during the dark period, which is their active feeding period, while, in humans, melatonin levels are high during the overnight fasting and sleeping period. This implies a different read-out of melatonin signaling in day-active species, including man. Dysregulation of circadian secretion may be a key to the increase of type 2 diabetes (T2D). This review discusses the impact of melatonin on insulin secretion transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 (MTNR1a) and MT2 (MTNR1b) and the second messengers cAMP, cGMP and IP3. This is an important topic since, in several genetic association studies, single nucleotide polymorphisms of the human MT2-receptor have been described as being causally linked with an elevated risk of developing T2D. This article summarizes interrelationships between melatonin and insulin in type 1 diabetic (T1D) and type 2 diabetic (T2D) rats and humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Locally, an inhibitory effect of melatonin on glucose-stimulated insulin secretion has been reported in isolated rat pancreatic islets and a rat insulinoma cell line (24,25).”
From Melatonin Impairs Glucose Tolerance, First-Phase Insulin Secretion, and Insulin Feedback Inhibition; Interaction With MTNR1B Diabetes Risk Variant (2026) · cites this paper as [24]
Citations
Cites
Molecular and Cellular Endocrinology
Rainey, W. E., & Rodgers, R. J. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2004.10.007 · Cited by 1,340
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096
Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882
Variants in MTNR1B influence fasting glucose levels
Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Þorleifsson, G., Loos, R. J. F., Manning, A. K., Jackson, A., Aulchenko, Y. S., et al. (2008) · Nature Genetics · doi:10.1038/ng.290 · Cited by 743
Lyssenko, V., Nagorny, C. L. F., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.288 · Cited by 742
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
Bendová, Z., Cermakian, N., Reppert, S. M., & Sassone‐Corsi, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102075599 · Cited by 555
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., et al. (2000) · Nature Cell Biology · doi:10.1038/35041046 · Cited by 481
Mammalian melatonin receptors: molecular biology and signal transduction
von Gall, C., Stehle, J. H., & Weaver, D. R. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0581-4 · Cited by 455
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
Åhrén, B. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2782 · Cited by 424
Arendt, J. (2006) · Chronobiology International · doi:10.1080/07420520500464361 · Cited by 383
Melatonin, endocrine pancreas and diabetes
Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309
Self-citationMelatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
Jockers, R., Maurice, P., Boutin, J. A., & Delagrange, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.184 · Cited by 293
Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins
Brydon, L., Roka, F., Petit, L., de Coppet, P., Tissot, M., Barrett, P., Morgan, P. J., Nanoff, C., Strosberg, A. D., & Jockers, R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0390 · Cited by 281
Molecular tools to study melatonin pathways and actions.
Boutin, J., Audinot, V., Ferry, G., & Delagrange, P. (2005) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.06.006 · Cited by 265
Kalsbeek, A., & Buijs, R. M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0577-0 · Cited by 261
Evidence for a circadian rhythm of insulin secretion
Boden, G., Ruiz, J., Urbain, J. L., & Chen, X. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e246 · Cited by 261
von Gall, C., Garabette, M. L., Kell, C. A., Frenzel, S., Dehghani, F., Schumm‐Draeger, P., Weaver, D. R., Korf, H., Hastings, M. H., & Stehle, J. H. (2002) · Nature Neuroscience · doi:10.1038/nn806 · Cited by 254
Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., & Matsumoto, A. M. (1999) · Endocrinology · doi:10.1210/endo.140.2.6674 · Cited by 250
Weaver, D. R., Liu, C., & Reppert, S. M. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923472 · Cited by 241
Targeted Disruption of the Mouse Mel1b Melatonin Receptor
Jin, X., von Gall, C., Pieschl, R. L., Gribkoff, V. K., Stehle, J. H., Reppert, S. M., & Weaver, D. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1054-1060.2003 · Cited by 240
Ayoub, M. A., Levoye, A., Delagrange, P., & Jockers, R. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.000398 · Cited by 208
Melatonin Receptor Signaling: Finding the Path Through the Dark
Masana, M. I., & Dubocovich, M. L. (2001) · Science s STKE · doi:10.1126/stke.2001.107.pe39 · Cited by 198
Peschke, E., Frese, T., Chankiewitz, E., Peschke, D., Preiß, U., Schneyer, U., Spessert, R., & Mühlbauer, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00287.x · Cited by 197
Self-citationOscillatory control of insulin secretion
Tengholm, A., & Gylfe, E. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.009 · Cited by 190
The Mel1aMelatonin Receptor Is Coupled to Parallel Signal Transduction Pathways1
Godson, C., & Reppert, S. M. (1997) · Endocrinology · doi:10.1210/endo.138.1.4824 · Cited by 188
Function and expression of melatonin receptors on human pancreatic islets
Ramracheya, R. D., Muller, D. S., Squires, P. E., Brereton, H., Sugden, D., Huang, G. C., Amiel, S. A., Jones, P. M., & Persaud, S. J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00523.x · Cited by 186
Dezaki, K., Kakei, M., & Yada, T. (2007) · Diabetes · doi:10.2337/db07-0345 · Cited by 184
Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene
Mulder, H., Nagorny, C. L. F., Lyssenko, V., & Groop, L. (2009) · Diabetologia · doi:10.1007/s00125-009-1359-y · Cited by 169
Melatonin and type 2 diabetes – a possible link?*
Peschke, E., Stumpf, I., Bazwinsky, I., Litvak, L., Dralle, H., & Mühlbauer, E. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00426.x · Cited by 161
Self-citationEvidence for a circadian rhythm of insulin release from perifused rat pancreatic islets
Peschke, E., & Peschke, D. (1998) · Diabetologia · doi:10.1007/s001250051034 · Cited by 150
Self-citationMühlbauer, E., Gross, E. C., Labucay, K., Wolgast, S., & Peschke, E. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.01.029 · Cited by 148
Self-citationIndication of circadian oscillations in the rat pancreas
Mühlbauer, E., Wolgast, S., Finckh, U., Peschke, D., & Peschke, E. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00322-9 · Cited by 147
Self-citationSparsø, T., Bonnefond, A., Galijatovic, E. A. A., Bouatia‐Naji, N., Holmkvist, J., Thørner, L. W., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., et al. (2009) · Diabetes · doi:10.2337/db08-1660 · Cited by 146
von Gall, C., Weaver, D. R., Moek, J., Jilg, A., Stehle, J. H., & Korf, H. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1327.105 · Cited by 144
la Fleur, S. E., Kalsbeek, A., Wortel, J., van der Vliet, J., & Buijs, R. M. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00717.x · Cited by 133
Picinato, M. C., Hirata, A. E., Cipolla‐Neto, J., Curi, R., Carvalho, C. R. D. O., Anhê, G. F., & Carpinelli, Â. R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00493.x · Cited by 124
Kemp, D. M., Ubeda, M., & Habener, J. F. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00064-3 · Cited by 122
Polymorphisms within the Novel Type 2 Diabetes Risk Locus MTNR1B Determine β-Cell Function
Staiger, H., Machicao, F. E., Schäfer, S., Kirchhoff, K., Kantartzis, K., Guthoff, M., Silbernagel, G., Stefan, N., Häring, H., & Fritsche, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003962 · Cited by 116
de Araújo, M. C. P. M., Haber, E. P., Carpinelli, Â. R., & Cipolla‐Neto, J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.02925.x · Cited by 116
Peschke, E., Fauteck, J., Mußhoff, U., Schmidt, F., Beckmann, A., & Peschke, D. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.280305.x · Cited by 112
Self-citationPeschke, E., Mühlbauer, E., Mußhoff, U., CSERNUS, V. J., Chankiewitz, E., & Peschke, D. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.02919.x · Cited by 109
Self-citationRönn, T., Wen, J., Yang, Z., Lü, B., Du, Y., Groop, L., Hu, R., & Ling, C. (2009) · Diabetologia · doi:10.1007/s00125-009-1297-8 · Cited by 108
The Mel1a Melatonin Receptor Is Coupled to Parallel Signal Transduction Pathways
Godson, C. (1997) · Endocrinology · doi:10.1210/en.138.1.397 · Cited by 105
Guanosine 3′:5′-Monophosphate-Dependent Protein Kinases in Mammalian Tissues
Kuo, J. F. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.10.4037 · Cited by 105
Melatonin in the multi‐oscillatory mammalian circadian world
Pévet, P., Agez, L., Bothorel, B., Saboureau, M., Gauer, F., Laurent, V., & Masson‐Pévet, M. (2006) · Chronobiology International · doi:10.1080/07420520500482074 · Cited by 100
Stumpf, I., Mühlbauer, E., & Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00593.x · Cited by 99
Self-citationMacKenzie, R. S., Melan, M. A., Passey, D. K., & Witt‐Enderby, P. A. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00881-4 · Cited by 99
Nishida, S., Sato, R., Murai, I., & Nakagawa, S. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00083.x · Cited by 97
Rhythms in clock proteins in the mouse pars tuberalis depend on MT1 melatonin receptor signalling
Jilg, A., Moek, J., Weaver, D. R., Korf, H., Stehle, J. H., & von Gall, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04485.x · Cited by 94
Daulat, A. M., Maurice, P., Froment, C., Guillaume, J., Broussard, C., Monsarrat, B., Delagrange, P., & Jockers, R. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600298-mcp200 · Cited by 93
Boden, G., Chen, X., & Polansky, M. (1999) · Diabetes · doi:10.2337/diabetes.48.11.2182 · Cited by 90
Oster, H., Werner, C. G., Magnone, M. C., Mayser, H., Feil, R., Seeliger, M. W., Hofmann, F. B., & Albrecht, U. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00252-5 · Cited by 84
The PDZ Protein Mupp1 Promotes Gi Coupling and Signaling of the Mt1 Melatonin Receptor
Guillaume, J., Daulat, A. M., Maurice, P., Levoye, A., Migaud, M., Brydon, L., Malpaux, B., Borg‐Capra, C., & Jockers, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802069200 · Cited by 83
Parallel signaling pathways of melatonin in the pancreatic β‐cell
Peschke, E., Bach, A. G., & Mühlbauer, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00297.x · Cited by 82
Self-citationIncreased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes
Peschke, E., Wolgast, S., Bazwinsky, I., Pönicke, K., & Mühlbauer, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00612.x · Cited by 76
Self-citationMühlbauer, E., & Peschke, E. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00399.x · Cited by 74
Self-citationModulation of the cGMP signaling pathway by melatonin in pancreatic β‐cells
Stumpf, I., Bazwinsky, I., & Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00638.x · Cited by 70
Self-citationInvestigational melatonin receptor agonists
Hardeland, R. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.482926 · Cited by 62
Peschke, E., Schucht, H., & Mühlbauer, E. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00804.x · Cited by 61
Self-citationExocytotic Properties of Human Pancreatic β‐cells
Braun, M., Ramracheya, R., Johnson, P. R., & Rorsman, P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03992.x · Cited by 60
Melatonin stimulates inositol‐1,4,5‐trisphosphate and Ca2+release from INS1 insulinoma cells
Bach, A. G., Wolgast, S., Mühlbauer, E., & Peschke, E. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00253.x · Cited by 58
Self-citationInsulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland
Garcia, R. A. P., Afeche, S. C., Scialfa, J. H., do Amaral, F. G., dos Santos, S. H. J., Lima, F. B., Young, M. E., & Cipolla‐Neto, J. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.10.016 · Cited by 56
Are G Protein‐Coupled Receptor Heterodimers of Physiological Relevance?—Focus on Melatonin Receptors
Levoye, A., Jockers, R., Ayoub, M. A., Delagrange, P., Savaskan, E., & Guillaume, J. (2006) · Chronobiology International · doi:10.1080/07420520500521863 · Cited by 49
Conti, A., & Maestroni, G. J. M. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00253.x · Cited by 44
Maurice, P., Daulat, A. M., Broussard, C., Mozo, J., Clary, G., Hotellier, F., Chafey, P., Guillaume, J., Ferry, G., Boutin, J. A., et al. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700435-mcp200 · Cited by 36
DIURNAL VARIATIONS IN INSULIN SECRETION AND K+ PERMEABILITY IN ISOLATED RAT ISLETS
Delattre, E., Cipolla‐Neto, J., & Boschero, A. C. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03073.x · Cited by 28
Yasuo, S., von Gall, C., Weaver, D. R., & Korf, H. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06541.x · Cited by 18
Kaminski, A., Gao, H., & Morgan, N. G. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00048-1 · Cited by 17
Cited by
Sorted by citations
Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 457
Melatonin secretion and the incidence of type 2 diabetes
McMullan, C. J., Schernhammer, E. S., Rimm, E. B., Hu, F. B., & Forman, J. P. (2013) · JAMA · doi:10.1001/jama.2013.2710 · Cited by 369
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
The Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC), Bonnefond, A., Clément, N., Fawcett, K., Yengo, L., Vaillant, E., Guillaume, J.-L., Dechaume, A., Payne, F., Roussel, R., et al. (2012) · Nature Genetics · doi:10.1038/ng.1053 · Cited by 363
Reutrakul, S., & Van Cauter, E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12355 · Cited by 321
Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives
Milagro, F. I., Mansego, M. L., de Miguel, C., & Martínez, J. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.010 · Cited by 323
Metadata
- Authors
- Peschke, E., & Mühlbauer, E.
- Affiliations
- Martin Luther University Halle-Wittenberg (DE)
- Saxon Academy of Sciences and Humanities in Leipzig (DE)
- ORCID
- Peschke, Elmar
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 24
- Issue
- 5
- Pages
- 829-841
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2096399658
- Cited by
- 137
- References
- 70
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 13
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- melatonin, glucose regulation, insulin secretion, pancreatic beta cells, circadian rhythm, type 2 diabetes, type 1 diabetes, MT1 receptor, MT2 receptor, cAMP signaling, cGMP signaling, IP3 signaling, single nucleotide polymorphisms, circadian misalignment
- MeSH terms
- Animals, Glucose, Humans, Male, Melatonin, Models, Biological, Signal Transduction, Receptors, Melatonin, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review