Cited by 137Circadian rhythm and melatoninPancreatic function and diabetesDiabetes Treatment and Management

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New evidence for a role of melatonin in glucose regulation

Peschke, Elmar, Mühlbauer, Eckhard·2010·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2010.09.001

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Abstract

Glucose triggers insulin secretion of the pancreatic β-cells. The pineal hormone melatonin interferes in this process by inhibiting secretion and transmitting circadian timing information to the islets. Circadian insulin secretion is adapted to day/night changes through melatonin-dependent synchronization. In rats and mice, melatonin levels are high during the dark period, which is their active feeding period, while, in humans, melatonin levels are high during the overnight fasting and sleeping period. This implies a different read-out of melatonin signaling in day-active species, including man. Dysregulation of circadian secretion may be a key to the increase of type 2 diabetes (T2D). This review discusses the impact of melatonin on insulin secretion transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 (MTNR1a) and MT2 (MTNR1b) and the second messengers cAMP, cGMP and IP3. This is an important topic since, in several genetic association studies, single nucleotide polymorphisms of the human MT2-receptor have been described as being causally linked with an elevated risk of developing T2D. This article summarizes interrelationships between melatonin and insulin in type 1 diabetic (T1D) and type 2 diabetic (T2D) rats and humans.

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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882
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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko, V., Nagorny, C. L. F., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.288 · Cited by 742
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Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
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Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
Bendová, Z., Cermakian, N., Reppert, S. M., & Sassone‐Corsi, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102075599 · Cited by 555
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Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., et al. (2000) · Nature Cell Biology · doi:10.1038/35041046 · Cited by 481
Mammalian melatonin receptors: molecular biology and signal transduction
von Gall, C., Stehle, J. H., & Weaver, D. R. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0581-4 · Cited by 455

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Authors: Peschke, E., & Mühlbauer, E.
Affiliations: Martin Luther University Halle-Wittenberg (DE)
Saxon Academy of Sciences and Humanities in Leipzig (DE)
ORCID: Peschke, Elmar
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-10
Volume: 24
Issue: 5
Pages: 829-841
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2010.09.001
OpenAlex: W2096399658
Cited by: 137
References: 70
Citations by year: 2026: 4 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 13
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: melatonin, glucose regulation, insulin secretion, pancreatic beta cells, circadian rhythm, type 2 diabetes, type 1 diabetes, MT1 receptor, MT2 receptor, cAMP signaling, cGMP signaling, IP3 signaling, single nucleotide polymorphisms, circadian misalignment
MeSH terms: Animals, Glucose, Humans, Male, Melatonin, Models, Biological, Signal Transduction, Receptors, Melatonin, Mice, Rats

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New evidence for a role of melatonin in glucose regulation

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