Indication of circadian oscillations in the rat pancreas
Open accessAbstract
The central circadian oscillator of the suprachiasmatic nucleus controls diurnal rhythmicity of the body with light as its dominant zeitgeber. Recently, peripheral oscillators have been detected in liver and heart, which follow as yet unidentified cues. In this study real-time reverse transcription-polymerase chain reaction (RT-PCR) was used in analysis of the expression of the major clock genes Per1, Per2, Bmal1, Cry1, Tim (timeless) and Clock, as well as of the output genes Dbp and Rev-erbalpha in the pancreatic tissue of rats. The results presented here indicate a robust circadian expression of clock genes (e.g. Per1 and Bmal1) and the probable existence of a peripheral oscillator in the pancreas. Whether this oscillator regulates the diverse functions of the islets of Langerhans remains to be elucidated.
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Animal and in vitro studies with BMAL1−/− and Per1−/− show a disruption on glucose homeostasis and insulin release despite normal activity and feeding-fasting rhythms.
“Animal and in vitro studies with BMAL1−/− and Per1−/− show a disruption on glucose homeostasis and insulin release despite displaying normal activity and feeding-fasting rhythms [251,254].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [254]
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- Authors
- Mühlbauer, E., Wolgast, S., Finckh, U., Peschke, D., & Peschke, E.
- Affiliations
- Saxon Academy of Sciences and Humanities in Leipzig (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Martin Luther University Halle-Wittenberg (DE)
- Corresponding author
- Mühlbauer, E
- ORCID
- Peschke, E
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2004-04-09
- Volume
- 564
- Issue
- 1-2
- Pages
- 91-96
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2080753539
- Cited by
- 147
- References
- 36
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 12 · 2014: 7 · 2013: 8 · 2012: 13
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, pancreas, peripheral circadian clock, clock genes, Per1, Per2, Bmal1, CRY1, TIM, clocks, DBP, NR1D1, pancreatic islets, suprachiasmatic nucleus, gene expression
- MeSH terms
- Animals, Circadian Rhythm, DNA-Binding Proteins, Eye Proteins, Flavoproteins, Male, Nuclear Proteins, Pancreas, RNA, Messenger, Transcription Factors, Trans-Activators, Rats, Wistar, Photoreceptor Cells, Invertebrate, Receptors, Cytoplasmic and Nuclear, Cell Cycle Proteins, Reverse Transcriptase Polymerase Chain Reaction, Drosophila Proteins, Receptors, G-Protein-Coupled, Rats, Basic Helix-Loop-Helix Proteins, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1
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