Spatiotemporal effects of a controlled-release anti-inflammatory drug on the cellular dynamics of host response
Open accessAbstract
In general, biomaterials induce a non-specific host response when implanted in the body. This reaction has the potential to interfere with the function of the implanted materials. One method for controlling the host response is through local, controlled-release of anti-inflammatory agents. Herein, we investigate the spatial and temporal effects of an anti-inflammatory drug on the cellular dynamics of the innate immune response to subcutaneously implanted poly(lactic-co-glycolic) microparticles. Noninvasive fluorescence imaging was used to investigate the influence of dexamethasone drug loading and release kinetics on the local and systemic inhibition of inflammatory cellular activities. Temporal monitoring of host response showed that inhibition of inflammatory proteases in the early phase was correlated with decreased cellular infiltration in the later phase of the foreign body response. We believe that using controlled-release anti-inflammatory platforms to modulate early cellular dynamics will be useful in reducing the foreign body response to implanted biomaterials and medical devices.
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Alginate microspheres placed in the intraperitoneal space of non-human primates or immunocompetent rodents cause foreign body reactions and fibrosis.
“When implanted into the intraperitoneal space of non-human primates or immunocompetent rodents, alginate microspheres elicit foreign body reactions and fibrosis29, 30.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [29]
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Self-citation
- Authors
- Dang, T. T., Bratlie, K. M., Bogatyrev, S. R., Chen, X. Y., Langer, R., & Anderson, D. G.
- Affiliations
- Massachusetts Institute of Technology (US)
- Boston Children's Hospital (US)
- Corresponding author
- Anderson, Daniel G.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 32
- Issue
- 19
- Pages
- 4464-4470
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC5279724
- OpenAlex
- W1972999454
- Cited by
- 38
- References
- 53
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1f32eb011580-01)
- National Institute of Biomedical Imaging and Bioengineering (F32 EB011580-01, F32 EB011580)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- controlled drug delivery, anti-inflammatory agents, dexamethasone, foreign body reaction, innate immune response, cell infiltration, fluorescence imaging, drug release kinetics
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Anti-Inflammatory Agents, Biocompatible Materials, Delayed-Action Preparations, Dexamethasone, Drug Carriers, Foreign-Body Reaction, Inflammation, Male, Materials Testing, Polyglycolic Acid, Lactic Acid, Prostheses and Implants, Mice
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