A dexamethasone‐loaded PLGA microspheres/collagen scaffold composite for implantable glucose sensors
Abstract
We have developed a new dexamethasone (Dex)‐loaded poly(lactic‐co‐glycolic acid) microspheres/porous collagen scaffold composite for implantable glucose sensors. The scaffolds were fabricated around the sensing element of the sensors and crosslinked using nordihydroguaiaretic acid (NDGA). The microspheres containing Dex were incorporated into the NDGA‐crosslinked collagen scaffold by dipping in microsphere suspension in either water or Pluronic. The loading efficiencies of Dex in the microspheres and the scaffold were determined using high performance liquid chromatography. The microspheres/scaffold composite fabricated using microspheres in the hydrogel solution had a better loading efficiency than when microspheres were in water suspension. The composite fabricated using the hydrogel also showed a slower and more sustained drug release than the standard microspheres in vitro during a 4 week study and did not significantly affect the function of the sensors in vitro. The sensors with the composite that were still functional retained above 50% of their original sensitivity at 2 weeks. Histology showed that the inflammatory response to the Dex‐loaded composite was much lower than for the control scaffold at 2 and 4 weeks after implantation. The Dex‐loaded composite system might be useful to reduce inflammation to implanted glucose sensors and therefore extend their function and lifetime. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
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Dexamethasone-releasing glucose biosensors retained more than 50% of their original sensitivity 2 weeks after implantation, while control membranes dropped to 15-42% of original levels.
“DX-releasing glucose biosensors retained >50% of their original sensitivity 2 weeks after implantation, the sensitivity of control membranes dropped to 15–42% of their original levels.187”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [187]
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Biocompatible Materials for Continuous Glucose Monitoring Devices
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- Authors
- Ju, Y. M., Yu, B., West, L., Moussy, Y., & Moussy, F.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Moussy, Francis
- Venue
- Journal of Biomedical Materials Research Part A
- Publisher
- Wiley
- Published
- 2009-06-17
- Volume
- 93A
- Issue
- 1
- Pages
- 200-210
- ISSN
- 1549-3296 (ISSN-L)
- 1552-4965
- OpenAlex
- W2068671192
- Cited by
- 44
- References
- 39
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB001640)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Keywords
- dexamethasone, PLGA microspheres, collagen scaffolds, implantable glucose sensor, sustained drug release, anti-inflammatory coatings, inflammation, poloxamer
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Animals, Collagen, Dexamethasone, Glucose, Inflammation, Microscopy, Electron, Scanning, Microspheres, Polyglycolic Acid, Solvents, Biosensing Techniques, Lactic Acid, Implants, Experimental, Rats, Tissue Scaffolds, Electrochemical Techniques
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