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Preformed albumin corona, a protective coating for nanoparticles based drug delivery system

Peng, Qiang, Zhang, Shu, Yang, Qin, Zhang, Ting, Wei, Xue-Qin, Jiang, Li, Zhang, Chao-Liang, Chen, Qian-Ming, Zhang, Zhi-Rong, Lin, Yun-Feng·2013·Biomaterials

Abstract

The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biological responses to the NPs are changed. This is one substantial reason for the two main problems of the NPs based drug delivery system, i.e. nanotoxicity and rapid clearance of NPs from the blood after intravenous injection. Here, we demonstrate the successful application of the preformed albumin corona in inhibiting the plasma proteins adsorption and decreasing the complement activation, and ultimately in prolonging the blood circulation time and reducing the toxicity of the polymeric PHBHHx NPs. Since the interaction of proteins with various nano-materials and/or -particles is ubiquitous, pre-forming albumin corona has a great potential to be a versatile strategy for optimizing the NPs based drug delivery system.

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Crossref · 10.1016/j.biomaterials.2013.07.102

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Research works printed but not linked: 26

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Metadata

Authors
Peng, Q., Zhang, S., Yang, Q., Zhang, T., Wei, X.-Q., Jiang, L., Zhang, C.-L., Chen, Q.-M., Zhang, Z.-R., & Lin, Y.-F.
Venue
Biomaterials
Publisher
Elsevier BV
Published
2013-11
Volume
34
Issue
33
Pages
8521-8530
ISSN
0142-9612
Cited by
366
References
6
Language
en
Funders
  • National Natural Science Foundation of China (81071273, 31170929)
  • Young Faculty Science Foundation of Sichuan University (2012SCU11100)
  • Foundation of State Key Laboratory of Oral Diseases (SKLODYISF2012-08)

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