Cited by 375Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics

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Extracellular vesicles: A bright star of nanomedicine

Open access

Wu, Peipei, Zhang, Bin, Ocansey, Dickson Kofi Wiredu, Xu, Wenrong, Qian, Hui·2021·Biomaterials

DOI 10.1016/j.biomaterials.2020.120467

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Abstract

Extracellular vesicles (EVs) have unique structural, compositional, and morphological characteristics as well as predominant physiochemical stability and biocompatibility properties. They play a crucial role in pathophysiological regulation, and also have broad prospects for clinical application in the diagnosis, prognosis, and therapy of disease, and tissue regeneration and repair. Herein, the biosynthesis and physiological functions and current methods for separation and identification of EVs are summarized. Specifically, engineered EVs may be used to enhance targeted therapy in cancer and repair damaged tissues, and they may be developed as an individualized imaging diagnostic reagent, among other potential applications. We will focus on reviewing recent studies on engineered EVs in which alterations enhanced their therapeutic capability or diagnostic imaging potential via physical, chemical, and biological modification approaches. This review will clarify the superior biological functions and powerful therapeutic potential of EVs, particularly with regard to new designs based on EVs and their utilization in a new generation of nanomedicine diagnosis and treatment platforms.

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Additional file 1 of Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
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Additional file 9 of Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
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Additional file 7 of Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
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Additional file 2 of Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
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Additional file 5 of Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
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Additional file 3 of Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
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Additional file 1 of Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
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Additional file 8 of Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
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Additional file 4 of Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
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Helmy, S., Lunghi, G., Koutsioubas, A. G., Hall, S. A., Grava, M., Vondracek, H., Almásy, L., Bottyan, L., Rosenthal, M., Fazzari, M., et al. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.116258
MSC-Derived Small Extracellular Vesicles Alleviate Renal Fibrosis in Hyperuricemic Nephropathy via Suppression of Epithelial Mesenchymal Transition
You, B., Hu, H., Wei, J., Xu, Y., & Zhou, C. (2026) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-026-00849-7

Authors: Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H.
Affiliations: Jiangsu University (CN)
Affiliated Hospital of Jining Medical University (CN)
Corresponding author: Xu, Wenrong
Qian, Hui
ORCID: Wu, Peipei
Zhang, Bin
Ocansey, Dickson Kofi Wiredu
Xu, Wenrong
Qian, Hui
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2021-02
Volume: 269
Pages: 120467
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2020.120467
OpenAlex: W3096805091
Cited by: 368
References: 261
Citations by year: 2026: 38 · 2025: 51 · 2024: 72 · 2023: 87 · 2022: 74 · 2021: 44
FWCI: 5.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 367 d)
Locations: Biomaterials (acceptedVersion)
PubMed (publishedVersion)
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders: Jiangsu Provincial Key Research and Development Program
National Natural Science Foundation of China
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: extracellular vesicles, engineered extracellular vesicles, nanomedicine, targeted cancer therapy, tissue regeneration, diagnostic imaging, disease diagnosis and prognosis
MeSH terms: Extracellular Vesicles, Humans, Neoplasms, Nanomedicine

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Extracellular vesicles: A bright star of nanomedicine

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