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Extracellular vesicles: A bright star of nanomedicine
Open accessAbstract
Extracellular vesicles (EVs) have unique structural, compositional, and morphological characteristics as well as predominant physiochemical stability and biocompatibility properties. They play a crucial role in pathophysiological regulation, and also have broad prospects for clinical application in the diagnosis, prognosis, and therapy of disease, and tissue regeneration and repair. Herein, the biosynthesis and physiological functions and current methods for separation and identification of EVs are summarized. Specifically, engineered EVs may be used to enhance targeted therapy in cancer and repair damaged tissues, and they may be developed as an individualized imaging diagnostic reagent, among other potential applications. We will focus on reviewing recent studies on engineered EVs in which alterations enhanced their therapeutic capability or diagnostic imaging potential via physical, chemical, and biological modification approaches. This review will clarify the superior biological functions and powerful therapeutic potential of EVs, particularly with regard to new designs based on EVs and their utilization in a new generation of nanomedicine diagnosis and treatment platforms.
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“Exosomes have gained growing attention in mRNA delivery because of their good biocompatibility, low immunogenicity, small size, unique capacity to traverse physiological barriers, and cell-specific tropism.”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [16]
In the citing paper
“Exosomes have gained particular interest in the field of mRNA delivery due to their unique ability to cross physiological barriers, favorable biocompatibility, low toxicity, cell-specific tropism, and ability to evade the mononuclear phagocytic system [16, 17].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [16]
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Metadata
- Authors
- Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H.
- Affiliations
- Jiangsu University (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Corresponding author
- Xu, Wenrong
- Qian, Hui
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 269
- Pages
- 120467
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W3096805091
- Cited by
- 368
- References
- 261
- Citations by year
- 2026: 38 · 2025: 51 · 2024: 72 · 2023: 87 · 2022: 74 · 2021: 44
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomaterials (acceptedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- Jiangsu Provincial Key Research and Development Program
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- extracellular vesicles, engineered extracellular vesicles, nanomedicine, targeted cancer therapy, tissue regeneration, diagnostic imaging, disease diagnosis and prognosis
- MeSH terms
- Extracellular Vesicles, Humans, Neoplasms, Nanomedicine
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